2yjd - Revision history

OCA at 10:10, 22 June 2022

OCA — Wed, 22 Jun 2022 10:10:40 GMT

←Older revision		Revision as of 10:10, 22 June 2022
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	<StructureSection load='2yjd' size='340' side='right'caption='[[2yjd]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='2yjd' size='340' side='right'caption='[[2yjd]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yjd]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2YJD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yjd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YJD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YJD:4-(2-PROPAN-2-YLOXYBENZIMIDAZOL-1-YL)PHENOL'>YJD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YJD:4-(2-PROPAN-2-YLOXYBENZIMIDAZOL-1-YL)PHENOL'>YJD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yly\|2yly]], [[1l2j\|1l2j]], [[2fsz\|2fsz]], [[1x7b\|1x7b]], [[1x76\|1x76]], [[1nde\|1nde]], [[2jj3\|2jj3]], [[1yy4\|1yy4]], [[1u3s\|1u3s]], [[1x78\|1x78]], [[1qkm\|1qkm]], [[1u3r\|1u3r]], [[1x7j\|1x7j]], [[1u9e\|1u9e]], [[1yye\|1yye]], [[1u3q\|1u3q]], [[2yja\|2yja]], [[2ldd\|2ldd]], [[2lda\|2lda]], [[2ldc\|2ldc]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yly\|2yly]], [[1l2j\|1l2j]], [[2fsz\|2fsz]], [[1x7b\|1x7b]], [[1x76\|1x76]], [[1nde\|1nde]], [[2jj3\|2jj3]], [[1yy4\|1yy4]], [[1u3s\|1u3s]], [[1x78\|1x78]], [[1qkm\|1qkm]], [[1u3r\|1u3r]], [[1x7j\|1x7j]], [[1u9e\|1u9e]], [[1yye\|1yye]], [[1u3q\|1u3q]], [[2yja\|2yja]], [[2ldd\|2ldd]], [[2lda\|2lda]], [[2ldc\|2ldc]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2yjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yjd OCA], [~~http~~://pdbe.org/2yjd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2yjd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2yjd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2yjd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yjd OCA], [https://pdbe.org/2yjd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yjd RCSB], [https://www.ebi.ac.uk/pdbsum/2yjd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yjd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN]] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.	+	[[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN]] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:46, 16 September 2020

OCA — Wed, 16 Sep 2020 10:46:16 GMT

←Older revision		Revision as of 10:46, 16 September 2020
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	==Stapled peptide bound to Estrogen Receptor Beta==		==Stapled peptide bound to Estrogen Receptor Beta==
-	<StructureSection load='2yjd' size='340' side='right' caption='[[2yjd]], [[Resolution\|resolution]] 1.93Å' scene=''>	+	<StructureSection load='2yjd' size='340' side='right'caption='[[2yjd]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yjd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YJD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yjd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YJD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YJD:4-(2-PROPAN-2-YLOXYBENZIMIDAZOL-1-YL)PHENOL'>YJD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YJD:4-(2-PROPAN-2-YLOXYBENZIMIDAZOL-1-YL)PHENOL'>YJD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yly\|2yly]], [[1l2j\|1l2j]], [[2fsz\|2fsz]], [[1x7b\|1x7b]], [[1x76\|1x76]], [[1nde\|1nde]], [[2jj3\|2jj3]], [[1yy4\|1yy4]], [[1u3s\|1u3s]], [[1x78\|1x78]], [[1qkm\|1qkm]], [[1u3r\|1u3r]], [[1x7j\|1x7j]], [[1u9e\|1u9e]], [[1yye\|1yye]], [[1u3q\|1u3q]], [[2yja\|2yja]], [[2ldd\|2ldd]], [[2lda\|2lda]], [[2ldc\|2ldc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yly\|2yly]], [[1l2j\|1l2j]], [[2fsz\|2fsz]], [[1x7b\|1x7b]], [[1x76\|1x76]], [[1nde\|1nde]], [[2jj3\|2jj3]], [[1yy4\|1yy4]], [[1u3s\|1u3s]], [[1x78\|1x78]], [[1qkm\|1qkm]], [[1u3r\|1u3r]], [[1x7j\|1x7j]], [[1u9e\|1u9e]], [[1yye\|1yye]], [[1u3q\|1u3q]], [[2yja\|2yja]], [[2ldd\|2ldd]], [[2lda\|2lda]], [[2ldc\|2ldc]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2yjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yjd OCA], [http://pdbe.org/2yjd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yjd RCSB], [http://www.ebi.ac.uk/pdbsum/2yjd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yjd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yjd OCA], [http://pdbe.org/2yjd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yjd RCSB], [http://www.ebi.ac.uk/pdbsum/2yjd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yjd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Estrogen receptor\|Estrogen receptor]]	+	*[[Estrogen receptor 3D structures\|Estrogen receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bent, A]]		[[Category: Bent, A]]
	[[Category: Brown, D G]]		[[Category: Brown, D G]]

