2ybo - Revision history

OCA at 10:49, 20 December 2023

OCA — Wed, 20 Dec 2023 10:49:14 GMT

←Older revision		Revision as of 10:49, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2ybo' size='340' side='right'caption='[[2ybo]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2ybo' size='340' side='right'caption='[[2ybo]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ybo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YBO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ybo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YBO FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SAH:S~~-~~ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2ybq\|2ybq]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Uroporphyrinogen~~-~~III_C~~-~~methyltransferase Uroporphyrinogen~~-~~III C-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.107 2.1.1.107]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ybo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ybo OCA], [https://pdbe.org/2ybo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ybo RCSB], [https://www.ebi.ac.uk/pdbsum/2ybo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ybo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ybo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ybo OCA], [https://pdbe.org/2ybo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ybo RCSB], [https://www.ebi.ac.uk/pdbsum/2ybo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ybo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/P95417_PSEAI P95417_PSEAI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pseae]]~~	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	~~[[Category: Uroporphyrinogen-III C-methyltransferase~~]]	+	[[Category: Heinz DW]]
-	[[Category: Heinz~~, D W~~]]	+	[[Category: Klink BU]]
-	[[Category: Klink~~, B U~~]]	+	[[Category: Krausze J]]
-	[[Category: Krausze, J]]	+	[[Category: Layer G]]
-	[[Category: Layer, G]]	+	[[Category: Saha S]]
-	[[Category: Saha, S]]	+	[[Category: Storbeck S]]
-	[[Category: Storbeck, S]]	+
-	~~[[Category: Heme d1 biosynthesis]]~~	+
-	~~[[Category: Nire]]~~	+
-	~~[[Category: Sumt]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 12:26, 27 April 2022

OCA — Wed, 27 Apr 2022 12:26:17 GMT

←Older revision		Revision as of 12:26, 27 April 2022
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	<StructureSection load='2ybo' size='340' side='right'caption='[[2ybo]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2ybo' size='340' side='right'caption='[[2ybo]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ybo]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2YBO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ybo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YBO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ybq\|2ybq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ybq\|2ybq]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Uroporphyrinogen-III_C-methyltransferase Uroporphyrinogen-III C-methyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.107 2.1.1.107] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Uroporphyrinogen-III_C-methyltransferase Uroporphyrinogen-III C-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.107 2.1.1.107] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2ybo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ybo OCA], [~~http~~://pdbe.org/2ybo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ybo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ybo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ybo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ybo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ybo OCA], [https://pdbe.org/2ybo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ybo RCSB], [https://www.ebi.ac.uk/pdbsum/2ybo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ybo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:42, 22 July 2020

OCA — Wed, 22 Jul 2020 12:42:53 GMT

←Older revision		Revision as of 12:42, 22 July 2020
Line 1:		Line 1:

	==The x-ray structure of the SAM-dependent uroporphyrinogen III methyltransferase NirE from Pseudomonas aeruginosa in complex with SAH==		==The x-ray structure of the SAM-dependent uroporphyrinogen III methyltransferase NirE from Pseudomonas aeruginosa in complex with SAH==
-	<StructureSection load='2ybo' size='340' side='right' caption='[[2ybo]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2ybo' size='340' side='right'caption='[[2ybo]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ybo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBO OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YBO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ybo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YBO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ybq\|2ybq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ybq\|2ybq]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uroporphyrinogen-III_C-methyltransferase Uroporphyrinogen-III C-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.107 2.1.1.107] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uroporphyrinogen-III_C-methyltransferase Uroporphyrinogen-III C-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.107 2.1.1.107] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ybo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ybo OCA], [http://pdbe.org/2ybo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ybo RCSB], [http://www.ebi.ac.uk/pdbsum/2ybo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ybo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2ybo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ybo OCA], [http://pdbe.org/2ybo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ybo RCSB], [http://www.ebi.ac.uk/pdbsum/2ybo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ybo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[SAM-dependent ~~methyltransferase~~\|SAM-dependent ~~methyltransferase~~]]	+	*[[SAM-dependent methyltrasferase 3D structures\|SAM-dependent methyltrasferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pseae]]		[[Category: Pseae]]
	[[Category: Uroporphyrinogen-III C-methyltransferase]]		[[Category: Uroporphyrinogen-III C-methyltransferase]]

OCA at 09:25, 10 October 2018

OCA — Wed, 10 Oct 2018 09:25:46 GMT

←Older revision		Revision as of 09:25, 10 October 2018
Line 1:		Line 1:

-	==~~THE X~~-~~RAY STRUCTURE OF THE~~ SAM-~~DEPENDENT UROPORPHYRINOGEN~~ III ~~METHYLTRANSFERASE NIRE FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH~~ SAH==	+	==The x-ray structure of the SAM-dependent uroporphyrinogen III methyltransferase NirE from Pseudomonas aeruginosa in complex with SAH==
	<StructureSection load='2ybo' size='340' side='right' caption='[[2ybo]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2ybo' size='340' side='right' caption='[[2ybo]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 2ybo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2ybo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[SAM-dependent methyltransferase\|SAM-dependent methyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:06, 5 August 2016

