2z4i - Revision history

OCA at 07:12, 10 November 2021

OCA — Wed, 10 Nov 2021 07:12:22 GMT

←Older revision		Revision as of 07:12, 10 November 2021
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	==Crystal structure of the Cpx pathway activator NlpE from Escherichia coli==		==Crystal structure of the Cpx pathway activator NlpE from Escherichia coli==
-	<StructureSection load='2z4i' size='340' side='right' caption='[[2z4i]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='2z4i' size='340' side='right'caption='[[2z4i]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z4i]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Z4I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z4i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z4I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z4h\|2z4h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2z4h\|2z4h]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nlpE ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nlpE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2z4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4i OCA], [~~http~~://pdbe.org/2z4i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2z4i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2z4i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2z4i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4i OCA], [https://pdbe.org/2z4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z4i RCSB], [https://www.ebi.ac.uk/pdbsum/2z4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z4i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NLPE_ECOLI NLPE_ECOLI]] Involved in copper homeostasis. Could be involved in both copper efflux and the delivery of copper to copper-dependent enzymes. When overproduced induces degP through the activation of the two-component system CpxA/CpxR.<ref>PMID:15252048</ref>	+	[[https://www.uniprot.org/uniprot/NLPE_ECOLI NLPE_ECOLI]] Involved in copper homeostasis. Could be involved in both copper efflux and the delivery of copper to copper-dependent enzymes. When overproduced induces degP through the activation of the two-component system CpxA/CpxR.<ref>PMID:15252048</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Hirano, Y]]		[[Category: Hirano, Y]]
	[[Category: Hossain, M M]]		[[Category: Hossain, M M]]

OCA at 08:48, 17 October 2018

OCA — Wed, 17 Oct 2018 08:48:45 GMT

←Older revision		Revision as of 08:48, 17 October 2018
Line 1:		Line 1:
		+
	==Crystal structure of the Cpx pathway activator NlpE from Escherichia coli==		==Crystal structure of the Cpx pathway activator NlpE from Escherichia coli==
	<StructureSection load='2z4i' size='340' side='right' caption='[[2z4i]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2z4i' size='340' side='right' caption='[[2z4i]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z4h\|2z4h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z4h\|2z4h]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nlpE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nlpE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4i OCA], [http://pdbe.org/2z4i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z4i RCSB], [http://www.ebi.ac.uk/pdbsum/2z4i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4i OCA], [http://pdbe.org/2z4i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z4i RCSB], [http://www.ebi.ac.uk/pdbsum/2z4i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z4i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/2z4i_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/2z4i_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 10:05, 7 February 2016

OCA — Sun, 07 Feb 2016 10:05:47 GMT

←Older revision		Revision as of 10:05, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2z4i' size='340' side='right' caption='[[2z4i]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2z4i' size='340' side='right' caption='[[2z4i]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z4i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z4I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z4i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z4I FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z4h\|2z4h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z4h\|2z4h]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nlpE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nlpE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z4i RCSB], [http://www.ebi.ac.uk/pdbsum/2z4i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4i OCA], [http://pdbe.org/2z4i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z4i RCSB], [http://www.ebi.ac.uk/pdbsum/2z4i PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NLPE_ECOLI NLPE_ECOLI]] Involved in copper homeostasis. Could be involved in both copper efflux and the delivery of copper to copper-dependent enzymes. When overproduced induces degP through the activation of the two-component system CpxA/CpxR.<ref>PMID:15252048</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z4i ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2z4i" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Hirano, Y]]		[[Category: Hirano, Y]]
	[[Category: Hossain, M M]]		[[Category: Hossain, M M]]

OCA at 07:40, 20 January 2015

OCA — Tue, 20 Jan 2015 07:40:04 GMT

←Older revision		Revision as of 07:40, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2z4i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z4I FirstGlance]. <br>		<table><tr><td colspan='2'>[[2z4i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z4I FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z4h\|2z4h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z4h\|2z4h]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nlpE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nlpE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z4i RCSB], [http://www.ebi.ac.uk/pdbsum/2z4i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z4i RCSB], [http://www.ebi.ac.uk/pdbsum/2z4i PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Hirano, Y.]]	+	[[Category: Hirano, Y]]
-	[[Category: Hossain, M M.]]	+	[[Category: Hossain, M M]]
-	[[Category: Miki, K.]]	+	[[Category: Miki, K]]
-	[[Category: Takeda, K.]]	+	[[Category: Takeda, K]]
-	[[Category: Tokuda, H.]]	+	[[Category: Tokuda, H]]
	[[Category: 3d domain swapping]]		[[Category: 3d domain swapping]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]

OCA at 06:14, 29 September 2014

OCA — Mon, 29 Sep 2014 06:14:54 GMT

←Older revision		Revision as of 06:14, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2z4i.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the Cpx pathway activator NlpE from Escherichia coli==
		+	<StructureSection load='2z4i' size='340' side='right' caption='[[2z4i]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2z4i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z4I FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z4h\|2z4h]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nlpE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z4i RCSB], [http://www.ebi.ac.uk/pdbsum/2z4i PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/2z4i_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	NlpE, an outer membrane lipoprotein, functions during envelope stress responses in Gram-negative bacteria. In Escherichia coli, adhesion to abiotic surfaces has been reported to activate the Cpx pathway in an NlpE-dependent manner. External copper ions are also thought to activate the Cpx pathway mediated by NlpE. We determined the crystal structure of NlpE from E. coli at 2.6 A resolution. The structure showed that NlpE consists of two beta barrel domains. The N-terminal domain resembles the bacterial lipocalin Blc, and the C-terminal domain has an oligonucleotide/oligosaccharide-binding (OB) fold. From both biochemical analyses and the crystal structure, it can be deduced that the cysteine residues in the CXXC motif may be chemically active. Furthermore, two monomers in the asymmetric unit form an unusual 3D domain-swapped dimer. These findings indicate that tertiary and/or quaternary structural instability may be responsible for Cpx pathway activation.

