2z8n - Revision history

OCA at 13:26, 1 November 2023

OCA — Wed, 01 Nov 2023 13:26:06 GMT

←Older revision		Revision as of 13:26, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='2z8n' size='340' side='right'caption='[[2z8n]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2z8n' size='340' side='right'caption='[[2z8n]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z8n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z8N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z8n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z8N FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2z8m\|2z8m]], [[2z8o\|2z8o]], [[2z8p\|2z8p]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8n OCA], [https://pdbe.org/2z8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z8n RCSB], [https://www.ebi.ac.uk/pdbsum/2z8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z8n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8n OCA], [https://pdbe.org/2z8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z8n RCSB], [https://www.ebi.ac.uk/pdbsum/2z8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z8n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SPVC_SALTY SPVC_SALTY]] Secreted effector that irreversibly inactivates host MAP kinases by catalyzing the dephosphorylation of the phosphothreonine residue in the pT-X-pY motif in MAPK2/ERK2, MAPK3/ERK1, and p38, via a beta-elimination reaction leading to a dehydrobutyrine residue. Is also able to remove the phosphate group from phospho-JNK in vitro, but JNK may not be a substrate in vivo. Could help suppress localized proinflammatory responses at infection foci in the spleen and liver, and thereby facilitate bacterial growth.<ref>PMID:17303758</ref> <ref>PMID:18060821</ref> <ref>PMID:18084305</ref> <ref>PMID:18284579</ref>	+	[https://www.uniprot.org/uniprot/SPVC_SALTY SPVC_SALTY] Secreted effector that irreversibly inactivates host MAP kinases by catalyzing the dephosphorylation of the phosphothreonine residue in the pT-X-pY motif in MAPK2/ERK2, MAPK3/ERK1, and p38, via a beta-elimination reaction leading to a dehydrobutyrine residue. Is also able to remove the phosphate group from phospho-JNK in vitro, but JNK may not be a substrate in vivo. Could help suppress localized proinflammatory responses at infection foci in the spleen and liver, and thereby facilitate bacterial growth.<ref>PMID:17303758</ref> <ref>PMID:18060821</ref> <ref>PMID:18084305</ref> <ref>PMID:18284579</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chai, J]]	+	[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
-	[[Category: Chen, L]]	+	[[Category: Chai J]]
-	[[Category: Gu, L]]	+	[[Category: Chen L]]
-	[[Category: Huang, N]]	+	[[Category: Gu L]]
-	[[Category: Wang, H]]	+	[[Category: Huang N]]
-	[[Category: Zhou~~, J M]]~~	+	[[Category: Wang H]]
-	~~[[Category: Distorted beta-strand sheet]]~~	+	[[Category: Zhou JM]]
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Short three-helix bundle~~]]	+

OCA at 13:22, 4 May 2022

OCA — Wed, 04 May 2022 13:22:34 GMT

←Older revision		Revision as of 13:22, 4 May 2022
Line 3:		Line 3:
	<StructureSection load='2z8n' size='340' side='right'caption='[[2z8n]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2z8n' size='340' side='right'caption='[[2z8n]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z8n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2Z8N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z8n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z8N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z8m\|2z8m]], [[2z8o\|2z8o]], [[2z8p\|2z8p]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2z8m\|2z8m]], [[2z8o\|2z8o]], [[2z8p\|2z8p]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2z8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8n OCA], [~~http~~://pdbe.org/2z8n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2z8n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2z8n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2z8n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8n OCA], [https://pdbe.org/2z8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z8n RCSB], [https://www.ebi.ac.uk/pdbsum/2z8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z8n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SPVC_SALTY SPVC_SALTY]] Secreted effector that irreversibly inactivates host MAP kinases by catalyzing the dephosphorylation of the phosphothreonine residue in the pT-X-pY motif in MAPK2/ERK2, MAPK3/ERK1, and p38, via a beta-elimination reaction leading to a dehydrobutyrine residue. Is also able to remove the phosphate group from phospho-JNK in vitro, but JNK may not be a substrate in vivo. Could help suppress localized proinflammatory responses at infection foci in the spleen and liver, and thereby facilitate bacterial growth.<ref>PMID:17303758</ref> <ref>PMID:18060821</ref> <ref>PMID:18084305</ref> <ref>PMID:18284579</ref>	+	[[https://www.uniprot.org/uniprot/SPVC_SALTY SPVC_SALTY]] Secreted effector that irreversibly inactivates host MAP kinases by catalyzing the dephosphorylation of the phosphothreonine residue in the pT-X-pY motif in MAPK2/ERK2, MAPK3/ERK1, and p38, via a beta-elimination reaction leading to a dehydrobutyrine residue. Is also able to remove the phosphate group from phospho-JNK in vitro, but JNK may not be a substrate in vivo. Could help suppress localized proinflammatory responses at infection foci in the spleen and liver, and thereby facilitate bacterial growth.<ref>PMID:17303758</ref> <ref>PMID:18060821</ref> <ref>PMID:18084305</ref> <ref>PMID:18284579</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:00, 29 July 2020