OCA — Fri, 05 Aug 2016 23:06:10 GMT

←Older revision		Revision as of 23:06, 5 August 2016
Line 1:		Line 1:
		+
	==THE X-RAY STRUCTURE OF THE SAM-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE NIRE FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH SAH==		==THE X-RAY STRUCTURE OF THE SAM-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE NIRE FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH SAH==
	<StructureSection load='2ybo' size='340' side='right' caption='[[2ybo]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2ybo' size='340' side='right' caption='[[2ybo]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ybo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_aeruginosa Pseudomonas aeruginosa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YBO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ybo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YBO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ybq\|2ybq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ybq\|2ybq]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uroporphyrinogen-III_C-methyltransferase Uroporphyrinogen-III C-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.107 2.1.1.107] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uroporphyrinogen-III_C-methyltransferase Uroporphyrinogen-III C-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.107 2.1.1.107] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ybo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ybo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ybo RCSB], [http://www.ebi.ac.uk/pdbsum/2ybo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ybo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ybo OCA], [http://pdbe.org/2ybo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ybo RCSB], [http://www.ebi.ac.uk/pdbsum/2ybo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ybo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ybo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pseudomonas aeruginosa~~]]	+	[[Category: Pseae]]
	[[Category: Uroporphyrinogen-III C-methyltransferase]]		[[Category: Uroporphyrinogen-III C-methyltransferase]]
	[[Category: Heinz, D W]]		[[Category: Heinz, D W]]

OCA at 23:10, 3 January 2015

OCA — Sat, 03 Jan 2015 23:10:48 GMT

←Older revision		Revision as of 23:10, 3 January 2015
Line 2:		Line 2:
	<StructureSection load='2ybo' size='340' side='right' caption='[[2ybo]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2ybo' size='340' side='right' caption='[[2ybo]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ybo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBO OCA]. <br>	+	<table><tr><td colspan='2'>[[2ybo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YBO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ybq\|2ybq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ybq\|2ybq]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Glucokinase Glucokinase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uroporphyrinogen-III_C-methyltransferase Uroporphyrinogen-III C-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.107 2.1.1.107] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ybo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ybo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ybo RCSB], [http://www.ebi.ac.uk/pdbsum/2ybo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ybo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ybo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ybo RCSB], [http://www.ebi.ac.uk/pdbsum/2ybo PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 14:
	Crystal structure of the heme d1 biosynthesis enzyme NirE in complex with its substrate reveals new insights into the catalytic mechanism of S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferases.,Storbeck S, Saha S, Krausze J, Klink BU, Heinz DW, Layer G J Biol Chem. 2011 Jul 29;286(30):26754-67. Epub 2011 May 31. PMID:21632530<ref>PMID:21632530</ref>		Crystal structure of the heme d1 biosynthesis enzyme NirE in complex with its substrate reveals new insights into the catalytic mechanism of S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferases.,Storbeck S, Saha S, Krausze J, Klink BU, Heinz DW, Layer G J Biol Chem. 2011 Jul 29;286(30):26754-67. Epub 2011 May 31. PMID:21632530<ref>PMID:21632530</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 22:		Line 22:
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: Uroporphyrinogen-III C-methyltransferase]]		[[Category: Uroporphyrinogen-III C-methyltransferase]]
-	[[Category: Heinz, D W.]]	+	[[Category: Heinz, D W]]
-	[[Category: Klink, B U.]]	+	[[Category: Klink, B U]]
-	[[Category: Krausze, J.]]	+	[[Category: Krausze, J]]
-	[[Category: Layer, G.]]	+	[[Category: Layer, G]]
-	[[Category: Saha, S.]]	+	[[Category: Saha, S]]
-	[[Category: Storbeck, S.]]	+	[[Category: Storbeck, S]]
	[[Category: Heme d1 biosynthesis]]		[[Category: Heme d1 biosynthesis]]
	[[Category: Nire]]		[[Category: Nire]]
	[[Category: Sumt]]		[[Category: Sumt]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:44, 14 May 2014

