2yla - Revision history

OCA at 14:05, 1 February 2024

OCA — Thu, 01 Feb 2024 14:05:53 GMT

←Older revision		Revision as of 14:05, 1 February 2024
Line 3:		Line 3:
	<StructureSection load='2yla' size='340' side='right'caption='[[2yla]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2yla' size='340' side='right'caption='[[2yla]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yla]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Strpn Strpn~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YLA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yla]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YLA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yl8\|2yl8]], [[2yl9\|2yl9]], [[2yl6\|2yl6]], [[2yl5\|2yl5]], [[2yll\|2yll]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yla OCA], [https://pdbe.org/2yla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yla RCSB], [https://www.ebi.ac.uk/pdbsum/2yla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yla ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yla OCA], [https://pdbe.org/2yla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yla RCSB], [https://www.ebi.ac.uk/pdbsum/2yla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yla ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/STRH_STRPN STRH_STRPN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	*[[Beta-Hexosaminidase\|Beta-Hexosaminidase]]		*[[Beta-Hexosaminidase\|Beta-Hexosaminidase]]
	*[[Beta-Hexosaminidase 3D structures\|Beta-Hexosaminidase 3D structures]]		*[[Beta-Hexosaminidase 3D structures\|Beta-Hexosaminidase 3D structures]]
		+	*[[Beta-N-acetylhexosaminidase 3D structures\|Beta-N-acetylhexosaminidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Beta-N-acetylhexosaminidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Strpn~~]]	+	[[Category: Streptococcus pneumoniae TIGR4]]
-	[[Category: Abbott~~, D W~~]]	+	[[Category: Abbott DW]]
-	[[Category: Boraston~~, A B~~]]	+	[[Category: Boraston AB]]
-	[[Category: Dalia~~, A B~~]]	+	[[Category: Dalia AB]]
-	[[Category: Deng, L]]	+	[[Category: Deng L]]
-	[[Category: Fairbanks~~, A J~~]]	+	[[Category: Fairbanks AJ]]
-	[[Category: Higgins~~, M A~~]]	+	[[Category: Higgins MA]]
-	[[Category: Parsons~~, T B~~]]	+	[[Category: Parsons TB]]
-	[[Category: Pluvinage, B]]	+	[[Category: Pluvinage B]]
-	[[Category: Robb, C]]	+	[[Category: Robb C]]
-	[[Category: Vocadlo~~, D J~~]]	+	[[Category: Vocadlo DJ]]
-	[[Category: Weiser~~, J N]]~~	+	[[Category: Weiser JN]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 12:32, 27 April 2022

OCA — Wed, 27 Apr 2022 12:32:18 GMT

←Older revision		Revision as of 12:32, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2yla' size='340' side='right'caption='[[2yla]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2yla' size='340' side='right'caption='[[2yla]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yla]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2YLA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yla]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YLA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yl8\|2yl8]], [[2yl9\|2yl9]], [[2yl6\|2yl6]], [[2yl5\|2yl5]], [[2yll\|2yll]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yl8\|2yl8]], [[2yl9\|2yl9]], [[2yl6\|2yl6]], [[2yl5\|2yl5]], [[2yll\|2yll]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2yla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yla OCA], [~~http~~://pdbe.org/2yla PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2yla RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2yla PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2yla ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yla OCA], [https://pdbe.org/2yla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yla RCSB], [https://www.ebi.ac.uk/pdbsum/2yla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yla ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:56, 22 July 2020

OCA — Wed, 22 Jul 2020 12:56:09 GMT

←Older revision		Revision as of 12:56, 22 July 2020
Line 1:		Line 1:

	==INHIBITION OF THE PNEUMOCOCCAL VIRULENCE FACTOR STRH AND MOLECULAR INSIGHTS INTO N-GLYCAN RECOGNITION AND HYDROLYSIS==		==INHIBITION OF THE PNEUMOCOCCAL VIRULENCE FACTOR STRH AND MOLECULAR INSIGHTS INTO N-GLYCAN RECOGNITION AND HYDROLYSIS==
-	<StructureSection load='2yla' size='340' side='right' caption='[[2yla]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='2yla' size='340' side='right'caption='[[2yla]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yla]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLA OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YLA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yla]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YLA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yl8\|2yl8]], [[2yl9\|2yl9]], [[2yl6\|2yl6]], [[2yl5\|2yl5]], [[2yll\|2yll]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yl8\|2yl8]], [[2yl9\|2yl9]], [[2yl6\|2yl6]], [[2yl5\|2yl5]], [[2yll\|2yll]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2yla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yla OCA], [http://pdbe.org/2yla PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yla RCSB], [http://www.ebi.ac.uk/pdbsum/2yla PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yla ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yla OCA], [http://pdbe.org/2yla PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yla RCSB], [http://www.ebi.ac.uk/pdbsum/2yla PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yla ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	==See Also==		==See Also==
	*[[Beta-Hexosaminidase\|Beta-Hexosaminidase]]		*[[Beta-Hexosaminidase\|Beta-Hexosaminidase]]
		+	*[[Beta-Hexosaminidase 3D structures\|Beta-Hexosaminidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Beta-N-acetylhexosaminidase]]		[[Category: Beta-N-acetylhexosaminidase]]
		+	[[Category: Large Structures]]
	[[Category: Strpn]]		[[Category: Strpn]]
	[[Category: Abbott, D W]]		[[Category: Abbott, D W]]

OCA at 09:12, 17 October 2018

OCA — Wed, 17 Oct 2018 09:12:42 GMT

←Older revision		Revision as of 09:12, 17 October 2018
Line 1:		Line 1:

-	==~~Inhibition of the pneumococcal virulence factor StrH and molecular insights into~~ N-~~glycan recognition and hydrolysis~~==	+	==INHIBITION OF THE PNEUMOCOCCAL VIRULENCE FACTOR STRH AND MOLECULAR INSIGHTS INTO N-GLYCAN RECOGNITION AND HYDROLYSIS==
	<StructureSection load='2yla' size='340' side='right' caption='[[2yla]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2yla' size='340' side='right' caption='[[2yla]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 01:53, 5 August 2016

OCA — Fri, 05 Aug 2016 01:53:43 GMT

←Older revision		Revision as of 01:53, 5 August 2016
Line 1:		Line 1:
		+
	==Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis==		==Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis==
	<StructureSection load='2yla' size='340' side='right' caption='[[2yla]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2yla' size='340' side='right' caption='[[2yla]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yla]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_pneumoniae Streptococcus pneumoniae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YLA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yla]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YLA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yl8\|2yl8]], [[2yl9\|2yl9]], [[2yl6\|2yl6]], [[2yl5\|2yl5]], [[2yll\|2yll]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yl8\|2yl8]], [[2yl9\|2yl9]], [[2yl6\|2yl6]], [[2yl5\|2yl5]], [[2yll\|2yll]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yla OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yla RCSB], [http://www.ebi.ac.uk/pdbsum/2yla PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yla OCA], [http://pdbe.org/2yla PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yla RCSB], [http://www.ebi.ac.uk/pdbsum/2yla PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yla ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2yla" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Beta-N-acetylhexosaminidase]]		[[Category: Beta-N-acetylhexosaminidase]]
-	[[Category: ~~Streptococcus pneumoniae~~]]	+	[[Category: Strpn]]
	[[Category: Abbott, D W]]		[[Category: Abbott, D W]]
	[[Category: Boraston, A B]]		[[Category: Boraston, A B]]

