2yci - Revision history

OCA at 14:03, 1 February 2024

OCA — Thu, 01 Feb 2024 14:03:32 GMT

←Older revision		Revision as of 14:03, 1 February 2024
Line 3:		Line 3:
	<StructureSection load='2yci' size='340' side='right'caption='[[2yci]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='2yci' size='340' side='right'caption='[[2yci]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yci]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Carhz Carhz~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YCI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yci]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Carboxydothermus_hydrogenoformans_Z-2901 Carboxydothermus hydrogenoformans Z-2901]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YCI FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.78Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2yck\|2yck]], [[2ycj\|2ycj]], [[2ycl\|2ycl]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yci OCA], [https://pdbe.org/2yci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yci RCSB], [https://www.ebi.ac.uk/pdbsum/2yci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yci ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yci OCA], [https://pdbe.org/2yci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yci RCSB], [https://www.ebi.ac.uk/pdbsum/2yci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yci ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q3ACR9_CARHZ Q3ACR9_CARHZ]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Carhz~~]]	+	[[Category: Carboxydothermus hydrogenoformans Z-2901]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dobbek, H]]	+	[[Category: Dobbek H]]
-	[[Category: Goetzl, S]]	+	[[Category: Goetzl S]]
-	[[Category: Hennig~~, S E~~]]	+	[[Category: Hennig SE]]
-	[[Category: Jeoung~~, J H]]~~	+	[[Category: Jeoung JH]]
-	~~[[Category: Transferase~~]]	+

OCA at 12:26, 27 April 2022

OCA — Wed, 27 Apr 2022 12:26:44 GMT

←Older revision		Revision as of 12:26, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2yci' size='340' side='right'caption='[[2yci]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='2yci' size='340' side='right'caption='[[2yci]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yci]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Carhz Carhz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YCI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2YCI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yci]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Carhz Carhz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YCI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yck\|2yck]], [[2ycj\|2ycj]], [[2ycl\|2ycl]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yck\|2yck]], [[2ycj\|2ycj]], [[2ycl\|2ycl]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2yci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yci OCA], [~~http~~://pdbe.org/2yci PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2yci RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2yci PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2yci ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yci OCA], [https://pdbe.org/2yci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yci RCSB], [https://www.ebi.ac.uk/pdbsum/2yci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yci ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:43, 22 July 2020

OCA — Wed, 22 Jul 2020 12:43:57 GMT

←Older revision		Revision as of 12:43, 22 July 2020
Line 1:		Line 1:

	==methyltransferase native==		==methyltransferase native==
-	<StructureSection load='2yci' size='340' side='right' caption='[[2yci]], [[Resolution\|resolution]] 1.78Å' scene=''>	+	<StructureSection load='2yci' size='340' side='right'caption='[[2yci]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yci]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Carhz Carhz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YCI OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YCI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yci]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Carhz Carhz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YCI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YCI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yck\|2yck]], [[2ycj\|2ycj]], [[2ycl\|2ycl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yck\|2yck]], [[2ycj\|2ycj]], [[2ycl\|2ycl]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2yci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yci OCA], [http://pdbe.org/2yci PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yci RCSB], [http://www.ebi.ac.uk/pdbsum/2yci PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yci ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yci OCA], [http://pdbe.org/2yci PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yci RCSB], [http://www.ebi.ac.uk/pdbsum/2yci PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yci ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Carhz]]		[[Category: Carhz]]
		+	[[Category: Large Structures]]
	[[Category: Dobbek, H]]		[[Category: Dobbek, H]]
	[[Category: Goetzl, S]]		[[Category: Goetzl, S]]

OCA at 08:51, 10 October 2018

OCA — Wed, 10 Oct 2018 08:51:14 GMT

←Older revision		Revision as of 08:51, 10 October 2018
Line 1:		Line 1:

-	==~~METHYLTRANSFERASE NATIVE~~==	+	==methyltransferase native==
	<StructureSection load='2yci' size='340' side='right' caption='[[2yci]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='2yci' size='340' side='right' caption='[[2yci]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 19:05, 4 August 2016

