2z34 - Revision history

OCA at 13:20, 1 November 2023

OCA — Wed, 01 Nov 2023 13:20:24 GMT

←Older revision		Revision as of 13:20, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='2z34' size='340' side='right'caption='[[2z34]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2z34' size='340' side='right'caption='[[2z34]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z34]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Cbs_356 Cbs 356~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z34 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z34]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe] and [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z34 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2cu9\|2cu9]], [[2dze\|2dze]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">cia1, asf1 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=4896 CBS 356])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z34 OCA], [https://pdbe.org/2z34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z34 RCSB], [https://www.ebi.ac.uk/pdbsum/2z34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z34 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z34 OCA], [https://pdbe.org/2z34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z34 RCSB], [https://www.ebi.ac.uk/pdbsum/2z34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z34 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ASF1_SCHPO ASF1_SCHPO]] Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.<ref>PMID:11856374</ref> [[https://www.uniprot.org/uniprot/HIR1_SCHPO HIR1_SCHPO]] Probably required for replication-independent chromatin assembly. Required for transcriptional silencing in the outer repeat (otr) centromeric repeats and the Tf2 long terminal repeat retrotransposons. Repressor of histone gene transcription in G1 arrested cells. Required for repression of htb1 gene expression outside of S phase.<ref>PMID:15121850</ref> <ref>PMID:16428807</ref>	+	[https://www.uniprot.org/uniprot/HIR1_SCHPO HIR1_SCHPO] Probably required for replication-independent chromatin assembly. Required for transcriptional silencing in the outer repeat (otr) centromeric repeats and the Tf2 long terminal repeat retrotransposons. Repressor of histone gene transcription in G1 arrested cells. Required for repression of htb1 gene expression outside of S phase.<ref>PMID:15121850</ref> <ref>PMID:16428807</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cbs 356]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Malay, A D~~]]	+	[[Category: Schizosaccharomyces pombe]]
-	[[Category: ~~Padmanabhan, B~~]]	+	[[Category: Schizosaccharomyces pombe 972h-]]
-	[[Category: ~~Structural genomic~~]]	+	[[Category: Malay AD]]
-	[[Category: ~~Yokoyama, S~~]]	+	[[Category: Padmanabhan B]]
-	[[Category: ~~Chaperone]]~~	+	[[Category: Yokoyama S]]
-	~~[[Category: Chromatin regulation]]~~	+
-	~~[[Category: Chromatin regulator]]~~	+
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Histone chaperone]]~~	+
-	~~[[Category: National project on protein structural and functional analyse]]~~	+
-	~~[[Category: Nppsfa]]~~	+
-	~~[[Category: Nucleosome disassmebly/assembly]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Repressor]]~~	+
-	~~[[Category: Rsgi]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Wd repeat~~]]	+

OCA at 10:44, 8 December 2021

OCA — Wed, 08 Dec 2021 10:44:32 GMT

←Older revision		Revision as of 10:44, 8 December 2021
Line 1:		Line 1:

	==Crystal structure of SpCia1/Asf1 complex with Hip1==		==Crystal structure of SpCia1/Asf1 complex with Hip1==
-	<StructureSection load='2z34' size='340' side='right' caption='[[2z34]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='2z34' size='340' side='right'caption='[[2z34]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z34]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z34 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Z34 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z34]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z34 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cu9\|2cu9]], [[2dze\|2dze]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2cu9\|2cu9]], [[2dze\|2dze]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cia1, asf1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cia1, asf1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z34 OCA], [~~http~~://pdbe.org/2z34 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2z34 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2z34 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2z34 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z34 OCA], [https://pdbe.org/2z34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z34 RCSB], [https://www.ebi.ac.uk/pdbsum/2z34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z34 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ASF1_SCHPO ASF1_SCHPO]] Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.<ref>PMID:11856374</ref> [[~~http~~://www.uniprot.org/uniprot/HIR1_SCHPO HIR1_SCHPO]] Probably required for replication-independent chromatin assembly. Required for transcriptional silencing in the outer repeat (otr) centromeric repeats and the Tf2 long terminal repeat retrotransposons. Repressor of histone gene transcription in G1 arrested cells. Required for repression of htb1 gene expression outside of S phase.<ref>PMID:15121850</ref> <ref>PMID:16428807</ref>	+	[[https://www.uniprot.org/uniprot/ASF1_SCHPO ASF1_SCHPO]] Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.<ref>PMID:11856374</ref> [[https://www.uniprot.org/uniprot/HIR1_SCHPO HIR1_SCHPO]] Probably required for replication-independent chromatin assembly. Required for transcriptional silencing in the outer repeat (otr) centromeric repeats and the Tf2 long terminal repeat retrotransposons. Repressor of histone gene transcription in G1 arrested cells. Required for repression of htb1 gene expression outside of S phase.<ref>PMID:15121850</ref> <ref>PMID:16428807</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Anti-silencing factor\|Anti-silencing factor]]	+	*[[Anti-silencing factor 3D structures\|Anti-silencing factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Cbs 356]]		[[Category: Cbs 356]]
		+	[[Category: Large Structures]]
	[[Category: Malay, A D]]		[[Category: Malay, A D]]
	[[Category: Padmanabhan, B]]		[[Category: Padmanabhan, B]]

