2yoz - Revision history

OCA at 13:38, 30 August 2023

OCA — Wed, 30 Aug 2023 13:38:22 GMT

←Older revision		Revision as of 13:38, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2yoz' size='340' side='right'caption='[[2yoz]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2yoz' size='340' side='right'caption='[[2yoz]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yoz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YOZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yoz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YOZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OVE:2-O-(SULFIDOPHOSPHINATO)ADENOSINE'>OVE</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xmi\|2xmi]], [[2y1p\|2y1p]], [[2y3x\|2y3x]], [[2ydb\|2ydb]], [[2ydc\|2ydc]], [[2ydd\|2ydd]], [[2yp0\|2yp0]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OVE:2-O-(SULFIDOPHOSPHINATO)ADENOSINE'>OVE</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/2',3'-cyclic-nucleotide_3'-phosphodiesterase 2',3'-cyclic-nucleotide 3'-phosphodiesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.37 3.1.4.37] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yoz OCA], [https://pdbe.org/2yoz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yoz RCSB], [https://www.ebi.ac.uk/pdbsum/2yoz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yoz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yoz OCA], [https://pdbe.org/2yoz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yoz RCSB], [https://www.ebi.ac.uk/pdbsum/2yoz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yoz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CN37_MOUSE CN37_MOUSE]] May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.<ref>PMID:22393399</ref>	+	[https://www.uniprot.org/uniprot/CN37_MOUSE CN37_MOUSE] May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.<ref>PMID:22393399</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Han, H]]	+	[[Category: Han H]]
-	[[Category: Kursula, P]]	+	[[Category: Kursula P]]
-	[[Category: Lehtimaki, M]]	+	[[Category: Lehtimaki M]]
-	[[Category: Myllykoski, M]]	+	[[Category: Myllykoski M]]
-	[[Category: Raasakka, A]]	+	[[Category: Raasakka A]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Myelin]]~~	+
-	~~[[Category: Nervous system~~]]	+

OCA at 13:34, 24 November 2021

OCA — Wed, 24 Nov 2021 13:34:16 GMT

←Older revision		Revision as of 13:34, 24 November 2021
Line 3:		Line 3:
	<StructureSection load='2yoz' size='340' side='right'caption='[[2yoz]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2yoz' size='340' side='right'caption='[[2yoz]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yoz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YOZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yoz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YOZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OVE:2-O-(SULFIDOPHOSPHINATO)ADENOSINE'>OVE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OVE:2-O-(SULFIDOPHOSPHINATO)ADENOSINE'>OVE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xmi\|2xmi]], [[2y1p\|2y1p]], [[2y3x\|2y3x]], [[2ydb\|2ydb]], [[2ydc\|2ydc]], [[2ydd\|2ydd]], [[2yp0\|2yp0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xmi\|2xmi]], [[2y1p\|2y1p]], [[2y3x\|2y3x]], [[2ydb\|2ydb]], [[2ydc\|2ydc]], [[2ydd\|2ydd]], [[2yp0\|2yp0]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/2',3'-cyclic-nucleotide_3'-phosphodiesterase 2',3'-cyclic-nucleotide 3'-phosphodiesterase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.37 3.1.4.37] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/2',3'-cyclic-nucleotide_3'-phosphodiesterase 2',3'-cyclic-nucleotide 3'-phosphodiesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.37 3.1.4.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2yoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yoz OCA], [~~http~~://pdbe.org/2yoz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2yoz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2yoz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2yoz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yoz OCA], [https://pdbe.org/2yoz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yoz RCSB], [https://www.ebi.ac.uk/pdbsum/2yoz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yoz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CN37_MOUSE CN37_MOUSE]] May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.<ref>PMID:22393399</ref>	+	[[https://www.uniprot.org/uniprot/CN37_MOUSE CN37_MOUSE]] May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.<ref>PMID:22393399</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Phosphodiesterase\|Phosphodiesterase]]	+	*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:52, 21 May 2019

OCA — Tue, 21 May 2019 07:52:38 GMT

←Older revision		Revision as of 07:52, 21 May 2019
Line 1:		Line 1:

	==Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, crystallized with 2'-AMPS==		==Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, crystallized with 2'-AMPS==
-	<StructureSection load='2yoz' size='340' side='right' caption='[[2yoz]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2yoz' size='340' side='right'caption='[[2yoz]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2yoz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YOZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2yoz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YOZ FirstGlance]. <br>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]		[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Han, H]]		[[Category: Han, H]]

OCA at 21:22, 4 August 2016

OCA — Thu, 04 Aug 2016 21:22:00 GMT

←Older revision		Revision as of 21:22, 4 August 2016
Line 1:		Line 1:
		+
	==Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, crystallized with 2'-AMPS==		==Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, crystallized with 2'-AMPS==
	<StructureSection load='2yoz' size='340' side='right' caption='[[2yoz]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2yoz' size='340' side='right' caption='[[2yoz]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xmi\|2xmi]], [[2y1p\|2y1p]], [[2y3x\|2y3x]], [[2ydb\|2ydb]], [[2ydc\|2ydc]], [[2ydd\|2ydd]], [[2yp0\|2yp0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xmi\|2xmi]], [[2y1p\|2y1p]], [[2y3x\|2y3x]], [[2ydb\|2ydb]], [[2ydc\|2ydc]], [[2ydd\|2ydd]], [[2yp0\|2yp0]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2',3'-cyclic-nucleotide_3'-phosphodiesterase 2',3'-cyclic-nucleotide 3'-phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.37 3.1.4.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2',3'-cyclic-nucleotide_3'-phosphodiesterase 2',3'-cyclic-nucleotide 3'-phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.37 3.1.4.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yoz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yoz RCSB], [http://www.ebi.ac.uk/pdbsum/2yoz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yoz OCA], [http://pdbe.org/2yoz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yoz RCSB], [http://www.ebi.ac.uk/pdbsum/2yoz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yoz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2yoz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 13:15, 25 December 2014

OCA — Thu, 25 Dec 2014 13:15:16 GMT

←Older revision		Revision as of 13:15, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2yoz\| PDB=2yoz \| SCENE= }}~~	+	==Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, crystallized with 2'-AMPS==
-	===Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, crystallized with 2'-AMPS===	+	<StructureSection load='2yoz' size='340' side='right' caption='[[2yoz]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23831225}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2yoz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YOZ FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OVE:2-O-(SULFIDOPHOSPHINATO)ADENOSINE'>OVE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xmi\|2xmi]], [[2y1p\|2y1p]], [[2y3x\|2y3x]], [[2ydb\|2ydb]], [[2ydc\|2ydc]], [[2ydd\|2ydd]], [[2yp0\|2yp0]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2',3'-cyclic-nucleotide_3'-phosphodiesterase 2',3'-cyclic-nucleotide 3'-phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.37 3.1.4.37] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yoz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yoz RCSB], [http://www.ebi.ac.uk/pdbsum/2yoz PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/CN37_MOUSE CN37_MOUSE]] May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.<ref>PMID:22393399</ref>		[[http://www.uniprot.org/uniprot/CN37_MOUSE CN37_MOUSE]] May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.<ref>PMID:22393399</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	2H phosphoesterases catalyze reactions on nucleotide substrates and contain two conserved histidine residues in the active site. Very limited information is currently available on the details of the active site and substrate/product binding during the catalytic cycle of these enzymes. We performed a comprehensive X-ray crystallographic study of mouse 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), a membrane-associated enzyme present at high levels in the tetrapod myelin sheath. We determined crystal structures of the CNPase phosphodiesterase domain complexed with substrate, product, and phosphorothioate analogues. The data provide detailed information on the CNPase reaction mechanism, including substrate binding mode and coordination of the nucleophilic water molecule. Linked to the reaction, an open/close motion of the beta5-alpha7 loop is observed. The role of the N terminus of helix alpha7 - unique for CNPase in the 2H family - during the reaction indicates that 2H phosphoesterases differ in their respective reaction mechanisms, despite the conserved catalytic residues. Furthermore, based on small-angle X-ray scattering, we present a model for the full-length enzyme, indicating the two domains of CNPase form an elongated molecule. Finally, based on our structural data and a comprehensive bioinformatics study, we discuss the conservation of CNPase in various organisms.
		+
		+	Crystallographic analysis of the reaction cycle of 2',3'-cyclic nucleotide 3'-phosphodiesterase, a unique member of the 2H phosphoesterase family.,Myllykoski M, Raasakka A, Lehtimaki M, Han H, Kursula I, Kursula P J Mol Biol. 2013 Jul 2. pii: S0022-2836(13)00391-4. doi:, 10.1016/j.jmb.2013.06.012. PMID:23831225<ref>PMID:23831225</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2yoz]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2YOZ OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023831225</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Phosphodiesterase\|Phosphodiesterase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]		[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
-	[[Category: Han, H.]]	+	[[Category: Han, H]]
-	[[Category: Kursula, P.]]	+	[[Category: Kursula, P]]
-	[[Category: Lehtimaki, M.]]	+	[[Category: Lehtimaki, M]]
-	[[Category: Myllykoski, M.]]	+	[[Category: Myllykoski, M]]
-	[[Category: Raasakka, A.]]	+	[[Category: Raasakka, A]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Myelin]]		[[Category: Myelin]]
	[[Category: Nervous system]]		[[Category: Nervous system]]

