2ziz - Revision history

OCA at 12:00, 30 August 2023

OCA — Wed, 30 Aug 2023 12:00:16 GMT

←Older revision		Revision as of 12:00, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2ziz' size='340' side='right'caption='[[2ziz]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2ziz' size='340' side='right'caption='[[2ziz]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ziz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZIZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ziz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZIZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AD3:3~~-~~DEAZA-ADENOSINE'>AD3</scene>~~, ~~<scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1li4\|1li4]], [[2zj0\|2zj0]], [[2zj1\|2zj1]], [[3ce6\|3ce6]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AD3:3-DEAZA-ADENOSINE'>AD3</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>ahcY, sahH, Rv3248c, MT3346, MTCY20B11.23c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~83332 MYCTU])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ziz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ziz OCA], [https://pdbe.org/2ziz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ziz RCSB], [https://www.ebi.ac.uk/pdbsum/2ziz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ziz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ziz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ziz OCA], [https://pdbe.org/2ziz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ziz RCSB], [https://www.ebi.ac.uk/pdbsum/2ziz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ziz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SAHH_MYCTU SAHH_MYCTU]] May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity).[HAMAP-Rule:MF_00563]	+	[https://www.uniprot.org/uniprot/SAHH_MYCTU SAHH_MYCTU] May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity).[HAMAP-Rule:MF_00563]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Adenosylhomocysteinase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Gokulan, K]]	+	[[Category: Gokulan K]]
-	[[Category: Ioerger~~, T R~~]]	+	[[Category: Ioerger TR]]
-	[[Category: Owen~~, J L~~]]	+	[[Category: Owen JL]]
-	[[Category: Reddy~~, M C.M~~]]	+	[[Category: Reddy MCM]]
-	[[Category: Sacchettini~~, J C~~]]	+	[[Category: Sacchettini JC]]
-	[[Category: Shetty~~, N D]]~~	+	[[Category: Shetty ND]]
-	~~[[Category: 37 amino acid insertional region]]~~	+
-	~~[[Category: Dimer of dimer]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Nad binding domain]]~~	+
-	~~[[Category: One-carbon metabolism]]~~	+
-	~~[[Category: Protein-substrate complex~~]]	+

OCA at 17:31, 15 December 2021

OCA — Wed, 15 Dec 2021 17:31:13 GMT

←Older revision		Revision as of 17:31, 15 December 2021
Line 1:		Line 1:

	==Crystal structure of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with NAD and 3-deazaadenosine==		==Crystal structure of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with NAD and 3-deazaadenosine==
-	<StructureSection load='2ziz' size='340' side='right' caption='[[2ziz]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2ziz' size='340' side='right'caption='[[2ziz]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ziz]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZIZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ziz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZIZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD3:3-DEAZA-ADENOSINE'>AD3</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AD3:3-DEAZA-ADENOSINE'>AD3</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1li4\|1li4]], [[2zj0\|2zj0]], [[2zj1\|2zj1]], [[3ce6\|3ce6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1li4\|1li4]], [[2zj0\|2zj0]], [[2zj1\|2zj1]], [[3ce6\|3ce6]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ahcY, sahH, Rv3248c, MT3346, MTCY20B11.23c ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ahcY, sahH, Rv3248c, MT3346, MTCY20B11.23c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ziz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ziz OCA], [~~http~~://pdbe.org/2ziz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ziz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ziz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ziz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ziz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ziz OCA], [https://pdbe.org/2ziz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ziz RCSB], [https://www.ebi.ac.uk/pdbsum/2ziz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ziz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SAHH_MYCTU SAHH_MYCTU]] May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity).[HAMAP-Rule:MF_00563]	+	[[https://www.uniprot.org/uniprot/SAHH_MYCTU SAHH_MYCTU]] May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity).[HAMAP-Rule:MF_00563]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Adenosylhomocysteinase]]		[[Category: Adenosylhomocysteinase]]
		+	[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Gokulan, K]]		[[Category: Gokulan, K]]

OCA at 07:12, 18 October 2018

OCA — Thu, 18 Oct 2018 07:12:18 GMT

←Older revision		Revision as of 07:12, 18 October 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zi/2ziz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zi/2ziz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:07, 5 August 2016

