2z9i - Revision history

OCA at 12:00, 29 July 2020

OCA — Wed, 29 Jul 2020 12:00:30 GMT

←Older revision		Revision as of 12:00, 29 July 2020
Line 1:		Line 1:

	==Crystal structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form==		==Crystal structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form==
-	<StructureSection load='2z9i' size='340' side='right' caption='[[2z9i]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2z9i' size='340' side='right'caption='[[2z9i]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z9i]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z9I OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Z9I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z9i]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z9I OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Z9I FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ky9\|1ky9]], [[1sot\|1sot]], [[1l1j\|1l1j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ky9\|1ky9]], [[1sot\|1sot]], [[1l1j\|1l1j]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2z9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z9i OCA], [http://pdbe.org/2z9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z9i RCSB], [http://www.ebi.ac.uk/pdbsum/2z9i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z9i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2z9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z9i OCA], [http://pdbe.org/2z9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z9i RCSB], [http://www.ebi.ac.uk/pdbsum/2z9i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z9i ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 2z9i" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2z9i" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Journal:Acta Cryst F:S2053230X18016217\|Journal:Acta Cryst F:S2053230X18016217]]
		+	*[[Proteins from Mycobacterium tuberculosis\|Proteins from Mycobacterium tuberculosis]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Mohamedmohaideen, N N]]		[[Category: Mohamedmohaideen, N N]]

OCA at 09:10, 17 October 2018

OCA — Wed, 17 Oct 2018 09:10:07 GMT

←Older revision		Revision as of 09:10, 17 October 2018
Line 1:		Line 1:
		+
	==Crystal structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form==		==Crystal structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form==
	<StructureSection load='2z9i' size='340' side='right' caption='[[2z9i]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2z9i' size='340' side='right' caption='[[2z9i]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ky9\|1ky9]], [[1sot\|1sot]], [[1l1j\|1l1j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ky9\|1ky9]], [[1sot\|1sot]], [[1l1j\|1l1j]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z9i OCA], [http://pdbe.org/2z9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z9i RCSB], [http://www.ebi.ac.uk/pdbsum/2z9i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z9i OCA], [http://pdbe.org/2z9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z9i RCSB], [http://www.ebi.ac.uk/pdbsum/2z9i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z9i ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z9/2z9i_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z9/2z9i_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:06, 10 February 2016

OCA — Wed, 10 Feb 2016 03:06:34 GMT

←Older revision		Revision as of 03:06, 10 February 2016
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ky9\|1ky9]], [[1sot\|1sot]], [[1l1j\|1l1j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ky9\|1ky9]], [[1sot\|1sot]], [[1l1j\|1l1j]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z9i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z9i RCSB], [http://www.ebi.ac.uk/pdbsum/2z9i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z9i OCA], [http://pdbe.org/2z9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z9i RCSB], [http://www.ebi.ac.uk/pdbsum/2z9i PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z9i ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2z9i" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:09, 20 January 2015

OCA — Tue, 20 Jan 2015 08:09:19 GMT

←Older revision		Revision as of 08:09, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2z9i]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z9I FirstGlance]. <br>		<table><tr><td colspan='2'>[[2z9i]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z9I FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ky9\|1ky9]], [[1sot\|1sot]], [[1l1j\|1l1j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ky9\|1ky9]], [[1sot\|1sot]], [[1l1j\|1l1j]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z9i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z9i RCSB], [http://www.ebi.ac.uk/pdbsum/2z9i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z9i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z9i RCSB], [http://www.ebi.ac.uk/pdbsum/2z9i PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Mohamedmohaideen, N N.]]	+	[[Category: Mohamedmohaideen, N N]]
-	[[Category: Palaninathan, S K.]]	+	[[Category: Palaninathan, S K]]
-	[[Category: Sacchettini, J C.]]	+	[[Category: Sacchettini, J C]]
	[[Category: Htra]]		[[Category: Htra]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Serine protease]]		[[Category: Serine protease]]

