2zku - Revision history

OCA at 18:46, 20 September 2023

OCA — Wed, 20 Sep 2023 18:46:13 GMT

←Older revision		Revision as of 18:46, 20 September 2023
Line 3:		Line 3:
	<StructureSection load='2zku' size='340' side='right'caption='[[2zku]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2zku' size='340' side='right'caption='[[2zku]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zku]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Hepatitis_c_virus_subtype_1b~~ Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZKU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zku]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_subtype_1b Hepatitis C virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZKU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>NS5B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~31647 Hepatitis C virus subtype 1b])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zku OCA], [https://pdbe.org/2zku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zku RCSB], [https://www.ebi.ac.uk/pdbsum/2zku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zku ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zku OCA], [https://pdbe.org/2zku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zku RCSB], [https://www.ebi.ac.uk/pdbsum/2zku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zku ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/POLG_HCVBK POLG_HCVBK] Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis) (By similarity).<ref>PMID:9710605</ref> <ref>PMID:16530520</ref> <ref>PMID:17188392</ref> E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection (By similarity).<ref>PMID:9710605</ref> <ref>PMID:16530520</ref> <ref>PMID:17188392</ref> P7 seems to be a heptameric ion channel protein (viroporin) and is inhibited by the antiviral drug amantadine. Also inhibited by long-alkyl-chain iminosugar derivatives. Essential for infectivity (By similarity).<ref>PMID:9710605</ref> <ref>PMID:16530520</ref> <ref>PMID:17188392</ref> Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. Seems to undergo self-inactivation following maturation (By similarity).<ref>PMID:9710605</ref> <ref>PMID:16530520</ref> <ref>PMID:17188392</ref> NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS3/NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand. Cleaves and inhibits the host antiviral protein MAVS (By similarity).<ref>PMID:9710605</ref> <ref>PMID:16530520</ref> <ref>PMID:17188392</ref> NS4B induces a specific membrane alteration that serves as a scaffold for the virus replication complex. This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex (By similarity).<ref>PMID:9710605</ref> <ref>PMID:16530520</ref> <ref>PMID:17188392</ref> NS5A is a component of the replication complex involved in RNA-binding. Its interaction with Human VAPB may target the viral replication complex to vesicles. Down-regulates viral IRES translation initiation. Mediates interferon resistance, presumably by interacting with and inhibiting human EIF2AK2/PKR. Seems to inhibit apoptosis by interacting with BIN1 and FKBP8. The hyperphosphorylated form of NS5A is an inhibitor of viral replication (By similarity).<ref>PMID:9710605</ref> <ref>PMID:16530520</ref> <ref>PMID:17188392</ref> NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication (By similarity).<ref>PMID:9710605</ref> <ref>PMID:16530520</ref> <ref>PMID:17188392</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Hepatitis c virus subtype 1b]]	+	[[Category: Hepatitis C virus subtype 1b]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: RNA-directed RNA polymerase]]~~	+	[[Category: Biswal BK]]
-	[[Category: Biswal~~, B K]]~~	+
-	~~[[Category: Allosteric nucleotide binding site]]~~	+
-	~~[[Category: Envelope protein]]~~	+
-	~~[[Category: Helicase]]~~	+
-	~~[[Category: Hepatitis c virus]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Oligomerisation]]~~	+
-	~~[[Category: Rna replication]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 17:32, 15 December 2021

OCA — Wed, 15 Dec 2021 17:32:07 GMT

←Older revision		Revision as of 17:32, 15 December 2021
Line 1:		Line 1:

	==Structure of hepatitis C virus NS5B polymerase in a new crystal form==		==Structure of hepatitis C virus NS5B polymerase in a new crystal form==
-	<StructureSection load='2zku' size='340' side='right' caption='[[2zku]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='2zku' size='340' side='right'caption='[[2zku]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zku]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZKU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZKU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zku]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZKU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS5B ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=31647 Hepatitis C virus subtype 1b])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS5B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=31647 Hepatitis C virus subtype 1b])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zku OCA], [~~http~~://pdbe.org/2zku PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zku RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zku PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zku ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zku OCA], [https://pdbe.org/2zku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zku RCSB], [https://www.ebi.ac.uk/pdbsum/2zku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zku ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Hepatitis c virus subtype 1b]]		[[Category: Hepatitis c virus subtype 1b]]
		+	[[Category: Large Structures]]
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]
	[[Category: Biswal, B K]]		[[Category: Biswal, B K]]

OCA at 10:15, 11 August 2016

OCA — Thu, 11 Aug 2016 10:15:35 GMT

←Older revision		Revision as of 10:15, 11 August 2016
Line 1:		Line 1:
		+
	==Structure of hepatitis C virus NS5B polymerase in a new crystal form==		==Structure of hepatitis C virus NS5B polymerase in a new crystal form==
	<StructureSection load='2zku' size='340' side='right' caption='[[2zku]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2zku' size='340' side='right' caption='[[2zku]], [[Resolution\|resolution]] 1.95Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS5B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=31647 Hepatitis C virus subtype 1b])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS5B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=31647 Hepatitis C virus subtype 1b])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zku RCSB], [http://www.ebi.ac.uk/pdbsum/2zku PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zku OCA], [http://pdbe.org/2zku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zku RCSB], [http://www.ebi.ac.uk/pdbsum/2zku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zku ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 11:05, 25 January 2015

