2zcn - Revision history

OCA at 13:31, 1 November 2023

OCA — Wed, 01 Nov 2023 13:31:55 GMT

←Older revision		Revision as of 13:31, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='2zcn' size='340' side='right'caption='[[2zcn]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2zcn' size='340' side='right'caption='[[2zcn]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zcn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Staeq Staeq~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZCN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zcn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_epidermidis_RP62A Staphylococcus epidermidis RP62A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZCN FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2zcm\|2zcm]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">IcaR ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=176279 STAEQ])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcn OCA], [https://pdbe.org/2zcn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zcn RCSB], [https://www.ebi.ac.uk/pdbsum/2zcn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcn OCA], [https://pdbe.org/2zcn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zcn RCSB], [https://www.ebi.ac.uk/pdbsum/2zcn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ICAR_STAEQ ICAR_STAEQ]] Represses transcription of the icaADBC operon necessary for biofilm production.<ref>PMID:12142410</ref>	+	[https://www.uniprot.org/uniprot/ICAR_STAEQ ICAR_STAEQ] Represses transcription of the icaADBC operon necessary for biofilm production.<ref>PMID:12142410</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Staeq~~]]	+	[[Category: Staphylococcus epidermidis RP62A]]
-	[[Category: Guo~~, R T~~]]	+	[[Category: Guo RT]]
-	[[Category: Jeng~~, W Y~~]]	+	[[Category: Jeng WY]]
-	[[Category: Ko~~, T P~~]]	+	[[Category: Ko TP]]
-	[[Category: Liu~~, C I~~]]	+	[[Category: Liu CI]]
-	[[Category: Liu~~, C L~~]]	+	[[Category: Liu CL]]
-	[[Category: Wang~~, A H.J]]~~	+	[[Category: Wang AHJ]]
-	~~[[Category: Biofilm]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Helix-turn-helix]]~~	+
-	~~[[Category: Repressor]]~~	+
-	~~[[Category: Tetr family]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation~~]]	+

OCA at 10:50, 8 December 2021

OCA — Wed, 08 Dec 2021 10:50:34 GMT

←Older revision		Revision as of 10:50, 8 December 2021
Line 1:		Line 1:

	==Crystal structure of IcaR, a repressor of the TetR family==		==Crystal structure of IcaR, a repressor of the TetR family==
-	<StructureSection load='2zcn' size='340' side='right' caption='[[2zcn]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2zcn' size='340' side='right'caption='[[2zcn]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zcn]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Staeq Staeq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZCN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zcn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staeq Staeq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZCN FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zcm\|2zcm]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zcm\|2zcm]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IcaR ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=176279 STAEQ])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IcaR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=176279 STAEQ])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcn OCA], [~~http~~://pdbe.org/2zcn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zcn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zcn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcn OCA], [https://pdbe.org/2zcn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zcn RCSB], [https://www.ebi.ac.uk/pdbsum/2zcn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ICAR_STAEQ ICAR_STAEQ]] Represses transcription of the icaADBC operon necessary for biofilm production.<ref>PMID:12142410</ref>	+	[[https://www.uniprot.org/uniprot/ICAR_STAEQ ICAR_STAEQ]] Represses transcription of the icaADBC operon necessary for biofilm production.<ref>PMID:12142410</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Staeq]]		[[Category: Staeq]]
	[[Category: Guo, R T]]		[[Category: Guo, R T]]

OCA at 07:07, 18 October 2018

OCA — Thu, 18 Oct 2018 07:07:12 GMT

←Older revision		Revision as of 07:07, 18 October 2018
Line 1:		Line 1:
		+
	==Crystal structure of IcaR, a repressor of the TetR family==		==Crystal structure of IcaR, a repressor of the TetR family==
	<StructureSection load='2zcn' size='340' side='right' caption='[[2zcn]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2zcn' size='340' side='right' caption='[[2zcn]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zcm\|2zcm]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zcm\|2zcm]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IcaR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=176279 STAEQ])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IcaR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=176279 STAEQ])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcn OCA], [http://pdbe.org/2zcn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zcn RCSB], [http://www.ebi.ac.uk/pdbsum/2zcn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcn OCA], [http://pdbe.org/2zcn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zcn RCSB], [http://www.ebi.ac.uk/pdbsum/2zcn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/2zcn_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/2zcn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:50, 7 February 2016

