2z6p - Revision history

OCA at 10:47, 8 December 2021

OCA — Wed, 08 Dec 2021 10:47:07 GMT

←Older revision		Revision as of 10:47, 8 December 2021
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	==Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1==		==Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1==
-	<StructureSection load='2z6p' size='340' side='right' caption='[[2z6p]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2z6p' size='340' side='right'caption='[[2z6p]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z6p]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Z6P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z6p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z6P FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z6o\|2z6o]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2z6o\|2z6o]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UFC1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UFC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2z6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6p OCA], [~~http~~://pdbe.org/2z6p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2z6p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2z6p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2z6p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6p OCA], [https://pdbe.org/2z6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z6p RCSB], [https://www.ebi.ac.uk/pdbsum/2z6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z6p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/UFC1_HUMAN UFC1_HUMAN]] E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.<ref>PMID:15071506</ref>	+	[[https://www.uniprot.org/uniprot/UFC1_HUMAN UFC1_HUMAN]] E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.<ref>PMID:15071506</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 2z6p" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2z6p" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ubiquitin-fold modifier\|Ubiquitin-fold modifier]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]
	[[Category: Kawakami, T]]		[[Category: Kawakami, T]]

OCA at 09:28, 17 October 2018

OCA — Wed, 17 Oct 2018 09:28:01 GMT

←Older revision		Revision as of 09:28, 17 October 2018
Line 1:		Line 1:
		+
	==Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1==		==Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1==
	<StructureSection load='2z6p' size='340' side='right' caption='[[2z6p]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2z6p' size='340' side='right' caption='[[2z6p]], [[Resolution\|resolution]] 1.80Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UFC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UFC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6p OCA], [http://pdbe.org/2z6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z6p RCSB], [http://www.ebi.ac.uk/pdbsum/2z6p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6p OCA], [http://pdbe.org/2z6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z6p RCSB], [http://www.ebi.ac.uk/pdbsum/2z6p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z6p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/2z6p_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/2z6p_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 39:		Line 40:
	[[Category: Komatsu, M]]		[[Category: Komatsu, M]]
	[[Category: Kominami, E]]		[[Category: Kominami, E]]
-	[[Category: Mizushima ,T]]	+	[[Category: Mizushima , T]]
	[[Category: Ogasahara, K]]		[[Category: Ogasahara, K]]
	[[Category: Ozaki, Y]]		[[Category: Ozaki, Y]]
Line 47:		Line 48:
	[[Category: Yamane, T]]		[[Category: Yamane, T]]
	[[Category: Ligase]]		[[Category: Ligase]]
		+	[[Category: Polymorphism]]
	[[Category: Ubiquitin]]		[[Category: Ubiquitin]]
	[[Category: Ubl]]		[[Category: Ubl]]

OCA at 15:36, 7 February 2016

OCA — Sun, 07 Feb 2016 15:36:09 GMT

←Older revision		Revision as of 15:36, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2z6p' size='340' side='right' caption='[[2z6p]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2z6p' size='340' side='right' caption='[[2z6p]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z6p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z6P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z6p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z6P FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z6o\|2z6o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z6o\|2z6o]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UFC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UFC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z6p RCSB], [http://www.ebi.ac.uk/pdbsum/2z6p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6p OCA], [http://pdbe.org/2z6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z6p RCSB], [http://www.ebi.ac.uk/pdbsum/2z6p PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z6p ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2z6p" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]
	[[Category: Kawakami, T]]		[[Category: Kawakami, T]]

OCA at 16:21, 24 December 2014

OCA — Wed, 24 Dec 2014 16:21:23 GMT

←Older revision		Revision as of 16:21, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2z6p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z6P FirstGlance]. <br>		<table><tr><td colspan='2'>[[2z6p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z6P FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z6o\|2z6o]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z6o\|2z6o]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UFC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UFC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z6p RCSB], [http://www.ebi.ac.uk/pdbsum/2z6p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z6p RCSB], [http://www.ebi.ac.uk/pdbsum/2z6p PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UFC1_HUMAN UFC1_HUMAN]] E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.<ref>PMID:15071506</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]
-	[[Category: Kawakami, T.]]	+	[[Category: Kawakami, T]]
-	[[Category: Komatsu, M.]]	+	[[Category: Komatsu, M]]
-	[[Category: Kominami, E.]]	+	[[Category: Kominami, E]]
-	[[Category: Mizushima ,T.]]	+	[[Category: Mizushima ,T]]
-	[[Category: Ogasahara, K.]]	+	[[Category: Ogasahara, K]]
-	[[Category: Ozaki, Y.]]	+	[[Category: Ozaki, Y]]
-	[[Category: Suzuki, A.]]	+	[[Category: Suzuki, A]]
-	[[Category: Tanaka, K.]]	+	[[Category: Tanaka, K]]
-	[[Category: Tatsumi, K.]]	+	[[Category: Tatsumi, K]]
-	[[Category: Yamane, T.]]	+	[[Category: Yamane, T]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Ubiquitin]]		[[Category: Ubiquitin]]

