2yd6 - Revision history

OCA at 10:50, 20 December 2023

OCA — Wed, 20 Dec 2023 10:50:12 GMT

←Older revision		Revision as of 10:50, 20 December 2023
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	<StructureSection load='2yd6' size='340' side='right'caption='[[2yd6]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='2yd6' size='340' side='right'caption='[[2yd6]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yd6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YD6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yd6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YD6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.35Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2yd7\|2yd7]], [[2yd1\|2yd1]], [[2yd8\|2yd8]], [[2yd5\|2yd5]], [[2yd2\|2yd2]], [[2yd4\|2yd4]], [[2yd9\|2yd9]], [[2yd3\|2yd3]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yd6 OCA], [https://pdbe.org/2yd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yd6 RCSB], [https://www.ebi.ac.uk/pdbsum/2yd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yd6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yd6 OCA], [https://pdbe.org/2yd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yd6 RCSB], [https://www.ebi.ac.uk/pdbsum/2yd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yd6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PTPRD_HUMAN PTPRD_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Protein-tyrosine-phosphatase]]~~	+	[[Category: Aricescu AR]]
-	[[Category: Aricescu~~, A R~~]]	+	[[Category: Coles CH]]
-	[[Category: Coles~~, C H~~]]	+	[[Category: Flanagan JG]]
-	[[Category: Flanagan~~, J G~~]]	+	[[Category: Gallagher JT]]
-	[[Category: Gallagher~~, J T~~]]	+	[[Category: Jones EY]]
-	[[Category: Jones~~, E Y~~]]	+	[[Category: Lu W]]
-	[[Category: Lu, W]]	+	[[Category: Shen Y]]
-	[[Category: Shen, Y]]	+	[[Category: Siebold C]]
-	[[Category: Siebold, C]]	+	[[Category: Sutton GC]]
-	[[Category: Sutton~~, G C~~]]	+	[[Category: Tenney AP]]
-	[[Category: Tenney~~, A P]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 12:27, 27 April 2022

OCA — Wed, 27 Apr 2022 12:27:08 GMT

←Older revision		Revision as of 12:27, 27 April 2022
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	<StructureSection load='2yd6' size='340' side='right'caption='[[2yd6]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='2yd6' size='340' side='right'caption='[[2yd6]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yd6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YD6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2YD6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yd6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YD6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yd7\|2yd7]], [[2yd1\|2yd1]], [[2yd8\|2yd8]], [[2yd5\|2yd5]], [[2yd2\|2yd2]], [[2yd4\|2yd4]], [[2yd9\|2yd9]], [[2yd3\|2yd3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yd7\|2yd7]], [[2yd1\|2yd1]], [[2yd8\|2yd8]], [[2yd5\|2yd5]], [[2yd2\|2yd2]], [[2yd4\|2yd4]], [[2yd9\|2yd9]], [[2yd3\|2yd3]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2yd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yd6 OCA], [~~http~~://pdbe.org/2yd6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2yd6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2yd6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2yd6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yd6 OCA], [https://pdbe.org/2yd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yd6 RCSB], [https://www.ebi.ac.uk/pdbsum/2yd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yd6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:44, 22 July 2020

OCA — Wed, 22 Jul 2020 12:44:56 GMT

←Older revision		Revision as of 12:44, 22 July 2020
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	==Crystal structure of the N-terminal Ig1-2 module of Human Receptor Protein Tyrosine Phosphatase Delta==		==Crystal structure of the N-terminal Ig1-2 module of Human Receptor Protein Tyrosine Phosphatase Delta==
-	<StructureSection load='2yd6' size='340' side='right' caption='[[2yd6]], [[Resolution\|resolution]] 1.35Å' scene=''>	+	<StructureSection load='2yd6' size='340' side='right'caption='[[2yd6]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yd6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YD6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YD6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yd6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YD6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YD6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yd7\|2yd7]], [[2yd1\|2yd1]], [[2yd8\|2yd8]], [[2yd5\|2yd5]], [[2yd2\|2yd2]], [[2yd4\|2yd4]], [[2yd9\|2yd9]], [[2yd3\|2yd3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yd7\|2yd7]], [[2yd1\|2yd1]], [[2yd8\|2yd8]], [[2yd5\|2yd5]], [[2yd2\|2yd2]], [[2yd4\|2yd4]], [[2yd9\|2yd9]], [[2yd3\|2yd3]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2yd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yd6 OCA], [http://pdbe.org/2yd6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yd6 RCSB], [http://www.ebi.ac.uk/pdbsum/2yd6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yd6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yd6 OCA], [http://pdbe.org/2yd6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yd6 RCSB], [http://www.ebi.ac.uk/pdbsum/2yd6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yd6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]	+	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Aricescu, A R]]		[[Category: Aricescu, A R]]

