2zcq - Revision history

OCA at 13:31, 1 November 2023

OCA — Wed, 01 Nov 2023 13:31:56 GMT

←Older revision		Revision as of 13:31, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='2zcq' size='340' side='right'caption='[[2zcq]], [[Resolution\|resolution]] 2.38Å' scene=''>		<StructureSection load='2zcq' size='340' side='right'caption='[[2zcq]], [[Resolution\|resolution]] 2.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zcq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZCQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zcq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZCQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=B65:(1R)~~-~~4-(3-PHENOXYPHENYL)-1-PHOSPHONOBUTANE-1-SULFONIC+ACID'>B65</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.38Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2zco\|2zco]], [[2zcp\|2zcp]], [[2zcr\|2zcr]], [[2zcs\|2zcs]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B65:(1R)-4-(3-PHENOXYPHENYL)-1-PHOSPHONOBUTANE-1-SULFONIC+ACID'>B65</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">CrtM ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcq OCA], [https://pdbe.org/2zcq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zcq RCSB], [https://www.ebi.ac.uk/pdbsum/2zcq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcq OCA], [https://pdbe.org/2zcq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zcq RCSB], [https://www.ebi.ac.uk/pdbsum/2zcq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CRTM_STAAU CRTM_STAAU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Jeng, W Y~~]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: ~~Liu, C I~~]]	+	[[Category: Jeng WY]]
-	[[Category: ~~Oldfield, E~~]]	+	[[Category: Liu CI]]
-	[[Category: ~~Wang, A H~~]]	+	[[Category: Oldfield E]]
-	[[Category: ~~Bisphosphonate]]~~	+	[[Category: Wang AH]]
-	~~[[Category: Carotenoid biosynthesis]]~~	+
-	~~[[Category: Crtm]]~~	+
-	~~[[Category: Head-to-head condensation]]~~	+
-	~~[[Category: Staphyloxanthin biosynthesis]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 10:50, 8 December 2021

OCA — Wed, 08 Dec 2021 10:50:39 GMT

←Older revision		Revision as of 10:50, 8 December 2021
Line 1:		Line 1:

	==Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-652==		==Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-652==
-	<StructureSection load='2zcq' size='340' side='right' caption='[[2zcq]], [[Resolution\|resolution]] 2.38Å' scene=''>	+	<StructureSection load='2zcq' size='340' side='right'caption='[[2zcq]], [[Resolution\|resolution]] 2.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zcq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZCQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zcq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZCQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B65:(1R)-4-(3-PHENOXYPHENYL)-1-PHOSPHONOBUTANE-1-SULFONIC+ACID'>B65</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B65:(1R)-4-(3-PHENOXYPHENYL)-1-PHOSPHONOBUTANE-1-SULFONIC+ACID'>B65</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zco\|2zco]], [[2zcp\|2zcp]], [[2zcr\|2zcr]], [[2zcs\|2zcs]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zco\|2zco]], [[2zcp\|2zcp]], [[2zcr\|2zcr]], [[2zcs\|2zcs]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CrtM ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CrtM ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcq OCA], [~~http~~://pdbe.org/2zcq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zcq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zcq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcq OCA], [https://pdbe.org/2zcq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zcq RCSB], [https://www.ebi.ac.uk/pdbsum/2zcq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</div>		</div>
	<div class="pdbe-citations 2zcq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2zcq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Squalene synthase\|Squalene synthase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Jeng, W Y]]		[[Category: Jeng, W Y]]
	[[Category: Liu, C I]]		[[Category: Liu, C I]]

OCA at 07:34, 18 October 2018

OCA — Thu, 18 Oct 2018 07:34:53 GMT

←Older revision		Revision as of 07:34, 18 October 2018
Line 1:		Line 1:
		+
	==Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-652==		==Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-652==
	<StructureSection load='2zcq' size='340' side='right' caption='[[2zcq]], [[Resolution\|resolution]] 2.38Å' scene=''>		<StructureSection load='2zcq' size='340' side='right' caption='[[2zcq]], [[Resolution\|resolution]] 2.38Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zco\|2zco]], [[2zcp\|2zcp]], [[2zcr\|2zcr]], [[2zcs\|2zcs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zco\|2zco]], [[2zcp\|2zcp]], [[2zcr\|2zcr]], [[2zcs\|2zcs]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CrtM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CrtM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcq OCA], [http://pdbe.org/2zcq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zcq RCSB], [http://www.ebi.ac.uk/pdbsum/2zcq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcq OCA], [http://pdbe.org/2zcq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zcq RCSB], [http://www.ebi.ac.uk/pdbsum/2zcq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/2zcq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/2zcq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:42, 8 February 2016