OCA — Sun, 25 Jan 2015 11:05:57 GMT

←Older revision		Revision as of 11:05, 25 January 2015
Line 12:		Line 12:
	[[Category: Hepatitis c virus subtype 1b]]		[[Category: Hepatitis c virus subtype 1b]]
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]
-	[[Category: Biswal, B K.]]	+	[[Category: Biswal, B K]]
	[[Category: Allosteric nucleotide binding site]]		[[Category: Allosteric nucleotide binding site]]
	[[Category: Envelope protein]]		[[Category: Envelope protein]]

OCA at 12:04, 29 October 2014

OCA — Wed, 29 Oct 2014 12:04:39 GMT

←Older revision		Revision as of 12:04, 29 October 2014
Line 1:		Line 1:
-	~~[[Image:2zku.png\|left\|200px]]~~	+	==Structure of hepatitis C virus NS5B polymerase in a new crystal form==
-		+	<StructureSection load='2zku' size='340' side='right' caption='[[2zku]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	~~{{STRUCTURE_2zku\| PDB=2zku \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2zku]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZKU FirstGlance]. <br>
-	===Structure of hepatitis C virus NS5B polymerase in a new crystal form===	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS5B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=31647 Hepatitis C virus subtype 1b])</td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
-	==~~About this Structure~~==	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zku RCSB], [http://www.ebi.ac.uk/pdbsum/2zku PDBsum]</span></td></tr>
-	[[2zku]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZKU OCA].	+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Hepatitis c virus subtype 1b]]		[[Category: Hepatitis c virus subtype 1b]]
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]

OCA: Protected "2zku" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 20:11:30 GMT

Protected "2zku" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:11, 7 January 2013

OCA at 20:11, 7 January 2013

OCA — Mon, 07 Jan 2013 20:11:25 GMT

←Older revision		Revision as of 20:11, 7 January 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2zku.png\|left\|200px]]
-	[[Image:2zku.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zku", creates the "Structure Box" on the page.
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zku\| PDB=2zku \| SCENE= }}		{{STRUCTURE_2zku\| PDB=2zku \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	~~2ZKU~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZKU OCA].	+	[[2zku]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZKU OCA].
	[[Category: Hepatitis c virus subtype 1b]]		[[Category: Hepatitis c virus subtype 1b]]
	[[Category: RNA-directed RNA polymerase]]		[[Category: RNA-directed RNA polymerase]]
Line 28:		Line 21:
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 9 12:21:50 2009''

OCA at 09:21, 9 April 2009

OCA — Thu, 09 Apr 2009 09:21:51 GMT

←Older revision		Revision as of 09:21, 9 April 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2zku.jpg\|left\|200px]]

-	The ~~entry 2zku~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2zku", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2zku\| PDB=2zku \| SCENE= }}

-	~~Authors: Biswal, B.K., Cherney, M.M., Chan, L., Yannopoulos,~~ C~~.G., Bilimoria, D., Bedard, J., James, M.N.G.~~	+	===Structure of hepatitis C virus NS5B polymerase in a new crystal form===

-	Description: Structure of hepatitis C virus NS5B polymerase in a new crystal form

		+	==About this Structure==
		+	2ZKU is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZKU OCA].
		+	[[Category: Hepatitis c virus subtype 1b]]
		+	[[Category: RNA-directed RNA polymerase]]
		+	[[Category: Biswal, B K.]]
		+	[[Category: Allosteric nucleotide binding site]]
		+	[[Category: Envelope protein]]
		+	[[Category: Helicase]]
		+	[[Category: Hepatitis c virus]]
		+	[[Category: Hydrolase]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Oligomerisation]]
		+	[[Category: Rna replication]]
		+	[[Category: Transferase]]
		+	[[Category: Transmembrane]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jun 11 09~~:20:~~06 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 9 12:21:50 2009''

OCA: New page: '''Unreleased structure''' The entry 2zku is ON HOLD until Paper Publication Authors: Biswal, B.K., Cherney, M.M., Chan, L., Yannopoulos, C.G., Bilimoria, D., Bedard, J., James, M.N.G. ...

OCA — Wed, 11 Jun 2008 06:20:07 GMT

New page: '''Unreleased structure''' The entry 2zku is ON HOLD until Paper Publication Authors: Biswal, B.K., Cherney, M.M., Chan, L., Yannopoulos, C.G., Bilimoria, D., Bedard, J., James, M.N.G. ...

New page

'''Unreleased structure'''

The entry 2zku is ON HOLD until Paper Publication

Authors: Biswal, B.K., Cherney, M.M., Chan, L., Yannopoulos, C.G., Bilimoria, D., Bedard, J., James, M.N.G.

Description: Structure of hepatitis C virus NS5B polymerase in a new crystal form

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 09:20:06 2008''