OCA at 08:11, 12 December 2018

OCA — Wed, 12 Dec 2018 08:11:56 GMT

←Older revision		Revision as of 08:11, 12 December 2018
Line 3:		Line 3:
	<StructureSection load='2yjd' size='340' side='right' caption='[[2yjd]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='2yjd' size='340' side='right' caption='[[2yjd]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yjd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YJD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yjd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YJD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YJD:4-(2-PROPAN-2-YLOXYBENZIMIDAZOL-1-YL)PHENOL'>YJD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YJD:4-(2-PROPAN-2-YLOXYBENZIMIDAZOL-1-YL)PHENOL'>YJD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Bent, A]]		[[Category: Bent, A]]
	[[Category: Brown, D G]]		[[Category: Brown, D G]]

OCA at 16:35, 25 January 2017

OCA — Wed, 25 Jan 2017 16:35:17 GMT

←Older revision		Revision as of 16:35, 25 January 2017
Line 1:		Line 1:

-	==~~STAPLED PEPTIDE BOUND TO ESTROGEN RECEPTOR BETA~~==	+	==Stapled peptide bound to Estrogen Receptor Beta==
	<StructureSection load='2yjd' size='340' side='right' caption='[[2yjd]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='2yjd' size='340' side='right' caption='[[2yjd]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yjd]] is a 4 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YJD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yjd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YJD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YJD:4-(2-PROPAN-2-YLOXYBENZIMIDAZOL-1-YL)PHENOL'>YJD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YJD:4-(2-PROPAN-2-YLOXYBENZIMIDAZOL-1-YL)PHENOL'>YJD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Bent, A]]		[[Category: Bent, A]]
	[[Category: Brown, D G]]		[[Category: Brown, D G]]

OCA at 15:18, 4 August 2016

OCA — Thu, 04 Aug 2016 15:18:24 GMT

←Older revision		Revision as of 15:18, 4 August 2016
Line 1:		Line 1:
		+
	==STAPLED PEPTIDE BOUND TO ESTROGEN RECEPTOR BETA==		==STAPLED PEPTIDE BOUND TO ESTROGEN RECEPTOR BETA==
	<StructureSection load='2yjd' size='340' side='right' caption='[[2yjd]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='2yjd' size='340' side='right' caption='[[2yjd]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yjd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YJD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yjd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YJD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YJD:4-(2-PROPAN-2-YLOXYBENZIMIDAZOL-1-YL)PHENOL'>YJD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YJD:4-(2-PROPAN-2-YLOXYBENZIMIDAZOL-1-YL)PHENOL'>YJD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yly\|2yly]], [[1l2j\|1l2j]], [[2fsz\|2fsz]], [[1x7b\|1x7b]], [[1x76\|1x76]], [[1nde\|1nde]], [[2jj3\|2jj3]], [[1yy4\|1yy4]], [[1u3s\|1u3s]], [[1x78\|1x78]], [[1qkm\|1qkm]], [[1u3r\|1u3r]], [[1x7j\|1x7j]], [[1u9e\|1u9e]], [[1yye\|1yye]], [[1u3q\|1u3q]], [[2yja\|2yja]], [[2ldd\|2ldd]], [[2lda\|2lda]], [[2ldc\|2ldc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yly\|2yly]], [[1l2j\|1l2j]], [[2fsz\|2fsz]], [[1x7b\|1x7b]], [[1x76\|1x76]], [[1nde\|1nde]], [[2jj3\|2jj3]], [[1yy4\|1yy4]], [[1u3s\|1u3s]], [[1x78\|1x78]], [[1qkm\|1qkm]], [[1u3r\|1u3r]], [[1x7j\|1x7j]], [[1u9e\|1u9e]], [[1yye\|1yye]], [[1u3q\|1u3q]], [[2yja\|2yja]], [[2ldd\|2ldd]], [[2lda\|2lda]], [[2ldc\|2ldc]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yjd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yjd RCSB], [http://www.ebi.ac.uk/pdbsum/2yjd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yjd OCA], [http://pdbe.org/2yjd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yjd RCSB], [http://www.ebi.ac.uk/pdbsum/2yjd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yjd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2yjd" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Estrogen receptor\|Estrogen receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bent, A]]		[[Category: Bent, A]]
	[[Category: Brown, D G]]		[[Category: Brown, D G]]

