2yab - Revision history

OCA at 08:11, 23 August 2023

OCA — Wed, 23 Aug 2023 08:11:24 GMT

←Older revision		Revision as of 08:11, 23 August 2023
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	<StructureSection load='2yab' size='340' side='right'caption='[[2yab]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2yab' size='340' side='right'caption='[[2yab]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yab]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YAB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yab]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YAB FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>~~, ~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2ya9\|2ya9]], [[2yaa\|2yaa]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yab OCA], [https://pdbe.org/2yab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yab RCSB], [https://www.ebi.ac.uk/pdbsum/2yab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yab ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yab OCA], [https://pdbe.org/2yab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yab RCSB], [https://www.ebi.ac.uk/pdbsum/2yab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yab ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DAPK2_MOUSE DAPK2_MOUSE]] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell deaths signal. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity).[UniProtKB:P53355][UniProtKB:Q9UIK4]	+	[https://www.uniprot.org/uniprot/DAPK2_MOUSE DAPK2_MOUSE] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell deaths signal. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity).[UniProtKB:P53355][UniProtKB:Q9UIK4]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice]]~~	+	[[Category: Mus musculus]]
-	~~[[Category: Non-specific serine/threonine protein kinase~~]]	+	[[Category: Kursula P]]
-	[[Category: Kursula, P]]	+	[[Category: Patel AK]]
-	[[Category: Patel~~, A K]]~~	+
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 15:02, 17 November 2021

OCA — Wed, 17 Nov 2021 15:02:39 GMT

←Older revision		Revision as of 15:02, 17 November 2021
Line 3:		Line 3:
	<StructureSection load='2yab' size='340' side='right'caption='[[2yab]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2yab' size='340' side='right'caption='[[2yab]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yab]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YAB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yab]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YAB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ya9\|2ya9]], [[2yaa\|2yaa]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ya9\|2ya9]], [[2yaa\|2yaa]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2yab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yab OCA], [~~http~~://pdbe.org/2yab PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2yab RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2yab PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2yab ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yab OCA], [https://pdbe.org/2yab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yab RCSB], [https://www.ebi.ac.uk/pdbsum/2yab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yab ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DAPK2_MOUSE DAPK2_MOUSE]] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell deaths signal. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity).[UniProtKB:P53355][UniProtKB:Q9UIK4]	+	[[https://www.uniprot.org/uniprot/DAPK2_MOUSE DAPK2_MOUSE]] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell deaths signal. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity).[UniProtKB:P53355][UniProtKB:Q9UIK4]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:04, 17 July 2019

OCA — Wed, 17 Jul 2019 11:04:10 GMT

←Older revision		Revision as of 11:04, 17 July 2019
Line 1:		Line 1:

	==Crystal structure of the autoinhibited form of mouse DAPK2 in complex with AMP==		==Crystal structure of the autoinhibited form of mouse DAPK2 in complex with AMP==
-	<StructureSection load='2yab' size='340' side='right' caption='[[2yab]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2yab' size='340' side='right'caption='[[2yab]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2yab]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YAB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2yab]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YAB FirstGlance]. <br>
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Death-associated protein kinase\|Death-associated protein kinase]]	+	*[[Death-associated protein kinase 3D structures\|Death-associated protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]

OCA at 15:54, 4 August 2016

OCA — Thu, 04 Aug 2016 15:54:53 GMT

←Older revision		Revision as of 15:54, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the autoinhibited form of mouse DAPK2 in complex with AMP==		==Crystal structure of the autoinhibited form of mouse DAPK2 in complex with AMP==
	<StructureSection load='2yab' size='340' side='right' caption='[[2yab]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2yab' size='340' side='right' caption='[[2yab]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ya9\|2ya9]], [[2yaa\|2yaa]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ya9\|2ya9]], [[2yaa\|2yaa]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yab OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yab RCSB], [http://www.ebi.ac.uk/pdbsum/2yab PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yab OCA], [http://pdbe.org/2yab PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yab RCSB], [http://www.ebi.ac.uk/pdbsum/2yab PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yab ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2yab" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 16:43, 24 December 2014