OCA — Wed, 29 Jul 2020 12:00:03 GMT

←Older revision		Revision as of 12:00, 29 July 2020
Line 1:		Line 1:

	==Structural basis for the catalytic mechanism of phosphothreonine lyase==		==Structural basis for the catalytic mechanism of phosphothreonine lyase==
-	<StructureSection load='2z8n' size='340' side='right' caption='[[2z8n]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2z8n' size='340' side='right'caption='[[2z8n]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z8n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8N OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Z8N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z8n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8N OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Z8N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z8m\|2z8m]], [[2z8o\|2z8o]], [[2z8p\|2z8p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z8m\|2z8m]], [[2z8o\|2z8o]], [[2z8p\|2z8p]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2z8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8n OCA], [http://pdbe.org/2z8n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z8n RCSB], [http://www.ebi.ac.uk/pdbsum/2z8n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z8n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2z8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8n OCA], [http://pdbe.org/2z8n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z8n RCSB], [http://www.ebi.ac.uk/pdbsum/2z8n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z8n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chai, J]]		[[Category: Chai, J]]
	[[Category: Chen, L]]		[[Category: Chen, L]]

OCA at 06:45, 5 August 2016

OCA — Fri, 05 Aug 2016 06:45:03 GMT

←Older revision		Revision as of 06:45, 5 August 2016
Line 1:		Line 1:
		+
	==Structural basis for the catalytic mechanism of phosphothreonine lyase==		==Structural basis for the catalytic mechanism of phosphothreonine lyase==
	<StructureSection load='2z8n' size='340' side='right' caption='[[2z8n]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2z8n' size='340' side='right' caption='[[2z8n]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z8n]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z8N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z8n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z8N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z8m\|2z8m]], [[2z8o\|2z8o]], [[2z8p\|2z8p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z8m\|2z8m]], [[2z8o\|2z8o]], [[2z8p\|2z8p]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mkaD, spvC, vsdD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella enterica subsp. enterica serovar Typhimurium])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8n OCA], [http://pdbe.org/2z8n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z8n RCSB], [http://www.ebi.ac.uk/pdbsum/2z8n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z8n ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z8n RCSB], [http://www.ebi.ac.uk/pdbsum/2z8n PDBsum]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~VRP3_SALTY VRP3_SALTY~~]] Secreted effector that irreversibly inactivates host MAP kinases by catalyzing the dephosphorylation of the phosphothreonine residue in the pT-X-pY motif in MAPK2/ERK2, MAPK3/ERK1, and p38, via a beta-elimination reaction leading to a dehydrobutyrine residue. Is also able to remove the phosphate group from phospho-JNK in vitro, but JNK may not be a substrate in vivo. Could help suppress localized proinflammatory responses at infection foci in the spleen and liver, and thereby facilitate bacterial growth.<ref>PMID:17303758</ref> <ref>PMID:18060821</ref> <ref>PMID:18084305</ref> <ref>PMID:18284579</ref>	+	[[http://www.uniprot.org/uniprot/SPVC_SALTY SPVC_SALTY]] Secreted effector that irreversibly inactivates host MAP kinases by catalyzing the dephosphorylation of the phosphothreonine residue in the pT-X-pY motif in MAPK2/ERK2, MAPK3/ERK1, and p38, via a beta-elimination reaction leading to a dehydrobutyrine residue. Is also able to remove the phosphate group from phospho-JNK in vitro, but JNK may not be a substrate in vivo. Could help suppress localized proinflammatory responses at infection foci in the spleen and liver, and thereby facilitate bacterial growth.<ref>PMID:17303758</ref> <ref>PMID:18060821</ref> <ref>PMID:18084305</ref> <ref>PMID:18284579</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2z8n" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Chai, J]]		[[Category: Chai, J]]
	[[Category: Chen, L]]		[[Category: Chen, L]]

