2zgh - Revision history

OCA at 13:35, 1 November 2023

OCA — Wed, 01 Nov 2023 13:35:45 GMT

←Older revision		Revision as of 13:35, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='2zgh' size='340' side='right'caption='[[2zgh]], [[Resolution\|resolution]] 2.17Å' scene=''>		<StructureSection load='2zgh' size='340' side='right'caption='[[2zgh]], [[Resolution\|resolution]] 2.17Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zgh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZGH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zgh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZGH FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.17Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[2zgc\|2zgc]], [[2zgj\|2zgj]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">GZMM, MET1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zgh OCA], [https://pdbe.org/2zgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zgh RCSB], [https://www.ebi.ac.uk/pdbsum/2zgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zgh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zgh OCA], [https://pdbe.org/2zgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zgh RCSB], [https://www.ebi.ac.uk/pdbsum/2zgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zgh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GRAM_HUMAN GRAM_HUMAN]] Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.<ref>PMID:18523284</ref> <ref>PMID:20406824</ref>	+	[https://www.uniprot.org/uniprot/GRAM_HUMAN GRAM_HUMAN] Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.<ref>PMID:18523284</ref> <ref>PMID:20406824</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fan~~, Z S~~]]	+	[[Category: Fan ZS]]
-	[[Category: Hua~~, G Q~~]]	+	[[Category: Hua GQ]]
-	[[Category: Liu, K]]	+	[[Category: Liu K]]
-	[[Category: Sun, F]]	+	[[Category: Sun F]]
-	[[Category: Wang, L]]	+	[[Category: Wang L]]
-	[[Category: Wu~~, L F~~]]	+	[[Category: Wu LF]]
-	[[Category: Zhai~~, Y J]]~~	+	[[Category: Zhai YJ]]
-	~~[[Category: Cytolysis]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Serine protease]]~~	+
-	~~[[Category: Synthesized peptide]]~~	+
-	~~[[Category: Zymogen~~]]	+

OCA at 17:29, 15 December 2021

OCA — Wed, 15 Dec 2021 17:29:44 GMT

←Older revision		Revision as of 17:29, 15 December 2021
Line 1:		Line 1:

	==Crystal Structure of active granzyme M bound to its product==		==Crystal Structure of active granzyme M bound to its product==
-	<StructureSection load='2zgh' size='340' side='right' caption='[[2zgh]], [[Resolution\|resolution]] 2.17Å' scene=''>	+	<StructureSection load='2zgh' size='340' side='right'caption='[[2zgh]], [[Resolution\|resolution]] 2.17Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zgh]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZGH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZGH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zgh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZGH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zgc\|2zgc]], [[2zgj\|2zgj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zgc\|2zgc]], [[2zgj\|2zgj]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GZMM, MET1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GZMM, MET1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zgh OCA], [~~http~~://pdbe.org/2zgh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zgh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zgh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zgh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zgh OCA], [https://pdbe.org/2zgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zgh RCSB], [https://www.ebi.ac.uk/pdbsum/2zgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zgh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GRAM_HUMAN GRAM_HUMAN]] Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.<ref>PMID:18523284</ref> <ref>PMID:20406824</ref>	+	[[https://www.uniprot.org/uniprot/GRAM_HUMAN GRAM_HUMAN]] Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.<ref>PMID:18523284</ref> <ref>PMID:20406824</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Fan, Z S]]		[[Category: Fan, Z S]]
	[[Category: Hua, G Q]]		[[Category: Hua, G Q]]

OCA at 07:36, 18 October 2018

OCA — Thu, 18 Oct 2018 07:36:05 GMT

←Older revision		Revision as of 07:36, 18 October 2018
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zg/2zgh_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zg/2zgh_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:47, 5 August 2016

OCA — Fri, 05 Aug 2016 07:47:22 GMT

←Older revision		Revision as of 07:47, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of active granzyme M bound to its product==		==Crystal Structure of active granzyme M bound to its product==
	<StructureSection load='2zgh' size='340' side='right' caption='[[2zgh]], [[Resolution\|resolution]] 2.17Å' scene=''>		<StructureSection load='2zgh' size='340' side='right' caption='[[2zgh]], [[Resolution\|resolution]] 2.17Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zgh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZGH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZGH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zgh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZGH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZGH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zgc\|2zgc]], [[2zgj\|2zgj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zgc\|2zgc]], [[2zgj\|2zgj]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GZMM, MET1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GZMM, MET1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zgh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zgh RCSB], [http://www.ebi.ac.uk/pdbsum/2zgh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zgh OCA], [http://pdbe.org/2zgh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zgh RCSB], [http://www.ebi.ac.uk/pdbsum/2zgh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zgh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zgh ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2zgh" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Fan, Z S]]		[[Category: Fan, Z S]]
	[[Category: Hua, G Q]]		[[Category: Hua, G Q]]

OCA at 17:01, 25 December 2014

OCA — Thu, 25 Dec 2014 17:01:08 GMT

←Older revision		Revision as of 17:01, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zgh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZGH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZGH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zgh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZGH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZGH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zgc\|2zgc]], [[2zgj\|2zgj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zgc\|2zgc]], [[2zgj\|2zgj]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GZMM, MET1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GZMM, MET1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zgh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zgh RCSB], [http://www.ebi.ac.uk/pdbsum/2zgh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zgh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zgh RCSB], [http://www.ebi.ac.uk/pdbsum/2zgh PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRAM_HUMAN GRAM_HUMAN]] Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.<ref>PMID:18523284</ref> <ref>PMID:20406824</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Fan, Z S.]]	+	[[Category: Fan, Z S]]
-	[[Category: Hua, G Q.]]	+	[[Category: Hua, G Q]]
-	[[Category: Liu, K.]]	+	[[Category: Liu, K]]
-	[[Category: Sun, F.]]	+	[[Category: Sun, F]]
-	[[Category: Wang, L.]]	+	[[Category: Wang, L]]
-	[[Category: Wu, L F.]]	+	[[Category: Wu, L F]]
-	[[Category: Zhai, Y J.]]	+	[[Category: Zhai, Y J]]
	[[Category: Cytolysis]]		[[Category: Cytolysis]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]

