2z5m - Revision history

OCA at 13:22, 1 November 2023

OCA — Wed, 01 Nov 2023 13:22:51 GMT

←Older revision		Revision as of 13:22, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='2z5m' size='340' side='right'caption='[[2z5m]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2z5m' size='340' side='right'caption='[[2z5m]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z5m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z5m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z5M FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1qbk\|1qbk]]~~, [[~~2h4m~~\|~~2h4m~~]]~~, [[2ot8\|2ot8]], [[2z5j\|2z5j]], [[2z5k\|2z5k]], [[2z5n\|2z5n]], [[2z5o\|2z5o]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5m OCA], [https://pdbe.org/2z5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z5m RCSB], [https://www.ebi.ac.uk/pdbsum/2z5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5m OCA], [https://pdbe.org/2z5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z5m RCSB], [https://www.ebi.ac.uk/pdbsum/2z5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TNPO1_HUMAN TNPO1_HUMAN]] Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner.<ref>PMID:8986607</ref> <ref>PMID:9687515</ref> <ref>PMID:11682607</ref> <ref>PMID:19124606</ref> [[https://www.uniprot.org/uniprot/NXF1_HUMAN NXF1_HUMAN]] Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5.<ref>PMID:9660949</ref> <ref>PMID:19165146</ref>	+	[https://www.uniprot.org/uniprot/TNPO1_HUMAN TNPO1_HUMAN] Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner.<ref>PMID:8986607</ref> <ref>PMID:9687515</ref> <ref>PMID:11682607</ref> <ref>PMID:19124606</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hashimoto, H]]	+	[[Category: Hashimoto H]]
-	[[Category: Hidaka, Y]]	+	[[Category: Hidaka Y]]
-	[[Category: Imamoto, N]]	+	[[Category: Imamoto N]]
-	[[Category: Imasaki, T]]	+	[[Category: Imasaki T]]
-	[[Category: Kose, S]]	+	[[Category: Kose S]]
-	[[Category: Sato, M]]	+	[[Category: Sato M]]
-	[[Category: Shimizu, T]]	+	[[Category: Shimizu T]]
-	[[Category: Yamada, M]]	+	[[Category: Yamada M]]
-	~~[[Category: Exportin]]~~	+
-	~~[[Category: Importin]]~~	+
-	~~[[Category: Karyopherin]]~~	+
-	~~[[Category: Nl]]~~	+
-	~~[[Category: Nuclear transport]]~~	+
-	~~[[Category: Nucleocytoplasmic]]~~	+
-	~~[[Category: Tap]]~~	+
-	~~[[Category: Transport protein-rna binding protein complex~~]]	+

OCA at 10:46, 8 December 2021

OCA — Wed, 08 Dec 2021 10:46:10 GMT

←Older revision		Revision as of 10:46, 8 December 2021
Line 3:		Line 3:
	<StructureSection load='2z5m' size='340' side='right'caption='[[2z5m]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2z5m' size='340' side='right'caption='[[2z5m]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z5m]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Z5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z5m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z5M FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qbk\|1qbk]], [[2h4m\|2h4m]], [[2ot8\|2ot8]], [[2z5j\|2z5j]], [[2z5k\|2z5k]], [[2z5n\|2z5n]], [[2z5o\|2z5o]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qbk\|1qbk]], [[2h4m\|2h4m]], [[2ot8\|2ot8]], [[2z5j\|2z5j]], [[2z5k\|2z5k]], [[2z5n\|2z5n]], [[2z5o\|2z5o]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2z5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5m OCA], [~~http~~://pdbe.org/2z5m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2z5m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2z5m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5m OCA], [https://pdbe.org/2z5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z5m RCSB], [https://www.ebi.ac.uk/pdbsum/2z5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TNPO1_HUMAN TNPO1_HUMAN]] Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner.<ref>PMID:8986607</ref> <ref>PMID:9687515</ref> <ref>PMID:11682607</ref> <ref>PMID:19124606</ref> [[~~http~~://www.uniprot.org/uniprot/NXF1_HUMAN NXF1_HUMAN]] Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5.<ref>PMID:9660949</ref> <ref>PMID:19165146</ref>	+	[[https://www.uniprot.org/uniprot/TNPO1_HUMAN TNPO1_HUMAN]] Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner.<ref>PMID:8986607</ref> <ref>PMID:9687515</ref> <ref>PMID:11682607</ref> <ref>PMID:19124606</ref> [[https://www.uniprot.org/uniprot/NXF1_HUMAN NXF1_HUMAN]] Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5.<ref>PMID:9660949</ref> <ref>PMID:19165146</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Importin\|Importin]]	+	*[[Importin 3D structures\|Importin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:00, 31 July 2019