OCA at 08:53, 17 October 2018

OCA — Wed, 17 Oct 2018 08:53:50 GMT

←Older revision		Revision as of 08:53, 17 October 2018
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/2z34_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/2z34_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 44:		Line 44:
	[[Category: Chromatin regulation]]		[[Category: Chromatin regulation]]
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]
		+	[[Category: Coiled coil]]
		+	[[Category: Cytoplasm]]
	[[Category: Histone chaperone]]		[[Category: Histone chaperone]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]

OCA at 22:46, 4 August 2016

OCA — Thu, 04 Aug 2016 22:46:34 GMT

←Older revision		Revision as of 22:46, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of SpCia1/Asf1 complex with Hip1==		==Crystal structure of SpCia1/Asf1 complex with Hip1==
	<StructureSection load='2z34' size='340' side='right' caption='[[2z34]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2z34' size='340' side='right' caption='[[2z34]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z34]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Schizosaccharomyces_pombe Schizosaccharomyces pombe~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z34 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z34]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z34 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cu9\|2cu9]], [[2dze\|2dze]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cu9\|2cu9]], [[2dze\|2dze]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cia1, asf1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 ~~Schizosaccharomyces pombe~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cia1, asf1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z34 RCSB], [http://www.ebi.ac.uk/pdbsum/2z34 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z34 OCA], [http://pdbe.org/2z34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z34 RCSB], [http://www.ebi.ac.uk/pdbsum/2z34 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z34 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z34 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2z34" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Schizosaccharomyces pombe~~]]	+	[[Category: Cbs 356]]
	[[Category: Malay, A D]]		[[Category: Malay, A D]]
	[[Category: Padmanabhan, B]]		[[Category: Padmanabhan, B]]

OCA at 13:44, 25 December 2014

OCA — Thu, 25 Dec 2014 13:44:06 GMT

←Older revision		Revision as of 13:44, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2z34]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z34 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2z34]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z34 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cu9\|2cu9]], [[2dze\|2dze]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cu9\|2cu9]], [[2dze\|2dze]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cia1, asf1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cia1, asf1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z34 RCSB], [http://www.ebi.ac.uk/pdbsum/2z34 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z34 RCSB], [http://www.ebi.ac.uk/pdbsum/2z34 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ASF1_SCHPO ASF1_SCHPO]] Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.<ref>PMID:11856374</ref> [[http://www.uniprot.org/uniprot/HIR1_SCHPO HIR1_SCHPO]] Probably required for replication-independent chromatin assembly. Required for transcriptional silencing in the outer repeat (otr) centromeric repeats and the Tf2 long terminal repeat retrotransposons. Repressor of histone gene transcription in G1 arrested cells. Required for repression of htb1 gene expression outside of S phase.<ref>PMID:15121850</ref> <ref>PMID:16428807</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
-	[[Category: Malay, A D.]]	+	[[Category: Malay, A D]]
-	[[Category: Padmanabhan, B.]]	+	[[Category: Padmanabhan, B]]
-	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Yokoyama, S.]]	+	[[Category: Yokoyama, S]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Chromatin regulation]]		[[Category: Chromatin regulation]]
Line 46:		Line 48:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Repressor]]		[[Category: Repressor]]
-	[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
-	[[Category: Structural genomic]]
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Wd repeat]]		[[Category: Wd repeat]]

OCA at 07:20, 29 September 2014

OCA — Mon, 29 Sep 2014 07:20:58 GMT

←Older revision		Revision as of 07:20, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2z34.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of SpCia1/Asf1 complex with Hip1==
		+	<StructureSection load='2z34' size='340' side='right' caption='[[2z34]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2z34]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z34 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cu9\|2cu9]], [[2dze\|2dze]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cia1, asf1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z34 RCSB], [http://www.ebi.ac.uk/pdbsum/2z34 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/2z34_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The assembly of core histones onto eukaryotic DNA is modulated by several histone chaperone complexes, including Asf1, CAF-1, and HIRA. Asf1 is a unique histone chaperone that participates in both the replication-dependent and replication-independent pathways. Here we report the crystal structures of the apo-form of fission yeast Asf1/Cia1 (SpAsf1N; residues 1-161) as well as its complexes with the B-domain of the fission yeast HIRA orthologue Hip1 (Hip1B) and the C-terminal region of the Cac2 subunit of CAF-1 (Cac2C). The mode of the fission yeast Asf1N-Hip1B recognition is similar to that of the human Asf1-HIRA recognition, suggesting that Asf1N recognition of Hip1B/HIRA is conserved from yeast to mammals. Interestingly, Hip1B and Cac2C show remarkably similar interaction modes with Asf1. The binding between Asf1N and Hip1B was almost completely abolished by the D37A and L60A/V62A mutations in Asf1N, indicating the critical role of salt bridge and van der Waals contacts in the complex formation. Consistently, both of the aforementioned Asf1 mutations also drastically reduced the binding to Cac2C. These results provide a structural basis for a mutually exclusive Asf1-binding model of CAF-1 and HIRA/Hip1, in which Asf1 and CAF-1 assemble histones H3/H4 (H3.1/H4 in vertebrates) in a replication-dependent pathway, whereas Asf1 and HIRA/Hip1 assemble histones H3/H4 (H3.3/H4 in vertebrates) in a replication-independent pathway.

