2yh1 - Revision history

OCA at 14:04, 1 February 2024

OCA — Thu, 01 Feb 2024 14:04:23 GMT

←Older revision		Revision as of 14:04, 1 February 2024
Line 1:		Line 1:

	==Model of human U2AF65 tandem RRM1 and RRM2 domains with eight-site uridine binding==		==Model of human U2AF65 tandem RRM1 and RRM2 domains with eight-site uridine binding==
-	<StructureSection load='2yh1' size='340' side='right'caption='[[2yh1~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2yh1' size='340' side='right'caption='[[2yh1]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yh1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YH1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yh1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YH1 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[2u2f\|2u2f]], [[1u2f\|1u2f]], [[1o0p\|1o0p]], [[1opi\|1opi]], [[2g4b\|2g4b]], [[1jmt\|1jmt]], [[2yh0\|2yh0]], [[2yh4\|2yh4]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yh1 OCA], [https://pdbe.org/2yh1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yh1 RCSB], [https://www.ebi.ac.uk/pdbsum/2yh1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yh1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yh1 OCA], [https://pdbe.org/2yh1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yh1 RCSB], [https://www.ebi.ac.uk/pdbsum/2yh1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yh1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/U2AF2_HUMAN U2AF2_HUMAN]] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:15009664</ref> <ref>PMID:19470458</ref> <ref>PMID:19574390</ref>	+	[https://www.uniprot.org/uniprot/U2AF2_HUMAN U2AF2_HUMAN] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:15009664</ref> <ref>PMID:19470458</ref> <ref>PMID:19574390</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gasch, A]]	+	[[Category: Gasch A]]
-	[[Category: Mackereth~~, C D~~]]	+	[[Category: Mackereth CD]]
-	[[Category: Madl, T]]	+	[[Category: Madl T]]
-	[[Category: Sattler, M]]	+	[[Category: Sattler M]]
-	[[Category: Simon, B]]	+	[[Category: Simon B]]
-	[[Category: Zanier, K]]	+	[[Category: Zanier K]]
-	~~[[Category: Pre-mrna splicing]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 12:29, 27 April 2022

OCA — Wed, 27 Apr 2022 12:29:51 GMT

←Older revision		Revision as of 12:29, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2yh1' size='340' side='right'caption='[[2yh1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2yh1' size='340' side='right'caption='[[2yh1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yh1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2YH1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yh1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YH1 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2u2f\|2u2f]], [[1u2f\|1u2f]], [[1o0p\|1o0p]], [[1opi\|1opi]], [[2g4b\|2g4b]], [[1jmt\|1jmt]], [[2yh0\|2yh0]], [[2yh4\|2yh4]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2u2f\|2u2f]], [[1u2f\|1u2f]], [[1o0p\|1o0p]], [[1opi\|1opi]], [[2g4b\|2g4b]], [[1jmt\|1jmt]], [[2yh0\|2yh0]], [[2yh4\|2yh4]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2yh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yh1 OCA], [~~http~~://pdbe.org/2yh1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2yh1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2yh1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2yh1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yh1 OCA], [https://pdbe.org/2yh1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yh1 RCSB], [https://www.ebi.ac.uk/pdbsum/2yh1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yh1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/U2AF2_HUMAN U2AF2_HUMAN]] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:15009664</ref> <ref>PMID:19470458</ref> <ref>PMID:19574390</ref>	+	[[https://www.uniprot.org/uniprot/U2AF2_HUMAN U2AF2_HUMAN]] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:15009664</ref> <ref>PMID:19470458</ref> <ref>PMID:19574390</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:50, 22 July 2020

OCA — Wed, 22 Jul 2020 12:50:49 GMT

←Older revision		Revision as of 12:50, 22 July 2020
Line 1:		Line 1:

	==Model of human U2AF65 tandem RRM1 and RRM2 domains with eight-site uridine binding==		==Model of human U2AF65 tandem RRM1 and RRM2 domains with eight-site uridine binding==
-	<StructureSection load='2yh1' size='340' side='right' caption='[[2yh1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2yh1' size='340' side='right'caption='[[2yh1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yh1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YH1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yh1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YH1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2u2f\|2u2f]], [[1u2f\|1u2f]], [[1o0p\|1o0p]], [[1opi\|1opi]], [[2g4b\|2g4b]], [[1jmt\|1jmt]], [[2yh0\|2yh0]], [[2yh4\|2yh4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2u2f\|2u2f]], [[1u2f\|1u2f]], [[1o0p\|1o0p]], [[1opi\|1opi]], [[2g4b\|2g4b]], [[1jmt\|1jmt]], [[2yh0\|2yh0]], [[2yh4\|2yh4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2yh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yh1 OCA], [http://pdbe.org/2yh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2yh1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yh1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yh1 OCA], [http://pdbe.org/2yh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2yh1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yh1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gasch, A]]		[[Category: Gasch, A]]
	[[Category: Mackereth, C D]]		[[Category: Mackereth, C D]]

OCA at 09:26, 10 October 2018

OCA — Wed, 10 Oct 2018 09:26:14 GMT

←Older revision		Revision as of 09:26, 10 October 2018
Line 1:		Line 1:

-	==~~MODEL OF HUMAN~~ U2AF65 ~~TANDEM~~ RRM1 ~~AND~~ RRM2 ~~DOMAINS WITH EIGHT~~-~~SITE URIDINE BINDING~~==	+	==Model of human U2AF65 tandem RRM1 and RRM2 domains with eight-site uridine binding==
	<StructureSection load='2yh1' size='340' side='right' caption='[[2yh1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2yh1' size='340' side='right' caption='[[2yh1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 14:08, 4 August 2016

OCA — Thu, 04 Aug 2016 14:08:14 GMT

←Older revision		Revision as of 14:08, 4 August 2016
Line 1:		Line 1:
		+
	==MODEL OF HUMAN U2AF65 TANDEM RRM1 AND RRM2 DOMAINS WITH EIGHT-SITE URIDINE BINDING==		==MODEL OF HUMAN U2AF65 TANDEM RRM1 AND RRM2 DOMAINS WITH EIGHT-SITE URIDINE BINDING==
	<StructureSection load='2yh1' size='340' side='right' caption='[[2yh1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2yh1' size='340' side='right' caption='[[2yh1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yh1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YH1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yh1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YH1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2u2f\|2u2f]], [[1u2f\|1u2f]], [[1o0p\|1o0p]], [[1opi\|1opi]], [[2g4b\|2g4b]], [[1jmt\|1jmt]], [[2yh0\|2yh0]], [[2yh4\|2yh4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2u2f\|2u2f]], [[1u2f\|1u2f]], [[1o0p\|1o0p]], [[1opi\|1opi]], [[2g4b\|2g4b]], [[1jmt\|1jmt]], [[2yh0\|2yh0]], [[2yh4\|2yh4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yh1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2yh1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yh1 OCA], [http://pdbe.org/2yh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2yh1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yh1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2yh1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Gasch, A]]		[[Category: Gasch, A]]
	[[Category: Mackereth, C D]]		[[Category: Mackereth, C D]]

