2yq6 - Revision history

OCA at 10:58, 20 December 2023

OCA — Wed, 20 Dec 2023 10:58:02 GMT

←Older revision		Revision as of 10:58, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2yq6' size='340' side='right'caption='[[2yq6]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2yq6' size='340' side='right'caption='[[2yq6]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yq6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YQ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yq6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YQ6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.799Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yq7\|2yq7]]</div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yq6 OCA], [https://pdbe.org/2yq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yq6 RCSB], [https://www.ebi.ac.uk/pdbsum/2yq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yq6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yq6 OCA], [https://pdbe.org/2yq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yq6 RCSB], [https://www.ebi.ac.uk/pdbsum/2yq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yq6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>	+	[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Czabotar~~, P E~~]]	+	[[Category: Czabotar PE]]
-	[[Category: Smith~~, B J]]~~	+	[[Category: Smith BJ]]
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Bcl-2 family]]~~	+
-	~~[[Category: Constrained peptide~~]]	+

OCA at 13:22, 4 May 2022

OCA — Wed, 04 May 2022 13:22:23 GMT

←Older revision		Revision as of 13:22, 4 May 2022
Line 3:		Line 3:
	<StructureSection load='2yq6' size='340' side='right'caption='[[2yq6]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2yq6' size='340' side='right'caption='[[2yq6]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yq6]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQ6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2YQ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yq6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YQ6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yq7\|2yq7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yq7\|2yq7]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2yq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yq6 OCA], [~~http~~://pdbe.org/2yq6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2yq6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2yq6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2yq6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yq6 OCA], [https://pdbe.org/2yq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yq6 RCSB], [https://www.ebi.ac.uk/pdbsum/2yq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yq6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>	+	[[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:02, 22 July 2020

OCA — Wed, 22 Jul 2020 13:02:30 GMT

←Older revision		Revision as of 13:02, 22 July 2020
Line 1:		Line 1:

	==Structure of Bcl-xL bound to BimSAHB==		==Structure of Bcl-xL bound to BimSAHB==
-	<StructureSection load='2yq6' size='340' side='right' caption='[[2yq6]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2yq6' size='340' side='right'caption='[[2yq6]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yq6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQ6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YQ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yq6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQ6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YQ6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yq7\|2yq7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yq7\|2yq7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2yq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yq6 OCA], [http://pdbe.org/2yq6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yq6 RCSB], [http://www.ebi.ac.uk/pdbsum/2yq6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yq6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yq6 OCA], [http://pdbe.org/2yq6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yq6 RCSB], [http://www.ebi.ac.uk/pdbsum/2yq6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yq6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[B-cell lymphoma ~~protein~~\|B-cell lymphoma ~~protein~~]]	+	*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Czabotar, P E]]		[[Category: Czabotar, P E]]
	[[Category: Smith, B J]]		[[Category: Smith, B J]]

OCA at 09:02, 17 October 2018

OCA — Wed, 17 Oct 2018 09:02:36 GMT

←Older revision		Revision as of 09:02, 17 October 2018
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 2yq6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2yq6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[B-cell lymphoma protein\|B-cell lymphoma protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:06, 5 August 2016

OCA — Fri, 05 Aug 2016 12:06:52 GMT

←Older revision		Revision as of 12:06, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of Bcl-xL bound to BimSAHB==		==Structure of Bcl-xL bound to BimSAHB==
	<StructureSection load='2yq6' size='340' side='right' caption='[[2yq6]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2yq6' size='340' side='right' caption='[[2yq6]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yq6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YQ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yq6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YQ6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yq7\|2yq7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yq7\|2yq7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yq6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yq6 RCSB], [http://www.ebi.ac.uk/pdbsum/2yq6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yq6 OCA], [http://pdbe.org/2yq6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yq6 RCSB], [http://www.ebi.ac.uk/pdbsum/2yq6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yq6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2yq6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Czabotar, P E]]		[[Category: Czabotar, P E]]
	[[Category: Smith, B J]]		[[Category: Smith, B J]]