OCA at 09:25, 10 October 2018

OCA — Wed, 10 Oct 2018 09:25:48 GMT

←Older revision		Revision as of 09:25, 10 October 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF THE~~ N-~~TERMINAL IG1~~-2 ~~MODULE OF HUMAN RECEPTOR PROTEIN TYROSINE PHOSPHATASE DELTA~~==	+	==Crystal structure of the N-terminal Ig1-2 module of Human Receptor Protein Tyrosine Phosphatase Delta==
	<StructureSection load='2yd6' size='340' side='right' caption='[[2yd6]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='2yd6' size='340' side='right' caption='[[2yd6]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 17:20, 11 August 2016

OCA — Thu, 11 Aug 2016 17:20:54 GMT

←Older revision		Revision as of 17:20, 11 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE N-TERMINAL IG1-2 MODULE OF HUMAN RECEPTOR PROTEIN TYROSINE PHOSPHATASE DELTA==		==CRYSTAL STRUCTURE OF THE N-TERMINAL IG1-2 MODULE OF HUMAN RECEPTOR PROTEIN TYROSINE PHOSPHATASE DELTA==
	<StructureSection load='2yd6' size='340' side='right' caption='[[2yd6]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='2yd6' size='340' side='right' caption='[[2yd6]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yd6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YD6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yd6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YD6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yd7\|2yd7]], [[2yd1\|2yd1]], [[2yd8\|2yd8]], [[2yd5\|2yd5]], [[2yd2\|2yd2]], [[2yd4\|2yd4]], [[2yd9\|2yd9]], [[2yd3\|2yd3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yd7\|2yd7]], [[2yd1\|2yd1]], [[2yd8\|2yd8]], [[2yd5\|2yd5]], [[2yd2\|2yd2]], [[2yd4\|2yd4]], [[2yd9\|2yd9]], [[2yd3\|2yd3]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yd6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yd6 RCSB], [http://www.ebi.ac.uk/pdbsum/2yd6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yd6 OCA], [http://pdbe.org/2yd6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yd6 RCSB], [http://www.ebi.ac.uk/pdbsum/2yd6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yd6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2yd6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Aricescu, A R]]		[[Category: Aricescu, A R]]

OCA at 11:12, 25 January 2015

OCA — Sun, 25 Jan 2015 11:12:04 GMT

←Older revision		Revision as of 11:12, 25 January 2015
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 25:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
-	[[Category: Aricescu, A R.]]	+	[[Category: Aricescu, A R]]
-	[[Category: Coles, C H.]]	+	[[Category: Coles, C H]]
-	[[Category: Flanagan, J G.]]	+	[[Category: Flanagan, J G]]
-	[[Category: Gallagher, J T.]]	+	[[Category: Gallagher, J T]]
-	[[Category: Jones, E Y.]]	+	[[Category: Jones, E Y]]
-	[[Category: Lu, W.]]	+	[[Category: Lu, W]]
-	[[Category: Shen, Y.]]	+	[[Category: Shen, Y]]
-	[[Category: Siebold, C.]]	+	[[Category: Siebold, C]]
-	[[Category: Sutton, G C.]]	+	[[Category: Sutton, G C]]
-	[[Category: Tenney, A P.]]	+	[[Category: Tenney, A P]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 11:55, 29 October 2014

