2zhn - Revision history

OCA at 13:57, 13 March 2024

OCA — Wed, 13 Mar 2024 13:57:38 GMT

←Older revision		Revision as of 13:57, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='2zhn' size='340' side='right'caption='[[2zhn]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='2zhn' size='340' side='right'caption='[[2zhn]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zhn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2ZHN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zhn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZHN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~"><~~scene name~~='~~pdbligand~~=~~RPN~~:~~(R)-1-PARA-NITRO-PHENYL-2-AZIDO-ETHANOL'~~>~~RPN~~</~~scene~~>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td>~~<td class="sblockDat">[[2zhk\|2zhk]], [[2zhl\|2zhl]], [[2zhm\|2zhm]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=RPN:(R)-1-PARA-NITRO-PHENYL-2-AZIDO-ETHANOL'>RPN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2zhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhn OCA], [~~http~~://pdbe.org/2zhn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zhn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zhn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zhn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhn OCA], [https://pdbe.org/2zhn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zhn RCSB], [https://www.ebi.ac.uk/pdbsum/2zhn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zhn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LEG9_HUMAN LEG9_HUMAN]] Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.<ref>PMID:16286920</ref> <ref>PMID:18005988</ref> <ref>PMID:18977853</ref>	+	[https://www.uniprot.org/uniprot/LEG9_HUMAN LEG9_HUMAN] Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.<ref>PMID:16286920</ref> <ref>PMID:18005988</ref> <ref>PMID:18977853</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zhn ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zhn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Galectins are a family of beta-galactoside-specific lectins bearing a conserved carbohydrate recognition domain. Interactions between galectins and poly-N-acetyllactosamine sequences are critical in a variety of biological processes. Galectin-9, a member of the galectin family, has two carbohydrate recognition domains at both the N- and C-terminal regions. Here we report the crystal structure of the human galectin-9 N-terminal carbohydrate recognition domain in complex with N-acetyllactosamine dimers and trimers. These complex structures revealed that the galectin-9 N-terminal carbohydrate recognition domain can recognize internal N-acetyllactosamine units within poly-N-acetyllactosamine chains. Based on these complex structures, we propose two putative recognition modes for poly-N-acetyllactosamine binding by galectins.
-
-	Structural analysis of the recognition mechanism of poly-N-acetyllactosamine by the human galectin-9 N-terminal carbohydrate recognition domain.,Nagae M, Nishi N, Murata T, Usui T, Nakamura T, Wakatsuki S, Kato R Glycobiology. 2009 Feb;19(2):112-7. Epub 2008 Oct 31. PMID:18977853<ref>PMID:18977853</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2zhn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kato, R]]	+	[[Category: Kato R]]
-	[[Category: Murata, T]]	+	[[Category: Murata T]]
-	[[Category: Nagae, M]]	+	[[Category: Nagae M]]
-	[[Category: Nakamura, T]]	+	[[Category: Nakamura T]]
-	[[Category: Nishi, N]]	+	[[Category: Nishi N]]
-	[[Category: Usui, T]]	+	[[Category: Usui T]]
-	[[Category: Wakatsuki, S]]	+	[[Category: Wakatsuki S]]
-	~~[[Category: Beta sandwich]]~~	+
-	~~[[Category: Carbohydrate binding protein]]~~	+
-	~~[[Category: Galectin]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 12:05, 29 July 2020

OCA — Wed, 29 Jul 2020 12:05:04 GMT

←Older revision		Revision as of 12:05, 29 July 2020
Line 1:		Line 1:

	==Crystal structure of human galectin-9 N-terminal CRD in complex with N-acetyllactosamine trimer (crystal 2)==		==Crystal structure of human galectin-9 N-terminal CRD in complex with N-acetyllactosamine trimer (crystal 2)==
-	<StructureSection load='2zhn' size='340' side='right' caption='[[2zhn]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='2zhn' size='340' side='right'caption='[[2zhn]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zhn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZHN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zhn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2ZHN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~GAL~~:~~BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~RPN~~:~~(R)~~-1-~~PARA~~-~~NITRO-PHENYL-2-AZIDO-ETHANOL~~'>~~RPN~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RPN:(R)-1-PARA-NITRO-PHENYL-2-AZIDO-ETHANOL'>RPN</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zhk\|2zhk]], [[2zhl\|2zhl]], [[2zhm\|2zhm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zhk\|2zhk]], [[2zhl\|2zhl]], [[2zhm\|2zhm]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhn OCA], [http://pdbe.org/2zhn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zhn RCSB], [http://www.ebi.ac.uk/pdbsum/2zhn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zhn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2zhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhn OCA], [http://pdbe.org/2zhn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zhn RCSB], [http://www.ebi.ac.uk/pdbsum/2zhn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zhn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Galectin\|Galectin]]	+	*[[Galectin 3D structures\|Galectin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Kato, R]]		[[Category: Kato, R]]
	[[Category: Murata, T]]		[[Category: Murata, T]]

OCA at 07:15, 18 October 2018

OCA — Thu, 18 Oct 2018 07:15:48 GMT

←Older revision		Revision as of 07:15, 18 October 2018
Line 1:		Line 1:
		+
	==Crystal structure of human galectin-9 N-terminal CRD in complex with N-acetyllactosamine trimer (crystal 2)==		==Crystal structure of human galectin-9 N-terminal CRD in complex with N-acetyllactosamine trimer (crystal 2)==
	<StructureSection load='2zhn' size='340' side='right' caption='[[2zhn]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='2zhn' size='340' side='right' caption='[[2zhn]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zhn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZHN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zhn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZHN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~RPN~~:~~(R)~~-1-~~PARA-NITRO-PHENYL-2-AZIDO-ETHANOL~~'>~~RPN~~</scene>, <scene name='pdbligand=~~GAL~~:~~BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene>, <scene name='pdbligand=~~NAG~~:N-~~ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=RPN:(R)-1-PARA-NITRO-PHENYL-2-AZIDO-ETHANOL'>RPN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zhk\|2zhk]], [[2zhl\|2zhl]], [[2zhm\|2zhm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zhk\|2zhk]], [[2zhl\|2zhl]], [[2zhm\|2zhm]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhn OCA], [http://pdbe.org/2zhn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zhn RCSB], [http://www.ebi.ac.uk/pdbsum/2zhn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhn OCA], [http://pdbe.org/2zhn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zhn RCSB], [http://www.ebi.ac.uk/pdbsum/2zhn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zhn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zh/2zhn_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zh/2zhn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 23:58, 9 February 2016

OCA — Tue, 09 Feb 2016 23:58:02 GMT

←Older revision		Revision as of 23:58, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2zhn' size='340' side='right' caption='[[2zhn]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='2zhn' size='340' side='right' caption='[[2zhn]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zhn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZHN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zhn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZHN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RPN:(R)-1-PARA-NITRO-PHENYL-2-AZIDO-ETHANOL'>RPN</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RPN:(R)-1-PARA-NITRO-PHENYL-2-AZIDO-ETHANOL'>RPN</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zhk\|2zhk]], [[2zhl\|2zhl]], [[2zhm\|2zhm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zhk\|2zhk]], [[2zhl\|2zhl]], [[2zhm\|2zhm]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zhn RCSB], [http://www.ebi.ac.uk/pdbsum/2zhn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhn OCA], [http://pdbe.org/2zhn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zhn RCSB], [http://www.ebi.ac.uk/pdbsum/2zhn PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zhn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2zhn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Kato, R]]		[[Category: Kato, R]]
	[[Category: Murata, T]]		[[Category: Murata, T]]

