2zjm - Revision history

OCA at 13:38, 1 November 2023

OCA — Wed, 01 Nov 2023 13:38:43 GMT

←Older revision

Revision as of 13:38, 1 November 2023

OCA at 07:16, 10 November 2021

OCA — Wed, 10 Nov 2021 07:16:46 GMT

←Older revision		Revision as of 07:16, 10 November 2021
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	==Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide==		==Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide==
-	<StructureSection load='2zjm' size='340' side='right' caption='[[2zjm]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2zjm' size='340' side='right'caption='[[2zjm]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zjm]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZJM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zjm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZJM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F1M:N-{1-[5-CHLORO-3-METHOXY-2-(1-METHYLETHOXY)BENZYL]PIPERIDIN-4-YL}-2-(4-SULFAMOYLPHENOXY)ACETAMIDE'>F1M</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F1M:N-{1-[5-CHLORO-3-METHOXY-2-(1-METHYLETHOXY)BENZYL]PIPERIDIN-4-YL}-2-(4-SULFAMOYLPHENOXY)ACETAMIDE'>F1M</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zjh\|2zjh]], [[2zji\|2zji]], [[2zjj\|2zjj]], [[2zjk\|2zjk]], [[2zjl\|2zjl]], [[2zjn\|2zjn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zjh\|2zjh]], [[2zji\|2zji]], [[2zjj\|2zjj]], [[2zjk\|2zjk]], [[2zjl\|2zjl]], [[2zjn\|2zjn]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjm OCA], [~~http~~://pdbe.org/2zjm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zjm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zjm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zjm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjm OCA], [https://pdbe.org/2zjm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zjm RCSB], [https://www.ebi.ac.uk/pdbsum/2zjm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zjm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>	+	[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Beta secretase\|Beta secretase]]	+	*[[Beta secretase 3D structures\|Beta secretase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Allison, T J]]		[[Category: Allison, T J]]

OCA at 07:18, 18 October 2018

OCA — Thu, 18 Oct 2018 07:18:17 GMT

←Older revision		Revision as of 07:18, 18 October 2018
Line 1:		Line 1:
		+
	==Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide==		==Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide==
	<StructureSection load='2zjm' size='340' side='right' caption='[[2zjm]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2zjm' size='340' side='right' caption='[[2zjm]], [[Resolution\|resolution]] 1.90Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjm OCA], [http://pdbe.org/2zjm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zjm RCSB], [http://www.ebi.ac.uk/pdbsum/2zjm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjm OCA], [http://pdbe.org/2zjm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zjm RCSB], [http://www.ebi.ac.uk/pdbsum/2zjm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zjm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zj/2zjm_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zj/2zjm_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 35:
	[[Category: Pham, P]]		[[Category: Pham, P]]
	[[Category: Romanowski, M J]]		[[Category: Romanowski, M J]]
		+	[[Category: Alternative splicing]]
	[[Category: Aspartyl protease]]		[[Category: Aspartyl protease]]
	[[Category: Bace]]		[[Category: Bace]]

OCA at 15:07, 8 February 2016

OCA — Mon, 08 Feb 2016 15:07:02 GMT

←Older revision		Revision as of 15:07, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2zjm' size='340' side='right' caption='[[2zjm]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2zjm' size='340' side='right' caption='[[2zjm]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zjm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZJM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zjm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZJM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F1M:N-{1-[5-CHLORO-3-METHOXY-2-(1-METHYLETHOXY)BENZYL]PIPERIDIN-4-YL}-2-(4-SULFAMOYLPHENOXY)ACETAMIDE'>F1M</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F1M:N-{1-[5-CHLORO-3-METHOXY-2-(1-METHYLETHOXY)BENZYL]PIPERIDIN-4-YL}-2-(4-SULFAMOYLPHENOXY)ACETAMIDE'>F1M</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zjh\|2zjh]], [[2zji\|2zji]], [[2zjj\|2zjj]], [[2zjk\|2zjk]], [[2zjl\|2zjl]], [[2zjn\|2zjn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zjh\|2zjh]], [[2zji\|2zji]], [[2zjj\|2zjj]], [[2zjk\|2zjk]], [[2zjl\|2zjl]], [[2zjn\|2zjn]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zjm RCSB], [http://www.ebi.ac.uk/pdbsum/2zjm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjm OCA], [http://pdbe.org/2zjm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zjm RCSB], [http://www.ebi.ac.uk/pdbsum/2zjm PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zjm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Allison, T J]]		[[Category: Allison, T J]]

