2yob - Revision history

OCA at 10:56, 20 December 2023

OCA — Wed, 20 Dec 2023 10:56:59 GMT

←Older revision		Revision as of 10:56, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2yob' size='340' side='right'caption='[[2yob]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2yob' size='340' side='right'caption='[[2yob]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yob]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YOB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yob]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YOB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1h0c\|1h0c]], [[1j04\|1j04]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yob OCA], [https://pdbe.org/2yob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yob RCSB], [https://www.ebi.ac.uk/pdbsum/2yob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yob ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yob OCA], [https://pdbe.org/2yob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yob RCSB], [https://www.ebi.ac.uk/pdbsum/2yob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yob ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/~~SPYA_HUMAN SPYA_HUMAN~~]~~] Defects in AGXT are the cause of~~ hyperoxaluria ~~primary~~ type 1 ~~(HP1) [MIM:~~[https://~~omim~~.org/~~entry~~/~~259900 259900~~]~~]; also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error~~ of glyoxylate ~~metabolism characterized by increased excretion of oxalate and glycolate,~~ and the ~~progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.<ref>PMID~~:~~1703535</ref> <ref>PMID~~:~~2039493</ref> <ref>PMID~~:~~1349575</ref> <ref>PMID~~:~~1301173</ref> <ref>PMID~~:~~8101040</ref> <ref>PMID~~:~~9192270</ref>~~ <ref>PMID:~~9604803</ref> <ref>PMID:10394939</ref> <ref>PMID:10453743</ref> <ref>PMID:10541294</ref> <ref>PMID:10862087~~</ref> <ref>PMID:10960483~~</ref> <ref>PMID:12559847~~</ref> <ref>PMID:12777626</ref> <ref>PMID:~~15253729</ref> <ref>PMID:15849466~~</ref> <ref>PMID:~~15961946~~</ref> <ref>PMID:~~15963748~~</ref>	+	[https://www.uniprot.org/uniprot/AGT1_HUMAN AGT1_HUMAN] Primary hyperoxaluria type 1. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/AGT1_HUMAN AGT1_HUMAN] Peroxisomal aminotransferase that catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification (PubMed:10960483, PubMed:12777626, PubMed:24055001, PubMed:23229545, PubMed:26149463). Also catalyzes the transamination between L-serine and pyruvate and contributes to gluconeogenesis from the L-serine metabolism (PubMed:10347152).<ref>PMID:10347152</ref> <ref>PMID:10960483</ref> <ref>PMID:12777626</ref> <ref>PMID:23229545</ref> <ref>PMID:24055001</ref> <ref>PMID:26149463</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Albert, A]]	+	[[Category: Albert A]]
-	[[Category: Fabelo-Rosa, I]]	+	[[Category: Fabelo-Rosa I]]
-	[[Category: Mesa-Torres, N]]	+	[[Category: Mesa-Torres N]]
-	[[Category: Pey~~, A L~~]]	+	[[Category: Pey AL]]
-	[[Category: Riverol, D]]	+	[[Category: Riverol D]]
-	[[Category: Salido, E]]	+	[[Category: Salido E]]
-	[[Category: Yunta, C]]	+	[[Category: Yunta C]]
-	~~[[Category: Agxt folding and stability defect]]~~	+
-	~~[[Category: Primary hyperoxaluria type i]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 12:34, 27 April 2022

OCA — Wed, 27 Apr 2022 12:34:02 GMT

←Older revision		Revision as of 12:34, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2yob' size='340' side='right'caption='[[2yob]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2yob' size='340' side='right'caption='[[2yob]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yob]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2YOB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yob]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YOB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h0c\|1h0c]], [[1j04\|1j04]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1h0c\|1h0c]], [[1j04\|1j04]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2yob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yob OCA], [~~http~~://pdbe.org/2yob PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2yob RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2yob PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2yob ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yob OCA], [https://pdbe.org/2yob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yob RCSB], [https://www.ebi.ac.uk/pdbsum/2yob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yob ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/SPYA_HUMAN SPYA_HUMAN]] Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1) [MIM:[~~http~~://omim.org/entry/259900 259900]]; also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.<ref>PMID:1703535</ref> <ref>PMID:2039493</ref> <ref>PMID:1349575</ref> <ref>PMID:1301173</ref> <ref>PMID:8101040</ref> <ref>PMID:9192270</ref> <ref>PMID:9604803</ref> <ref>PMID:10394939</ref> <ref>PMID:10453743</ref> <ref>PMID:10541294</ref> <ref>PMID:10862087</ref> <ref>PMID:10960483</ref> <ref>PMID:12559847</ref> <ref>PMID:12777626</ref> <ref>PMID:15253729</ref> <ref>PMID:15849466</ref> <ref>PMID:15961946</ref> <ref>PMID:15963748</ref>	+	[[https://www.uniprot.org/uniprot/SPYA_HUMAN SPYA_HUMAN]] Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1) [MIM:[https://omim.org/entry/259900 259900]]; also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.<ref>PMID:1703535</ref> <ref>PMID:2039493</ref> <ref>PMID:1349575</ref> <ref>PMID:1301173</ref> <ref>PMID:8101040</ref> <ref>PMID:9192270</ref> <ref>PMID:9604803</ref> <ref>PMID:10394939</ref> <ref>PMID:10453743</ref> <ref>PMID:10541294</ref> <ref>PMID:10862087</ref> <ref>PMID:10960483</ref> <ref>PMID:12559847</ref> <ref>PMID:12777626</ref> <ref>PMID:15253729</ref> <ref>PMID:15849466</ref> <ref>PMID:15961946</ref> <ref>PMID:15963748</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:00, 22 July 2020