OCA — Wed, 31 Jul 2019 08:00:02 GMT

←Older revision		Revision as of 08:00, 31 July 2019
Line 1:		Line 1:

	==Complex of Transportin 1 with TAP NLS, crystal form 2==		==Complex of Transportin 1 with TAP NLS, crystal form 2==
-	<StructureSection load='2z5m' size='340' side='right' caption='[[2z5m]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='2z5m' size='340' side='right'caption='[[2z5m]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2z5m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z5M FirstGlance]. <br>		<table><tr><td colspan='2'>[[2z5m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z5M FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/2z5m_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/2z5m_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2z5m" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2z5m" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Importin\|Importin]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hashimoto, H]]		[[Category: Hashimoto, H]]
	[[Category: Hidaka, Y]]		[[Category: Hidaka, Y]]

OCA at 16:34, 12 October 2017

OCA — Thu, 12 Oct 2017 16:34:57 GMT

←Older revision		Revision as of 16:34, 12 October 2017
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2z5m" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2z5m" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Importin\|Importin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:04, 5 August 2016

OCA — Fri, 05 Aug 2016 18:04:51 GMT

←Older revision		Revision as of 18:04, 5 August 2016
Line 1:		Line 1:
		+
	==Complex of Transportin 1 with TAP NLS, crystal form 2==		==Complex of Transportin 1 with TAP NLS, crystal form 2==
	<StructureSection load='2z5m' size='340' side='right' caption='[[2z5m]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2z5m' size='340' side='right' caption='[[2z5m]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z5m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z5m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z5M FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qbk\|1qbk]], [[2h4m\|2h4m]], [[2ot8\|2ot8]], [[2z5j\|2z5j]], [[2z5k\|2z5k]], [[2z5n\|2z5n]], [[2z5o\|2z5o]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qbk\|1qbk]], [[2h4m\|2h4m]], [[2ot8\|2ot8]], [[2z5j\|2z5j]], [[2z5k\|2z5k]], [[2z5n\|2z5n]], [[2z5o\|2z5o]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z5m RCSB], [http://www.ebi.ac.uk/pdbsum/2z5m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5m OCA], [http://pdbe.org/2z5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z5m RCSB], [http://www.ebi.ac.uk/pdbsum/2z5m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z5m ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2z5m" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hashimoto, H]]		[[Category: Hashimoto, H]]
	[[Category: Hidaka, Y]]		[[Category: Hidaka, Y]]

OCA at 20:50, 25 December 2014

OCA — Thu, 25 Dec 2014 20:50:12 GMT

←Older revision		Revision as of 20:50, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z5m RCSB], [http://www.ebi.ac.uk/pdbsum/2z5m PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z5m RCSB], [http://www.ebi.ac.uk/pdbsum/2z5m PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TNPO1_HUMAN TNPO1_HUMAN]] Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner.<ref>PMID:8986607</ref> <ref>PMID:9687515</ref> <ref>PMID:11682607</ref> <ref>PMID:19124606</ref> [[http://www.uniprot.org/uniprot/NXF1_HUMAN NXF1_HUMAN]] Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5.<ref>PMID:9660949</ref> <ref>PMID:19165146</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hashimoto, H.]]	+	[[Category: Hashimoto, H]]
-	[[Category: Hidaka, Y.]]	+	[[Category: Hidaka, Y]]
-	[[Category: Imamoto, N.]]	+	[[Category: Imamoto, N]]
-	[[Category: Imasaki, T.]]	+	[[Category: Imasaki, T]]
-	[[Category: Kose, S.]]	+	[[Category: Kose, S]]
-	[[Category: Sato, M.]]	+	[[Category: Sato, M]]
-	[[Category: Shimizu, T.]]	+	[[Category: Shimizu, T]]
-	[[Category: Yamada, M.]]	+	[[Category: Yamada, M]]
	[[Category: Exportin]]		[[Category: Exportin]]
	[[Category: Importin]]		[[Category: Importin]]

