2z4v - Revision history

OCA at 13:21, 1 November 2023

OCA — Wed, 01 Nov 2023 13:21:25 GMT

←Older revision		Revision as of 13:21, 1 November 2023
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	<StructureSection load='2z4v' size='340' side='right'caption='[[2z4v]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='2z4v' size='340' side='right'caption='[[2z4v]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z4v]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2Z4V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z4v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z4V FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.86Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[2z4w\|2z4w]]~~, ~~[[2z4x\|2z4x]], [[2z4y\|2z4y]], [[2z4z\|2z4z]], [[2z50\|2z50]], [[2z52\|2z52]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2z4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4v OCA], [~~http~~://pdbe.org/2z4v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2z4v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2z4v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2z4v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4v OCA], [https://pdbe.org/2z4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z4v RCSB], [https://www.ebi.ac.uk/pdbsum/2z4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z4v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GGPPS_YEAST GGPPS_YEAST]] Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting.<ref>PMID:7665600</ref> <ref>PMID:15296494</ref>	+	[https://www.uniprot.org/uniprot/GGPPS_YEAST GGPPS_YEAST] Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting.<ref>PMID:7665600</ref> <ref>PMID:15296494</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cao, R]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Chen~~, C K.~~M]]	+	[[Category: Cao R]]
-	[[Category: Guo~~, R T~~]]	+	[[Category: Chen CK-M]]
-	[[Category: Hudock, M]]	+	[[Category: Guo RT]]
-	[[Category: Oldfield, E]]	+	[[Category: Hudock M]]
-	[[Category: Wang~~, A H.~~J]]	+	[[Category: Oldfield E]]
-	~~[[Category: Bisphosphonate]]~~	+	[[Category: Wang AH-J]]
-	~~[[Category: Geranylgeranyl pyrophosphate]]~~	+
-	~~[[Category: Prenyltransferase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:57, 29 July 2020

OCA — Wed, 29 Jul 2020 11:57:34 GMT

←Older revision		Revision as of 11:57, 29 July 2020
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	==S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and GGPP (inhibitory site)==		==S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and GGPP (inhibitory site)==
-	<StructureSection load='2z4v' size='340' side='right' caption='[[2z4v]], [[Resolution\|resolution]] 1.86Å' scene=''>	+	<StructureSection load='2z4v' size='340' side='right'caption='[[2z4v]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z4v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4V OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Z4V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z4v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Z4V FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z4w\|2z4w]], [[2z4x\|2z4x]], [[2z4y\|2z4y]], [[2z4z\|2z4z]], [[2z50\|2z50]], [[2z52\|2z52]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z4w\|2z4w]], [[2z4x\|2z4x]], [[2z4y\|2z4y]], [[2z4z\|2z4z]], [[2z50\|2z50]], [[2z52\|2z52]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2z4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4v OCA], [http://pdbe.org/2z4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z4v RCSB], [http://www.ebi.ac.uk/pdbsum/2z4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z4v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2z4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4v OCA], [http://pdbe.org/2z4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z4v RCSB], [http://www.ebi.ac.uk/pdbsum/2z4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z4v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
	*[[Geranylgeranyl pyrophosphate synthase\|Geranylgeranyl pyrophosphate synthase]]		*[[Geranylgeranyl pyrophosphate synthase\|Geranylgeranyl pyrophosphate synthase]]
		+	*[[Geranylgeranyl pyrophosphate synthase 3D structures\|Geranylgeranyl pyrophosphate synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Cao, R]]		[[Category: Cao, R]]
	[[Category: Chen, C K.M]]		[[Category: Chen, C K.M]]

