2zhx - Revision history

OCA at 13:36, 1 November 2023

OCA — Wed, 01 Nov 2023 13:36:30 GMT

←Older revision		Revision as of 13:36, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='2zhx' size='340' side='right'caption='[[2zhx]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='2zhx' size='340' side='right'caption='[[2zhx]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zhx]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bppb2 Bppb2~~] and [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZHX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zhx]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_phage_PBS2 Bacillus phage PBS2] and [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZHX FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>ung, Rv2976c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=83332 MYCTU]), ugi, J04434 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10684 BPPB2])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>~~[~~https://en.wikipedia.org/wiki/Uridine_nucleosidase Uridine nucleosidase~~]~~, with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~3.~~2.2.3 3.2.2.3] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhx OCA], [https://pdbe.org/2zhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zhx RCSB], [https://www.ebi.ac.uk/pdbsum/2zhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zhx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhx OCA], [https://pdbe.org/2zhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zhx RCSB], [https://www.ebi.ac.uk/pdbsum/2zhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zhx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/UNG_MYCTU UNG_MYCTU]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity). [[https://www.uniprot.org/uniprot/UNGI_BPPB2 UNGI_BPPB2]] This protein binds specifically and reversibly to the host uracil-DNA glycosylase, preventing removal of uracil residues from PBS2 DNA by the host uracil-excision repair system.	+	[https://www.uniprot.org/uniprot/UNG_MYCTU UNG_MYCTU] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bppb2~~]]	+	[[Category: Bacillus phage PBS2]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu]]~~	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	~~[[Category: Uridine nucleosidase~~]]	+	[[Category: Kaushal PS]]
-	[[Category: Kaushal~~, P S~~]]	+	[[Category: Krishna PDV]]
-	[[Category: Krishna~~, P D.V~~]]	+	[[Category: Talawar RK]]
-	[[Category: Talawar~~, R K~~]]	+	[[Category: Varshney U]]
-	[[Category: Varshney, U]]	+	[[Category: Vijayan M]]
-	[[Category: Vijayan, M]]	+
-	~~[[Category: Dna damage]]~~	+
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Glycosidase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Ung-dna interaction]]~~	+
-	~~[[Category: Ung-ugi complex~~]]	+

OCA at 17:30, 15 December 2021

OCA — Wed, 15 Dec 2021 17:30:28 GMT

←Older revision		Revision as of 17:30, 15 December 2021
Line 1:		Line 1:
		+
	==Crystal structure of Uracil-DNA Glycosylase from Mycobacterium tuberculosis in complex with a proteinaceous inhibitor==		==Crystal structure of Uracil-DNA Glycosylase from Mycobacterium tuberculosis in complex with a proteinaceous inhibitor==
-	<StructureSection load='2zhx' size='340' side='right' caption='[[2zhx]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='2zhx' size='340' side='right'caption='[[2zhx]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zhx]] is a 14 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bacteriophage_pbs2 Bacteriophage pbs2~~] and [~~http~~://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZHX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zhx]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Bppb2 Bppb2] and [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZHX FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ung, Rv2976c ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1773 Mycobacterium tuberculosis~~]), ugi, J04434 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= ~~Bacteriophage PBS2~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ung, Rv2976c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU]), ugi, J04434 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10684 BPPB2])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Uridine_nucleosidase Uridine nucleosidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.3 3.2.2.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Uridine_nucleosidase Uridine nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.3 3.2.2.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhx OCA], [~~http~~://pdbe.org/2zhx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zhx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zhx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhx OCA], [https://pdbe.org/2zhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zhx RCSB], [https://www.ebi.ac.uk/pdbsum/2zhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zhx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/UNG_MYCTU UNG_MYCTU]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity). [[~~http~~://www.uniprot.org/uniprot/UNGI_BPPB2 UNGI_BPPB2]] This protein binds specifically and reversibly to the host uracil-DNA glycosylase, preventing removal of uracil residues from PBS2 DNA by the host uracil-excision repair system.	+	[[https://www.uniprot.org/uniprot/UNG_MYCTU UNG_MYCTU]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity). [[https://www.uniprot.org/uniprot/UNGI_BPPB2 UNGI_BPPB2]] This protein binds specifically and reversibly to the host uracil-DNA glycosylase, preventing removal of uracil residues from PBS2 DNA by the host uracil-excision repair system.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zh/2zhx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zh/2zhx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:

	==See Also==		==See Also==
-	*[[DNA glycosylase\|DNA glycosylase]]	+	*[[DNA glycosylase 3D structures\|DNA glycosylase 3D structures]]
-	*[[Uracil ~~glycosylate inhibitor\|Uracil glycosylate inhibitor]]~~	+	*[[Uracil glycosylase inhibitor\|Uracil glycosylase inhibitor]]
-	*[[Uracil-DNA glycosylase\|Uracil-DNA glycosylase]]	+
-	*[[Uracil-DNA glycosylase inhibitor\|Uracil~~-DNA~~ glycosylase inhibitor]]	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacteriophage pbs2~~]]	+	[[Category: Bppb2]]
-	[[Category: ~~Mycobacterium tuberculosis~~]]	+	[[Category: Large Structures]]
		+	[[Category: Myctu]]
	[[Category: Uridine nucleosidase]]		[[Category: Uridine nucleosidase]]
	[[Category: Kaushal, P S]]		[[Category: Kaushal, P S]]

OCA at 08:31, 8 February 2016

OCA — Mon, 08 Feb 2016 08:31:00 GMT

←Older revision		Revision as of 08:31, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2zhx' size='340' side='right' caption='[[2zhx]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='2zhx' size='340' side='right' caption='[[2zhx]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zhx]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_phage_pbs2 Bacillus phage~~ pbs2] and [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZHX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zhx]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteriophage_pbs2 Bacteriophage pbs2] and [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZHX FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ung, Rv2976c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis]), ugi, J04434 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~10684 Bacillus phage~~ PBS2])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ung, Rv2976c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis]), ugi, J04434 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Bacteriophage PBS2])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uridine_nucleosidase Uridine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.3 3.2.2.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uridine_nucleosidase Uridine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.3 3.2.2.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zhx RCSB], [http://www.ebi.ac.uk/pdbsum/2zhx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhx OCA], [http://pdbe.org/2zhx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zhx RCSB], [http://www.ebi.ac.uk/pdbsum/2zhx PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zhx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2zhx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus phage~~ pbs2]]	+	[[Category: Bacteriophage pbs2]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Uridine nucleosidase]]		[[Category: Uridine nucleosidase]]

OCA at 21:59, 24 December 2014

OCA — Wed, 24 Dec 2014 21:59:23 GMT

←Older revision		Revision as of 21:59, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zhx RCSB], [http://www.ebi.ac.uk/pdbsum/2zhx PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zhx RCSB], [http://www.ebi.ac.uk/pdbsum/2zhx PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UNG_MYCTU UNG_MYCTU]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity). [[http://www.uniprot.org/uniprot/UNGI_BPPB2 UNGI_BPPB2]] This protein binds specifically and reversibly to the host uracil-DNA glycosylase, preventing removal of uracil residues from PBS2 DNA by the host uracil-excision repair system.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 40:
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Uridine nucleosidase]]		[[Category: Uridine nucleosidase]]
-	[[Category: Kaushal, P S.]]	+	[[Category: Kaushal, P S]]
-	[[Category: Krishna, P D.V.]]	+	[[Category: Krishna, P D.V]]
-	[[Category: Talawar, R K.]]	+	[[Category: Talawar, R K]]
-	[[Category: Varshney, U.]]	+	[[Category: Varshney, U]]
-	[[Category: Vijayan, M.]]	+	[[Category: Vijayan, M]]
	[[Category: Dna damage]]		[[Category: Dna damage]]
	[[Category: Dna repair]]		[[Category: Dna repair]]