OCA — Wed, 29 Oct 2014 11:55:11 GMT

←Older revision		Revision as of 11:55, 29 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2yd6.~~png~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE OF THE N-TERMINAL IG1-2 MODULE OF HUMAN RECEPTOR PROTEIN TYROSINE PHOSPHATASE DELTA==
		+	<StructureSection load='2yd6' size='340' side='right' caption='[[2yd6]], [[Resolution\|resolution]] 1.35Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2yd6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YD6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yd7\|2yd7]], [[2yd1\|2yd1]], [[2yd8\|2yd8]], [[2yd5\|2yd5]], [[2yd2\|2yd2]], [[2yd4\|2yd4]], [[2yd9\|2yd9]], [[2yd3\|2yd3]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yd6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yd6 RCSB], [http://www.ebi.ac.uk/pdbsum/2yd6 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Heparan and chondroitin sulfate proteoglycans (HSPGs and CSPGs) regulate numerous cell surface signaling events, with typically opposite effects on cell function. CSPGs inhibit nerve regeneration through receptor protein tyrosine phosphatase sigma (RPTPsigma). Here, we report that RPTPsigma acts bimodally in sensory neuron extension, mediating CSPG inhibition and HSPG growth promotion. Crystallographic analyses of a shared HSPG-CSPG binding site reveal a conformational plasticity that can accommodate diverse glycosaminoglycans with comparable affinities. Heparan sulfate and analogues induced RPTPsigma ectodomain oligomerization in solution, which chondroitin sulfate inhibited. RPTPsigma and HSPGs colocalize in puncta on sensory neurons in culture, whereas CSPGs occupy the extracellular matrix. These results lead to a model where proteoglycans can exert opposing effects on neuronal extension by competing to control the oligomerization of a common receptor.

-	{~~{STRUCTURE_2yd6\| PDB=2yd6 \| SCENE= }~~}	+	Proteoglycan-Specific Molecular Switch for RPTP{sigma} Clustering and Neuronal Extension.,Coles CH, Shen Y, Tenney AP, Siebold C, Sutton GC, Lu W, Gallagher JT, Jones EY, Flanagan JG, Aricescu AR Science. 2011 Mar 31. PMID:21454754<ref>PMID:21454754</ref>

-	~~===CRYSTAL STRUCTURE OF THE N-TERMINAL IG1-2 MODULE OF HUMAN RECEPTOR PROTEIN TYROSINE PHOSPHATASE DELTA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21454754}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2yd6]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2YD6 OCA].~~	+	</StructureSection>
-		+
-	==~~See Also==~~	+
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]	+
-		+
-	~~==Reference~~==	+
-	<~~ref group="xtra">PMID:021454754<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]

OCA at 12:42, 20 October 2012

OCA — Sat, 20 Oct 2012 12:42:28 GMT

←Older revision		Revision as of 12:42, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2yd6]] is a 1 chain structure ~~of [[Tyrosine phosphatase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YD6 OCA].	+	[[2yd6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YD6 OCA].

	==See Also==		==See Also==

OCA at 11:33, 14 August 2012

OCA — Tue, 14 Aug 2012 11:33:08 GMT

←Older revision		Revision as of 11:33, 14 August 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2yd6]] is a 1 chain structure of ~~[[Proten tyrosine phosphatase]] and~~ [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YD6 OCA].	+	[[2yd6]] is a 1 chain structure of [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YD6 OCA].

	==See Also==		==See Also==
-	*[[Proten tyrosine phosphatase\|Proten tyrosine phosphatase]]
	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]		*[[Tyrosine phosphatase\|Tyrosine phosphatase]]

OCA at 09:36, 26 July 2012

OCA — Thu, 26 Jul 2012 09:36:17 GMT

←Older revision		Revision as of 09:36, 26 July 2012
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	[[Image:2yd6.png\|left\|200px]]		[[Image:2yd6.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2yd6\| PDB=2yd6 \| SCENE= }}		{{STRUCTURE_2yd6\| PDB=2yd6 \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE N-TERMINAL IG1-2 MODULE OF HUMAN RECEPTOR PROTEIN TYROSINE PHOSPHATASE DELTA===		===CRYSTAL STRUCTURE OF THE N-TERMINAL IG1-2 MODULE OF HUMAN RECEPTOR PROTEIN TYROSINE PHOSPHATASE DELTA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21454754}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21454754 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_21454754}}		{{ABSTRACT_PUBMED_21454754}}

	==About this Structure==		==About this Structure==
-	[[2yd6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YD6 OCA].	+	[[2yd6]] is a 1 chain structure of [[Proten tyrosine phosphatase]] and [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YD6 OCA].
		+
		+	==See Also==
		+	*[[Proten tyrosine phosphatase\|Proten tyrosine phosphatase]]
		+	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]

	==Reference==		==Reference==
Line 35:		Line 28:
	[[Category: Sutton, G C.]]		[[Category: Sutton, G C.]]
	[[Category: Tenney, A P.]]		[[Category: Tenney, A P.]]
		+	[[Category: Hydrolase]]