OCA at 16:18, 24 December 2014

OCA — Wed, 24 Dec 2014 16:18:50 GMT

←Older revision		Revision as of 16:18, 24 December 2014
Line 2:		Line 2:
	<StructureSection load='2yjd' size='340' side='right' caption='[[2yjd]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='2yjd' size='340' side='right' caption='[[2yjd]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yjd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJD OCA]. <br>	+	<table><tr><td colspan='2'>[[2yjd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YJD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YJD:4-(2-PROPAN-2-YLOXYBENZIMIDAZOL-1-YL)PHENOL'>YJD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YJD:4-(2-PROPAN-2-YLOXYBENZIMIDAZOL-1-YL)PHENOL'>YJD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yly\|2yly]], [[1l2j\|1l2j]], [[2fsz\|2fsz]], [[1x7b\|1x7b]], [[1x76\|1x76]], [[1nde\|1nde]], [[2jj3\|2jj3]], [[1yy4\|1yy4]], [[1u3s\|1u3s]], [[1x78\|1x78]], [[1qkm\|1qkm]], [[1u3r\|1u3r]], [[1x7j\|1x7j]], [[1u9e\|1u9e]], [[1yye\|1yye]], [[1u3q\|1u3q]], [[2yja\|2yja]], [[2ldd\|2ldd]], [[2lda\|2lda]], [[2ldc\|2ldc]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yly\|2yly]], [[1l2j\|1l2j]], [[2fsz\|2fsz]], [[1x7b\|1x7b]], [[1x76\|1x76]], [[1nde\|1nde]], [[2jj3\|2jj3]], [[1yy4\|1yy4]], [[1u3s\|1u3s]], [[1x78\|1x78]], [[1qkm\|1qkm]], [[1u3r\|1u3r]], [[1x7j\|1x7j]], [[1u9e\|1u9e]], [[1yye\|1yye]], [[1u3q\|1u3q]], [[2yja\|2yja]], [[2ldd\|2ldd]], [[2lda\|2lda]], [[2ldc\|2ldc]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yjd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yjd RCSB], [http://www.ebi.ac.uk/pdbsum/2yjd PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yjd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yjd RCSB], [http://www.ebi.ac.uk/pdbsum/2yjd PDBsum]</span></td></tr>	+	</table>
-	<table>	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN]] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 16:
	Design and structure of stapled peptides binding to estrogen receptors.,Phillips C, Roberts LR, Schade M, Bazin R, Bent A, Davies NL, Moore R, Pannifer AD, Pickford AR, Prior SH, Read CM, Scott A, Brown DG, Xu B, Irving SL J Am Chem Soc. 2011 Jun 29;133(25):9696-9. Epub 2011 Jun 6. PMID:21612236<ref>PMID:21612236</ref>		Design and structure of stapled peptides binding to estrogen receptors.,Phillips C, Roberts LR, Schade M, Bazin R, Bent A, Davies NL, Moore R, Pannifer AD, Pickford AR, Prior SH, Read CM, Scott A, Brown DG, Xu B, Irving SL J Am Chem Soc. 2011 Jun 29;133(25):9696-9. Epub 2011 Jun 6. PMID:21612236<ref>PMID:21612236</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 22:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bent, A.]]	+	[[Category: Bent, A]]
-	[[Category: Brown, D G.]]	+	[[Category: Brown, D G]]
-	[[Category: Davies, N L.]]	+	[[Category: Davies, N L]]
-	[[Category: Irving, S L.]]	+	[[Category: Irving, S L]]
-	[[Category: Moore, R.]]	+	[[Category: Moore, R]]
-	[[Category: Pannifer, A D.]]	+	[[Category: Pannifer, A D]]
-	[[Category: Phillips, C.]]	+	[[Category: Phillips, C]]
-	[[Category: Pickford, A R.]]	+	[[Category: Pickford, A R]]
-	[[Category: Roberts, L R.]]	+	[[Category: Roberts, L R]]
-	[[Category: Schade, M.]]	+	[[Category: Schade, M]]
	[[Category: Hormone receptor-peptide complex]]		[[Category: Hormone receptor-peptide complex]]