OCA — Thu, 04 Aug 2016 19:05:30 GMT

←Older revision		Revision as of 19:05, 4 August 2016
Line 1:		Line 1:
		+
	==METHYLTRANSFERASE NATIVE==		==METHYLTRANSFERASE NATIVE==
	<StructureSection load='2yci' size='340' side='right' caption='[[2yci]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='2yci' size='340' side='right' caption='[[2yci]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yci]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Carboxydothermus_hydrogenoformans Carboxydothermus hydrogenoformans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YCI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yci]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Carhz Carhz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YCI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yck\|2yck]], [[2ycj\|2ycj]], [[2ycl\|2ycl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yck\|2yck]], [[2ycj\|2ycj]], [[2ycl\|2ycl]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yci OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yci RCSB], [http://www.ebi.ac.uk/pdbsum/2yci PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yci OCA], [http://pdbe.org/2yci PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yci RCSB], [http://www.ebi.ac.uk/pdbsum/2yci PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yci ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2yci" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Carboxydothermus hydrogenoformans~~]]	+	[[Category: Carhz]]
	[[Category: Dobbek, H]]		[[Category: Dobbek, H]]
	[[Category: Goetzl, S]]		[[Category: Goetzl, S]]

OCA at 21:10, 3 January 2015

OCA — Sat, 03 Jan 2015 21:10:03 GMT

←Older revision		Revision as of 21:10, 3 January 2015
Line 2:		Line 2:
	<StructureSection load='2yci' size='340' side='right' caption='[[2yci]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='2yci' size='340' side='right' caption='[[2yci]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yci]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Carboxydothermus_hydrogenoformans Carboxydothermus hydrogenoformans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YCI OCA]. <br>	+	<table><tr><td colspan='2'>[[2yci]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Carboxydothermus_hydrogenoformans Carboxydothermus hydrogenoformans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YCI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yck\|2yck]], [[2ycj\|2ycj]], [[2ycl\|2ycl]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yck\|2yck]], [[2ycj\|2ycj]], [[2ycl\|2ycl]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yci OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yci RCSB], [http://www.ebi.ac.uk/pdbsum/2yci PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yci OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yci RCSB], [http://www.ebi.ac.uk/pdbsum/2yci PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 13:
	Structural Basis for Electron and Methyl-Group Transfer in a Methyltransferase System Operating in the Reductive Acetyl-CoA Pathway.,Goetzl S, Jeoung JH, Hennig SE, Dobbek H J Mol Biol. 2011 Aug 5;411(1):96-109. Epub 2011 May 27. PMID:21640123<ref>PMID:21640123</ref>		Structural Basis for Electron and Methyl-Group Transfer in a Methyltransferase System Operating in the Reductive Acetyl-CoA Pathway.,Goetzl S, Jeoung JH, Hennig SE, Dobbek H J Mol Biol. 2011 Aug 5;411(1):96-109. Epub 2011 May 27. PMID:21640123<ref>PMID:21640123</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Carboxydothermus hydrogenoformans]]		[[Category: Carboxydothermus hydrogenoformans]]
-	[[Category: Dobbek, H.]]	+	[[Category: Dobbek, H]]
-	[[Category: Goetzl, S.]]	+	[[Category: Goetzl, S]]
-	[[Category: Hennig, S E.]]	+	[[Category: Hennig, S E]]
-	[[Category: Jeoung, J H.]]	+	[[Category: Jeoung, J H]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:40, 14 May 2014

OCA — Wed, 14 May 2014 07:40:39 GMT

←Older revision		Revision as of 07:40, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2yci.~~png~~\|~~left~~\|~~200px~~]]	+	==METHYLTRANSFERASE NATIVE==
		+	<StructureSection load='2yci' size='340' side='right' caption='[[2yci]], [[Resolution\|resolution]] 1.78Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2yci]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Carboxydothermus_hydrogenoformans Carboxydothermus hydrogenoformans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YCI OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yck\|2yck]], [[2ycj\|2ycj]], [[2ycl\|2ycl]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yci OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yci RCSB], [http://www.ebi.ac.uk/pdbsum/2yci PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Several anaerobic acetogenic, methanogenic, hydrogenogenic, and sulfate-reducing microorganisms are able to use the reductive acetyl-CoA (Wood-Ljungdahl) pathway to convert CO(2) into biomass. The reductive acetyl-CoA pathway consists of two branches connected by the Co/Fe-containing corrinoid iron-sulfur protein (CoFeSP), which transfers a methyl group from a methyltransferase (MeTr)/methyltetrahydrofolate (CH(3)-H(4) folate) complex to the reduced Ni-Ni-[4Fe-4S] cluster (cluster A) of acetyl-CoA synthase. We investigated the CoFeSP and MeTr couple of the hydrogenogenic bacterium Carboxydothermus hydrogenoformans and show that the two proteins are able to catalyze the methyl-group transfer reaction from CH(3)-H(4) folate to the Co(I) center of CoFeSP. We determined the crystal structures of both proteins. The structure of CoFeSP includes the previously unresolved N-terminal domain of the large subunit of CoFeSP, revealing a unique four-helix-bundle-like architecture in which a [4Fe-4S] cluster is shielded by hydrophobic amino acids. It further reveals that the corrinoid and the [4Fe-4S] cluster binding domains are mobile, which is mandatory for the postulated electron transfer between them. Furthermore, we solved the crystal structures of apo-MeTr, CH(3)-H(4)-folate-bound MeTr, and H(4)-folate-bound MeTr, revealing a substrate-induced closure of the CH(3)-H(4) folate binding cavity of MeTr. We observed three different conformations of Asn200 depending on the substrate bound in the active site, demonstrating its conformational modulation by hydrogen-bonding interactions with the substrate. The observed flexibility could be essential to stabilize the transition state during methyl-group transfer. The conformational space and role of Asn200 are likely conserved in homologous cobalamin-dependent MeTrs such as methionine synthase.