OCA at 09:00, 17 October 2018

OCA — Wed, 17 Oct 2018 09:00:27 GMT

←Older revision		Revision as of 09:00, 17 October 2018
Line 1:		Line 1:
		+
	==S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and GGPP (inhibitory site)==		==S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and GGPP (inhibitory site)==
	<StructureSection load='2z4v' size='340' side='right' caption='[[2z4v]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='2z4v' size='340' side='right' caption='[[2z4v]], [[Resolution\|resolution]] 1.86Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z4w\|2z4w]], [[2z4x\|2z4x]], [[2z4y\|2z4y]], [[2z4z\|2z4z]], [[2z50\|2z50]], [[2z52\|2z52]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z4w\|2z4w]], [[2z4x\|2z4x]], [[2z4y\|2z4y]], [[2z4z\|2z4z]], [[2z50\|2z50]], [[2z52\|2z52]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4v OCA], [http://pdbe.org/2z4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z4v RCSB], [http://www.ebi.ac.uk/pdbsum/2z4v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4v OCA], [http://pdbe.org/2z4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z4v RCSB], [http://www.ebi.ac.uk/pdbsum/2z4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z4v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/2z4v_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/2z4v_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:28, 8 February 2016

OCA — Mon, 08 Feb 2016 07:28:50 GMT

←Older revision		Revision as of 07:28, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2z4v' size='340' side='right' caption='[[2z4v]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='2z4v' size='340' side='right' caption='[[2z4v]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z4v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z4V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z4v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z4V FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z4w\|2z4w]], [[2z4x\|2z4x]], [[2z4y\|2z4y]], [[2z4z\|2z4z]], [[2z50\|2z50]], [[2z52\|2z52]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z4w\|2z4w]], [[2z4x\|2z4x]], [[2z4y\|2z4y]], [[2z4z\|2z4z]], [[2z50\|2z50]], [[2z52\|2z52]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z4v RCSB], [http://www.ebi.ac.uk/pdbsum/2z4v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4v OCA], [http://pdbe.org/2z4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z4v RCSB], [http://www.ebi.ac.uk/pdbsum/2z4v PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z4v ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2z4v" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Cao, R]]		[[Category: Cao, R]]
	[[Category: Chen, C K.M]]		[[Category: Chen, C K.M]]

OCA at 21:39, 24 December 2014

OCA — Wed, 24 Dec 2014 21:39:06 GMT

←Older revision		Revision as of 21:39, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2z4v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[2z4v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z4V FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z4w\|2z4w]], [[2z4x\|2z4x]], [[2z4y\|2z4y]], [[2z4z\|2z4z]], [[2z50\|2z50]], [[2z52\|2z52]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z4w\|2z4w]], [[2z4x\|2z4x]], [[2z4y\|2z4y]], [[2z4z\|2z4z]], [[2z50\|2z50]], [[2z52\|2z52]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z4v RCSB], [http://www.ebi.ac.uk/pdbsum/2z4v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z4v RCSB], [http://www.ebi.ac.uk/pdbsum/2z4v PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GGPPS_YEAST GGPPS_YEAST]] Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting.<ref>PMID:7665600</ref> <ref>PMID:15296494</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Cao, R.]]	+	[[Category: Cao, R]]
-	[[Category: Chen, C K.M.]]	+	[[Category: Chen, C K.M]]
-	[[Category: Guo, R T.]]	+	[[Category: Guo, R T]]
-	[[Category: Hudock, M.]]	+	[[Category: Hudock, M]]
-	[[Category: Oldfield, E.]]	+	[[Category: Oldfield, E]]
-	[[Category: Wang, A H.J.]]	+	[[Category: Wang, A H.J]]
	[[Category: Bisphosphonate]]		[[Category: Bisphosphonate]]
	[[Category: Geranylgeranyl pyrophosphate]]		[[Category: Geranylgeranyl pyrophosphate]]
	[[Category: Prenyltransferase]]		[[Category: Prenyltransferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 05:22, 2 October 2014