OCA at 06:52, 10 October 2014

OCA — Fri, 10 Oct 2014 06:52:59 GMT

←Older revision		Revision as of 06:52, 10 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2zhx~~\| ~~PDB~~=2zhx \| ~~SCENE~~= }}	+	==Crystal structure of Uracil-DNA Glycosylase from Mycobacterium tuberculosis in complex with a proteinaceous inhibitor==
-	===~~Crystal~~ structure of Uracil-DNA ~~Glycosylase~~ from Mycobacterium tuberculosis in complex with a proteinaceous inhibitor~~===~~	+	<StructureSection load='2zhx' size='340' side='right' caption='[[2zhx]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18453691}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2zhx]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_phage_pbs2 Bacillus phage pbs2] and [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZHX FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ung, Rv2976c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis]), ugi, J04434 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10684 Bacillus phage PBS2])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uridine_nucleosidase Uridine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.3 3.2.2.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zhx RCSB], [http://www.ebi.ac.uk/pdbsum/2zhx PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zh/2zhx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Uracil-DNA glycosylase (UNG), a repair enzyme involved in the excision of uracil from DNA, from mycobacteria differs from UNGs from other sources, particularly in the sequence in the catalytically important loops. The structure of the enzyme from Mycobacterium tuberculosis (MtUng) in complex with a proteinaceous inhibitor (Ugi) has been determined by X-ray analysis of a crystal containing seven crystallographically independent copies of the complex. This structure provides the first geometric characterization of a mycobacterial UNG. A comparison of the structure with those of other UNG proteins of known structure shows that a central core region of the molecule is relatively invariant in structure and sequence, while the N- and C-terminal tails exhibit high variability. The tails are probably important in folding and stability. The mycobacterial enzyme exhibits differences in UNG-Ugi interactions compared with those involving UNG from other sources. The MtUng-DNA complex modelled on the basis of the known structure of the complex involving the human enzyme indicates a domain closure in the enzyme when binding to DNA. The binding involves a larger burial of surface area than is observed in binding by human UNG. The DNA-binding site of MtUng is characterized by the presence of a higher proportion of arginyl residues than is found in the binding site of any other UNG of known structure. In addition to the electrostatic effects produced by the arginyl residues, the hydrogen bonds in which they are involved compensate for the loss of some interactions arising from changes in amino-acid residues, particularly in the catalytic loops. The results arising from the present investigation represent unique features of the structure and interaction of mycobacterial Ungs.

-	~~==About this Structure==~~	+	Unique features of the structure and interactions of mycobacterial uracil-DNA glycosylase: structure of a complex of the Mycobacterium tuberculosis enzyme in comparison with those from other sources.,Kaushal PS, Talawar RK, Krishna PD, Varshney U, Vijayan M Acta Crystallogr D Biol Crystallogr. 2008 May;64(Pt 5):551-60. Epub 2008, Apr 19. PMID:18453691<ref>PMID:18453691</ref>
-	~~[[2zhx]] is~~ a ~~14 chain structure~~ with ~~sequence~~ from ~~[http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_phage_pbs2 Bacillus phage pbs2] and [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2ZHX OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
-	*[[DNA ~~glycosylate~~\|DNA ~~glycosylate~~]]	+	*[[DNA glycosylase\|DNA glycosylase]]
	*[[Uracil glycosylate inhibitor\|Uracil glycosylate inhibitor]]		*[[Uracil glycosylate inhibitor\|Uracil glycosylate inhibitor]]
-		+	*[[Uracil-DNA glycosylase\|Uracil-DNA glycosylase]]
-	==~~Reference~~==	+	*[[Uracil-DNA glycosylase inhibitor\|Uracil-DNA glycosylase inhibitor]]
-	<~~ref group="xtra">PMID:018453691<~~/~~ref~~><~~ref group="xtra">PMID:012136137</ref><references group="xtra"~~/>	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus phage pbs2]]		[[Category: Bacillus phage pbs2]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA at 11:12, 11 March 2013

OCA — Mon, 11 Mar 2013 11:12:38 GMT

←Older revision		Revision as of 11:12, 11 March 2013
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-	[[Image:2zhx.png\|left\|200px]]
-
	{{STRUCTURE_2zhx\| PDB=2zhx \| SCENE= }}		{{STRUCTURE_2zhx\| PDB=2zhx \| SCENE= }}
-
	===Crystal structure of Uracil-DNA Glycosylase from Mycobacterium tuberculosis in complex with a proteinaceous inhibitor===		===Crystal structure of Uracil-DNA Glycosylase from Mycobacterium tuberculosis in complex with a proteinaceous inhibitor===
-
	{{ABSTRACT_PUBMED_18453691}}		{{ABSTRACT_PUBMED_18453691}}

OCA at 09:33, 20 October 2012

OCA — Sat, 20 Oct 2012 09:33:21 GMT

←Older revision		Revision as of 09:33, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2zhx]] is a 14 chain structure ~~of [[DNA glycosylate]]~~ with sequence from [http://en.wikipedia.org/wiki/Bacillus_phage_pbs2 Bacillus phage pbs2] and [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHX OCA].	+	[[2zhx]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_phage_pbs2 Bacillus phage pbs2] and [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHX OCA].