OCA — Wed, 24 Dec 2014 16:43:35 GMT

←Older revision		Revision as of 16:43, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2yab\| PDB=2yab \| SCENE= }}~~	+	==Crystal structure of the autoinhibited form of mouse DAPK2 in complex with AMP==
-	===Crystal structure of the autoinhibited form of mouse DAPK2 in complex with AMP===	+	<StructureSection load='2yab' size='340' side='right' caption='[[2yab]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21497605}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2yab]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YAB FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ya9\|2ya9]], [[2yaa\|2yaa]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yab OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yab RCSB], [http://www.ebi.ac.uk/pdbsum/2yab PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/DAPK2_MOUSE DAPK2_MOUSE]] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell deaths signal. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity).[UniProtKB:P53355][UniProtKB:Q9UIK4]		[[http://www.uniprot.org/uniprot/DAPK2_MOUSE DAPK2_MOUSE]] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell deaths signal. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity).[UniProtKB:P53355][UniProtKB:Q9UIK4]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The death-associated protein kinase (DAPK) family has been characterized as a group of pro-apoptotic serine/threonine kinases that share specific structural features in their catalytic kinase domain. Two of the DAPK family members, DAPK1 and DAPK2, are calmodulin-dependent protein kinases that are regulated by oligomerization, calmodulin binding, and autophosphorylation. In this study, we have determined the crystal and solution structures of murine DAPK2 in the presence of the autoinhibitory domain, with and without bound nucleotides in the active site. The crystal structure shows dimers of DAPK2 in a conformation that is not permissible for protein substrate binding. Two different conformations were seen in the active site upon the introduction of nucleotide ligands. The monomeric and dimeric forms of DAPK2 were further analyzed for solution structure, and the results indicate that the dimers of DAPK2 are indeed formed through the association of two apposed catalytic domains, as seen in the crystal structure. The structures can be further used to build a model for DAPK2 autophosphorylation and to compare with closely related kinases, of which especially DAPK1 is an actively studied drug target. Our structures also provide a model for both homodimerization and heterodimerization of the catalytic domain between members of the DAPK family. The fingerprint of the DAPK family, the basic loop, plays a central role in the dimerization of the kinase domain.

-	~~==About this~~ Structure==	+	Structure of the Dimeric Autoinhibited Conformation of DAPK2, a Pro-Apoptotic Protein Kinase.,Patel AK, Yadav RP, Majava V, Kursula I, Kursula P J Mol Biol. 2011 Apr 8. PMID:21497605<ref>PMID:21497605</ref>
-	~~[[2yab]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2YAB OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Death-associated protein kinase\|Death-associated protein kinase]]		*[[Death-associated protein kinase\|Death-associated protein kinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021497605</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
-	[[Category: Kursula, P.]]	+	[[Category: Kursula, P]]
-	[[Category: Patel, A K.]]	+	[[Category: Patel, A K]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:01, 15 January 2014

OCA — Wed, 15 Jan 2014 07:01:46 GMT

←Older revision		Revision as of 07:01, 15 January 2014
Line 1:		Line 1:
-	[[Image:2yab.png\|left\|200px]]
-
	{{STRUCTURE_2yab\| PDB=2yab \| SCENE= }}		{{STRUCTURE_2yab\| PDB=2yab \| SCENE= }}
		+	===Crystal structure of the autoinhibited form of mouse DAPK2 in complex with AMP===
		+	{{ABSTRACT_PUBMED_21497605}}

-	===~~CRYSTAL STRUCTURE OF THE AUTOINHIBITED FORM OF MOUSE DAPK2 IN COMPLEX WITH AMP~~===	+	==Function==
-		+	[[http://www.uniprot.org/uniprot/DAPK2_MOUSE DAPK2_MOUSE]] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell deaths signal. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity).[UniProtKB:P53355][UniProtKB:Q9UIK4]
-	~~{{ABSTRACT_PUBMED_21497605}}~~	+

	==About this Structure==		==About this Structure==
-	[[2yab]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAB OCA].	+	[[2yab]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAB OCA].

