2z4q - Revision history

OCA at 13:21, 1 November 2023

OCA — Wed, 01 Nov 2023 13:21:18 GMT

←Older revision		Revision as of 13:21, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='2z4q' size='340' side='right'caption='[[2z4q]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2z4q' size='340' side='right'caption='[[2z4q]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z4q]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2Z4Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z4q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z4Q FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>~~, ~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[1wt5\|1wt5]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2z4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4q OCA], [~~http~~://pdbe.org/2z4q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2z4q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2z4q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2z4q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4q OCA], [https://pdbe.org/2z4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z4q RCSB], [https://www.ebi.ac.uk/pdbsum/2z4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z4q ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 38:		Line 38:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Asano, R]]	+	[[Category: Asano R]]
-	[[Category: Kondo, H]]	+	[[Category: Kondo H]]
-	[[Category: Kumagai, I]]	+	[[Category: Kumagai I]]
-	[[Category: Nakanishi, T]]	+	[[Category: Nakanishi T]]
-	[[Category: Tsumoto, K]]	+	[[Category: Tsumoto K]]
-	~~[[Category: Immune system~~]]	+

OCA at 11:57, 29 July 2020

OCA — Wed, 29 Jul 2020 11:57:27 GMT

←Older revision		Revision as of 11:57, 29 July 2020
Line 1:		Line 1:

	==Crystal structure of a murine antibody FAB 528==		==Crystal structure of a murine antibody FAB 528==
-	<StructureSection load='2z4q' size='340' side='right' caption='[[2z4q]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='2z4q' size='340' side='right'caption='[[2z4q]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4Q OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Z4Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Z4Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wt5\|1wt5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wt5\|1wt5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2z4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4q OCA], [http://pdbe.org/2z4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z4q RCSB], [http://www.ebi.ac.uk/pdbsum/2z4q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z4q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2z4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4q OCA], [http://pdbe.org/2z4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z4q RCSB], [http://www.ebi.ac.uk/pdbsum/2z4q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z4q ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Sandbox 20009\|Sandbox 20009]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Asano, R]]		[[Category: Asano, R]]

OCA at 09:18, 17 October 2018

OCA — Wed, 17 Oct 2018 09:18:35 GMT

←Older revision		Revision as of 09:18, 17 October 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/2z4q_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/2z4q_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[3D structures ~~of antibody~~\|3D structures ~~of antibody~~]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:05, 11 August 2016

OCA — Thu, 11 Aug 2016 21:05:26 GMT

←Older revision		Revision as of 21:05, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of a murine antibody FAB 528==		==Crystal structure of a murine antibody FAB 528==
	<StructureSection load='2z4q' size='340' side='right' caption='[[2z4q]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2z4q' size='340' side='right' caption='[[2z4q]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wt5\|1wt5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wt5\|1wt5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z4q RCSB], [http://www.ebi.ac.uk/pdbsum/2z4q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4q OCA], [http://pdbe.org/2z4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z4q RCSB], [http://www.ebi.ac.uk/pdbsum/2z4q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z4q ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z4q ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2z4q" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[~~Antibody~~\|~~Antibody~~]]	+	*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:34, 20 January 2015

OCA — Tue, 20 Jan 2015 11:34:40 GMT

←Older revision		Revision as of 11:34, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2z4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z4Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[2z4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z4Q FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wt5\|1wt5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wt5\|1wt5]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z4q RCSB], [http://www.ebi.ac.uk/pdbsum/2z4q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z4q RCSB], [http://www.ebi.ac.uk/pdbsum/2z4q PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Asano, R.]]	+	[[Category: Asano, R]]
-	[[Category: Kondo, H.]]	+	[[Category: Kondo, H]]
-	[[Category: Kumagai, I.]]	+	[[Category: Kumagai, I]]
-	[[Category: Nakanishi, T.]]	+	[[Category: Nakanishi, T]]
-	[[Category: Tsumoto, K.]]	+	[[Category: Tsumoto, K]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 10:08, 29 September 2014