-	<!--	+	Structural Basis for Electron and Methyl-Group Transfer in a Methyltransferase System Operating in the Reductive Acetyl-CoA Pathway.,Goetzl S, Jeoung JH, Hennig SE, Dobbek H J Mol Biol. 2011 Aug 5;411(1):96-109. Epub 2011 May 27. PMID:21640123<ref>PMID:21640123</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2yci"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2yci\| PDB=2yci \| SCENE= }}~~	+

-	~~===METHYLTRANSFERASE NATIVE===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21640123}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21640123 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21640123}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2yci]] is a 1 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Carboxydothermus_hydrogenoformans Carboxydothermus hydrogenoformans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YCI OCA].	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021640123<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Carboxydothermus hydrogenoformans]]		[[Category: Carboxydothermus hydrogenoformans]]
	[[Category: Dobbek, H.]]		[[Category: Dobbek, H.]]

OCA at 07:53, 3 August 2011

OCA — Wed, 03 Aug 2011 07:53:02 GMT

←Older revision		Revision as of 07:53, 3 August 2011
Line 1:		Line 1:
-	[[Image:2yci.~~jpg~~\|left\|200px]]	+	[[Image:2yci.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===METHYLTRANSFERASE NATIVE===		===METHYLTRANSFERASE NATIVE===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21640123}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21640123 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21640123}}

	==About this Structure==		==About this Structure==
	[[2yci]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Carboxydothermus_hydrogenoformans Carboxydothermus hydrogenoformans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YCI OCA].		[[2yci]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Carboxydothermus_hydrogenoformans Carboxydothermus hydrogenoformans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YCI OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021640123</ref><references group="xtra"/>
	[[Category: Carboxydothermus hydrogenoformans]]		[[Category: Carboxydothermus hydrogenoformans]]
	[[Category: Dobbek, H.]]		[[Category: Dobbek, H.]]
Line 19:		Line 28:
	[[Category: Hennig, S E.]]		[[Category: Hennig, S E.]]
	[[Category: Jeoung, J H.]]		[[Category: Jeoung, J H.]]
		+	[[Category: Transferase]]

OCA at 05:15, 8 June 2011

OCA — Wed, 08 Jun 2011 05:15:28 GMT

←Older revision		Revision as of 05:15, 8 June 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2yci.jpg\|left\|200px]]

-	The ~~entry 2yci~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2yci", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2yci\| PDB=2yci \| SCENE= }}

-	~~Authors: Goetzl, S., Jeoung, J.H., Hennig, S.E., Dobbek, H.~~	+	===METHYLTRANSFERASE NATIVE===

-	~~Description~~: ~~methyltransferase native~~	+
		+	==About this Structure==
		+	[[2yci]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Carboxydothermus_hydrogenoformans Carboxydothermus hydrogenoformans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YCI OCA].
		+	[[Category: Carboxydothermus hydrogenoformans]]
		+	[[Category: Dobbek, H.]]
		+	[[Category: Goetzl, S.]]
		+	[[Category: Hennig, S E.]]
		+	[[Category: Jeoung, J H.]]

OCA at 04:54, 25 May 2011

OCA — Wed, 25 May 2011 04:54:41 GMT

←Older revision		Revision as of 04:54, 25 May 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2yci is ON HOLD	+	The entry 2yci is ON HOLD until Paper Publication

	Authors: Goetzl, S., Jeoung, J.H., Hennig, S.E., Dobbek, H.		Authors: Goetzl, S., Jeoung, J.H., Hennig, S.E., Dobbek, H.

	Description: methyltransferase native		Description: methyltransferase native