OCA at 23:01, 3 January 2015

OCA — Sat, 03 Jan 2015 23:01:24 GMT

←Older revision		Revision as of 23:01, 3 January 2015
Line 2:		Line 2:
	<StructureSection load='2yla' size='340' side='right' caption='[[2yla]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2yla' size='340' side='right' caption='[[2yla]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yla]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLA OCA]. <br>	+	<table><tr><td colspan='2'>[[2yla]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YLA FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yl8\|2yl8]], [[2yl9\|2yl9]], [[2yl6\|2yl6]], [[2yl5\|2yl5]], [[2yll\|2yll]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yl8\|2yl8]], [[2yl9\|2yl9]], [[2yl6\|2yl6]], [[2yl5\|2yl5]], [[2yll\|2yll]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Glucokinase Glucokinase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yla OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yla RCSB], [http://www.ebi.ac.uk/pdbsum/2yla PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yla OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yla RCSB], [http://www.ebi.ac.uk/pdbsum/2yla PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 14:
	Inhibition of the Pneumococcal Virulence Factor StrH and Molecular Insights into N-Glycan Recognition and Hydrolysis.,Pluvinage B, Higgins MA, Abbott DW, Robb C, Dalia AB, Deng L, Weiser JN, Parsons TB, Fairbanks AJ, Vocadlo DJ, Boraston AB Structure. 2011 Nov 9;19(11):1603-14. PMID:22078560<ref>PMID:22078560</ref>		Inhibition of the Pneumococcal Virulence Factor StrH and Molecular Insights into N-Glycan Recognition and Hydrolysis.,Pluvinage B, Higgins MA, Abbott DW, Robb C, Dalia AB, Deng L, Weiser JN, Parsons TB, Fairbanks AJ, Vocadlo DJ, Boraston AB Structure. 2011 Nov 9;19(11):1603-14. PMID:22078560<ref>PMID:22078560</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Beta-Hexosaminidase\|Beta-Hexosaminidase]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 25:
	[[Category: Beta-N-acetylhexosaminidase]]		[[Category: Beta-N-acetylhexosaminidase]]
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]
-	[[Category: Abbott, D W.]]	+	[[Category: Abbott, D W]]
-	[[Category: Boraston, A B.]]	+	[[Category: Boraston, A B]]
-	[[Category: Dalia, A B.]]	+	[[Category: Dalia, A B]]
-	[[Category: Deng, L.]]	+	[[Category: Deng, L]]
-	[[Category: Fairbanks, A J.]]	+	[[Category: Fairbanks, A J]]
-	[[Category: Higgins, M A.]]	+	[[Category: Higgins, M A]]
-	[[Category: Parsons, T B.]]	+	[[Category: Parsons, T B]]
-	[[Category: Pluvinage, B.]]	+	[[Category: Pluvinage, B]]
-	[[Category: Robb, C.]]	+	[[Category: Robb, C]]
-	[[Category: Vocadlo, D J.]]	+	[[Category: Vocadlo, D J]]
-	[[Category: Weiser, J N.]]	+	[[Category: Weiser, J N]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 07:38, 14 May 2014

OCA — Wed, 14 May 2014 07:38:30 GMT

←Older revision		Revision as of 07:38, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2yla.~~png~~\|~~left~~\|~~200px~~]]	+	==Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis==
		+	<StructureSection load='2yla' size='340' side='right' caption='[[2yla]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2yla]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLA OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yl8\|2yl8]], [[2yl9\|2yl9]], [[2yl6\|2yl6]], [[2yl5\|2yl5]], [[2yll\|2yll]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yla OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yla RCSB], [http://www.ebi.ac.uk/pdbsum/2yla PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The complete degradation of N-linked glycans by the pathogenic bacterium Streptococcus pneumoniae is facilitated by the large multimodular cell wall-attached exo-beta-D-N-acetylglucosaminidase StrH. Structural dissection of this virulence factor using X-ray crystallography showed it to have two structurally related glycoside hydrolase family 20 catalytic domains, which displayed the expected specificity for complex N-glycans terminating in N-acetylglucosamine but exhibited unexpected differences in their preferences for the substructures present in these glycans. The structures of the two catalytic domains in complex with unhydrolyzed substrates, including an N-glycan possessing a bisecting N-acetylglucosamine residue, revealed the specific architectural features in the active sites that confer their differential specificities. Inhibitors of StrH are demonstrated to be effective tools in modulating the interaction of StrH with components of the host, such as the innate immune system. Overall, new structural and functional insight into a carbohydrate-mediated component of the pneumococcus-host interaction is provided.