OCA — Mon, 29 Sep 2014 10:08:19 GMT

←Older revision		Revision as of 10:08, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2z4q.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of a murine antibody FAB 528==
		+	<StructureSection load='2z4q' size='340' side='right' caption='[[2z4q]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2z4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z4Q FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wt5\|1wt5]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z4q RCSB], [http://www.ebi.ac.uk/pdbsum/2z4q PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/2z4q_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To investigate the role of Vernier zone residues, which are comprised in the framework regions and underlie the complementarity-determining regions (CDRs) of antibodies, in the specific, high affinity interactions of antibodies with their targets, we focused on the variable domain fragment of murine anti-human epidermal growth factor receptor antibody 528 (m528Fv). Grafting of the CDRs of m528Fv onto a selected framework region of human antibodies, referred to as humanization, reduced the antibody's affinity for its target by a factor of 1/40. The reduction in affinity was due to a substantial reduction in the negative enthalpy change associated with binding. Crystal structures of the ligand-free antibody fragments showed no noteworthy conformational changes due to humanization, and the loop structures of the CDRs of the humanized antibodies were identical to those of the parent antibodies. Several mutants of the CDR-grafted (humanized) variable domain fragment (h528Fv), in which some of the Vernier zone residues in the heavy chain were replaced with the parental murine residues, were constructed and prepared using a bacterial expression system. Thermodynamic analyses of the interactions between the mutants and the soluble extracellular domain of epidermal growth factor receptor showed that several single mutations and a double mutation increased the negative enthalpy and heat capacity changes. Combination of these mutations, however, led to somewhat reduced negative enthalpy and heat capacity changes. The affinity of each mutant for the target was within the range for the wild-type h528Fv, and this similarity was due to enthalpy-entropy compensation. These results suggest that Vernier zone residues make enthalpic contributions to antigen binding and that the regulation of conformational entropy changes upon humanization of murine antibodies must be carefully considered and optimized.

-	~~{{STRUCTURE_2z4q\| PDB=2z4q \| SCENE= }}~~	+	Thermodynamic consequences of mutations in vernier zone residues of a humanized anti-human epidermal growth factor receptor murine antibody, 528.,Makabe K, Nakanishi T, Tsumoto K, Tanaka Y, Kondo H, Umetsu M, Sone Y, Asano R, Kumagai I J Biol Chem. 2008 Jan 11;283(2):1156-66. Epub 2007 Oct 17. PMID:17947238<ref>PMID:17947238</ref>

-	~~===Crystal structure~~ of ~~a murine antibody FAB 528===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17947238}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2z4q]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4Q OCA].~~	+

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017947238<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Asano, R.]]		[[Category: Asano, R.]]

OCA at 18:02, 20 October 2012

OCA — Sat, 20 Oct 2012 18:02:50 GMT

←Older revision		Revision as of 18:02, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2z4q]] is a 2 chain structure ~~of [[Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4Q OCA].	+	[[2z4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4Q OCA].

	==See Also==		==See Also==

OCA: Protected "2z4q" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 02:48:34 GMT

Protected "2z4q" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:48, 27 July 2012

OCA at 02:48, 27 July 2012

OCA — Fri, 27 Jul 2012 02:48:32 GMT

←Older revision		Revision as of 02:48, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2z4q.png\|left\|200px]]		[[Image:2z4q.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2z4q", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2z4q\| PDB=2z4q \| SCENE= }}		{{STRUCTURE_2z4q\| PDB=2z4q \| SCENE= }}

	===Crystal structure of a murine antibody FAB 528===		===Crystal structure of a murine antibody FAB 528===

-
-	<!--
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	==About this Structure==		==About this Structure==
-	~~2Z4Q~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4Q OCA].	+	[[2z4q]] is a 2 chain structure of [[Antibody]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4Q OCA].
		+
		+	==See Also==
		+	*[[Antibody\|Antibody]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17947238~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017947238</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Asano, R.]]		[[Category: Asano, R.]]
Line 31:		Line 22:
	[[Category: Tsumoto, K.]]		[[Category: Tsumoto, K.]]
	[[Category: Immune system]]		[[Category: Immune system]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:18:50 2009''

OCA at 17:18, 17 February 2009

OCA — Tue, 17 Feb 2009 17:18:54 GMT

←Older revision		Revision as of 17:18, 17 February 2009
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	==About this Structure==		==About this Structure==
-	2Z4Q is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4Q OCA].	+	2Z4Q is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4Q OCA].

	==Reference==		==Reference==
-	Thermodynamic consequences of mutations in vernier zone residues of a humanized anti-human epidermal growth factor receptor murine antibody, 528., Makabe K, Nakanishi T, Tsumoto K, Tanaka Y, Kondo H, Umetsu M, Sone Y, Asano R, Kumagai I, J Biol Chem. 2008 Jan 11;283(2):1156-66. Epub 2007 Oct 17. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17947238 17947238]~~	+	<ref group="xtra">PMID:17947238</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Protein complex]]
	[[Category: Asano, R.]]		[[Category: Asano, R.]]
	[[Category: Kondo, H.]]		[[Category: Kondo, H.]]
Line 33:		Line 32:
	[[Category: Immune system]]		[[Category: Immune system]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 03~~:24:~~42 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:18:50 2009''