OCA — Fri, 05 Aug 2016 11:07:04 GMT

←Older revision		Revision as of 11:07, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with NAD and 3-deazaadenosine==		==Crystal structure of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with NAD and 3-deazaadenosine==
	<StructureSection load='2ziz' size='340' side='right' caption='[[2ziz]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2ziz' size='340' side='right' caption='[[2ziz]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ziz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZIZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ziz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZIZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD3:3-DEAZA-ADENOSINE'>AD3</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD3:3-DEAZA-ADENOSINE'>AD3</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1li4\|1li4]], [[2zj0\|2zj0]], [[2zj1\|2zj1]], [[3ce6\|3ce6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1li4\|1li4]], [[2zj0\|2zj0]], [[2zj1\|2zj1]], [[3ce6\|3ce6]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ahcY, sahH, Rv3248c, MT3346, MTCY20B11.23c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1773 Mycobacterium tuberculosis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ahcY, sahH, Rv3248c, MT3346, MTCY20B11.23c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ziz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ziz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ziz RCSB], [http://www.ebi.ac.uk/pdbsum/2ziz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ziz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ziz OCA], [http://pdbe.org/2ziz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ziz RCSB], [http://www.ebi.ac.uk/pdbsum/2ziz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ziz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ziz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ziz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Adenosylhomocysteinase]]		[[Category: Adenosylhomocysteinase]]
-	[[Category: ~~Mycobacterium tuberculosis~~]]	+	[[Category: Myctu]]
	[[Category: Gokulan, K]]		[[Category: Gokulan, K]]
	[[Category: Ioerger, T R]]		[[Category: Ioerger, T R]]

OCA at 18:17, 25 December 2014

OCA — Thu, 25 Dec 2014 18:17:49 GMT

←Older revision		Revision as of 18:17, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ziz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZIZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ziz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZIZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD3:3-DEAZA-ADENOSINE'>AD3</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD3:3-DEAZA-ADENOSINE'>AD3</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1li4\|1li4]], [[2zj0\|2zj0]], [[2zj1\|2zj1]], [[3ce6\|3ce6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1li4\|1li4]], [[2zj0\|2zj0]], [[2zj1\|2zj1]], [[3ce6\|3ce6]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ahcY, sahH, Rv3248c, MT3346, MTCY20B11.23c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ahcY, sahH, Rv3248c, MT3346, MTCY20B11.23c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ziz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ziz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ziz RCSB], [http://www.ebi.ac.uk/pdbsum/2ziz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ziz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ziz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ziz RCSB], [http://www.ebi.ac.uk/pdbsum/2ziz PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SAHH_MYCTU SAHH_MYCTU]] May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity).[HAMAP-Rule:MF_00563]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Adenosylhomocysteinase]]		[[Category: Adenosylhomocysteinase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Gokulan, K.]]	+	[[Category: Gokulan, K]]
-	[[Category: Ioerger, T R.]]	+	[[Category: Ioerger, T R]]
-	[[Category: Owen, J L.]]	+	[[Category: Owen, J L]]
-	[[Category: Reddy, M C.M.]]	+	[[Category: Reddy, M C.M]]
-	[[Category: Sacchettini, J C.]]	+	[[Category: Sacchettini, J C]]
-	[[Category: Shetty, N D.]]	+	[[Category: Shetty, N D]]
	[[Category: 37 amino acid insertional region]]		[[Category: 37 amino acid insertional region]]
	[[Category: Dimer of dimer]]		[[Category: Dimer of dimer]]

OCA at 04:57, 2 October 2014

OCA — Thu, 02 Oct 2014 04:57:20 GMT

←Older revision		Revision as of 04:57, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2ziz.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with NAD and 3-deazaadenosine==
		+	<StructureSection load='2ziz' size='340' side='right' caption='[[2ziz]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ziz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZIZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD3:3-DEAZA-ADENOSINE'>AD3</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1li4\|1li4]], [[2zj0\|2zj0]], [[2zj1\|2zj1]], [[3ce6\|3ce6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ahcY, sahH, Rv3248c, MT3346, MTCY20B11.23c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ziz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ziz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ziz RCSB], [http://www.ebi.ac.uk/pdbsum/2ziz PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zi/2ziz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	S-adenosylhomocysteine hydrolase (SAHH) is a ubiquitous enzyme that plays a central role in methylation-based processes by maintaining the intracellular balance between S-adenosylhomocysteine (SAH) and S-adenosylmethionine. We report the first prokaryotic crystal structure of SAHH, from Mycobacterium tuberculosis (Mtb), in complex with adenosine (ADO) and nicotinamide adenine dinucleotide. Structures of complexes with three inhibitors are also reported: 3'-keto aristeromycin (ARI), 2-fluoroadenosine, and 3-deazaadenosine. The ARI complex is the first reported structure of SAHH complexed with this inhibitor, and confirms the oxidation of the 3' hydroxyl to a planar keto group, consistent with its prediction as a mechanism-based inhibitor. We demonstrate the in vivo enzyme inhibition activity of the three inhibitors and also show that 2-fluoradenosine has bactericidal activity. While most of the residues lining the ADO-binding pocket are identical between Mtb and human SAHH, less is known about the binding mode of the homocysteine (HCY) appendage of the full substrate. We report the 2.0 A resolution structure of the complex of SAHH cocrystallized with SAH. The most striking change in the structure is that binding of HCY forces a rotation of His363 around the backbone to flip out of contact with the 5' hydroxyl of the ADO and opens access to a nearby channel that leads to the surface. This complex suggests that His363 acts as a switch that opens up to permit binding of substrate, then closes down after release of the cleaved HCY. Differences in the entrance to this access channel between human and Mtb SAHH are identified.