OCA at 10:24, 25 December 2014

OCA — Thu, 25 Dec 2014 10:24:27 GMT

←Older revision		Revision as of 10:24, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zhn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZHN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zhn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZHN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RPN:(R)-1-PARA-NITRO-PHENYL-2-AZIDO-ETHANOL'>RPN</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RPN:(R)-1-PARA-NITRO-PHENYL-2-AZIDO-ETHANOL'>RPN</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zhk\|2zhk]], [[2zhl\|2zhl]], [[2zhm\|2zhm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zhk\|2zhk]], [[2zhl\|2zhl]], [[2zhm\|2zhm]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zhn RCSB], [http://www.ebi.ac.uk/pdbsum/2zhn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zhn RCSB], [http://www.ebi.ac.uk/pdbsum/2zhn PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LEG9_HUMAN LEG9_HUMAN]] Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.<ref>PMID:16286920</ref> <ref>PMID:18005988</ref> <ref>PMID:18977853</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Kato, R.]]	+	[[Category: Kato, R]]
-	[[Category: Murata, T.]]	+	[[Category: Murata, T]]
-	[[Category: Nagae, M.]]	+	[[Category: Nagae, M]]
-	[[Category: Nakamura, T.]]	+	[[Category: Nakamura, T]]
-	[[Category: Nishi, N.]]	+	[[Category: Nishi, N]]
-	[[Category: Usui, T.]]	+	[[Category: Usui, T]]
-	[[Category: Wakatsuki, S.]]	+	[[Category: Wakatsuki, S]]
	[[Category: Beta sandwich]]		[[Category: Beta sandwich]]
	[[Category: Carbohydrate binding protein]]		[[Category: Carbohydrate binding protein]]
	[[Category: Galectin]]		[[Category: Galectin]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

OCA at 09:02, 29 September 2014

OCA — Mon, 29 Sep 2014 09:02:59 GMT

←Older revision		Revision as of 09:02, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2zhn.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of human galectin-9 N-terminal CRD in complex with N-acetyllactosamine trimer (crystal 2)==
		+	<StructureSection load='2zhn' size='340' side='right' caption='[[2zhn]], [[Resolution\|resolution]] 1.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2zhn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZHN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RPN:(R)-1-PARA-NITRO-PHENYL-2-AZIDO-ETHANOL'>RPN</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zhk\|2zhk]], [[2zhl\|2zhl]], [[2zhm\|2zhm]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zhn RCSB], [http://www.ebi.ac.uk/pdbsum/2zhn PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zh/2zhn_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Galectins are a family of beta-galactoside-specific lectins bearing a conserved carbohydrate recognition domain. Interactions between galectins and poly-N-acetyllactosamine sequences are critical in a variety of biological processes. Galectin-9, a member of the galectin family, has two carbohydrate recognition domains at both the N- and C-terminal regions. Here we report the crystal structure of the human galectin-9 N-terminal carbohydrate recognition domain in complex with N-acetyllactosamine dimers and trimers. These complex structures revealed that the galectin-9 N-terminal carbohydrate recognition domain can recognize internal N-acetyllactosamine units within poly-N-acetyllactosamine chains. Based on these complex structures, we propose two putative recognition modes for poly-N-acetyllactosamine binding by galectins.

-	~~{{STRUCTURE_2zhn\| PDB=2zhn \| SCENE= }}~~	+	Structural analysis of the recognition mechanism of poly-N-acetyllactosamine by the human galectin-9 N-terminal carbohydrate recognition domain.,Nagae M, Nishi N, Murata T, Usui T, Nakamura T, Wakatsuki S, Kato R Glycobiology. 2009 Feb;19(2):112-7. Epub 2008 Oct 31. PMID:18977853<ref>PMID:18977853</ref>

-	~~===Crystal structure~~ of ~~human galectin-9 N-terminal CRD in complex with N-acetyllactosamine trimer (crystal 2)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18977853}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2zhn]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHN OCA].~~	+

	==See Also==		==See Also==
	*[[Galectin\|Galectin]]		*[[Galectin\|Galectin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018977853<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kato, R.]]		[[Category: Kato, R.]]