OCA at 04:57, 2 October 2014

OCA — Thu, 02 Oct 2014 04:57:13 GMT

←Older revision		Revision as of 04:57, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2z9i.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form==
		+	<StructureSection load='2z9i' size='340' side='right' caption='[[2z9i]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2z9i]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z9I FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ky9\|1ky9]], [[1sot\|1sot]], [[1l1j\|1l1j]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z9i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z9i RCSB], [http://www.ebi.ac.uk/pdbsum/2z9i PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z9/2z9i_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The high-temperature requirement A (HtrA) family of serine proteases has been shown to play an important role in the environmental and cellular stress damage control system in Escherichia coli. Mycobacterium tuberculosis ( Mtb) has three putative HtrA-like proteases, HtrA1, HtrA2, and HtrA3. The deletion of htrA2 gives attenuated virulence in a mouse model of TB. Biochemical analysis reveals that HtrA2 can function both as a protease and as a chaperone. The three-dimensional structure of HtrA2 determined at 2.0 A resolution shows that the protease domains form the central core of the trimer and the PDZ domains extend to the periphery. Unlike E. coli DegS and DegP, the protease is naturally active due to the formation of the serine protease-like catalytic triad and its uniquely designed oxyanion hole. Both protease and PDZ binding pockets of each HtrA2 molecule are occupied by autoproteolytic peptide products and reveal clues for a novel autoregulatory mechanism that might have significant importance in HtrA-associated virulence of Mtb.

-	~~{{STRUCTURE_2z9i\| PDB=2z9i \| SCENE= }}~~	+	Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis.,Mohamedmohaideen NN, Palaninathan SK, Morin PM, Williams BJ, Braunstein M, Tichy SE, Locker J, Russell DH, Jacobs WR Jr, Sacchettini JC Biochemistry. 2008 Jun 10;47(23):6092-102. Epub 2008 May 15. PMID:18479146<ref>PMID:18479146</ref>

-	~~===Crystal structure~~ of ~~RV0983 from Mycobacterium tuberculosis- Proteolytically active form===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18479146}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2z9i]] is a 9 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2Z9I OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018479146<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Mohamedmohaideen, N N.]]		[[Category: Mohamedmohaideen, N N.]]

OCA: Protected "2z9i" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 18:03:58 GMT

Protected "2z9i" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:03, 7 January 2013

OCA at 18:03, 7 January 2013

OCA — Mon, 07 Jan 2013 18:03:55 GMT

←Older revision		Revision as of 18:03, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2z9i.png\|left\|200px]]		[[Image:2z9i.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2z9i", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2z9i\| PDB=2z9i \| SCENE= }}		{{STRUCTURE_2z9i\| PDB=2z9i \| SCENE= }}

	===Crystal structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form===		===Crystal structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18479146}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18479146 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18479146}}		{{ABSTRACT_PUBMED_18479146}}

	==About this Structure==		==About this Structure==
-	~~2Z9I~~ is a 9 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z9I OCA].	+	[[2z9i]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z9I OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18479146~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018479146</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Mohamedmohaideen, N N.]]		[[Category: Mohamedmohaideen, N N.]]
Line 31:		Line 19:
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Serine protease]]		[[Category: Serine protease]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:55:51 2009''

OCA at 12:55, 17 February 2009

OCA — Tue, 17 Feb 2009 12:55:53 GMT

←Older revision		Revision as of 12:55, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2Z9I is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z9I OCA].	+	2Z9I is a 9 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z9I OCA].

	==Reference==		==Reference==
-	Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis., Mohamedmohaideen NN, Palaninathan SK, Morin PM, Williams BJ, Braunstein M, Tichy SE, Locker J, Russell DH, Jacobs WR Jr, Sacchettini JC, Biochemistry. 2008 Jun 10;47(23):6092-102. Epub 2008 May 15. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18479146 18479146]~~	+	<ref group="xtra">PMID:18479146</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Protein complex]]
	[[Category: Mohamedmohaideen, N N.]]		[[Category: Mohamedmohaideen, N N.]]
	[[Category: Palaninathan, S K.]]		[[Category: Palaninathan, S K.]]
Line 33:		Line 32:
	[[Category: Serine protease]]		[[Category: Serine protease]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 20~~:28:~~40 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:55:51 2009''

OCA at 17:28, 28 July 2008

OCA — Mon, 28 Jul 2008 17:28:41 GMT

←Older revision		Revision as of 17:28, 28 July 2008
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-	[[Image:2z9i.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2z9i.png\|left\|200px]]