OCA at 06:53, 10 October 2014

OCA — Fri, 10 Oct 2014 06:53:57 GMT

←Older revision		Revision as of 06:53, 10 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2z5m.~~png~~\|~~left~~\|200px]]	+	==Complex of Transportin 1 with TAP NLS, crystal form 2==
		+	<StructureSection load='2z5m' size='340' side='right' caption='[[2z5m]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2z5m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z5M FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qbk\|1qbk]], [[2h4m\|2h4m]], [[2ot8\|2ot8]], [[2z5j\|2z5j]], [[2z5k\|2z5k]], [[2z5n\|2z5n]], [[2z5o\|2z5o]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z5m RCSB], [http://www.ebi.ac.uk/pdbsum/2z5m PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/2z5m_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Transportin 1 (Trn1) is a transport receptor that transports substrates from the cytoplasm to the nucleus through nuclear pore complexes by recognizing nuclear localization signals (NLSs). Here we describe four crystal structures of human Trn1 in a substrate-free form as well as in the complex with three NLSs (hnRNP D, JKTBP, and TAP, respectively). Our data have revealed that (1) Trn1 has two sites for binding NLSs, one with high affinity (site A) and one with low affinity (site B), and NLS interaction at site B controls overall binding affinity for Trn1; (2) Trn1 recognizes the NLSs at site A followed by conformational change at site B to interact with the NLSs; and (3) a long flexible loop, characteristic of Trn1, interacts with site B, thereby displacing transport substrate in the nucleus. These studies provide deep understanding of substrate recognition and dissociation by Trn1 in import pathways.

-	~~{{STRUCTURE_2z5m\| PDB=2z5m \| SCENE= }}~~	+	Structural basis for substrate recognition and dissociation by human transportin 1.,Imasaki T, Shimizu T, Hashimoto H, Hidaka Y, Kose S, Imamoto N, Yamada M, Sato M Mol Cell. 2007 Oct 12;28(1):57-67. PMID:17936704<ref>PMID:17936704</ref>

-	~~===Complex of Transportin 1 with TAP NLS~~, ~~crystal form 2===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_17936704}}~~	+	==See Also==
-		+	*[[Importin\|Importin]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2z5m~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5M OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:017936704<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hashimoto, H.]]		[[Category: Hashimoto, H.]]

OCA: Protected "2z5m" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 20:29:18 GMT

Protected "2z5m" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:29, 7 January 2013

OCA at 20:29, 7 January 2013

OCA — Mon, 07 Jan 2013 20:29:14 GMT

←Older revision		Revision as of 20:29, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2z5m.png\|left\|200px]]		[[Image:2z5m.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2z5m", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2z5m\| PDB=2z5m \| SCENE= }}		{{STRUCTURE_2z5m\| PDB=2z5m \| SCENE= }}

	===Complex of Transportin 1 with TAP NLS, crystal form 2===		===Complex of Transportin 1 with TAP NLS, crystal form 2===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17936704}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17936704 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17936704}}		{{ABSTRACT_PUBMED_17936704}}

	==About this Structure==		==About this Structure==
-	~~2Z5M~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5M OCA].	+	[[2z5m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5M OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17936704~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017936704</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hashimoto, H.]]		[[Category: Hashimoto, H.]]
Line 40:		Line 28:
	[[Category: Nucleocytoplasmic]]		[[Category: Nucleocytoplasmic]]
	[[Category: Tap]]		[[Category: Tap]]
-	[[Category: Transport protein/rna binding protein complex]]	+	[[Category: Transport protein-rna binding protein complex]]
-		+
-	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:49:11 2009''~~	+

OCA at 04:49, 18 February 2009

OCA — Wed, 18 Feb 2009 04:49:14 GMT

←Older revision		Revision as of 04:49, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2Z5M is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5M OCA].	+	2Z5M is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5M OCA].

	==Reference==		==Reference==
-	Structural basis for substrate recognition and dissociation by human transportin 1., Imasaki T, Shimizu T, Hashimoto H, Hidaka Y, Kose S, Imamoto N, Yamada M, Sato M, Mol Cell. 2007 Oct 12;28(1):57-67. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17936704 17936704]~~	+	<ref group="xtra">PMID:17936704</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Protein complex]]
	[[Category: Hashimoto, H.]]		[[Category: Hashimoto, H.]]
	[[Category: Hidaka, Y.]]		[[Category: Hidaka, Y.]]
Line 43:		Line 42:
	[[Category: Transport protein/rna binding protein complex]]		[[Category: Transport protein/rna binding protein complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 13~~:34:~~24 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:49:11 2009''