OCA — Sun, 07 Feb 2016 12:50:56 GMT

←Older revision		Revision as of 12:50, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2zcn' size='340' side='right' caption='[[2zcn]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2zcn' size='340' side='right' caption='[[2zcn]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zcn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_epidermidis_rp62a Staphylococcus epidermidis rp62a~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zcn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staeq Staeq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zcm\|2zcm]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zcm\|2zcm]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IcaR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=176279 ~~Staphylococcus epidermidis RP62A~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IcaR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=176279 STAEQ])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zcn RCSB], [http://www.ebi.ac.uk/pdbsum/2zcn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcn OCA], [http://pdbe.org/2zcn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zcn RCSB], [http://www.ebi.ac.uk/pdbsum/2zcn PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zcn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2zcn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Staphylococcus epidermidis rp62a~~]]	+	[[Category: Staeq]]
	[[Category: Guo, R T]]		[[Category: Guo, R T]]
	[[Category: Jeng, W Y]]		[[Category: Jeng, W Y]]

OCA at 15:14, 24 December 2014

OCA — Wed, 24 Dec 2014 15:14:22 GMT

←Older revision		Revision as of 15:14, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zcn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis_rp62a Staphylococcus epidermidis rp62a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zcn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis_rp62a Staphylococcus epidermidis rp62a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zcm\|2zcm]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zcm\|2zcm]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IcaR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=176279 Staphylococcus epidermidis RP62A])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IcaR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=176279 Staphylococcus epidermidis RP62A])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zcn RCSB], [http://www.ebi.ac.uk/pdbsum/2zcn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zcn RCSB], [http://www.ebi.ac.uk/pdbsum/2zcn PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ICAR_STAEQ ICAR_STAEQ]] Represses transcription of the icaADBC operon necessary for biofilm production.<ref>PMID:12142410</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Staphylococcus epidermidis rp62a]]		[[Category: Staphylococcus epidermidis rp62a]]
-	[[Category: Guo, R T.]]	+	[[Category: Guo, R T]]
-	[[Category: Jeng, W Y.]]	+	[[Category: Jeng, W Y]]
-	[[Category: Ko, T P.]]	+	[[Category: Ko, T P]]
-	[[Category: Liu, C I.]]	+	[[Category: Liu, C I]]
-	[[Category: Liu, C L.]]	+	[[Category: Liu, C L]]
-	[[Category: Wang, A H.J.]]	+	[[Category: Wang, A H.J]]
	[[Category: Biofilm]]		[[Category: Biofilm]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]

OCA at 05:25, 2 October 2014

OCA — Thu, 02 Oct 2014 05:25:28 GMT

←Older revision		Revision as of 05:25, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2zcn.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of IcaR, a repressor of the TetR family==
		+	<StructureSection load='2zcn' size='340' side='right' caption='[[2zcn]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2zcn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis_rp62a Staphylococcus epidermidis rp62a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zcm\|2zcm]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IcaR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=176279 Staphylococcus epidermidis RP62A])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zcn RCSB], [http://www.ebi.ac.uk/pdbsum/2zcn PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/2zcn_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Expression of the gene cluster icaADBC is necessary for biofilm production in Staphylococcus epidermidis. The ica operon is negatively controlled by the repressor IcaR. Here, the crystal structure of IcaR was determined and the refined structure revealed a homodimer comprising entirely alpha-helices, typical of the tetracycline repressor protein family for gene regulations. The N-terminal domain contains a conserved helix-turn-helix DNA-binding motif with some conformational variations, indicating flexibility in this region. The C-terminal domain shows a complementary surface charge distribution about the dyad axis, ideal for efficient and specific dimer formation. The results of the electrophoretic mobility shift assay and isothermal titration calorimetry suggested that a 28 bp core segment of the ica operator is implicated in the cooperative binding of two IcaR dimers on opposite sides of the duplex DNA. Computer modeling based on the known DNA-complex structure of QacR and site-specific mutagenesis experiments showed that direct protein-DNA interactions are mostly conserved, but with slight variations for recognizing the different sequences. By interfering with the binding of IcaR to DNA, aminoglycoside gentamicin and other antibiotics may activate the icaADBC genes and elicit biofilm production in S. epidermidis, and likely S. aureus, as a defense mechanism.

-	~~{{STRUCTURE_2zcn\| PDB=2zcn \| SCENE= }}~~	+	Crystal structure of IcaR, a repressor of the TetR family implicated in biofilm formation in Staphylococcus epidermidis.,Jeng WY, Ko TP, Liu CI, Guo RT, Liu CL, Shr HL, Wang AH Nucleic Acids Res. 2008 Mar;36(5):1567-77. Epub 2008 Jan 21. PMID:18208836<ref>PMID:18208836</ref>

-	~~===Crystal structure of IcaR~~, a ~~repressor~~ of the ~~TetR family===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18208836}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2zcn]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Staphylococcus_epidermidis_rp62a Staphylococcus epidermidis rp62a]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCN OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018208836<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Staphylococcus epidermidis rp62a]]		[[Category: Staphylococcus epidermidis rp62a]]
	[[Category: Guo, R T.]]		[[Category: Guo, R T.]]