OCA at 06:34, 13 November 2013

OCA — Wed, 13 Nov 2013 06:34:51 GMT

←Older revision		Revision as of 06:34, 13 November 2013
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[2yoz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOZ OCA].	+	[[2yoz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOZ OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:023831225</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:023831225</ref><references group="xtra"/><references/>
	[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]		[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Han, H.]]		[[Category: Han, H.]]
	[[Category: Kursula, P.]]		[[Category: Kursula, P.]]

OCA at 04:12, 18 July 2013

OCA — Thu, 18 Jul 2013 04:12:35 GMT

←Older revision		Revision as of 04:12, 18 July 2013
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	{{STRUCTURE_2yoz\| PDB=2yoz \| SCENE= }}		{{STRUCTURE_2yoz\| PDB=2yoz \| SCENE= }}
	===Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, crystallized with 2'-AMPS===		===Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, crystallized with 2'-AMPS===
		+	{{ABSTRACT_PUBMED_23831225}}

	==Function==		==Function==
Line 9:		Line 10:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:023831225</ref><references group="xtra"/><references/>
	[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]		[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 15:47, 10 July 2013

OCA — Wed, 10 Jul 2013 15:47:06 GMT

←Older revision		Revision as of 15:47, 10 July 2013
Line 1:		Line 1:
-	'''~~Unreleased structure''~~'	+	{{STRUCTURE_2yoz\| PDB=2yoz \| SCENE= }}
		+	===Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, crystallized with 2'-AMPS===

-	~~The entry 2yoz~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CN37_MOUSE CN37_MOUSE]] May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.<ref>PMID:22393399</ref>

-	~~Authors~~: ~~Myllykoski, M~~.~~, Raasakka, A~~.~~, Lehtimaki, M~~.~~, Han, H~~.~~, Kursula, P~~.	+	==About this Structure==
		+	[[2yoz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOZ OCA].

-	~~Description~~: ~~Catalytic domain of mouse~~ 2',3'-cyclic nucleotide 3'-phosphodiesterase, ~~crystallized with 2'-AMPS~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]
		+	[[Category: Mus musculus]]
		+	[[Category: Han, H.]]
		+	[[Category: Kursula, P.]]
		+	[[Category: Lehtimaki, M.]]
		+	[[Category: Myllykoski, M.]]
		+	[[Category: Raasakka, A.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Myelin]]
		+	[[Category: Nervous system]]

OCA at 08:49, 21 November 2012

OCA — Wed, 21 Nov 2012 08:49:28 GMT

←Older revision		Revision as of 08:49, 21 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2yoz is ON HOLD	+	The entry 2yoz is ON HOLD until Paper Publication

	Authors: Myllykoski, M., Raasakka, A., Lehtimaki, M., Han, H., Kursula, P.		Authors: Myllykoski, M., Raasakka, A., Lehtimaki, M., Han, H., Kursula, P.

	Description: Catalytic domain of mouse 2',3'-cyclic nucleotide 3'-phosphodiesterase, crystallized with 2'-AMPS		Description: Catalytic domain of mouse 2',3'-cyclic nucleotide 3'-phosphodiesterase, crystallized with 2'-AMPS

OCA: Protected "2yoz" [edit=sysop:move=sysop]

OCA — Thu, 08 Nov 2012 13:06:17 GMT

Protected "2yoz" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:06, 8 November 2012