OCA at 07:46, 14 May 2014

OCA — Wed, 14 May 2014 07:46:24 GMT

←Older revision		Revision as of 07:46, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2yjd.~~jpg~~\|~~left~~\|~~200px~~]]	+	==STAPLED PEPTIDE BOUND TO ESTROGEN RECEPTOR BETA==
		+	<StructureSection load='2yjd' size='340' side='right' caption='[[2yjd]], [[Resolution\|resolution]] 1.93Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2yjd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJD OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YJD:4-(2-PROPAN-2-YLOXYBENZIMIDAZOL-1-YL)PHENOL'>YJD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yly\|2yly]], [[1l2j\|1l2j]], [[2fsz\|2fsz]], [[1x7b\|1x7b]], [[1x76\|1x76]], [[1nde\|1nde]], [[2jj3\|2jj3]], [[1yy4\|1yy4]], [[1u3s\|1u3s]], [[1x78\|1x78]], [[1qkm\|1qkm]], [[1u3r\|1u3r]], [[1x7j\|1x7j]], [[1u9e\|1u9e]], [[1yye\|1yye]], [[1u3q\|1u3q]], [[2yja\|2yja]], [[2ldd\|2ldd]], [[2lda\|2lda]], [[2ldc\|2ldc]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yjd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yjd RCSB], [http://www.ebi.ac.uk/pdbsum/2yjd PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Synthetic peptides that specifically bind nuclear hormone receptors offer an alternative approach to small molecules for the modulation of receptor signaling and subsequent gene expression. Here we describe the design of a series of novel stapled peptides that bind the coactivator peptide site of estrogen receptors. Using a number of biophysical techniques, including crystal structure analysis of receptor-stapled peptide complexes, we describe in detail the molecular interactions and demonstrate that all-hydrocarbon staples modulate molecular recognition events. The findings have implications for the design of stapled peptides in general.

-	~~<!--~~	+	Design and structure of stapled peptides binding to estrogen receptors.,Phillips C, Roberts LR, Schade M, Bazin R, Bent A, Davies NL, Moore R, Pannifer AD, Pickford AR, Prior SH, Read CM, Scott A, Brown DG, Xu B, Irving SL J Am Chem Soc. 2011 Jun 29;133(25):9696-9. Epub 2011 Jun 6. PMID:21612236<ref>PMID:21612236</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2yjd"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_2yjd\| PDB=2yjd \| SCENE= }}~~	+

-	~~===STAPLED PEPTIDE BOUND TO ESTROGEN RECEPTOR BETA===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21612236}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21612236 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21612236}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2yjd]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJD OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021612236<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bent, A.]]		[[Category: Bent, A.]]

OCA at 08:51, 3 August 2011

OCA — Wed, 03 Aug 2011 08:51:10 GMT

←Older revision		Revision as of 08:51, 3 August 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2yjd.jpg\|left\|200px]]

-	The ~~entry 2yjd~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2yjd", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2yjd\| PDB=2yjd \| SCENE= }}

-	~~Authors: Phillips, C., Roberts, L.R., Schade, M., Bent, A., Davies, N.L., Moore, R., Pannifer, A.D., Brown, D.G., Pickford, A., Irving, S.L.~~	+	===STAPLED PEPTIDE BOUND TO ESTROGEN RECEPTOR BETA===

-	~~Description~~: ~~Stapled~~ peptide ~~bound to Estrogen Receptor Beta~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21612236}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21612236 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21612236}}
		+
		+	==About this Structure==
		+	[[2yjd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJD OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021612236</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Bent, A.]]
		+	[[Category: Brown, D G.]]
		+	[[Category: Davies, N L.]]
		+	[[Category: Irving, S L.]]
		+	[[Category: Moore, R.]]
		+	[[Category: Pannifer, A D.]]
		+	[[Category: Phillips, C.]]
		+	[[Category: Pickford, A R.]]
		+	[[Category: Roberts, L R.]]
		+	[[Category: Schade, M.]]
		+	[[Category: Hormone receptor-peptide complex]]

OCA at 16:06, 22 June 2011

OCA — Wed, 22 Jun 2011 16:06:56 GMT

←Older revision		Revision as of 16:06, 22 June 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2yjd is ON HOLD ~~until sometime in the future~~	+	The entry 2yjd is ON HOLD

	Authors: Phillips, C., Roberts, L.R., Schade, M., Bent, A., Davies, N.L., Moore, R., Pannifer, A.D., Brown, D.G., Pickford, A., Irving, S.L.		Authors: Phillips, C., Roberts, L.R., Schade, M., Bent, A., Davies, N.L., Moore, R., Pannifer, A.D., Brown, D.G., Pickford, A., Irving, S.L.

	Description: Stapled peptide bound to Estrogen Receptor Beta		Description: Stapled peptide bound to Estrogen Receptor Beta

OCA: Protected "2yjd" [edit=sysop:move=sysop]

OCA — Wed, 15 Jun 2011 05:41:43 GMT

Protected "2yjd" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:41, 15 June 2011