OCA — Wed, 22 Jul 2020 13:00:08 GMT

←Older revision		Revision as of 13:00, 22 July 2020
Line 1:		Line 1:

	==High resolution AGXT_M structure==		==High resolution AGXT_M structure==
-	<StructureSection load='2yob' size='340' side='right' caption='[[2yob]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2yob' size='340' side='right'caption='[[2yob]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yob]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YOB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yob]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YOB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h0c\|1h0c]], [[1j04\|1j04]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h0c\|1h0c]], [[1j04\|1j04]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2yob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yob OCA], [http://pdbe.org/2yob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yob RCSB], [http://www.ebi.ac.uk/pdbsum/2yob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yob ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yob OCA], [http://pdbe.org/2yob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yob RCSB], [http://www.ebi.ac.uk/pdbsum/2yob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yob ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Aminotransferase\|Aminotransferase]]	+	*[[Aminotransferase 3D structures\|Aminotransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Albert, A]]		[[Category: Albert, A]]
	[[Category: Fabelo-Rosa, I]]		[[Category: Fabelo-Rosa, I]]

OCA at 10:06, 4 August 2016

OCA — Thu, 04 Aug 2016 10:06:26 GMT

←Older revision		Revision as of 10:06, 4 August 2016
Line 1:		Line 1:
		+
	==High resolution AGXT_M structure==		==High resolution AGXT_M structure==
	<StructureSection load='2yob' size='340' side='right' caption='[[2yob]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2yob' size='340' side='right' caption='[[2yob]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h0c\|1h0c]], [[1j04\|1j04]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h0c\|1h0c]], [[1j04\|1j04]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yob OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yob RCSB], [http://www.ebi.ac.uk/pdbsum/2yob PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yob OCA], [http://pdbe.org/2yob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yob RCSB], [http://www.ebi.ac.uk/pdbsum/2yob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yob ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2yob" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminotransferase\|Aminotransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:11, 25 December 2014

OCA — Thu, 25 Dec 2014 08:11:26 GMT

←Older revision		Revision as of 08:11, 25 December 2014
Line 9:		Line 9:
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/SPYA_HUMAN SPYA_HUMAN]] Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1) [MIM:[http://omim.org/entry/259900 259900]]; also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.<ref>PMID:1703535</ref> <ref>PMID:2039493</ref> <ref>PMID:1349575</ref> <ref>PMID:1301173</ref> <ref>PMID:8101040</ref> <ref>PMID:9192270</ref> <ref>PMID:9604803</ref> <ref>PMID:10394939</ref> <ref>PMID:10453743</ref> <ref>PMID:10541294</ref> <ref>PMID:10862087</ref> <ref>PMID:10960483</ref> <ref>PMID:12559847</ref> <ref>PMID:12777626</ref> <ref>PMID:15253729</ref> <ref>PMID:15849466</ref> <ref>PMID:15961946</ref> <ref>PMID:15963748</ref>		[[http://www.uniprot.org/uniprot/SPYA_HUMAN SPYA_HUMAN]] Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1) [MIM:[http://omim.org/entry/259900 259900]]; also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.<ref>PMID:1703535</ref> <ref>PMID:2039493</ref> <ref>PMID:1349575</ref> <ref>PMID:1301173</ref> <ref>PMID:8101040</ref> <ref>PMID:9192270</ref> <ref>PMID:9604803</ref> <ref>PMID:10394939</ref> <ref>PMID:10453743</ref> <ref>PMID:10541294</ref> <ref>PMID:10862087</ref> <ref>PMID:10960483</ref> <ref>PMID:12559847</ref> <ref>PMID:12777626</ref> <ref>PMID:15253729</ref> <ref>PMID:15849466</ref> <ref>PMID:15961946</ref> <ref>PMID:15963748</ref>
-	== Function ==
-
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:59, 21 December 2014

