2yp5 - Revision history

OCA at 13:38, 30 August 2023

OCA — Wed, 30 Aug 2023 13:38:38 GMT

←Older revision		Revision as of 13:38, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2yp5' size='340' side='right'caption='[[2yp5]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='2yp5' size='340' side='right'caption='[[2yp5]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yp5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Influenza_a_virus_~~(a/~~finland~~/486/2004_(~~h3n2~~)) Influenza a virus (a/~~finland~~/486/2004 (~~h3n2~~))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YP5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yp5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Finland/486/2004_(H3N2)) Influenza A virus (A/Finland/486/2004 (H3N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YP5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~TAM~~:~~TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=GAL:BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-~~MANNOSE~~'>~~MAN~~</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.79Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[2yp2\|2yp2]], [[2yp3\|2yp3]], [[2yp4\|2yp4]], [[2yp7\|2yp7]], [[2yp8\|2yp8]], [[2yp9\|2yp9]], [[2ypg\|2ypg]]~~</~~div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yp5 OCA], [https://pdbe.org/2yp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yp5 RCSB], [https://www.ebi.ac.uk/pdbsum/2yp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yp5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yp5 OCA], [https://pdbe.org/2yp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yp5 RCSB], [https://www.ebi.ac.uk/pdbsum/2yp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yp5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/A0FCI1_9INFA A0FCI1_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00145386]	+	[https://www.uniprot.org/uniprot/K7N5L2_9INFA K7N5L2_9INFA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Christodoulou, E]]	+	[[Category: Christodoulou E]]
-	[[Category: Coombs~~, P J~~]]	+	[[Category: Coombs PJ]]
-	[[Category: Daniels~~, R S~~]]	+	[[Category: Daniels RS]]
-	[[Category: Gamblin~~, S J~~]]	+	[[Category: Gamblin SJ]]
-	[[Category: Hay~~, A J~~]]	+	[[Category: Hay AJ]]
-	[[Category: Lin~~, Y P~~]]	+	[[Category: Lin YP]]
-	[[Category: Liu, J]]	+	[[Category: Liu J]]
-	[[Category: Martin~~, S R~~]]	+	[[Category: Martin SR]]
-	[[Category: McCauley~~, J W~~]]	+	[[Category: McCauley JW]]
-	[[Category: Skehel~~, J J~~]]	+	[[Category: Skehel JJ]]
-	[[Category: Vachieri~~, S G~~]]	+	[[Category: Vachieri SG]]
-	[[Category: Walker~~, P A~~]]	+	[[Category: Walker PA]]
-	[[Category: Wharton~~, S A~~]]	+	[[Category: Wharton SA]]
-	[[Category: Xiong, X]]	+	[[Category: Xiong X]]
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Influenza virus evolution]]~~	+
-	~~[[Category: Membrane fusion]]~~	+
-	~~[[Category: Receptor binding]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 13:34, 24 November 2021

OCA — Wed, 24 Nov 2021 13:34:30 GMT

←Older revision		Revision as of 13:34, 24 November 2021
Line 3:		Line 3:
	<StructureSection load='2yp5' size='340' side='right'caption='[[2yp5]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='2yp5' size='340' side='right'caption='[[2yp5]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yp5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Influenza_a_virus_(a/finland/486/2004_(h3n2)) Influenza a virus (a/finland/486/2004 (h3n2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YP5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YP5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yp5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_a_virus_(a/finland/486/2004_(h3n2)) Influenza a virus (a/finland/486/2004 (h3n2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YP5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=~~GAL~~:~~BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA-D-MANNOSE~~'>~~MAN~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~SIA~~:O-~~SIALIC+ACID~~'>~~SIA~~</scene>, <scene name='pdbligand=~~TAM~~:~~TRIS(HYDROXYETHYL)AMINOMETHANE~~'>~~TAM~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yp2\|2yp2]], [[2yp3\|2yp3]], [[2yp4\|2yp4]], [[2yp7\|2yp7]], [[2yp8\|2yp8]], [[2yp9\|2yp9]], [[2ypg\|2ypg]]</td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yp5 OCA], [~~http~~://pdbe.org/2yp5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2yp5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2yp5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2yp5 ProSAT]</span></td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yp2\|2yp2]], [[2yp3\|2yp3]], [[2yp4\|2yp4]], [[2yp7\|2yp7]], [[2yp8\|2yp8]], [[2yp9\|2yp9]], [[2ypg\|2ypg]]</div></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yp5 OCA], [https://pdbe.org/2yp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yp5 RCSB], [https://www.ebi.ac.uk/pdbsum/2yp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yp5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/A0FCI1_9INFA A0FCI1_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00145386]	+	[[https://www.uniprot.org/uniprot/A0FCI1_9INFA A0FCI1_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00145386]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:

	==See Also==		==See Also==
-	*[[Hemagglutinin\|Hemagglutinin]]	+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:29, 10 May 2019

OCA — Fri, 10 May 2019 12:29:21 GMT

←Older revision		Revision as of 12:29, 10 May 2019
Line 1:		Line 1:

	==Haemagglutinin of 2004 Human H3N2 Virus in Complex with Avian Receptor Analogue 3SLN==		==Haemagglutinin of 2004 Human H3N2 Virus in Complex with Avian Receptor Analogue 3SLN==
-	<StructureSection load='2yp5' size='340' side='right' caption='[[2yp5]], [[Resolution\|resolution]] 1.79Å' scene=''>	+	<StructureSection load='2yp5' size='340' side='right'caption='[[2yp5]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~9infa 9infa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YP5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/finland/486/2004_(h3n2)) Influenza a virus (a/finland/486/2004 (h3n2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YP5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yp2\|2yp2]], [[2yp3\|2yp3]], [[2yp4\|2yp4]], [[2yp7\|2yp7]], [[2yp8\|2yp8]], [[2yp9\|2yp9]], [[2ypg\|2ypg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yp2\|2yp2]], [[2yp3\|2yp3]], [[2yp4\|2yp4]], [[2yp7\|2yp7]], [[2yp8\|2yp8]], [[2yp9\|2yp9]], [[2ypg\|2ypg]]</td></tr>
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Christodoulou, E]]		[[Category: Christodoulou, E]]
	[[Category: Coombs, P J]]		[[Category: Coombs, P J]]

OCA at 14:01, 11 April 2018

OCA — Wed, 11 Apr 2018 14:01:09 GMT

←Older revision		Revision as of 14:01, 11 April 2018
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YP5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YP5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~TAM~~:~~TRIS(HYDROXYETHYL)AMINOMETHANE~~'>~~TAM~~</scene>, <scene name='pdbligand=~~GAL~~:~~BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-~~D-MANNOSE~~'>~~MAN~~</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~SIA~~:~~O-SIALIC+ACID~~'>~~SIA~~</scene></td></tr>	+
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yp2\|2yp2]], [[2yp3\|2yp3]], [[2yp4\|2yp4]], [[2yp7\|2yp7]], [[2yp8\|2yp8]], [[2yp9\|2yp9]], [[2ypg\|2ypg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yp2\|2yp2]], [[2yp3\|2yp3]], [[2yp4\|2yp4]], [[2yp7\|2yp7]], [[2yp8\|2yp8]], [[2yp9\|2yp9]], [[2ypg\|2ypg]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yp5 OCA], [http://pdbe.org/2yp5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yp5 RCSB], [http://www.ebi.ac.uk/pdbsum/2yp5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yp5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yp5 OCA], [http://pdbe.org/2yp5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yp5 RCSB], [http://www.ebi.ac.uk/pdbsum/2yp5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yp5 ProSAT]</span></td></tr>

OCA at 23:21, 4 August 2016

OCA — Thu, 04 Aug 2016 23:21:43 GMT

←Older revision		Revision as of 23:21, 4 August 2016
Line 1:		Line 1:
		+
	==Haemagglutinin of 2004 Human H3N2 Virus in Complex with Avian Receptor Analogue 3SLN==		==Haemagglutinin of 2004 Human H3N2 Virus in Complex with Avian Receptor Analogue 3SLN==
	<StructureSection load='2yp5' size='340' side='right' caption='[[2yp5]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='2yp5' size='340' side='right' caption='[[2yp5]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus Influenza a virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YP5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YP5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yp2\|2yp2]], [[2yp3\|2yp3]], [[2yp4\|2yp4]], [[2yp7\|2yp7]], [[2yp8\|2yp8]], [[2yp9\|2yp9]], [[2ypg\|2ypg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yp2\|2yp2]], [[2yp3\|2yp3]], [[2yp4\|2yp4]], [[2yp7\|2yp7]], [[2yp8\|2yp8]], [[2yp9\|2yp9]], [[2ypg\|2ypg]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yp5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yp5 RCSB], [http://www.ebi.ac.uk/pdbsum/2yp5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yp5 OCA], [http://pdbe.org/2yp5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yp5 RCSB], [http://www.ebi.ac.uk/pdbsum/2yp5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yp5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2yp5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Influenza a virus]]
	[[Category: Christodoulou, E]]		[[Category: Christodoulou, E]]
	[[Category: Coombs, P J]]		[[Category: Coombs, P J]]