	==See Also==		==See Also==
Line 14:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021497605</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021497605</ref><references group="xtra"/><references/>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Kursula, P.]]		[[Category: Kursula, P.]]

OCA at 07:14, 20 October 2012

OCA — Sat, 20 Oct 2012 07:14:25 GMT

←Older revision		Revision as of 07:14, 20 October 2012
Line 1:		Line 1:
	[[Image:2yab.png\|left\|200px]]		[[Image:2yab.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2yab", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2yab\| PDB=2yab \| SCENE= }}		{{STRUCTURE_2yab\| PDB=2yab \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE AUTOINHIBITED FORM OF MOUSE DAPK2 IN COMPLEX WITH AMP===		===CRYSTAL STRUCTURE OF THE AUTOINHIBITED FORM OF MOUSE DAPK2 IN COMPLEX WITH AMP===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21497605}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21497605 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21497605}}		{{ABSTRACT_PUBMED_21497605}}

	==About this Structure==		==About this Structure==
	[[2yab]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAB OCA].		[[2yab]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAB OCA].
		+
		+	==See Also==
		+	*[[Death-associated protein kinase\|Death-associated protein kinase]]

	==Reference==		==Reference==
Line 27:		Line 19:
	[[Category: Kursula, P.]]		[[Category: Kursula, P.]]
	[[Category: Patel, A K.]]		[[Category: Patel, A K.]]
		+	[[Category: Apoptosis]]
		+	[[Category: Transferase]]

OCA at 05:32, 18 May 2011

OCA — Wed, 18 May 2011 05:32:56 GMT

←Older revision		Revision as of 05:32, 18 May 2011
Line 1:		Line 1:
-	[[Image:2yab.~~jpg~~\|left\|200px]]	+	[[Image:2yab.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===CRYSTAL STRUCTURE OF THE AUTOINHIBITED FORM OF MOUSE DAPK2 IN COMPLEX WITH AMP===		===CRYSTAL STRUCTURE OF THE AUTOINHIBITED FORM OF MOUSE DAPK2 IN COMPLEX WITH AMP===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21497605}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21497605 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21497605}}

	==About this Structure==		==About this Structure==
	[[2yab]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAB OCA].		[[2yab]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAB OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021497605</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Kursula, P.]]		[[Category: Kursula, P.]]
	[[Category: Patel, A K.]]		[[Category: Patel, A K.]]

OCA at 05:20, 13 April 2011

OCA — Wed, 13 Apr 2011 05:20:08 GMT

←Older revision		Revision as of 05:20, 13 April 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2yab.jpg\|left\|200px]]

-	The ~~entry 2yab~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2yab", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2yab\| PDB=2yab \| SCENE= }}

-	~~Authors: Patel, A.K., Kursula, P.~~	+	===CRYSTAL STRUCTURE OF THE AUTOINHIBITED FORM OF MOUSE DAPK2 IN COMPLEX WITH AMP===

-	~~Description: Crystal~~ structure ~~of the autoinhibited form of mouse DAPK2 in complex~~ with ~~AMP~~	+
		+	==About this Structure==
		+	[[2yab]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAB OCA].
		+	[[Category: Mus musculus]]
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Kursula, P.]]
		+	[[Category: Patel, A K.]]

OCA at 07:35, 30 March 2011

OCA — Wed, 30 Mar 2011 07:35:51 GMT

←Older revision		Revision as of 07:35, 30 March 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2yab is ON HOLD	+	The entry 2yab is ON HOLD until Paper Publication

	Authors: Patel, A.K., Kursula, P.		Authors: Patel, A.K., Kursula, P.

	Description: Crystal structure of the autoinhibited form of mouse DAPK2 in complex with AMP		Description: Crystal structure of the autoinhibited form of mouse DAPK2 in complex with AMP