OCA — Mon, 08 Feb 2016 01:42:20 GMT

←Older revision		Revision as of 01:42, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2zcq' size='340' side='right' caption='[[2zcq]], [[Resolution\|resolution]] 2.38Å' scene=''>		<StructureSection load='2zcq' size='340' side='right' caption='[[2zcq]], [[Resolution\|resolution]] 2.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zcq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zcq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B65:(1R)-4-(3-PHENOXYPHENYL)-1-PHOSPHONOBUTANE-1-SULFONIC+ACID'>B65</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B65:(1R)-4-(3-PHENOXYPHENYL)-1-PHOSPHONOBUTANE-1-SULFONIC+ACID'>B65</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zco\|2zco]], [[2zcp\|2zcp]], [[2zcr\|2zcr]], [[2zcs\|2zcs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zco\|2zco]], [[2zcp\|2zcp]], [[2zcr\|2zcr]], [[2zcs\|2zcs]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CrtM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 ~~Staphylococcus~~ aureus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CrtM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zcq RCSB], [http://www.ebi.ac.uk/pdbsum/2zcq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcq OCA], [http://pdbe.org/2zcq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zcq RCSB], [http://www.ebi.ac.uk/pdbsum/2zcq PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zcq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2zcq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Staphylococcus aureus]]
	[[Category: Jeng, W Y]]		[[Category: Jeng, W Y]]
	[[Category: Liu, C I]]		[[Category: Liu, C I]]

OCA at 19:37, 24 December 2014

OCA — Wed, 24 Dec 2014 19:37:57 GMT

←Older revision		Revision as of 19:37, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zcq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zcq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B65:(1R)-4-(3-PHENOXYPHENYL)-1-PHOSPHONOBUTANE-1-SULFONIC+ACID'>B65</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B65:(1R)-4-(3-PHENOXYPHENYL)-1-PHOSPHONOBUTANE-1-SULFONIC+ACID'>B65</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zco\|2zco]], [[2zcp\|2zcp]], [[2zcr\|2zcr]], [[2zcs\|2zcs]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zco\|2zco]], [[2zcp\|2zcp]], [[2zcr\|2zcr]], [[2zcs\|2zcs]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CrtM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CrtM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zcq RCSB], [http://www.ebi.ac.uk/pdbsum/2zcq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zcq RCSB], [http://www.ebi.ac.uk/pdbsum/2zcq PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Jeng, W Y.]]	+	[[Category: Jeng, W Y]]
-	[[Category: Liu, C I.]]	+	[[Category: Liu, C I]]
-	[[Category: Oldfield, E.]]	+	[[Category: Oldfield, E]]
-	[[Category: Wang, A H.]]	+	[[Category: Wang, A H]]
	[[Category: Bisphosphonate]]		[[Category: Bisphosphonate]]
	[[Category: Carotenoid biosynthesis]]		[[Category: Carotenoid biosynthesis]]

OCA at 05:40, 2 October 2014

OCA — Thu, 02 Oct 2014 05:40:25 GMT

←Older revision		Revision as of 05:40, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2zcq.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-652==
		+	<StructureSection load='2zcq' size='340' side='right' caption='[[2zcq]], [[Resolution\|resolution]] 2.38Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2zcq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B65:(1R)-4-(3-PHENOXYPHENYL)-1-PHOSPHONOBUTANE-1-SULFONIC+ACID'>B65</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zco\|2zco]], [[2zcp\|2zcp]], [[2zcr\|2zcr]], [[2zcs\|2zcs]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CrtM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zcq RCSB], [http://www.ebi.ac.uk/pdbsum/2zcq PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/2zcq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Staphylococcus aureus produces hospital- and community-acquired infections, with methicillin-resistant S. aureus posing a serious public health threat. The golden carotenoid pigment of S. aureus, staphyloxanthin, promotes resistance to reactive oxygen species and host neutrophil-based killing, and early enzymatic steps in staphyloxanthin production resemble those for cholesterol biosynthesis. We determined the crystal structures of S. aureus dehydrosqualene synthase (CrtM) at 1.58 angstrom resolution, finding structural similarity to human squalene synthase (SQS). We screened nine SQS inhibitors and determined the structures of three, bound to CrtM. One, previously tested for cholesterol-lowering activity in humans, blocked staphyloxanthin biosynthesis in vitro (median inhibitory concentration approximately 100 nM), resulting in colorless bacteria with increased susceptibility to killing by human blood and to innate immune clearance in a mouse infection model. This finding represents proof of principle for a virulence factor-based therapy against S. aureus.