OCA at 13:57, 25 December 2014

OCA — Thu, 25 Dec 2014 13:57:27 GMT

←Older revision		Revision as of 13:57, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2yp5\| PDB=2yp5 \| SCENE= }}~~	+	==Haemagglutinin of 2004 Human H3N2 Virus in Complex with Avian Receptor Analogue 3SLN==
-	===Haemagglutinin of 2004 Human H3N2 Virus in Complex with Avian Receptor Analogue 3SLN===	+	<StructureSection load='2yp5' size='340' side='right' caption='[[2yp5]], [[Resolution\|resolution]] 1.79Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23236176}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YP5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yp2\|2yp2]], [[2yp3\|2yp3]], [[2yp4\|2yp4]], [[2yp7\|2yp7]], [[2yp8\|2yp8]], [[2yp9\|2yp9]], [[2ypg\|2ypg]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yp5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yp5 RCSB], [http://www.ebi.ac.uk/pdbsum/2yp5 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A0FCI1_9INFA A0FCI1_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00145386]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The hemagglutinin (HA) of influenza A(H3N2) virus responsible for the 1968 influenza pandemic derived from an avian virus. On introduction into humans, its receptor binding properties had changed from a preference for avian receptors (alpha2,3-linked sialic acid) to a preference for human receptors (alpha2,6-linked sialic acid). By 2001, the avidity of human H3 viruses for avian receptors had declined, and since then the affinity for human receptors has also decreased significantly. These changes in receptor binding, which correlate with increased difficulties in virus propagation in vitro and in antigenic analysis, have been assessed by virus hemagglutination of erythrocytes from different species and quantified by measuring virus binding to receptor analogs using surface biolayer interferometry. Crystal structures of HA-receptor analog complexes formed with HAs from viruses isolated in 2004 and 2005 reveal significant differences in the conformation of the 220-loop of HA1, relative to the 1968 structure, resulting in altered interactions between the HA and the receptor analog that explain the changes in receptor affinity. Site-specific mutagenesis shows the HA1 Asp-225-->Asn substitution to be the key determinant of the decreased receptor binding in viruses circulating since 2005. Our results indicate that the evolution of human influenza A(H3N2) viruses since 1968 has produced a virus with a low propensity to bind human receptor analogs, and this loss of avidity correlates with the marked reduction in A(H3N2) virus disease impact in the last 10 y.

-	~~==About this Structure==~~	+	Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin.,Lin YP, Xiong X, Wharton SA, Martin SR, Coombs PJ, Vachieri SG, Christodoulou E, Walker PA, Liu J, Skehel JJ, Gamblin SJ, Hay AJ, Daniels RS, McCauley JW Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21474-9. doi:, 10.1073/pnas.1218841110. Epub 2012 Dec 10. PMID:23236176<ref>PMID:23236176</ref>
-	~~[[2yp5]] is a 1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Influenza_a_virus Influenza a virus]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2YP5 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Hemagglutinin\|Hemagglutinin]]		*[[Hemagglutinin\|Hemagglutinin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
-	[[Category: Christodoulou, E.]]	+	[[Category: Christodoulou, E]]
-	[[Category: Coombs, P J.]]	+	[[Category: Coombs, P J]]
-	[[Category: Daniels, R S.]]	+	[[Category: Daniels, R S]]
-	[[Category: Gamblin, S J.]]	+	[[Category: Gamblin, S J]]
-	[[Category: Hay, A J.]]	+	[[Category: Hay, A J]]
-	[[Category: Lin, Y P.]]	+	[[Category: Lin, Y P]]
-	[[Category: Liu, J.]]	+	[[Category: Liu, J]]
-	[[Category: Martin, S R.]]	+	[[Category: Martin, S R]]
-	[[Category: McCauley, J W.]]	+	[[Category: McCauley, J W]]
-	[[Category: Skehel, J J.]]	+	[[Category: Skehel, J J]]
-	[[Category: Vachieri, S G.]]	+	[[Category: Vachieri, S G]]
-	[[Category: Walker, P A.]]	+	[[Category: Walker, P A]]
-	[[Category: Wharton, S A.]]	+	[[Category: Wharton, S A]]
-	[[Category: Xiong, X.]]	+	[[Category: Xiong, X]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Influenza virus evolution]]		[[Category: Influenza virus evolution]]