OCA at 18:41, 25 December 2014

OCA — Thu, 25 Dec 2014 18:41:39 GMT

←Older revision		Revision as of 18:41, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yq6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yq6 RCSB], [http://www.ebi.ac.uk/pdbsum/2yq6 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yq6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yq6 RCSB], [http://www.ebi.ac.uk/pdbsum/2yq6 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:21, 3 December 2014

OCA — Wed, 03 Dec 2014 10:21:28 GMT

←Older revision		Revision as of 10:21, 3 December 2014
Line 1:		Line 1:
-	[[~~Image:~~2yq6.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of Bcl-xL bound to BimSAHB==
		+	<StructureSection load='2yq6' size='340' side='right' caption='[[2yq6]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2yq6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YQ6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yq7\|2yq7]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yq6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yq6 RCSB], [http://www.ebi.ac.uk/pdbsum/2yq6 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	An attractive approach for developing therapeutic peptides is to enhance binding to their targets by stabilizing their helical conformation, for example stabilized BimBH3 peptides (BimSAHB) designed to induce apoptosis. Unexpectedly, we found that such modified peptides have reduced affinity for their targets, the pro-survival Bcl-2 proteins. We attribute this loss in affinity to disruption of a network of stabilizing intramolecular interactions present in the bound state of the native peptide. Altering this network may compromise binding affinity, as in the case of the BimBH3 stapled peptide studied here. Moreover, cells exposed to these peptides do not readily undergo apoptosis, strongly indicating that BimSAHB is not inherently cell permeable.

-	~~{{STRUCTURE_2yq6\| PDB=2yq6 \| SCENE= }}~~	+	Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity.,Okamoto T, Zobel K, Fedorova A, Quan C, Yang H, Fairbrother WJ, Huang DC, Smith BJ, Deshayes K, Czabotar PE ACS Chem Biol. 2012 Nov 14. PMID:23151250<ref>PMID:23151250</ref>

-	~~===Structure~~ of ~~Bcl-xL bound to BimSAHB===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23151250}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[2yq6]] is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQ6 OCA].~~	+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Czabotar, P E.]]	+	[[Category: Czabotar, P E]]
-	[[Category: Smith, B J.]]	+	[[Category: Smith, B J]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Bcl-2 family]]		[[Category: Bcl-2 family]]
	[[Category: Constrained peptide]]		[[Category: Constrained peptide]]

OCA at 13:36, 27 February 2013

OCA — Wed, 27 Feb 2013 13:36:42 GMT

←Older revision		Revision as of 13:36, 27 February 2013
Line 1:		Line 1:
-	[[Image:2yq6.~~jpg~~\|left\|200px]]	+	[[Image:2yq6.png\|left\|200px]]

	{{STRUCTURE_2yq6\| PDB=2yq6 \| SCENE= }}		{{STRUCTURE_2yq6\| PDB=2yq6 \| SCENE= }}

OCA at 14:24, 28 November 2012

OCA — Wed, 28 Nov 2012 14:24:35 GMT

←Older revision		Revision as of 14:24, 28 November 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2yq6.jpg\|left\|200px]]

-	~~The entry~~ 2yq6 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_2yq6\| PDB=2yq6 \| SCENE= }}

-	~~Authors: Smith, B.J., Czabotar, P.E.~~	+	===Structure of Bcl-xL bound to BimSAHB===

-	~~Description:~~ Structure of Bcl-~~xL bound to BimSAHB~~	+	{{ABSTRACT_PUBMED_23151250}}
		+
		+	==About this Structure==
		+	[[2yq6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQ6 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Czabotar, P E.]]
		+	[[Category: Smith, B J.]]
		+	[[Category: Apoptosis]]
		+	[[Category: Bcl-2 family]]
		+	[[Category: Constrained peptide]]

OCA: Protected "2yq6" [edit=sysop:move=sysop]

OCA — Wed, 14 Nov 2012 06:02:22 GMT

Protected "2yq6" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:02, 14 November 2012