-	~~{{STRUCTURE_2ziz\| PDB=2ziz \| SCENE= }}~~	+	Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.,Reddy MC, Kuppan G, Shetty ND, Owen JL, Ioerger TR, Sacchettini JC Protein Sci. 2008 Dec;17(12):2134-44. Epub 2008 Sep 24. PMID:18815415<ref>PMID:18815415</ref>

-	~~===Crystal structure~~ of ~~Mycobacterium tuberculosis~~ S~~-adenosyl-L-homocysteine hydrolase in ternary complex with NAD and 3-deazaadenosine===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_18815415}}~~	+	==See Also==
-		+	*[[S-adenosylhomocysteine hydrolase\|S-adenosylhomocysteine hydrolase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2ziz~~]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIZ OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:018815415<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Adenosylhomocysteinase]]		[[Category: Adenosylhomocysteinase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA: Protected "2ziz" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 22:09:53 GMT

Protected "2ziz" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:09, 7 January 2013

OCA at 22:09, 7 January 2013

OCA — Mon, 07 Jan 2013 22:09:50 GMT

←Older revision		Revision as of 22:09, 7 January 2013
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-	{{Seed}}
	[[Image:2ziz.png\|left\|200px]]		[[Image:2ziz.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2ziz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2ziz\| PDB=2ziz \| SCENE= }}		{{STRUCTURE_2ziz\| PDB=2ziz \| SCENE= }}

	===Crystal structure of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with NAD and 3-deazaadenosine===		===Crystal structure of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with NAD and 3-deazaadenosine===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18815415}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18815415 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18815415}}		{{ABSTRACT_PUBMED_18815415}}

	==About this Structure==		==About this Structure==
-	~~2ZIZ~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis_h37rv~~ Mycobacterium tuberculosis ~~h37rv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIZ OCA].	+	[[2ziz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIZ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18815415~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018815415</ref><references group="xtra"/>
	[[Category: Adenosylhomocysteinase]]		[[Category: Adenosylhomocysteinase]]
-	[[Category: Mycobacterium tuberculosis ~~h37rv~~]]	+	[[Category: Mycobacterium tuberculosis]]
	[[Category: Gokulan, K.]]		[[Category: Gokulan, K.]]
	[[Category: Ioerger, T R.]]		[[Category: Ioerger, T R.]]
Line 33:		Line 21:
	[[Category: Shetty, N D.]]		[[Category: Shetty, N D.]]
	[[Category: 37 amino acid insertional region]]		[[Category: 37 amino acid insertional region]]
-	[[Category: Cytoplasm]]
	[[Category: Dimer of dimer]]		[[Category: Dimer of dimer]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
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	[[Category: One-carbon metabolism]]		[[Category: One-carbon metabolism]]
	[[Category: Protein-substrate complex]]		[[Category: Protein-substrate complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 01:55:23 2009''

OCA at 23:55, 17 February 2009

OCA — Tue, 17 Feb 2009 23:55:25 GMT

←Older revision		Revision as of 23:55, 17 February 2009
Line 23:		Line 23:

	==Reference==		==Reference==
-	Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors., Reddy MC, Kuppan G, Shetty ND, Owen JL, Ioerger TR, Sacchettini JC, Protein Sci. 2008 Dec;17(12):2134-44. Epub 2008 Sep 24. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18815415 18815415]~~	+	<ref group="xtra">PMID:18815415</ref><references group="xtra"/>
	[[Category: Adenosylhomocysteinase]]		[[Category: Adenosylhomocysteinase]]
	[[Category: Mycobacterium tuberculosis h37rv]]		[[Category: Mycobacterium tuberculosis h37rv]]
Line 40:		Line 40:
	[[Category: Protein-substrate complex]]		[[Category: Protein-substrate complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 10 15~~:50:~~52 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 01:55:23 2009''

OCA at 13:50, 10 December 2008

OCA — Wed, 10 Dec 2008 13:50:52 GMT

←Older revision		Revision as of 13:50, 10 December 2008
Line 26:		Line 26:
	[[Category: Adenosylhomocysteinase]]		[[Category: Adenosylhomocysteinase]]
	[[Category: Mycobacterium tuberculosis h37rv]]		[[Category: Mycobacterium tuberculosis h37rv]]
-	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx~~:~~audit_author~~.]]	+	[[Category: Gokulan, K.]]
		+	[[Category: Ioerger, T R.]]
		+	[[Category: Owen, J L.]]
		+	[[Category: Reddy, M C.M.]]
		+	[[Category: Sacchettini, J C.]]
		+	[[Category: Shetty, N D.]]
	[[Category: 37 amino acid insertional region]]		[[Category: 37 amino acid insertional region]]
	[[Category: Cytoplasm]]		[[Category: Cytoplasm]]
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	[[Category: Protein-substrate complex]]		[[Category: Protein-substrate complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri~~ Dec ~~5 09~~:47:21 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 15:50:52 2008''