OCA — Sun, 21 Dec 2014 06:59:16 GMT

←Older revision		Revision as of 06:59, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2yob\| PDB~~=2yob \| ~~SCENE~~= }}	+	==High resolution AGXT_M structure==
-	===~~High resolution AGXT_M~~ structure===	+	<StructureSection load='2yob' size='340' side='right' caption='[[2yob]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24205397}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2yob]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YOB FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h0c\|1h0c]], [[1j04\|1j04]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yob OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yob RCSB], [http://www.ebi.ac.uk/pdbsum/2yob PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/SPYA_HUMAN SPYA_HUMAN]] Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1) [MIM:[http://omim.org/entry/259900 259900]]; also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.<ref>PMID:1703535</ref> <ref>PMID:2039493</ref> <ref>PMID:1349575</ref> <ref>PMID:1301173</ref> <ref>PMID:8101040</ref> <ref>PMID:9192270</ref> <ref>PMID:9604803</ref> <ref>PMID:10394939</ref> <ref>PMID:10453743</ref> <ref>PMID:10541294</ref> <ref>PMID:10862087</ref> <ref>PMID:10960483</ref> <ref>PMID:12559847</ref> <ref>PMID:12777626</ref> <ref>PMID:15253729</ref> <ref>PMID:15849466</ref> <ref>PMID:15961946</ref> <ref>PMID:15963748</ref>		[[http://www.uniprot.org/uniprot/SPYA_HUMAN SPYA_HUMAN]] Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1) [MIM:[http://omim.org/entry/259900 259900]]; also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.<ref>PMID:1703535</ref> <ref>PMID:2039493</ref> <ref>PMID:1349575</ref> <ref>PMID:1301173</ref> <ref>PMID:8101040</ref> <ref>PMID:9192270</ref> <ref>PMID:9604803</ref> <ref>PMID:10394939</ref> <ref>PMID:10453743</ref> <ref>PMID:10541294</ref> <ref>PMID:10862087</ref> <ref>PMID:10960483</ref> <ref>PMID:12559847</ref> <ref>PMID:12777626</ref> <ref>PMID:15253729</ref> <ref>PMID:15849466</ref> <ref>PMID:15961946</ref> <ref>PMID:15963748</ref>
		+	== Function ==
		+
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Primary hyperoxaluria type I (PH1) is a conformational disease which result in the loss of alanine:glyoxylate aminotransferase (AGT) function. The study of AGT has important implications for protein folding and trafficking because PH1 mutants may cause protein aggregation and mitochondrial mistargeting. We herein describe a multidisciplinary study aimed to understand the molecular basis of protein aggregation and mistargeting in PH1 by studying twelve AGT variants. Expression studies in cell cultures reveal strong protein folding defects in PH1 causing mutants leading to enhanced aggregation, and in two cases, mitochondrial mistargeting. Immunoprecipitation studies in a cell-free system reveal that most mutants enhance the interactions with Hsc70 chaperones along their folding process, while in vitro binding experiments show no changes in the interaction of folded AGT dimers with the peroxisomal receptor Pex5p. Thermal denaturation studies by calorimetry support that PH1 causing mutants often kinetically destabilize the folded apo-protein through significant changes in the denaturation free energy barrier, whereas coenzyme binding overcomes this destabilization. Modeling of the mutations on a 1.9 A crystal structure suggests that PH1 causing mutants perturb locally the native structure. Our work support that a misbalance between denaturation energetics and interactions with chaperones underlie aggregation and mistargeting in PH1, suggesting that native state stabilizers and protein homeostasis modulators are potential drugs to restore the complex and delicate balance of AGT protein homeostasis in PH1.