OCA — Thu, 02 Oct 2014 05:22:38 GMT

←Older revision		Revision as of 05:22, 2 October 2014
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-	[[~~Image:~~2z4v.~~png~~\|~~left~~\|200px]]	+	==S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and GGPP (inhibitory site)==
		+	<StructureSection load='2z4v' size='340' side='right' caption='[[2z4v]], [[Resolution\|resolution]] 1.86Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2z4v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z4V FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z4w\|2z4w]], [[2z4x\|2z4x]], [[2z4y\|2z4y]], [[2z4z\|2z4z]], [[2z50\|2z50]], [[2z52\|2z52]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z4v RCSB], [http://www.ebi.ac.uk/pdbsum/2z4v PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/2z4v_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We report the X-ray structures of several bisphosphonate inhibitors of geranylgeranyl diphosphate synthase, a target for anticancer drugs. Bisphosphonates containing unbranched side chains bind to either the farnesyl diphosphate (FPP) substrate site, the geranylgeranyl diphosphate (GGPP) product site, and in one case, both sites, with the bisphosphonate moiety interacting with 3 Mg (2+) that occupy the same position as found in FPP synthase. However, each of three "V-shaped" bisphosphonates bind to both the FPP and GGPP sites. Using the Glide program, we reproduced the binding modes of 10 bisphosphonates with an rms error of 1.3 A. Activities of the bisphosphonates in GGPPS inhibition were predicted with an overall error of 2x by using a comparative molecular similarity analysis based on a docked-structure alignment. These results show that some GGPPS inhibitors can occupy both substrate and product site and that binding modes as well as activity can be accurately predicted, facilitating the further development of GGPPS inhibitors as anticancer agents.

-	~~{{STRUCTURE_2z4v\| PDB=2z4v \| SCENE= }}~~	+	Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.,K-M Chen C, Hudock MP, Zhang Y, Guo RT, Cao R, No JH, Liang PH, Ko TP, Chang TH, Chang SC, Song Y, Axelson J, Kumar A, Wang AH, Oldfield E J Med Chem. 2008 Sep 25;51(18):5594-607. PMID:18800762<ref>PMID:18800762</ref>

-	~~===~~S. ~~cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and GGPP (inhibitory site)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_18800762}}~~	+	==See Also==
-		+	*[[Geranylgeranyl pyrophosphate synthase\|Geranylgeranyl pyrophosphate synthase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2z4v~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4V OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:018800762<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Cao, R.]]		[[Category: Cao, R.]]

OCA at 22:50, 7 January 2013

OCA — Mon, 07 Jan 2013 22:50:45 GMT

←Older revision		Revision as of 22:50, 7 January 2013
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	[[Image:2z4v.png\|left\|200px]]		[[Image:2z4v.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2z4v\| PDB=2z4v \| SCENE= }}		{{STRUCTURE_2z4v\| PDB=2z4v \| SCENE= }}

	===S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and GGPP (inhibitory site)===		===S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and GGPP (inhibitory site)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18800762}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18800762 is the PubMed ID number.
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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18800762~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018800762</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Cao, R.]]		[[Category: Cao, R.]]

OCA: Protected "2z4v" [edit=sysop:move=sysop]

OCA — Wed, 29 Dec 2010 17:49:35 GMT

Protected "2z4v" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:49, 29 December 2010

OCA at 17:49, 29 December 2010

OCA — Wed, 29 Dec 2010 17:49:34 GMT

←Older revision		Revision as of 17:49, 29 December 2010
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-	{{Seed}}
	[[Image:2z4v.png\|left\|200px]]		[[Image:2z4v.png\|left\|200px]]

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	===S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and GGPP (inhibitory site)===		===S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and GGPP (inhibitory site)===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18800762}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18800762 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18800762}}

	==About this Structure==		==About this Structure==
-	~~2Z4V~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4V OCA].	+	[[2z4v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4V OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:18800762</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Cao, R.]]		[[Category: Cao, R.]]
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	[[Category: Geranylgeranyl pyrophosphate]]		[[Category: Geranylgeranyl pyrophosphate]]
	[[Category: Prenyltransferase]]		[[Category: Prenyltransferase]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 20:11:55 2009''~~	+

OCA at 18:11, 16 February 2009

OCA — Mon, 16 Feb 2009 18:11:57 GMT

←Older revision		Revision as of 18:11, 16 February 2009
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	{{Seed}}		{{Seed}}
-	[[Image:2z4v.~~jpg~~\|left\|200px]]	+	[[Image:2z4v.png\|left\|200px]]

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	2Z4V is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4V OCA].	+	2Z4V is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4V OCA].
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Single protein]]
	[[Category: Cao, R.]]		[[Category: Cao, R.]]
	[[Category: Chen, C K.M.]]		[[Category: Chen, C K.M.]]
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	[[Category: Prenyltransferase]]		[[Category: Prenyltransferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jul 3 11~~:24:~~21 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:11:55 2009''