2yel - Revision history

OCA at 10:51, 20 December 2023

OCA — Wed, 20 Dec 2023 10:51:09 GMT

←Older revision		Revision as of 10:51, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2yel' size='340' side='right'caption='[[2yel]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='2yel' size='340' side='right'caption='[[2yel]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yel]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yel]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YEL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=WSH:BENZYL+[(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE'>WSH</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yem\|2yem]], [[2yek\|2yek]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=WSH:BENZYL+[(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE'>WSH</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yel OCA], [https://pdbe.org/2yel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yel RCSB], [https://www.ebi.ac.uk/pdbsum/2yel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yel ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yel OCA], [https://pdbe.org/2yel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yel RCSB], [https://www.ebi.ac.uk/pdbsum/2yel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yel ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chung~~, C W]]~~	+	[[Category: Chung CW]]
-	~~[[Category: Epigenetic reader]]~~	+
-	~~[[Category: Histone]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 12:28, 27 April 2022

OCA — Wed, 27 Apr 2022 12:28:15 GMT

OCA at 12:47, 22 July 2020

OCA — Wed, 22 Jul 2020 12:47:16 GMT

←Older revision		Revision as of 12:47, 22 July 2020
Line 1:		Line 1:

	==Crystal Structure of the First Bromodomain of Human Brd4 with the inhibitor GW841819X==		==Crystal Structure of the First Bromodomain of Human Brd4 with the inhibitor GW841819X==
-	<StructureSection load='2yel' size='340' side='right' caption='[[2yel]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='2yel' size='340' side='right'caption='[[2yel]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YEL OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YEL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YEL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=WSH:BENZYL+[(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE'>WSH</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=WSH:BENZYL+[(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE'>WSH</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yem\|2yem]], [[2yek\|2yek]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yem\|2yem]], [[2yek\|2yek]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2yel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yel OCA], [http://pdbe.org/2yel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yel RCSB], [http://www.ebi.ac.uk/pdbsum/2yel PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yel ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yel OCA], [http://pdbe.org/2yel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yel RCSB], [http://www.ebi.ac.uk/pdbsum/2yel PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yel ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]	+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chung, C W]]		[[Category: Chung, C W]]
	[[Category: Epigenetic reader]]		[[Category: Epigenetic reader]]
	[[Category: Histone]]		[[Category: Histone]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 09:15, 10 October 2018

OCA — Wed, 10 Oct 2018 09:15:41 GMT

←Older revision		Revision as of 09:15, 10 October 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 WITH THE INHIBITOR~~ GW841819X==	+	==Crystal Structure of the First Bromodomain of Human Brd4 with the inhibitor GW841819X==
	<StructureSection load='2yel' size='340' side='right' caption='[[2yel]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='2yel' size='340' side='right' caption='[[2yel]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 13:54, 4 August 2016

OCA — Thu, 04 Aug 2016 13:54:28 GMT

←Older revision		Revision as of 13:54, 4 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 WITH THE INHIBITOR GW841819X==		==CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 WITH THE INHIBITOR GW841819X==
	<StructureSection load='2yel' size='340' side='right' caption='[[2yel]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='2yel' size='340' side='right' caption='[[2yel]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YEL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=WSH:BENZYL+[(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE'>WSH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=WSH:BENZYL+[(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE'>WSH</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yem\|2yem]], [[2yek\|2yek]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yem\|2yem]], [[2yek\|2yek]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yel RCSB], [http://www.ebi.ac.uk/pdbsum/2yel PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yel OCA], [http://pdbe.org/2yel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yel RCSB], [http://www.ebi.ac.uk/pdbsum/2yel PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yel ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2yel" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chung, C W]]		[[Category: Chung, C W]]
	[[Category: Epigenetic reader]]		[[Category: Epigenetic reader]]
	[[Category: Histone]]		[[Category: Histone]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 13:50, 18 December 2014

OCA — Thu, 18 Dec 2014 13:50:19 GMT

←Older revision		Revision as of 13:50, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2yel\| PDB=2yel \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 WITH THE INHIBITOR GW841819X==
-	===CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 WITH THE INHIBITOR GW841819X===	+	<StructureSection load='2yel' size='340' side='right' caption='[[2yel]], [[Resolution\|resolution]] 1.65Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21568322}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2yel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YEL FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=WSH:BENZYL+[(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE'>WSH</scene></td></tr>
-	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref><ref>PMID:11733348</ref>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yem\|2yem]], [[2yek\|2yek]]</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yel RCSB], [http://www.ebi.ac.uk/pdbsum/2yel PDBsum]</span></td></tr>
-	==Function==	+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).		[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Epigenetic mechanisms of gene regulation have a profound role in normal development and disease processes. An integral part of this mechanism occurs through lysine acetylation of histone tails which are recognized by bromodomains. While the biological and structural characterization of many bromodomain containing proteins has advanced considerably, the therapeutic tractability of this protein family is only now becoming understood. This paper describes the discovery and molecular characterization of potent (nM) small molecule inhibitors that disrupt the function of the BET family of bromodomains (Brd2, Brd3, and Brd4). By using a combination of phenotypic screening, chemoproteomics, and biophysical studies, we have discovered that the protein-protein interactions between bromodomains and acetylated histones can be antagonized by selective small molecules that bind at the acetylated lysine recognition pocket. X-ray crystal structures of compounds bound into bromodomains of Brd2 and Brd4 elucidate the molecular interactions of binding and explain the precisely defined stereochemistry required for activity.