OCA at 10:00, 25 December 2014

OCA — Thu, 25 Dec 2014 10:00:54 GMT

←Older revision		Revision as of 10:00, 25 December 2014
Line 2:		Line 2:
	<StructureSection load='2yh1' size='340' side='right' caption='[[2yh1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2yh1' size='340' side='right' caption='[[2yh1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yh1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH1 OCA]. <br>	+	<table><tr><td colspan='2'>[[2yh1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YH1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2u2f\|2u2f]], [[1u2f\|1u2f]], [[1o0p\|1o0p]], [[1opi\|1opi]], [[2g4b\|2g4b]], [[1jmt\|1jmt]], [[2yh0\|2yh0]], [[2yh4\|2yh4]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2u2f\|2u2f]], [[1u2f\|1u2f]], [[1o0p\|1o0p]], [[1opi\|1opi]], [[2g4b\|2g4b]], [[1jmt\|1jmt]], [[2yh0\|2yh0]], [[2yh4\|2yh4]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yh1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2yh1 PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yh1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2yh1 PDBsum]</span></td></tr>	+	</table>
-	<table>	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/U2AF2_HUMAN U2AF2_HUMAN]] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:15009664</ref> <ref>PMID:19470458</ref> <ref>PMID:19574390</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 14:
	Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF.,Mackereth CD, Madl T, Bonnal S, Simon B, Zanier K, Gasch A, Rybin V, Valcarcel J, Sattler M Nature. 2011 Jul 13;475(7356):408-11. doi: 10.1038/nature10171. PMID:21753750<ref>PMID:21753750</ref>		Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF.,Mackereth CD, Madl T, Bonnal S, Simon B, Zanier K, Gasch A, Rybin V, Valcarcel J, Sattler M Nature. 2011 Jul 13;475(7356):408-11. doi: 10.1038/nature10171. PMID:21753750<ref>PMID:21753750</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Gasch, A.]]	+	[[Category: Gasch, A]]
-	[[Category: Mackereth, C D.]]	+	[[Category: Mackereth, C D]]
-	[[Category: Madl, T.]]	+	[[Category: Madl, T]]
-	[[Category: Sattler, M.]]	+	[[Category: Sattler, M]]
-	[[Category: Simon, B.]]	+	[[Category: Simon, B]]
-	[[Category: Zanier, K.]]	+	[[Category: Zanier, K]]
	[[Category: Pre-mrna splicing]]		[[Category: Pre-mrna splicing]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 07:45, 14 May 2014

OCA — Wed, 14 May 2014 07:45:11 GMT

←Older revision		Revision as of 07:45, 14 May 2014
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-	[[~~Image:~~2yh1.~~png~~\|~~left~~\|~~200px~~]]	+	==MODEL OF HUMAN U2AF65 TANDEM RRM1 AND RRM2 DOMAINS WITH EIGHT-SITE URIDINE BINDING==
		+	<StructureSection load='2yh1' size='340' side='right' caption='[[2yh1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2yh1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH1 OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2u2f\|2u2f]], [[1u2f\|1u2f]], [[1o0p\|1o0p]], [[1opi\|1opi]], [[2g4b\|2g4b]], [[1jmt\|1jmt]], [[2yh0\|2yh0]], [[2yh4\|2yh4]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yh1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2yh1 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many cellular functions involve multi-domain proteins, which are composed of structurally independent modules connected by flexible linkers. Although it is often well understood how a given domain recognizes a cognate oligonucleotide or peptide motif, the dynamic interaction of multiple domains in the recognition of these ligands remains to be characterized. Here we have studied the molecular mechanisms of the recognition of the 3'-splice-site-associated polypyrimidine tract RNA by the large subunit of the human U2 snRNP auxiliary factor (U2AF65) as a key early step in pre-mRNA splicing. We show that the tandem RNA recognition motif domains of U2AF65 adopt two remarkably distinct domain arrangements in the absence or presence of a strong (that is, high affinity) polypyrimidine tract. Recognition of sequence variations in the polypyrimidine tract RNA involves a population shift between these closed and open conformations. The equilibrium between the two conformations functions as a molecular rheostat that quantitatively correlates the natural variations in polypyrimidine tract nucleotide composition, length and functional strength to the efficiency to recruit U2 snRNP to the intron during spliceosome assembly. Mutations that shift the conformational equilibrium without directly affecting RNA binding modulate splicing activity accordingly. Similar mechanisms of cooperative multi-domain conformational selection may operate more generally in the recognition of degenerate nucleotide or amino acid motifs by multi-domain proteins.