-	~~==About this Structure==~~	+	The role of protein denaturation energetics and molecular chaperones in the aggregation and mistargeting of mutants causing primary hyperoxaluria type I.,Mesa-Torres N, Fabelo-Rosa I, Riverol D, Yunta C, Albert A, Salido E, Pey AL PLoS One. 2013 Aug 27;8(8):e71963. doi: 10.1371/journal.pone.0071963. PMID:24205397<ref>PMID:24205397</ref>
-	~~[[2yob]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2YOB OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024205397</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Albert, A.]]	+	[[Category: Albert, A]]
-	[[Category: Fabelo-Rosa, I.]]	+	[[Category: Fabelo-Rosa, I]]
-	[[Category: Mesa-Torres, N.]]	+	[[Category: Mesa-Torres, N]]
-	[[Category: Pey, A L.]]	+	[[Category: Pey, A L]]
-	[[Category: Riverol, D.]]	+	[[Category: Riverol, D]]
-	[[Category: Salido, E.]]	+	[[Category: Salido, E]]
-	[[Category: Yunta, C.]]	+	[[Category: Yunta, C]]
	[[Category: Agxt folding and stability defect]]		[[Category: Agxt folding and stability defect]]
	[[Category: Primary hyperoxaluria type i]]		[[Category: Primary hyperoxaluria type i]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 12:17, 20 November 2013

OCA — Wed, 20 Nov 2013 12:17:10 GMT

←Older revision		Revision as of 12:17, 20 November 2013
Line 1:		Line 1:
	{{STRUCTURE_2yob\| PDB=2yob \| SCENE= }}		{{STRUCTURE_2yob\| PDB=2yob \| SCENE= }}
	===High resolution AGXT_M structure===		===High resolution AGXT_M structure===
		+	{{ABSTRACT_PUBMED_24205397}}

	==Disease==		==Disease==
Line 6:		Line 7:

	==About this Structure==		==About this Structure==
-	[[2yob]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOB OCA].	+	[[2yob]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOB OCA].

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:024205397</ref><references group="xtra"/><references/>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Albert, A.]]		[[Category: Albert, A.]]
	[[Category: Fabelo-Rosa, I.]]		[[Category: Fabelo-Rosa, I.]]

OCA at 09:45, 30 October 2013

OCA — Wed, 30 Oct 2013 09:45:25 GMT

←Older revision		Revision as of 09:45, 30 October 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_2yob\| PDB=2yob \| SCENE= }}
		+	===High resolution AGXT_M structure===

-	~~The~~ entry ~~2yob~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/SPYA_HUMAN SPYA_HUMAN]] Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1) [MIM:[http://omim.org/entry/259900 259900]]; also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.<ref>PMID:1703535</ref> <ref>PMID:2039493</ref> <ref>PMID:1349575</ref> <ref>PMID:1301173</ref> <ref>PMID:8101040</ref> <ref>PMID:9192270</ref> <ref>PMID:9604803</ref> <ref>PMID:10394939</ref> <ref>PMID:10453743</ref> <ref>PMID:10541294</ref> <ref>PMID:10862087</ref> <ref>PMID:10960483</ref> <ref>PMID:12559847</ref> <ref>PMID:12777626</ref> <ref>PMID:15253729</ref> <ref>PMID:15849466</ref> <ref>PMID:15961946</ref> <ref>PMID:15963748</ref>

-	~~Authors~~: ~~Fabelo-Rosa, I~~.~~, Mesa-Torres, N~~.~~, Riverol, D~~.~~, Yunta, C~~.~~, Albert, A~~.~~, Salido, E~~.~~, Pey, A.L~~.	+	==About this Structure==
		+	[[2yob]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOB OCA].

-	~~Description~~: ~~High resolution AGXT_M structure~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Albert, A.]]
		+	[[Category: Fabelo-Rosa, I.]]
		+	[[Category: Mesa-Torres, N.]]
		+	[[Category: Pey, A L.]]
		+	[[Category: Riverol, D.]]
		+	[[Category: Salido, E.]]
		+	[[Category: Yunta, C.]]
		+	[[Category: Agxt folding and stability defect]]
		+	[[Category: Primary hyperoxaluria type i]]
		+	[[Category: Transferase]]

OCA at 00:30, 4 April 2013

OCA — Thu, 04 Apr 2013 00:30:03 GMT

←Older revision		Revision as of 00:30, 4 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2yob is ON HOLD	+	The entry 2yob is ON HOLD until Paper Publication

	Authors: Fabelo-Rosa, I., Mesa-Torres, N., Riverol, D., Yunta, C., Albert, A., Salido, E., Pey, A.L.		Authors: Fabelo-Rosa, I., Mesa-Torres, N., Riverol, D., Yunta, C., Albert, A., Salido, E., Pey, A.L.

	Description: High resolution AGXT_M structure		Description: High resolution AGXT_M structure

OCA: Protected "2yob" [edit=sysop:move=sysop]

OCA — Wed, 31 Oct 2012 08:22:47 GMT

Protected "2yob" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:22, 31 October 2012