-	~~{{STRUCTURE_2zcq\| PDB=2zcq \| SCENE= }}~~	+	A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.,Liu CI, Liu GY, Song Y, Yin F, Hensler ME, Jeng WY, Nizet V, Wang AH, Oldfield E Science. 2008 Mar 7;319(5868):1391-4. Epub 2008 Feb 14. PMID:18276850<ref>PMID:18276850</ref>

-	~~===Crystal structure~~ of the ~~C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-652===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18276850}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2zcq]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Staphylococcus_aureus Staphylococcus aureus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCQ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018276850<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Jeng, W Y.]]		[[Category: Jeng, W Y.]]

OCA: Protected "2zcq" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 20:30:37 GMT

Protected "2zcq" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:30, 7 January 2013

OCA at 20:30, 7 January 2013

OCA — Mon, 07 Jan 2013 20:30:34 GMT

←Older revision		Revision as of 20:30, 7 January 2013
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-	{{Seed}}
	[[Image:2zcq.png\|left\|200px]]		[[Image:2zcq.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zcq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zcq\| PDB=2zcq \| SCENE= }}		{{STRUCTURE_2zcq\| PDB=2zcq \| SCENE= }}

	===Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-652===		===Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-652===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18276850}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18276850 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18276850}}		{{ABSTRACT_PUBMED_18276850}}

	==About this Structure==		==About this Structure==
-	~~2ZCQ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCQ OCA].	+	[[2zcq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCQ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18276850~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018276850</ref><references group="xtra"/>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Jeng, W Y.]]		[[Category: Jeng, W Y.]]
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	[[Category: Staphyloxanthin biosynthesis]]		[[Category: Staphyloxanthin biosynthesis]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:53:49 2009''

OCA at 15:53, 16 February 2009

OCA — Mon, 16 Feb 2009 15:53:50 GMT

←Older revision		Revision as of 15:53, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2ZCQ is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCQ OCA].	+	2ZCQ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCQ OCA].

	==Reference==		==Reference==
-	A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence., Liu CI, Liu GY, Song Y, Yin F, Hensler ME, Jeng WY, Nizet V, Wang AH, Oldfield E, Science. 2008 Mar 7;319(5868):1391-4. Epub 2008 Feb 14. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18276850 18276850]~~	+	<ref group="xtra">PMID:18276850</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Jeng, W Y.]]		[[Category: Jeng, W Y.]]
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	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 21~~:23:~~09 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:53:49 2009''

OCA at 18:23, 27 July 2008

OCA — Sun, 27 Jul 2008 18:23:10 GMT

←Older revision		Revision as of 18:23, 27 July 2008
Line 1:		Line 1:
-	[[Image:2zcq.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2zcq.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2zcq\| PDB=2zcq \| SCENE= }}		{{STRUCTURE_2zcq\| PDB=2zcq \| SCENE= }}

-	~~'''~~Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-652~~'''~~	+	===Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-652===


-	~~==Overview==~~	+	<!--
-	~~Staphylococcus aureus produces hospital~~- ~~and community~~-~~acquired infections, with methicillin-resistant S. aureus posing a serious public health threat.~~ The ~~golden carotenoid pigment of S. aureus~~, ~~staphyloxanthin~~, ~~promotes resistance~~ to ~~reactive oxygen species and host neutrophil-based killing, and early enzymatic steps in staphyloxanthin production resemble those for cholesterol biosynthesis. We determined~~ the ~~crystal structures of S. aureus dehydrosqualene synthase~~ (~~CrtM)~~ at 1.~~58 angstrom resolution, finding structural similarity to human squalene synthase (SQS)~~. We screened nine SQS inhibitors and determined the structures of three, bound to CrtM. One, previously tested for cholesterol-lowering activity in humans, blocked staphyloxanthin biosynthesis in vitro (median inhibitory concentration approximately 100 nM), ~~resulting in colorless bacteria with increased susceptibility to killing by human blood and to innate immune clearance in a mouse infection model~~. ~~This finding represents proof of principle for a virulence factor~~-~~based therapy against S. aureus.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_18276850}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18276850 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18276850}}

	==About this Structure==		==About this Structure==
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	[[Category: Staphyloxanthin biosynthesis]]		[[Category: Staphyloxanthin biosynthesis]]
	[[Category: Transferase]]		[[Category: Transferase]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 20~~:09:25 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:23:09 2008''