OCA at 00:13, 25 December 2014

OCA — Thu, 25 Dec 2014 00:13:58 GMT

←Older revision		Revision as of 00:13, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zjm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZJM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zjm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZJM FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F1M:N-{1-[5-CHLORO-3-METHOXY-2-(1-METHYLETHOXY)BENZYL]PIPERIDIN-4-YL}-2-(4-SULFAMOYLPHENOXY)ACETAMIDE'>F1M</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F1M:N-{1-[5-CHLORO-3-METHOXY-2-(1-METHYLETHOXY)BENZYL]PIPERIDIN-4-YL}-2-(4-SULFAMOYLPHENOXY)ACETAMIDE'>F1M</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zjh\|2zjh]], [[2zji\|2zji]], [[2zjj\|2zjj]], [[2zjk\|2zjk]], [[2zjl\|2zjl]], [[2zjn\|2zjn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zjh\|2zjh]], [[2zji\|2zji]], [[2zjj\|2zjj]], [[2zjk\|2zjk]], [[2zjl\|2zjl]], [[2zjn\|2zjn]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zjm RCSB], [http://www.ebi.ac.uk/pdbsum/2zjm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zjm RCSB], [http://www.ebi.ac.uk/pdbsum/2zjm PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 22:		Line 24:
	==See Also==		==See Also==
	*[[Beta secretase\|Beta secretase]]		*[[Beta secretase\|Beta secretase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
-	[[Category: Allison, T J.]]	+	[[Category: Allison, T J]]
-	[[Category: Munshi, S K.]]	+	[[Category: Munshi, S K]]
-	[[Category: Pham, P.]]	+	[[Category: Pham, P]]
-	[[Category: Romanowski, M J.]]	+	[[Category: Romanowski, M J]]
	[[Category: Aspartyl protease]]		[[Category: Aspartyl protease]]
	[[Category: Bace]]		[[Category: Bace]]

OCA at 10:06, 29 September 2014

OCA — Mon, 29 Sep 2014 10:06:26 GMT

←Older revision		Revision as of 10:06, 29 September 2014
Line 1:		Line 1:
-	~~[[Image:2zjm.png\|left\|200px]]~~	+	==Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide==
-		+	<StructureSection load='2zjm' size='340' side='right' caption='[[2zjm]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{STRUCTURE_2zjm\| PDB=2zjm \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2zjm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZJM FirstGlance]. <br>
-	===Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F1M:N-{1-[5-CHLORO-3-METHOXY-2-(1-METHYLETHOXY)BENZYL]PIPERIDIN-4-YL}-2-(4-SULFAMOYLPHENOXY)ACETAMIDE'>F1M</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zjh\|2zjh]], [[2zji\|2zji]], [[2zjj\|2zjj]], [[2zjk\|2zjk]], [[2zjl\|2zjl]], [[2zjn\|2zjn]]</td></tr>
-	~~{{ABSTRACT_PUBMED_019284778}}~~	+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	==~~About this Structure~~==	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zjm RCSB], [http://www.ebi.ac.uk/pdbsum/2zjm PDBsum]</span></td></tr>
-	[[2zjm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJM OCA].	+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zj/2zjm_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Beta secretase\|Beta secretase]]		*[[Beta secretase\|Beta secretase]]
-		+	__TOC__
-	~~==Reference==~~	+	</StructureSection>
-	~~<ref group="xtra">PMID:019284778</ref>~~<~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]

OCA at 10:33, 20 October 2012

OCA — Sat, 20 Oct 2012 10:33:28 GMT

←Older revision		Revision as of 10:33, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2zjm]] is a 1 chain structure ~~of [[Beta secretase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJM OCA].	+	[[2zjm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJM OCA].

	==See Also==		==See Also==

OCA: Protected "2zjm" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 02:30:48 GMT

Protected "2zjm" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:30, 26 July 2012

OCA at 02:30, 26 July 2012

OCA — Thu, 26 Jul 2012 02:30:46 GMT

←Older revision		Revision as of 02:30, 26 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2zjm.png\|left\|200px]]
-	[[Image:2zjm.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zjm", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zjm\| PDB=2zjm \| SCENE= }}		{{STRUCTURE_2zjm\| PDB=2zjm \| SCENE= }}

	===Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide===		===Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide===

		+	{{ABSTRACT_PUBMED_019284778}}

	==About this Structure==		==About this Structure==
-	~~2ZJM~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJM OCA].	+	[[2zjm]] is a 1 chain structure of [[Beta secretase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJM OCA].
		+
		+	==See Also==
		+	*[[Beta secretase\|Beta secretase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:019284778</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
Line 21:		Line 21:
	[[Category: Pham, P.]]		[[Category: Pham, P.]]
	[[Category: Romanowski, M J.]]		[[Category: Romanowski, M J.]]
-	[[Category: Alternative splicing]]
	[[Category: Aspartyl protease]]		[[Category: Aspartyl protease]]
	[[Category: Bace]]		[[Category: Bace]]
Line 32:		Line 31:
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	[[Category: Zymogen]]		[[Category: Zymogen]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 10:40:38 2009''

OCA at 08:40, 21 January 2009

OCA — Wed, 21 Jan 2009 08:40:39 GMT

←Older revision		Revision as of 08:40, 21 January 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2zjm.jpg\|left\|200px]]

-	The ~~entry 2zjm~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2zjm", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2zjm\| PDB=2zjm \| SCENE= }}

-	~~Authors: Yang, W., Fucini, R.V., Fahr, B.T., Randal, M., Lind, K.E., Lam, M.B., Lu, W., Lu, Y., Cary, D.R., Romanowski, M.J.~~	+	===Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide===

-	Description: Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide

		+	==About this Structure==
		+	2ZJM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJM OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Memapsin 2]]
		+	[[Category: Allison, T J.]]
		+	[[Category: Munshi, S K.]]
		+	[[Category: Pham, P.]]
		+	[[Category: Romanowski, M J.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Aspartyl protease]]
		+	[[Category: Bace]]
		+	[[Category: Fragment-based discovery]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Hydrolase]]
		+	[[Category: Membrane]]
		+	[[Category: Protease]]
		+	[[Category: Small-molecule inhibitor]]
		+	[[Category: Transmembrane]]
		+	[[Category: Zymogen]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 11 09:~~10:~~37 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 10:40:38 2009''