OCA: Protected "2zcn" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 21:25:37 GMT

Protected "2zcn" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:25, 7 January 2013

OCA at 21:25, 7 January 2013

OCA — Mon, 07 Jan 2013 21:25:34 GMT

←Older revision		Revision as of 21:25, 7 January 2013
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-	{{Seed}}
	[[Image:2zcn.png\|left\|200px]]		[[Image:2zcn.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zcn", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zcn\| PDB=2zcn \| SCENE= }}		{{STRUCTURE_2zcn\| PDB=2zcn \| SCENE= }}

	===Crystal structure of IcaR, a repressor of the TetR family===		===Crystal structure of IcaR, a repressor of the TetR family===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18208836}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18208836 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18208836}}		{{ABSTRACT_PUBMED_18208836}}

	==About this Structure==		==About this Structure==
-	~~2ZCN~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Staphylococcus_epidermidis~~ Staphylococcus epidermidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCN OCA].	+	[[2zcn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis_rp62a Staphylococcus epidermidis rp62a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCN OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18208836~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018208836</ref><references group="xtra"/>
-	[[Category: Staphylococcus epidermidis]]	+	[[Category: Staphylococcus epidermidis rp62a]]
	[[Category: Guo, R T.]]		[[Category: Guo, R T.]]
	[[Category: Jeng, W Y.]]		[[Category: Jeng, W Y.]]
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	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:55:29 2009''

OCA at 11:55, 16 February 2009

OCA — Mon, 16 Feb 2009 11:55:30 GMT

←Older revision		Revision as of 11:55, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2ZCN is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCN OCA].	+	2ZCN is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCN OCA].

	==Reference==		==Reference==
-	Crystal structure of IcaR, a repressor of the TetR family implicated in biofilm formation in Staphylococcus epidermidis., Jeng WY, Ko TP, Liu CI, Guo RT, Liu CL, Shr HL, Wang AH, Nucleic Acids Res. 2008 Jan 21;. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18208836 18208836]~~	+	<ref group="xtra">PMID:18208836</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Staphylococcus epidermidis]]		[[Category: Staphylococcus epidermidis]]
	[[Category: Guo, R T.]]		[[Category: Guo, R T.]]
Line 40:		Line 39:
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27~~ 16:28:~~52 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:55:29 2009''

OCA at 13:28, 27 July 2008

OCA — Sun, 27 Jul 2008 13:28:55 GMT

←Older revision		Revision as of 13:28, 27 July 2008
Line 1:		Line 1:
-	[[Image:2zcn.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2zcn.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2zcn\| PDB=2zcn \| SCENE= }}		{{STRUCTURE_2zcn\| PDB=2zcn \| SCENE= }}

-	~~'''~~Crystal structure of IcaR, a repressor of the TetR family~~'''~~	+	===Crystal structure of IcaR, a repressor of the TetR family===


-	~~==Overview==~~	+	<!--
-	~~Expression of the gene cluster icaADBC is necessary for biofilm production in Staphylococcus epidermidis.~~ The ~~ica operon is negatively controlled by the repressor IcaR. Here~~, the ~~crystal structure of IcaR was determined and~~ the ~~refined structure revealed a homodimer comprising entirely alpha-helices, typical of the tetracycline repressor protein family for gene regulations~~. ~~The N-terminal domain contains a conserved helix-turn-helix DNA-binding motif with some conformational variations, indicating flexibility in this region~~. ~~The C-terminal domain shows a complementary surface charge distribution about the dyad axis~~, ~~ideal for efficient and specific dimer formation. The results of the electrophoretic mobility shift assay and isothermal titration calorimetry suggested that a 28 bp core segment of the ica operator~~ is ~~implicated in~~ the ~~cooperative binding of two IcaR dimers on opposite sides of the duplex DNA~~. ~~Computer modeling based on the known DNA~~-~~complex structure of QacR and site~~-specific mutagenesis experiments showed that direct protein-DNA interactions are mostly conserved, but with slight variations for recognizing the different sequences. By interfering with the binding of IcaR to DNA, aminoglycoside gentamicin and other antibiotics may activate the icaADBC genes and elicit biofilm production in S. epidermidis, and likely S. aureus, as a defense mechanism.	+	The line below this paragraph, {{ABSTRACT_PUBMED_18208836}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18208836 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18208836}}

	==About this Structure==		==About this Structure==
Line 35:		Line 39:
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Apr 9 14~~:44:58 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:28:52 2008''