-	~~{{STRUCTURE_2z4i\| PDB=2z4i \| SCENE= }}~~	+	Structural studies of the Cpx pathway activator NlpE on the outer membrane of Escherichia coli.,Hirano Y, Hossain MM, Takeda K, Tokuda H, Miki K Structure. 2007 Aug;15(8):963-76. PMID:17698001<ref>PMID:17698001</ref>

-	~~===Crystal structure~~ of the ~~Cpx pathway activator NlpE from Escherichia coli===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17698001}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2z4i]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4I OCA].~~	+

	==See Also==		==See Also==
	*[[Copper homeostasis protein\|Copper homeostasis protein]]		*[[Copper homeostasis protein\|Copper homeostasis protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017698001<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Hirano, Y.]]		[[Category: Hirano, Y.]]

OCA at 06:19, 20 October 2012

OCA — Sat, 20 Oct 2012 06:19:28 GMT

←Older revision		Revision as of 06:19, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2z4i]] is a 2 chain structure ~~of [[Copper homeostasis protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4I OCA].	+	[[2z4i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4I OCA].

	==See Also==		==See Also==

OCA: Protected "2z4i" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 12:49:07 GMT

Protected "2z4i" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:49, 25 July 2012

OCA at 12:49, 25 July 2012

OCA — Wed, 25 Jul 2012 12:49:06 GMT

←Older revision		Revision as of 12:49, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2z4i.png\|left\|200px]]		[[Image:2z4i.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2z4i", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2z4i\| PDB=2z4i \| SCENE= }}		{{STRUCTURE_2z4i\| PDB=2z4i \| SCENE= }}

	===Crystal structure of the Cpx pathway activator NlpE from Escherichia coli===		===Crystal structure of the Cpx pathway activator NlpE from Escherichia coli===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17698001}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17698001 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17698001}}		{{ABSTRACT_PUBMED_17698001}}

	==About this Structure==		==About this Structure==
-	~~2Z4I~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4I OCA].	+	[[2z4i]] is a 2 chain structure of [[Copper homeostasis protein]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4I OCA].
		+
		+	==See Also==
		+	*[[Copper homeostasis protein\|Copper homeostasis protein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17698001~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017698001</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Hirano, Y.]]		[[Category: Hirano, Y.]]
Line 35:		Line 26:
	[[Category: Outer memblane lipoprotein]]		[[Category: Outer memblane lipoprotein]]
	[[Category: Signaling protein activator]]		[[Category: Signaling protein activator]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:04:37 2009''

OCA at 11:04, 16 February 2009

OCA — Mon, 16 Feb 2009 11:04:38 GMT

←Older revision		Revision as of 11:04, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2Z4I is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4I OCA].	+	2Z4I is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4I OCA].

	==Reference==		==Reference==
-	~~Structural studies of the Cpx pathway activator NlpE on the outer membrane of Escherichia coli., Hirano Y, Hossain MM, Takeda K, Tokuda H, Miki K, Structure. 2007 Aug;15(8):963-76.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17698001 17698001]~~	+	<ref group="xtra">PMID:17698001</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Single protein]]
	[[Category: Hirano, Y.]]		[[Category: Hirano, Y.]]
	[[Category: Hossain, M M.]]		[[Category: Hossain, M M.]]
Line 37:		Line 36:
	[[Category: Signaling protein activator]]		[[Category: Signaling protein activator]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 15~~:25:~~24 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:04:37 2009''

OCA at 12:25, 27 July 2008

OCA — Sun, 27 Jul 2008 12:25:29 GMT

←Older revision		Revision as of 12:25, 27 July 2008
Line 1:		Line 1:
-	[[Image:2z4i.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2z4i.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2z4i\| PDB=2z4i \| SCENE= }}		{{STRUCTURE_2z4i\| PDB=2z4i \| SCENE= }}

-	~~'''~~Crystal structure of the Cpx pathway activator NlpE from Escherichia coli~~'''~~	+	===Crystal structure of the Cpx pathway activator NlpE from Escherichia coli===


-	~~==Overview==~~	+	<!--
-	~~NlpE~~, ~~an outer membrane lipoprotein~~, ~~functions during envelope stress responses in Gram-negative bacteria. In Escherichia coli, adhesion to abiotic surfaces has been reported to activate~~ the ~~Cpx pathway in an NlpE-dependent manner. External copper ions are also thought~~ to ~~activate~~ the ~~Cpx pathway mediated by NlpE. We determined the crystal structure of NlpE from E. coli~~ at 2.~~6 A resolution~~. The structure showed that NlpE consists of two beta barrel domains. The N-terminal domain resembles the bacterial lipocalin Blc, and the C-terminal domain has an oligonucleotide/oligosaccharide-binding (OB) ~~fold. From both biochemical analyses and the crystal structure~~, ~~it can be deduced that~~ the ~~cysteine residues in the CXXC motif may be chemically active~~. ~~Furthermore, two monomers in the asymmetric unit form an unusual 3D domain~~-~~swapped dimer. These findings indicate that tertiary and/or quaternary structural instability may be responsible for Cpx pathway activation.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_17698001}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17698001 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17698001}}

	==About this Structure==		==About this Structure==
Line 32:		Line 36:
	[[Category: Outer memblane lipoprotein]]		[[Category: Outer memblane lipoprotein]]
	[[Category: Signaling protein activator]]		[[Category: Signaling protein activator]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 19~~:56:36 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:25:24 2008''