-	<!--	+	Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF.,Mackereth CD, Madl T, Bonnal S, Simon B, Zanier K, Gasch A, Rybin V, Valcarcel J, Sattler M Nature. 2011 Jul 13;475(7356):408-11. doi: 10.1038/nature10171. PMID:21753750<ref>PMID:21753750</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2yh1"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_2yh1\| PDB=2yh1 \| SCENE= }}~~	+

-	~~===MODEL OF HUMAN U2AF65 TANDEM RRM1 AND RRM2 DOMAINS WITH EIGHT-SITE URIDINE BINDING===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21753750}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21753750 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21753750}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2yh1]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH1 OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021753750<~~/~~ref~~><~~ref group="xtra">PMID:016818232</ref><references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Gasch, A.]]		[[Category: Gasch, A.]]

OCA at 04:57, 27 July 2011

OCA — Wed, 27 Jul 2011 04:57:45 GMT

←Older revision		Revision as of 04:57, 27 July 2011
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-	[[Image:2yh1.~~jpg~~\|left\|200px]]	+	[[Image:2yh1.png\|left\|200px]]

	<!--		<!--
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	<!--		<!--
-	The line below this paragraph, {{~~ABSTRACT_PUBMED_16818232~~}}, adds the Publication Abstract to the page	+	The line below this paragraph, {{ABSTRACT_PUBMED_21753750}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where ~~16818232~~ is the PubMed ID number.	+	(as it appears on PubMed at http://www.pubmed.gov), where 21753750 is the PubMed ID number.
	-->		-->
-	{{~~ABSTRACT_PUBMED_16818232~~}}	+	{{ABSTRACT_PUBMED_21753750}}

	==About this Structure==		==About this Structure==
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	==Reference==		==Reference==
-	<ref group="xtra">PMID:016818232</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021753750</ref><ref group="xtra">PMID:016818232</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Gasch, A.]]		[[Category: Gasch, A.]]

OCA at 06:50, 20 July 2011

OCA — Wed, 20 Jul 2011 06:50:10 GMT

←Older revision		Revision as of 06:50, 20 July 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:2yh1.jpg\|left\|200px]]

-	The ~~entry 2yh1~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2yh1", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2yh1\| PDB=2yh1 \| SCENE= }}

-	~~Authors: Mackereth, C.D., Madl, T., Simon, B., Zanier, K., Gasch, A., Sattler, M.~~	+	===MODEL OF HUMAN U2AF65 TANDEM RRM1 AND RRM2 DOMAINS WITH EIGHT-SITE URIDINE BINDING===

-	~~Description~~: ~~Model of human U2AF65 tandem RRM1 and RRM2 domains~~ with ~~eight~~-~~site uridine binding~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_16818232}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16818232 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16818232}}
		+
		+	==About this Structure==
		+	[[2yh1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH1 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:016818232</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Gasch, A.]]
		+	[[Category: Mackereth, C D.]]
		+	[[Category: Madl, T.]]
		+	[[Category: Sattler, M.]]
		+	[[Category: Simon, B.]]
		+	[[Category: Zanier, K.]]
		+	[[Category: Pre-mrna splicing]]
		+	[[Category: Transcription]]

OCA at 05:03, 18 May 2011

OCA — Wed, 18 May 2011 05:03:06 GMT

←Older revision		Revision as of 05:03, 18 May 2011
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2yh1 is ON HOLD	+	The entry 2yh1 is ON HOLD until Paper Publication

	Authors: Mackereth, C.D., Madl, T., Simon, B., Zanier, K., Gasch, A., Sattler, M.		Authors: Mackereth, C.D., Madl, T., Simon, B., Zanier, K., Gasch, A., Sattler, M.

	Description: Model of human U2AF65 tandem RRM1 and RRM2 domains with eight-site uridine binding		Description: Model of human U2AF65 tandem RRM1 and RRM2 domains with eight-site uridine binding