OCA at 05:09, 2 October 2014

OCA — Thu, 02 Oct 2014 05:09:10 GMT

←Older revision		Revision as of 05:09, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2z6p.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1==
		+	<StructureSection load='2z6p' size='340' side='right' caption='[[2z6p]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2z6p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z6P FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z6o\|2z6o]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UFC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z6p RCSB], [http://www.ebi.ac.uk/pdbsum/2z6p PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/2z6p_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ubiquitin and ubiquitin-like protein-conjugating enzymes play central roles in posttranslational modification processes. The ubiquitin-fold modifier 1 (Ufm1), one of a variety of ubiquitin-like modifiers, is covalently attached to target proteins via Uba5 and Ufm1-conjugating enzyme 1 (Ufc1), which are analogous to the E1 and E2 ubiquitylation enzymes. As Ufm1-related proteins are conserved in metazoa and plants, the Ufm1 system likely plays important roles in various multicellular organisms. Herein, we report the X-ray structure of human Ufc1 determined at 1.6 A resolution. The Ufc1 structure comprises a canonical E2 domain and an additional N-terminal domain. The Uba5 binding site on Ufc1 was assigned by structural comparison of Ufc1 and Ubc12 and related mutational analyses. In addition, we show that the N-terminal unique domain of Ufc1 contributes to thermal stability.

-	~~{{STRUCTURE_2z6p\| PDB=2z6p \| SCENE= }}~~	+	Crystal structure of Ufc1, the Ufm1-conjugating enzyme.,Mizushima T, Tatsumi K, Ozaki Y, Kawakami T, Suzuki A, Ogasahara K, Komatsu M, Kominami E, Tanaka K, Yamane T Biochem Biophys Res Commun. 2007 Nov 3;362(4):1079-84. Epub 2007 Aug 30. PMID:17825256<ref>PMID:17825256</ref>

-	~~===Crystal Structure~~ of the ~~Ufc1, Ufm1 conjugating enzyme 1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17825256}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2z6p]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6P OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017825256<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]

OCA: Protected "2z6p" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 22:31:33 GMT

Protected "2z6p" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:31, 7 January 2013

OCA at 22:31, 7 January 2013

OCA — Mon, 07 Jan 2013 22:31:30 GMT

←Older revision		Revision as of 22:31, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2z6p.png\|left\|200px]]		[[Image:2z6p.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2z6p", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2z6p\| PDB=2z6p \| SCENE= }}		{{STRUCTURE_2z6p\| PDB=2z6p \| SCENE= }}

	===Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1===		===Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17825256}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17825256 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17825256}}		{{ABSTRACT_PUBMED_17825256}}

	==About this Structure==		==About this Structure==
-	~~2Z6P~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6P OCA].	+	[[2z6p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6P OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17825256~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017825256</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]
Line 37:		Line 25:
	[[Category: Yamane, T.]]		[[Category: Yamane, T.]]
	[[Category: Ligase]]		[[Category: Ligase]]
-	[[Category: Polymorphism]]
	[[Category: Ubiquitin]]		[[Category: Ubiquitin]]
	[[Category: Ubl]]		[[Category: Ubl]]
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	[[Category: Ufc1]]		[[Category: Ufc1]]
	[[Category: Ufm1]]		[[Category: Ufm1]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:49:17 2009''

OCA at 12:49, 16 February 2009

OCA — Mon, 16 Feb 2009 12:49:18 GMT

←Older revision		Revision as of 12:49, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2Z6P is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6P OCA].	+	2Z6P is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6P OCA].