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	{{STRUCTURE_2z9i\| PDB=2z9i \| SCENE= }}		{{STRUCTURE_2z9i\| PDB=2z9i \| SCENE= }}

-	~~'''~~Crystal structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form~~'''~~	+	===Crystal structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form===


-	~~==Overview==~~	+	<!--
-	The ~~high-temperature requirement A (HtrA) family of serine proteases has been shown~~ to ~~play an important role in~~ the ~~environmental and cellular stress damage control system in Escherichia coli. Mycobacterium tuberculosis~~ ( ~~Mtb) has three putative HtrA-like proteases, HtrA1, HtrA2, and HtrA3. The deletion of htrA2 gives attenuated virulence in a mouse model of TB. Biochemical analysis reveals that HtrA2 can function both~~ as ~~a protease and as a chaperone. The three-dimensional structure of HtrA2 determined~~ at 2.~~0 A resolution shows that the protease domains form the central core of the trimer and the PDZ domains extend to the periphery~~. ~~Unlike E. coli DegS and DegP~~, ~~the protease~~ is ~~naturally active due to~~ the ~~formation of the serine protease-like catalytic triad and its uniquely designed oxyanion hole~~. Both protease and PDZ binding pockets of each HtrA2 molecule are occupied by autoproteolytic peptide products and reveal clues for a novel autoregulatory mechanism that might have significant importance in HtrA-~~associated virulence of Mtb.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_18479146}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18479146 is the PubMed ID number.
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		+	{{ABSTRACT_PUBMED_18479146}}

	==About this Structure==		==About this Structure==
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	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Serine protease]]		[[Category: Serine protease]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jun 11 10~~:46:02 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:28:40 2008''

OCA at 07:46, 11 June 2008

OCA — Wed, 11 Jun 2008 07:46:03 GMT

←Older revision		Revision as of 07:46, 11 June 2008
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-	~~'''Unreleased structure'''~~	+	[[Image:2z9i.jpg\|left\|200px]]

-	The ~~entry 2z9i~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2z9i", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
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		+	{{STRUCTURE_2z9i\| PDB=2z9i \| SCENE= }}

-	~~Authors: Palaninathan, S.K., Mohamedmohaideen, N.N., Sacchettini, J.C.~~	+	'''Crystal structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form'''

-	Description: Crystal structure of RV0983 from Mycobacterium tuberculosis-Proteolytically active form

		+	==Overview==
		+	The high-temperature requirement A (HtrA) family of serine proteases has been shown to play an important role in the environmental and cellular stress damage control system in Escherichia coli. Mycobacterium tuberculosis ( Mtb) has three putative HtrA-like proteases, HtrA1, HtrA2, and HtrA3. The deletion of htrA2 gives attenuated virulence in a mouse model of TB. Biochemical analysis reveals that HtrA2 can function both as a protease and as a chaperone. The three-dimensional structure of HtrA2 determined at 2.0 A resolution shows that the protease domains form the central core of the trimer and the PDZ domains extend to the periphery. Unlike E. coli DegS and DegP, the protease is naturally active due to the formation of the serine protease-like catalytic triad and its uniquely designed oxyanion hole. Both protease and PDZ binding pockets of each HtrA2 molecule are occupied by autoproteolytic peptide products and reveal clues for a novel autoregulatory mechanism that might have significant importance in HtrA-associated virulence of Mtb.

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 09:06:35 2008''	+	==About this Structure==
		+	2Z9I is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z9I OCA].
		+
		+	==Reference==
		+	Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis., Mohamedmohaideen NN, Palaninathan SK, Morin PM, Williams BJ, Braunstein M, Tichy SE, Locker J, Russell DH, Jacobs WR Jr, Sacchettini JC, Biochemistry. 2008 Jun 10;47(23):6092-102. Epub 2008 May 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18479146 18479146]
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Protein complex]]
		+	[[Category: Mohamedmohaideen, N N.]]
		+	[[Category: Palaninathan, S K.]]
		+	[[Category: Sacchettini, J C.]]
		+	[[Category: Htra]]
		+	[[Category: Hydrolase]]
		+	[[Category: Serine protease]]
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 10:46:02 2008''