-	<!--	+	Inhibition of the Pneumococcal Virulence Factor StrH and Molecular Insights into N-Glycan Recognition and Hydrolysis.,Pluvinage B, Higgins MA, Abbott DW, Robb C, Dalia AB, Deng L, Weiser JN, Parsons TB, Fairbanks AJ, Vocadlo DJ, Boraston AB Structure. 2011 Nov 9;19(11):1603-14. PMID:22078560<ref>PMID:22078560</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2yla"~~, ~~creates the "~~Structure ~~Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2yla\| PDB=2yla \| SCENE= }}~~	+

-	~~===Inhibition~~ of the ~~pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22078560}}, adds the Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22078560 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22078560}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2yla]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLA OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022078560<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Beta-N-acetylhexosaminidase]]		[[Category: Beta-N-acetylhexosaminidase]]
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]

OCA at 05:34, 28 December 2011

OCA — Wed, 28 Dec 2011 05:34:58 GMT

←Older revision		Revision as of 05:34, 28 December 2011
Line 1:		Line 1:
-	[[Image:2yla.~~jpg~~\|left\|200px]]	+	[[Image:2yla.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 9:
	{{STRUCTURE_2yla\| PDB=2yla \| SCENE= }}		{{STRUCTURE_2yla\| PDB=2yla \| SCENE= }}

-	===~~INHIBITION OF THE PNEUMOCOCCAL VIRULENCE FACTOR STRH AND MOLECULAR INSIGHTS INTO~~ N-~~GLYCAN RECOGNITION AND HYDROLYSIS~~===	+	===Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22078560}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22078560 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22078560}}

	==About this Structure==		==About this Structure==
	[[2yla]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLA OCA].		[[2yla]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLA OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022078560</ref><references group="xtra"/>
	[[Category: Beta-N-acetylhexosaminidase]]		[[Category: Beta-N-acetylhexosaminidase]]
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]
-	[[Category: Abbott, W D.]]	+	[[Category: Abbott, D W.]]
	[[Category: Boraston, A B.]]		[[Category: Boraston, A B.]]
	[[Category: Dalia, A B.]]		[[Category: Dalia, A B.]]

OCA at 06:15, 7 September 2011

OCA — Wed, 07 Sep 2011 06:15:29 GMT

←Older revision		Revision as of 06:15, 7 September 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2yla.jpg\|left\|200px]]

-	The ~~entry 2yla~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2yla", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2yla\| PDB=2yla \| SCENE= }}

-	~~Authors: Pluvinage, B., Higgins, M.A., Abbott, W.D., Robb, C., Dalia, A.B., Deng, L., Weiser, J.~~N~~., Parsons, T.B., Fairbanks, A.J., Vocadlo, D.J., Boraston, A.B.~~	+	===INHIBITION OF THE PNEUMOCOCCAL VIRULENCE FACTOR STRH AND MOLECULAR INSIGHTS INTO N-GLYCAN RECOGNITION AND HYDROLYSIS===

-	~~Description~~: ~~Inhibition of the pneumococcal virulence factor StrH and molecular insights into~~ N-~~glycan recognition and hydrolysis~~	+
		+	==About this Structure==
		+	[[2yla]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLA OCA].
		+	[[Category: Beta-N-acetylhexosaminidase]]
		+	[[Category: Streptococcus pneumoniae]]
		+	[[Category: Abbott, W D.]]
		+	[[Category: Boraston, A B.]]
		+	[[Category: Dalia, A B.]]
		+	[[Category: Deng, L.]]
		+	[[Category: Fairbanks, A J.]]
		+	[[Category: Higgins, M A.]]
		+	[[Category: Parsons, T B.]]
		+	[[Category: Pluvinage, B.]]
		+	[[Category: Robb, C.]]
		+	[[Category: Vocadlo, D J.]]
		+	[[Category: Weiser, J N.]]
		+	[[Category: Hydrolase]]

OCA: Protected "2yla" [edit=sysop:move=sysop]

OCA — Wed, 08 Jun 2011 04:41:09 GMT

Protected "2yla" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:41, 8 June 2011