	==Reference==		==Reference==
-	Crystal structure of Ufc1, the Ufm1-conjugating enzyme., Mizushima T, Tatsumi K, Ozaki Y, Kawakami T, Suzuki A, Ogasahara K, Komatsu M, Kominami E, Tanaka K, Yamane T, Biochem Biophys Res Commun. 2007 Nov 3;362(4):1079-84. Epub 2007 Aug 30. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17825256 17825256]~~	+	<ref group="xtra">PMID:17825256</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]
	[[Category: Kawakami, T.]]		[[Category: Kawakami, T.]]
Line 45:		Line 44:
	[[Category: Ufm1]]		[[Category: Ufm1]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 17~~:33:~~11 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:49:17 2009''

OCA at 14:33, 27 July 2008

OCA — Sun, 27 Jul 2008 14:33:12 GMT

←Older revision		Revision as of 14:33, 27 July 2008
Line 1:		Line 1:
-	[[Image:2z6p.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2z6p.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2z6p\| PDB=2z6p \| SCENE= }}		{{STRUCTURE_2z6p\| PDB=2z6p \| SCENE= }}

-	~~'''~~Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1~~'''~~	+	===Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1===


-	~~==Overview==~~	+	<!--
-	~~Ubiquitin and ubiquitin~~-~~like protein~~-~~conjugating enzymes play central roles in posttranslational modification processes.~~ The ~~ubiquitin-fold modifier 1 (Ufm1)~~, ~~one of a variety of ubiquitin-like modifiers~~, ~~is covalently attached~~ to ~~target proteins via Uba5 and Ufm1-conjugating enzyme 1~~ (~~Ufc1), which are analogous to the E1 and E2 ubiquitylation enzymes~~. ~~As Ufm1-related proteins are conserved in metazoa and plants, the Ufm1 system likely plays important roles in various multicellular organisms~~. ~~Herein~~, ~~we report~~ the ~~X-ray structure of human Ufc1 determined at 1~~.~~6 A resolution. The Ufc1 structure comprises a canonical E2 domain and an additional N~~-~~terminal domain. The Uba5 binding site on Ufc1 was assigned by structural comparison of Ufc1 and Ubc12 and related mutational analyses. In addition, we show that the N~~-~~terminal unique domain of Ufc1 contributes to thermal stability.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_17825256}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17825256 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17825256}}

	==About this Structure==		==About this Structure==
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	[[Category: Ufc1]]		[[Category: Ufc1]]
	[[Category: Ufm1]]		[[Category: Ufm1]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 20~~:00:35 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:33:11 2008''

OCA at 17:00, 4 May 2008

OCA — Sun, 04 May 2008 17:00:36 GMT

←Older revision		Revision as of 17:00, 4 May 2008
Line 1:		Line 1:
	[[Image:2z6p.gif\|left\|200px]]		[[Image:2z6p.gif\|left\|200px]]

-	~~{{Structure~~	+	<!--
-	~~\|PDB= 2z6p \|SIZE=350\|CAPTION= <scene name='initialview01'>2z6p</scene>~~, ~~resolution 1~~.~~80Å~~	+	The line below this paragraph, containing "STRUCTURE_2z6p", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <~~scene ~~name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	~~\|ACTIVITY= <span class='plainlinks'>[http://en~~.~~wikipedia.org/wiki/Ubiquitin~~--~~protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span~~>	+	or leave the SCENE parameter empty for the default display.
-	\|~~GENE~~= ~~UFC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])~~	+	-->
-	\|~~DOMAIN~~=	+	{{STRUCTURE_2z6p\| PDB=2z6p \| SCENE= }}
-	~~\|RELATEDENTRY=[[2z6o\|2Z6O]]~~	+
-	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6p OCA], [http://www.ebi.ac.uk/pdbsum/2z6p PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2z6p RCSB]</span>	+
-	}}	+

	'''Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1'''		'''Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1'''
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	[[Category: Tatsumi, K.]]		[[Category: Tatsumi, K.]]
	[[Category: Yamane, T.]]		[[Category: Yamane, T.]]
-	[[Category: ~~ligase~~]]	+	[[Category: Ligase]]
-	[[Category: ~~polymorphism~~]]	+	[[Category: Polymorphism]]
-	[[Category: ~~ubiquitin~~]]	+	[[Category: Ubiquitin]]
-	[[Category: ~~ubl~~]]	+	[[Category: Ubl]]
-	[[Category: ~~ubl~~ conjugation pathway]]	+	[[Category: Ubl conjugation pathway]]
-	[[Category: ~~ufc1~~]]	+	[[Category: Ufc1]]
-	[[Category: ~~ufm1~~]]	+	[[Category: Ufm1]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:00:35 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 05~~:19:02 2008''	+