-	~~{{STRUCTURE_2z34\| PDB=2z34 \| SCENE= }}~~	+	Crystal structures of fission yeast histone chaperone Asf1 complexed with the Hip1 B-domain or the Cac2 C terminus.,Malay AD, Umehara T, Matsubara-Malay K, Padmanabhan B, Yokoyama S J Biol Chem. 2008 May 16;283(20):14022-31. Epub 2008 Mar 11. PMID:18334479<ref>PMID:18334479</ref>

-	~~===Crystal structure of SpCia1~~/~~Asf1 complex with Hip1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18334479}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2z34]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2Z34 OCA].~~	+

	==See Also==		==See Also==
	*[[Anti-silencing factor\|Anti-silencing factor]]		*[[Anti-silencing factor\|Anti-silencing factor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018334479<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
	[[Category: Malay, A D.]]		[[Category: Malay, A D.]]

OCA: Protected "2z34" [edit=sysop:move=sysop]

OCA — Sat, 20 Oct 2012 17:23:55 GMT

Protected "2z34" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:23, 20 October 2012

OCA at 17:23, 20 October 2012

OCA — Sat, 20 Oct 2012 17:23:53 GMT

←Older revision		Revision as of 17:23, 20 October 2012
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-	{{Seed}}
	[[Image:2z34.png\|left\|200px]]		[[Image:2z34.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2z34", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2z34\| PDB=2z34 \| SCENE= }}		{{STRUCTURE_2z34\| PDB=2z34 \| SCENE= }}

	===Crystal structure of SpCia1/Asf1 complex with Hip1===		===Crystal structure of SpCia1/Asf1 complex with Hip1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18334479}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18334479 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18334479}}		{{ABSTRACT_PUBMED_18334479}}

	==About this Structure==		==About this Structure==
-	~~2Z34~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z34 OCA].	+	[[2z34]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z34 OCA].
		+
		+	==See Also==
		+	*[[Anti-silencing factor\|Anti-silencing factor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18334479~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018334479</ref><references group="xtra"/>
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
	[[Category: Malay, A D.]]		[[Category: Malay, A D.]]
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	[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]		[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S.]]
		+	[[Category: Chaperone]]
	[[Category: Chromatin regulation]]		[[Category: Chromatin regulation]]
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]
-	[[Category: Coiled coil]]
-	[[Category: Cytoplasm]]
	[[Category: Histone chaperone]]		[[Category: Histone chaperone]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
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	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Wd repeat]]		[[Category: Wd repeat]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:45:30 2009''

OCA at 15:45, 17 February 2009

OCA — Tue, 17 Feb 2009 15:45:30 GMT

←Older revision		Revision as of 15:45, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2Z34 is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z34 OCA].	+	2Z34 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z34 OCA].

	==Reference==		==Reference==
-	Crystal Structures of Fission Yeast Histone Chaperone Asf1 Complexed with the Hip1 B-domain or the Cac2 C Terminus., Malay AD, Umehara T, Matsubara-Malay K, Padmanabhan B, Yokoyama S, J Biol Chem. 2008 May 16;283(20):14022-31. Epub 2008 Mar 11. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18334479 18334479]~~	+	<ref group="xtra">PMID:18334479</ref><references group="xtra"/>
-	~~[[Category: Protein complex]]~~	+
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
	[[Category: Malay, A D.]]		[[Category: Malay, A D.]]
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	[[Category: Wd repeat]]		[[Category: Wd repeat]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 2 21~~:50:~~24 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:45:30 2009''

OCA at 18:50, 2 July 2008

OCA — Wed, 02 Jul 2008 18:50:24 GMT

←Older revision		Revision as of 18:50, 2 July 2008
Line 1:		Line 1:
-	[[Image:2z34.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2z34.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2z34\| PDB=2z34 \| SCENE= }}		{{STRUCTURE_2z34\| PDB=2z34 \| SCENE= }}

-	~~'''~~Crystal structure of SpCia1/Asf1 complex with Hip1~~'''~~	+	===Crystal structure of SpCia1/Asf1 complex with Hip1===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18334479}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18334479 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18334479}}

	==About this Structure==		==About this Structure==
	2Z34 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z34 OCA].		2Z34 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z34 OCA].
		+
		+	==Reference==
		+	Crystal Structures of Fission Yeast Histone Chaperone Asf1 Complexed with the Hip1 B-domain or the Cac2 C Terminus., Malay AD, Umehara T, Matsubara-Malay K, Padmanabhan B, Yokoyama S, J Biol Chem. 2008 May 16;283(20):14022-31. Epub 2008 Mar 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18334479 18334479]
	[[Category: Protein complex]]		[[Category: Protein complex]]
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
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	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Wd repeat]]		[[Category: Wd repeat]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 19~~:53:39 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:50:24 2008''