OCA at 16:37, 25 December 2014

OCA — Thu, 25 Dec 2014 16:37:18 GMT

←Older revision		Revision as of 16:37, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z8n RCSB], [http://www.ebi.ac.uk/pdbsum/2z8n PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z8n RCSB], [http://www.ebi.ac.uk/pdbsum/2z8n PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VRP3_SALTY VRP3_SALTY]] Secreted effector that irreversibly inactivates host MAP kinases by catalyzing the dephosphorylation of the phosphothreonine residue in the pT-X-pY motif in MAPK2/ERK2, MAPK3/ERK1, and p38, via a beta-elimination reaction leading to a dehydrobutyrine residue. Is also able to remove the phosphate group from phospho-JNK in vitro, but JNK may not be a substrate in vivo. Could help suppress localized proinflammatory responses at infection foci in the spleen and liver, and thereby facilitate bacterial growth.<ref>PMID:17303758</ref> <ref>PMID:18060821</ref> <ref>PMID:18084305</ref> <ref>PMID:18284579</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
-	[[Category: Chai, J.]]	+	[[Category: Chai, J]]
-	[[Category: Chen, L.]]	+	[[Category: Chen, L]]
-	[[Category: Gu, L.]]	+	[[Category: Gu, L]]
-	[[Category: Huang, N.]]	+	[[Category: Huang, N]]
-	[[Category: Wang, H.]]	+	[[Category: Wang, H]]
-	[[Category: Zhou, J M.]]	+	[[Category: Zhou, J M]]
	[[Category: Distorted beta-strand sheet]]		[[Category: Distorted beta-strand sheet]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Short three-helix bundle]]		[[Category: Short three-helix bundle]]

OCA at 11:53, 29 October 2014

OCA — Wed, 29 Oct 2014 11:53:39 GMT

←Older revision		Revision as of 11:53, 29 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2z8n.~~png~~\|~~left~~\|~~200px~~]]	+	==Structural basis for the catalytic mechanism of phosphothreonine lyase==
		+	<StructureSection load='2z8n' size='340' side='right' caption='[[2z8n]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2z8n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z8N FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z8m\|2z8m]], [[2z8o\|2z8o]], [[2z8p\|2z8p]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mkaD, spvC, vsdD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 Salmonella enterica subsp. enterica serovar Typhimurium])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z8n RCSB], [http://www.ebi.ac.uk/pdbsum/2z8n PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Salmonella SpvC belongs to a new enzyme family designated phosphothreonine lyases that irreversibly inactivate mitogen-activated protein kinases. The crystal structure of SpvC reported here reveals that the two phosphorylated residues in the substrate peptide predominantly mediate its recognition by SpvC. Substrate-induced conformational changes in SpvC sequester the phosphothreonine in a completely solvent-free environment, preventing the hydrolysis of the phosphate group and facilitating the elimination reaction.

-	~~{{STRUCTURE_2z8n\| PDB=2z8n \| SCENE= }}~~	+	Structural basis for the catalytic mechanism of phosphothreonine lyase.,Chen L, Wang H, Zhang J, Gu L, Huang N, Zhou JM, Chai J Nat Struct Mol Biol. 2008 Jan;15(1):101-2. Epub 2007 Dec 16. PMID:18084305<ref>PMID:18084305</ref>

-	~~===Structural basis for~~ the ~~catalytic mechanism of phosphothreonine lyase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18084305}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2z8n]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Salmonella_enterica_subsp~~.~~_enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8N OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018084305<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Chai, J.]]		[[Category: Chai, J.]]

OCA: Protected "2z8n" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 19:57:31 GMT

Protected "2z8n" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:57, 7 January 2013

OCA at 19:57, 7 January 2013

OCA — Mon, 07 Jan 2013 19:57:29 GMT

←Older revision		Revision as of 19:57, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2z8n.png\|left\|200px]]		[[Image:2z8n.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2z8n", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2z8n\| PDB=2z8n \| SCENE= }}		{{STRUCTURE_2z8n\| PDB=2z8n \| SCENE= }}

	===Structural basis for the catalytic mechanism of phosphothreonine lyase===		===Structural basis for the catalytic mechanism of phosphothreonine lyase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18084305}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18084305 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18084305}}		{{ABSTRACT_PUBMED_18084305}}