OCA: Protected "2zhn" [edit=sysop:move=sysop]

OCA — Sat, 20 Oct 2012 15:35:46 GMT

Protected "2zhn" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:35, 20 October 2012

OCA at 15:35, 20 October 2012

OCA — Sat, 20 Oct 2012 15:35:44 GMT

←Older revision		Revision as of 15:35, 20 October 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2zhn.png\|left\|200px]]		[[Image:2zhn.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zhn", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zhn\| PDB=2zhn \| SCENE= }}		{{STRUCTURE_2zhn\| PDB=2zhn \| SCENE= }}

	===Crystal structure of human galectin-9 N-terminal CRD in complex with N-acetyllactosamine trimer (crystal 2)===		===Crystal structure of human galectin-9 N-terminal CRD in complex with N-acetyllactosamine trimer (crystal 2)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18977853}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18977853 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18977853}}		{{ABSTRACT_PUBMED_18977853}}

	==About this Structure==		==About this Structure==
-	~~2ZHN~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHN OCA].	+	[[2zhn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHN OCA].
		+
		+	==See Also==
		+	*[[Galectin\|Galectin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18977853~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018977853</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kato, R.]]		[[Category: Kato, R.]]
Line 36:		Line 27:
	[[Category: Galectin]]		[[Category: Galectin]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:46:43 2010''

OCA at 08:37, 22 September 2010

OCA — Wed, 22 Sep 2010 08:37:45 GMT

←Older revision		Revision as of 08:37, 22 September 2010
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2ZHN is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHN OCA].	+	2ZHN is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHN OCA].

	==Reference==		==Reference==
-	Structural analysis of the recognition mechanism of poly-N-acetyllactosamine by the human galectin-9 N-terminal carbohydrate recognition domain., Nagae M, Nishi N, Murata T, Usui T, Nakamura T, Wakatsuki S, Kato R, Glycobiology. 2009 Feb;19(2):112-7. Epub 2008 Oct 31. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18977853 18977853]~~	+	<ref group="xtra">PMID:18977853</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: ~~Single protein~~]]	+	[[Category: Kato, R.]]
-	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx~~:~~audit_author~~.]]	+	[[Category: Murata, T.]]
		+	[[Category: Nagae, M.]]
		+	[[Category: Nakamura, T.]]
		+	[[Category: Nishi, N.]]
		+	[[Category: Usui, T.]]
		+	[[Category: Wakatsuki, S.]]
	[[Category: Beta sandwich]]		[[Category: Beta sandwich]]
	[[Category: Carbohydrate binding protein]]		[[Category: Carbohydrate binding protein]]
Line 32:		Line 37:
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Feb 4 20~~:09:~~53 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:46:43 2010''

OCA at 05:10, 6 February 2009

OCA — Fri, 06 Feb 2009 05:10:49 GMT

←Older revision		Revision as of 05:10, 6 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2ZHN is a ~~1 chain~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHN OCA].	+	2ZHN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHN OCA].

	==Reference==		==Reference==
-	~~<ref group="xtra">~~PMID:~~18977853<~~/~~ref><references group="xtra"~~/>	+	Structural analysis of the recognition mechanism of poly-N-acetyllactosamine by the human galectin-9 N-terminal carbohydrate recognition domain., Nagae M, Nishi N, Murata T, Usui T, Nakamura T, Wakatsuki S, Kato R, Glycobiology. 2009 Feb;19(2):112-7. Epub 2008 Oct 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18977853 18977853]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: ~~Kato, R.~~]]	+	[[Category: Single protein]]
-	[[Category: ~~Murata~~, ~~T.]]~~	+	[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
-	~~[[Category~~: ~~Nagae, M.]]~~	+
-	~~[[Category: Nakamura, T.]]~~	+
-	~~[[Category: Nishi, N.]]~~	+
-	~~[[Category: Usui, T.]]~~	+
-	~~[[Category: Wakatsuki, S~~.]]	+
	[[Category: Beta sandwich]]		[[Category: Beta sandwich]]
	[[Category: Carbohydrate binding protein]]		[[Category: Carbohydrate binding protein]]
Line 37:		Line 32:
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 4 11:49:48 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 4 20:09:53 2009''