-	~~==About this Structure==~~	+	Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains.,Chung CW, Coste H, White JH, Mirguet O, Wilde J, Gosmini RL, Delves C, Magny SM, Woodward R, Hughes SA, Boursier EV, Flynn H, Bouillot AM, Bamborough P, Brusq JM, Gellibert FJ, Jones EJ, Riou AM, Homes P, Martin SL, Uings IJ, Toum J, Clement CA, Boullay AB, Grimley RL, Blandel FM, Prinjha RK, Lee K, Kirilovsky J, Nicodeme E J Med Chem. 2011 Jun 9;54(11):3827-3838. Epub 2011 May 13. PMID:21568322<ref>PMID:21568322</ref>
-	~~[[2yel]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2YEL OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:021568322</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chung, C W.]]	+	[[Category: Chung, C W]]
	[[Category: Epigenetic reader]]		[[Category: Epigenetic reader]]
	[[Category: Histone]]		[[Category: Histone]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 19:50, 24 March 2013

OCA — Sun, 24 Mar 2013 19:50:13 GMT

←Older revision		Revision as of 19:50, 24 March 2013
Line 1:		Line 1:
-	[[Image:2yel.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2yel", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2yel\| PDB=2yel \| SCENE= }}		{{STRUCTURE_2yel\| PDB=2yel \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 WITH THE INHIBITOR GW841819X===		===CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 WITH THE INHIBITOR GW841819X===
		+	{{ABSTRACT_PUBMED_21568322}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref><ref>PMID:11733348</ref>

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21568322}}, adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 21568322 is the PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_21568322}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021568322</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021568322</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chung, C W.]]		[[Category: Chung, C W.]]

OCA at 06:22, 15 June 2011

OCA — Wed, 15 Jun 2011 06:22:10 GMT

←Older revision		Revision as of 06:22, 15 June 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2yel.jpg\|left\|200px]]

-	The ~~entry 2yel~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2yel", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2yel\| PDB=2yel \| SCENE= }}

-	~~Authors: Chung, C.~~	+	===CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 WITH THE INHIBITOR GW841819X===

-	~~Description~~: ~~Crystal Structure of~~ the ~~First Bromodomain of Human Brd4~~ with ~~the inhibitor GW841819X~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21568322}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21568322 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21568322}}
		+
		+	==About this Structure==
		+	[[2yel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YEL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021568322</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Chung, C W.]]
		+	[[Category: Epigenetic reader]]
		+	[[Category: Histone]]
		+	[[Category: Signaling protein]]

OCA at 04:10, 12 May 2011

OCA — Thu, 12 May 2011 04:10:56 GMT

←Older revision		Revision as of 04:10, 12 May 2011
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2yel is ON HOLD	+	The entry 2yel is ON HOLD until Paper Publication

	Authors: Chung, C.		Authors: Chung, C.

	Description: Crystal Structure of the First Bromodomain of Human Brd4 with the inhibitor GW841819X		Description: Crystal Structure of the First Bromodomain of Human Brd4 with the inhibitor GW841819X

OCA: Protected "2yel" [edit=sysop:move=sysop]

OCA — Wed, 06 Apr 2011 08:26:53 GMT

Protected "2yel" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:26, 6 April 2011

←Older revision		Revision as of 12:28, 27 April 2022
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	<StructureSection load='2yel' size='340' side='right'caption='[[2yel]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='2yel' size='340' side='right'caption='[[2yel]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yel]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YEL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2YEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yel]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YEL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=WSH:BENZYL+[(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE'>WSH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=WSH:BENZYL+[(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE'>WSH</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yem\|2yem]], [[2yek\|2yek]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yem\|2yem]], [[2yek\|2yek]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2yel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yel OCA], [~~http~~://pdbe.org/2yel PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2yel RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2yel PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2yel ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yel OCA], [https://pdbe.org/2yel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yel RCSB], [https://www.ebi.ac.uk/pdbsum/2yel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yel ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>	+	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).	+	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==