	==See Also==		==See Also==
	*[[DNA glycosylate\|DNA glycosylate]]		*[[DNA glycosylate\|DNA glycosylate]]
		+	*[[Uracil glycosylate inhibitor\|Uracil glycosylate inhibitor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018453691</ref><ref group="xtra">PMID:012136137~~</ref><ref group="xtra">PMID:009776748~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018453691</ref><ref group="xtra">PMID:012136137</ref><references group="xtra"/>
	[[Category: Bacillus phage pbs2]]		[[Category: Bacillus phage pbs2]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA at 23:15, 25 July 2012

OCA — Wed, 25 Jul 2012 23:15:54 GMT

←Older revision		Revision as of 23:15, 25 July 2012
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	[[Image:2zhx.png\|left\|200px]]		[[Image:2zhx.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zhx", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zhx\| PDB=2zhx \| SCENE= }}		{{STRUCTURE_2zhx\| PDB=2zhx \| SCENE= }}

	===Crystal structure of Uracil-DNA Glycosylase from Mycobacterium tuberculosis in complex with a proteinaceous inhibitor===		===Crystal structure of Uracil-DNA Glycosylase from Mycobacterium tuberculosis in complex with a proteinaceous inhibitor===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18453691}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18453691 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18453691}}		{{ABSTRACT_PUBMED_18453691}}

	==About this Structure==		==About this Structure==
-	[[2zhx]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_phage_pbs2 Bacillus phage pbs2] and [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHX OCA].	+	[[2zhx]] is a 14 chain structure of [[DNA glycosylate]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_phage_pbs2 Bacillus phage pbs2] and [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHX OCA].
		+
		+	==See Also==
		+	*[[DNA glycosylate\|DNA glycosylate]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18453691~~</ref><ref group="xtra">PMID:~~12136137~~</ref><ref group="xtra">PMID:~~9776748~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018453691</ref><ref group="xtra">PMID:012136137</ref><ref group="xtra">PMID:009776748</ref><references group="xtra"/>
	[[Category: Bacillus phage pbs2]]		[[Category: Bacillus phage pbs2]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
Line 31:		Line 23:
	[[Category: Varshney, U.]]		[[Category: Varshney, U.]]
	[[Category: Vijayan, M.]]		[[Category: Vijayan, M.]]
-	[[Category: Cytoplasm]]
	[[Category: Dna damage]]		[[Category: Dna damage]]
	[[Category: Dna repair]]		[[Category: Dna repair]]
	[[Category: Glycosidase]]		[[Category: Glycosidase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: Hydrolase/hydrolase inhibitor complex]]	+	[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Ung-dna interaction]]		[[Category: Ung-dna interaction]]
	[[Category: Ung-ugi complex]]		[[Category: Ung-ugi complex]]

OCA: Protected "2zhx" [edit=sysop:move=sysop]

OCA — Tue, 15 Mar 2011 00:33:08 GMT

Protected "2zhx" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:33, 15 March 2011

OCA at 00:33, 15 March 2011

OCA — Tue, 15 Mar 2011 00:33:06 GMT

←Older revision		Revision as of 00:33, 15 March 2011
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-	{{Seed}}
	[[Image:2zhx.png\|left\|200px]]		[[Image:2zhx.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~2ZHX~~ is a 14 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Bacillus_phage_pbs2 Bacillus phage pbs2] and [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHX OCA].	+	[[2zhx]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_phage_pbs2 Bacillus phage pbs2] and [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHX OCA].

	==Reference==		==Reference==
Line 40:		Line 39:
	[[Category: Ung-dna interaction]]		[[Category: Ung-dna interaction]]
	[[Category: Ung-ugi complex]]		[[Category: Ung-ugi complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:37:15 2009''