	==About this Structure==		==About this Structure==
-	~~2Z8N~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8N OCA].	+	[[2z8n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8N OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18084305~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018084305</ref><references group="xtra"/>
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Chai, J.]]		[[Category: Chai, J.]]
Line 34:		Line 22:
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Short three-helix bundle]]		[[Category: Short three-helix bundle]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 25 08:22:51 2010''

OCA at 04:15, 25 August 2010

OCA — Wed, 25 Aug 2010 04:15:00 GMT

←Older revision		Revision as of 04:15, 25 August 2010
Line 1:		Line 1:
-	[[Image:2z8n.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2z8n.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2z8n\| PDB=2z8n \| SCENE= }}		{{STRUCTURE_2z8n\| PDB=2z8n \| SCENE= }}

-	~~'''~~Structural basis for the catalytic mechanism of phosphothreonine lyase~~'''~~	+	===Structural basis for the catalytic mechanism of phosphothreonine lyase===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18084305}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18084305 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18084305}}

	==About this Structure==		==About this Structure==
-	2Z8N is a ~~[[Single protein]]~~ structure ~~of sequence~~ from [http://en.wikipedia.org/wiki/~~Salmonella_typhimurium~~ Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8N OCA].	+	2Z8N is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8N OCA].
-	[[Category: Salmonella typhimurium]]	+
-	~~[[Category: Single protein~~]]	+	==Reference==
-	[[Category: Chai, J J.]]	+	<ref group="xtra">PMID:18084305</ref><references group="xtra"/>
-	[[Category: Chen, L J.]]	+	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
-	[[Category: Gu, L C.]]	+	[[Category: Chai, J.]]
		+	[[Category: Chen, L.]]
		+	[[Category: Gu, L.]]
	[[Category: Huang, N.]]		[[Category: Huang, N.]]
-	[[Category: Wang, H Y.]]	+	[[Category: Wang, H.]]
	[[Category: Zhou, J M.]]		[[Category: Zhou, J M.]]
	[[Category: Distorted beta-strand sheet]]		[[Category: Distorted beta-strand sheet]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Short three-helix bundle]]		[[Category: Short three-helix bundle]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 20~~:02:~~33 2008~~''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 25 08:22:51 2010''

OCA at 17:02, 4 May 2008

OCA — Sun, 04 May 2008 17:02:34 GMT

←Older revision		Revision as of 17:02, 4 May 2008
Line 1:		Line 1:
	[[Image:2z8n.jpg\|left\|200px]]		[[Image:2z8n.jpg\|left\|200px]]

-	~~{{Structure~~	+	<!--
-	~~\|PDB= 2z8n \|SIZE=350\|CAPTION= <scene name='initialview01'>2z8n</scene>~~, ~~resolution 1~~.~~8Å~~	+	The line below this paragraph, containing "STRUCTURE_2z8n", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <~~scene ~~name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	~~\|ACTIVITY=~~	+	or leave the SCENE parameter empty for the default display.
-	~~\|GENE= mkaD, spvC, vsdD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=602 Salmonella typhimurium]~~)	+	-->
-	~~\|DOMAIN=~~	+	{{STRUCTURE_2z8n\| PDB=2z8n \| SCENE= }}
-	~~\|RELATEDENTRY=[[2z8m\|2Z8M]]~~, ~~[[2z8o\|2Z8O]], [[2z8p\|2Z8P]]~~	+
-	~~\|RESOURCES=<span class='plainlinks'>[http://oca~~.~~weizmann.ac.il/oca~~-~~docs/fgij/fg.htm?mol=2z8n FirstGlance], [http://oca.weizmann.ac.il/oca~~-~~bin/ocaids?id~~=2z8n ~~OCA], [http://www.ebi.ac.uk/pdbsum/2z8n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId~~=~~2z8n RCSB]</span>~~	+
-	}}	+

	'''Structural basis for the catalytic mechanism of phosphothreonine lyase'''		'''Structural basis for the catalytic mechanism of phosphothreonine lyase'''
Line 25:		Line 22:
	[[Category: Wang, H Y.]]		[[Category: Wang, H Y.]]
	[[Category: Zhou, J M.]]		[[Category: Zhou, J M.]]
-	[[Category: ~~distorted~~ beta-strand sheet]]	+	[[Category: Distorted beta-strand sheet]]
-	[[Category: ~~lyase~~]]	+	[[Category: Lyase]]
-	[[Category: ~~short~~ three-helix bundle]]	+	[[Category: Short three-helix bundle]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:02:33 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 05~~:19:26 2008''	+