OCA at 09:58, 11 March 2013

OCA — Mon, 11 Mar 2013 09:58:55 GMT

←Older revision		Revision as of 09:58, 11 March 2013
Line 1:		Line 1:
-	[[Image:2yp5.png\|left\|200px]]
-
	{{STRUCTURE_2yp5\| PDB=2yp5 \| SCENE= }}		{{STRUCTURE_2yp5\| PDB=2yp5 \| SCENE= }}
-
	===Haemagglutinin of 2004 Human H3N2 Virus in Complex with Avian Receptor Analogue 3SLN===		===Haemagglutinin of 2004 Human H3N2 Virus in Complex with Avian Receptor Analogue 3SLN===
-
	{{ABSTRACT_PUBMED_23236176}}		{{ABSTRACT_PUBMED_23236176}}

OCA at 09:23, 13 February 2013

OCA — Wed, 13 Feb 2013 09:23:16 GMT

←Older revision		Revision as of 09:23, 13 February 2013
Line 9:		Line 9:
	==About this Structure==		==About this Structure==
	[[2yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YP5 OCA].		[[2yp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YP5 OCA].
		+
		+	==See Also==
		+	*[[Hemagglutinin\|Hemagglutinin]]
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
	[[Category: Christodoulou, E.]]		[[Category: Christodoulou, E.]]
Line 18:		Line 21:
	[[Category: Liu, J.]]		[[Category: Liu, J.]]
	[[Category: Martin, S R.]]		[[Category: Martin, S R.]]
-	[[Category: ~~Mccauley~~, J W.]]	+	[[Category: McCauley, J W.]]
	[[Category: Skehel, J J.]]		[[Category: Skehel, J J.]]
	[[Category: Vachieri, S G.]]		[[Category: Vachieri, S G.]]

OCA at 07:07, 2 January 2013

OCA — Wed, 02 Jan 2013 07:07:41 GMT

←Older revision		Revision as of 07:07, 2 January 2013
Line 5:		Line 5:
	===Haemagglutinin of 2004 Human H3N2 Virus in Complex with Avian Receptor Analogue 3SLN===		===Haemagglutinin of 2004 Human H3N2 Virus in Complex with Avian Receptor Analogue 3SLN===

		+	{{ABSTRACT_PUBMED_23236176}}

	==About this Structure==		==About this Structure==
Line 10:		Line 11:
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
	[[Category: Christodoulou, E.]]		[[Category: Christodoulou, E.]]
-	[[Category: Coombs, P.]]	+	[[Category: Coombs, P J.]]
	[[Category: Daniels, R S.]]		[[Category: Daniels, R S.]]
	[[Category: Gamblin, S J.]]		[[Category: Gamblin, S J.]]
Line 19:		Line 20:
	[[Category: Mccauley, J W.]]		[[Category: Mccauley, J W.]]
	[[Category: Skehel, J J.]]		[[Category: Skehel, J J.]]
-	[[Category: Vachieri, S.]]	+	[[Category: Vachieri, S G.]]
	[[Category: Walker, P A.]]		[[Category: Walker, P A.]]
	[[Category: Wharton, S A.]]		[[Category: Wharton, S A.]]

OCA at 21:30, 12 December 2012

OCA — Wed, 12 Dec 2012 21:30:38 GMT

←Older revision		Revision as of 21:30, 12 December 2012
Line 1:		Line 1:
-	[[Image:2yp5.~~jpg~~\|left\|200px]]	+	[[Image:2yp5.png\|left\|200px]]

	{{STRUCTURE_2yp5\| PDB=2yp5 \| SCENE= }}		{{STRUCTURE_2yp5\| PDB=2yp5 \| SCENE= }}