OCA at 05:40, 2 October 2014

OCA — Thu, 02 Oct 2014 05:40:53 GMT

←Older revision		Revision as of 05:40, 2 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2zgh\| PDB=2zgh \| SCENE= }}~~	+	==Crystal Structure of active granzyme M bound to its product==
-	===Crystal Structure of active granzyme M bound to its product===	+	<StructureSection load='2zgh' size='340' side='right' caption='[[2zgh]], [[Resolution\|resolution]] 2.17Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19542453}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2zgh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZGH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZGH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zgc\|2zgc]], [[2zgj\|2zgj]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GZMM, MET1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zgh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zgh RCSB], [http://www.ebi.ac.uk/pdbsum/2zgh PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zg/2zgh_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Granzyme M (GzmM), a unique serine protease constitutively expressed in NK cells, is important for granule-mediated cytolysis and can induce rapid caspase-dependent apoptosis of tumor cells. However, few substrates of GzmM have been reported to date, and the mechanism by which this enzyme recognizes and hydrolyzes substrates is unknown. To provide structural insights into the proteolytic specificity of human GzmM (hGzmM), crystal structures of wild-type hGzmM, the inactive D86N-GzmM mutant with bound peptide substrate, and the complexes with a catalytic product and with a tetrapeptide chloromethylketone inhibitor were solved to 1.96 A, 2.30 A, 2.17 A and 2.70 A, respectively. Structure-based mutagenesis revealed that the N terminus and catalytic triad of hGzmM are most essential for proteolytic function. In particular, D86N-GzmM was found to be an ideal inactive enzyme for functional studies. Structural comparisons indicated a large conformational change of the L3 loop upon substrate binding, and suggest this loop mediates the substrate specificity of hGzmM. Based on the complex structure of GzmM with its catalytic product, a tetrapeptide chloromethylketone inhibitor was designed and found to specifically block the catalytic activity of hGzmM.

-	~~==About this Structure==~~	+	Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M.,Wu L, Wang L, Hua G, Liu K, Yang X, Zhai Y, Bartlam M, Sun F, Fan Z J Immunol. 2009 Jul 1;183(1):421-9. PMID:19542453<ref>PMID:19542453</ref>
-	~~[[2zgh]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2ZGH OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Granzyme\|Granzyme]]		*[[Granzyme\|Granzyme]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019542453<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fan, Z S.]]		[[Category: Fan, Z S.]]

OCA at 11:14, 11 March 2013

OCA — Mon, 11 Mar 2013 11:14:18 GMT

←Older revision		Revision as of 11:14, 11 March 2013
Line 1:		Line 1:
-	[[Image:2zgh.png\|left\|200px]]
-
	{{STRUCTURE_2zgh\| PDB=2zgh \| SCENE= }}		{{STRUCTURE_2zgh\| PDB=2zgh \| SCENE= }}
-
	===Crystal Structure of active granzyme M bound to its product===		===Crystal Structure of active granzyme M bound to its product===
-
	{{ABSTRACT_PUBMED_19542453}}		{{ABSTRACT_PUBMED_19542453}}

OCA: Protected "2zgh" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 20:31:15 GMT

Protected "2zgh" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:31, 7 January 2013

OCA at 20:31, 7 January 2013

OCA — Mon, 07 Jan 2013 20:31:13 GMT

←Older revision		Revision as of 20:31, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2zgh.png\|left\|200px]]		[[Image:2zgh.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zgh", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zgh\| PDB=2zgh \| SCENE= }}		{{STRUCTURE_2zgh\| PDB=2zgh \| SCENE= }}

	===Crystal Structure of active granzyme M bound to its product===		===Crystal Structure of active granzyme M bound to its product===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19542453}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19542453 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19542453}}		{{ABSTRACT_PUBMED_19542453}}

	==About this Structure==		==About this Structure==
-	~~2ZGH~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZGH OCA].	+	[[2zgh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZGH OCA].
		+
		+	==See Also==
		+	*[[Granzyme\|Granzyme]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19542453~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019542453</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fan, Z S.]]		[[Category: Fan, Z S.]]
Line 40:		Line 31:
	[[Category: Synthesized peptide]]		[[Category: Synthesized peptide]]
	[[Category: Zymogen]]		[[Category: Zymogen]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jan 18 09:14:01 2010''

OCA at 07:14, 18 January 2010

OCA — Mon, 18 Jan 2010 07:14:02 GMT

←Older revision		Revision as of 07:14, 18 January 2010
Line 12:		Line 12:
	===Crystal Structure of active granzyme M bound to its product===		===Crystal Structure of active granzyme M bound to its product===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19542453}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19542453 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19542453}}

	==About this Structure==		==About this Structure==
	2ZGH is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZGH OCA].		2ZGH is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZGH OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19542453</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fan, Z S.]]		[[Category: Fan, Z S.]]
Line 32:		Line 41:
	[[Category: Zymogen]]		[[Category: Zymogen]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 8 20~~:10:~~38 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jan 18 09:14:01 2010''