OCA — Wed, 14 May 2014 07:44:54 GMT

←Older revision		Revision as of 07:44, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2ybo.~~png~~\|~~left~~\|~~200px~~]]	+	==THE X-RAY STRUCTURE OF THE SAM-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE NIRE FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH SAH==
		+	<StructureSection load='2ybo' size='340' side='right' caption='[[2ybo]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ybo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBO OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ybq\|2ybq]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ybo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ybo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ybo RCSB], [http://www.ebi.ac.uk/pdbsum/2ybo PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	During the biosynthesis of heme d(1), the essential cofactor of cytochrome cd(1) nitrite reductase, the NirE protein catalyzes the methylation of uroporphyrinogen III to precorrin-2 using S-adenosyl-L-methionine (SAM) as the methyl group donor. The crystal structure of Pseudomonas aeruginosa NirE in complex with its substrate uroporphyrinogen III and the reaction by-product S-adenosyl-L-homocysteine (SAH) was solved to 2.0 A resolution. This represents the first enzyme-substrate complex structure for a SAM-dependent uroporphyrinogen III methyltransferase. The large substrate binds on top of the SAH in a "puckered" conformation in which the two pyrrole rings facing each other point into the same direction either upward or downward. Three arginine residues, a histidine, and a methionine are involved in the coordination of uroporphyrinogen III. Through site-directed mutagenesis of the nirE gene and biochemical characterization of the corresponding NirE variants the amino acid residues Arg-111, Glu-114, and Arg-149 were identified to be involved in NirE catalysis. Based on our structural and biochemical findings, we propose a potential catalytic mechanism for NirE in which the methyl transfer reaction is initiated by an arginine catalyzed proton abstraction from the C-20 position of the substrate.

-	<!--	+	Crystal structure of the heme d1 biosynthesis enzyme NirE in complex with its substrate reveals new insights into the catalytic mechanism of S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferases.,Storbeck S, Saha S, Krausze J, Klink BU, Heinz DW, Layer G J Biol Chem. 2011 Jul 29;286(30):26754-67. Epub 2011 May 31. PMID:21632530<ref>PMID:21632530</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2ybo"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2ybo\| PDB=2ybo \| SCENE= }}~~	+

-	~~===THE X-RAY STRUCTURE OF THE SAM-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE NIRE FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH SAH===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21632530}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21632530 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21632530}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2ybo]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBO OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021632530<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: Uroporphyrinogen-III C-methyltransferase]]		[[Category: Uroporphyrinogen-III C-methyltransferase]]

OCA at 04:57, 28 September 2011

OCA — Wed, 28 Sep 2011 04:57:56 GMT

←Older revision		Revision as of 04:57, 28 September 2011
Line 1:		Line 1:
-	[[Image:2ybo.~~jpg~~\|left\|200px]]	+	[[Image:2ybo.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===THE X-RAY STRUCTURE OF THE SAM-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE NIRE FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH SAH===		===THE X-RAY STRUCTURE OF THE SAM-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE NIRE FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH SAH===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21632530}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21632530 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21632530}}

	==About this Structure==		==About this Structure==
	[[2ybo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBO OCA].		[[2ybo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBO OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021632530</ref><references group="xtra"/>
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: Uroporphyrinogen-III C-methyltransferase]]		[[Category: Uroporphyrinogen-III C-methyltransferase]]
Line 22:		Line 31:
	[[Category: Saha, S.]]		[[Category: Saha, S.]]
	[[Category: Storbeck, S.]]		[[Category: Storbeck, S.]]
		+	[[Category: Heme d1 biosynthesis]]
		+	[[Category: Nire]]
		+	[[Category: Sumt]]
		+	[[Category: Transferase]]

OCA at 05:50, 1 June 2011

OCA — Wed, 01 Jun 2011 05:50:02 GMT

←Older revision		Revision as of 05:50, 1 June 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2ybo.jpg\|left\|200px]]

-	The ~~entry 2ybo~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2ybo", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2ybo\| PDB=2ybo \| SCENE= }}

-	~~Authors: Storbeck, S., Saha, S., Krausze, J., Klink, B.U., Heinz, D.W., Layer, G.~~	+	===THE X-RAY STRUCTURE OF THE SAM-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE NIRE FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH SAH===

-	~~Description~~: ~~The x~~-~~ray structure of the SAM~~-~~dependent uroporphyrinogen~~ III methyltransferase ~~NirE from Pseudomonas aeruginosa in complex with SAH~~	+
		+	==About this Structure==
		+	[[2ybo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBO OCA].
		+	[[Category: Pseudomonas aeruginosa]]
		+	[[Category: Uroporphyrinogen-III C-methyltransferase]]
		+	[[Category: Heinz, D W.]]
		+	[[Category: Klink, B U.]]
		+	[[Category: Krausze, J.]]
		+	[[Category: Layer, G.]]
		+	[[Category: Saha, S.]]
		+	[[Category: Storbeck, S.]]

OCA at 06:34, 23 March 2011

OCA — Wed, 23 Mar 2011 06:34:24 GMT

←Older revision		Revision as of 06:34, 23 March 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2ybo is ON HOLD	+	The entry 2ybo is ON HOLD until Paper Publication

	Authors: Storbeck, S., Saha, S., Krausze, J., Klink, B.U., Heinz, D.W., Layer, G.		Authors: Storbeck, S., Saha, S., Krausze, J., Klink, B.U., Heinz, D.W., Layer, G.

	Description: The x-ray structure of the SAM-dependent uroporphyrinogen III methyltransferase NirE from Pseudomonas aeruginosa in complex with SAH		Description: The x-ray structure of the SAM-dependent uroporphyrinogen III methyltransferase NirE from Pseudomonas aeruginosa in complex with SAH