2zme - Revision history

OCA at 13:43, 1 November 2023

OCA — Wed, 01 Nov 2023 13:43:34 GMT

←Older revision		Revision as of 13:43, 1 November 2023
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	<StructureSection load='2zme' size='340' side='right'caption='[[2zme]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2zme' size='340' side='right'caption='[[2zme]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zme]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZME FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zme]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZME FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3cuq\|3cuq]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">SNF8, EAP30 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&srchmode=5&id=9606 HUMAN]), VPS36, C13orf9, EAP45 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), VPS25, DERP9, EAP20 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zme OCA], [https://pdbe.org/2zme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zme RCSB], [https://www.ebi.ac.uk/pdbsum/2zme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zme ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zme OCA], [https://pdbe.org/2zme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zme RCSB], [https://www.ebi.ac.uk/pdbsum/2zme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zme ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SNF8_HUMAN SNF8_HUMAN]] Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.<ref>PMID:17959629</ref> <ref>PMID:17714434</ref> <ref>PMID:18031739</ref> [[https://www.uniprot.org/uniprot/VPS25_HUMAN VPS25_HUMAN]] Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses.<ref>PMID:18723511</ref> [[https://www.uniprot.org/uniprot/VPS36_HUMAN VPS36_HUMAN]] Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.<ref>PMID:15755741</ref>	+	[https://www.uniprot.org/uniprot/SNF8_HUMAN SNF8_HUMAN] Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.<ref>PMID:17959629</ref> <ref>PMID:17714434</ref> <ref>PMID:18031739</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hurley~~, J H~~]]	+	[[Category: Hurley JH]]
-	[[Category: Im~~, Y J]]~~	+	[[Category: Im YJ]]
-	~~[[Category: Endosome]]~~	+
-	~~[[Category: Escrt]]~~	+
-	~~[[Category: Lipid-binding]]~~	+
-	~~[[Category: Mbv]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Sorting]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Transport]]~~	+
-	~~[[Category: Vp~~]]	+

OCA at 17:32, 15 December 2021

OCA — Wed, 15 Dec 2021 17:32:48 GMT

←Older revision		Revision as of 17:32, 15 December 2021
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	==Integrated structural and functional model of the human ESCRT-II complex==		==Integrated structural and functional model of the human ESCRT-II complex==
-	<StructureSection load='2zme' size='340' side='right' caption='[[2zme]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='2zme' size='340' side='right'caption='[[2zme]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zme]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZME OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZME FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zme]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZME FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cuq\|3cuq]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3cuq\|3cuq]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNF8, EAP30 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), VPS36, C13orf9, EAP45 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), VPS25, DERP9, EAP20 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNF8, EAP30 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), VPS36, C13orf9, EAP45 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), VPS25, DERP9, EAP20 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zme OCA], [~~http~~://pdbe.org/2zme PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zme RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zme PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zme ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zme OCA], [https://pdbe.org/2zme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zme RCSB], [https://www.ebi.ac.uk/pdbsum/2zme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zme ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SNF8_HUMAN SNF8_HUMAN]] Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.<ref>PMID:17959629</ref> <ref>PMID:17714434</ref> <ref>PMID:18031739</ref> [[~~http~~://www.uniprot.org/uniprot/VPS25_HUMAN VPS25_HUMAN]] Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses.<ref>PMID:18723511</ref> [[~~http~~://www.uniprot.org/uniprot/VPS36_HUMAN VPS36_HUMAN]] Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.<ref>PMID:15755741</ref>	+	[[https://www.uniprot.org/uniprot/SNF8_HUMAN SNF8_HUMAN]] Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.<ref>PMID:17959629</ref> <ref>PMID:17714434</ref> <ref>PMID:18031739</ref> [[https://www.uniprot.org/uniprot/VPS25_HUMAN VPS25_HUMAN]] Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses.<ref>PMID:18723511</ref> [[https://www.uniprot.org/uniprot/VPS36_HUMAN VPS36_HUMAN]] Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.<ref>PMID:15755741</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 2zme" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2zme" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Vacuolar protein sorting-associated protein 3D structures\|Vacuolar protein sorting-associated protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hurley, J H]]		[[Category: Hurley, J H]]
	[[Category: Im, Y J]]		[[Category: Im, Y J]]

OCA at 07:27, 18 October 2018

OCA — Thu, 18 Oct 2018 07:27:58 GMT

←Older revision		Revision as of 07:27, 18 October 2018
Line 1:		Line 1:
		+
	==Integrated structural and functional model of the human ESCRT-II complex==		==Integrated structural and functional model of the human ESCRT-II complex==
	<StructureSection load='2zme' size='340' side='right' caption='[[2zme]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2zme' size='340' side='right' caption='[[2zme]], [[Resolution\|resolution]] 2.90Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cuq\|3cuq]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cuq\|3cuq]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNF8, EAP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), VPS36, C13orf9, EAP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), VPS25, DERP9, EAP20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNF8, EAP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), VPS36, C13orf9, EAP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), VPS25, DERP9, EAP20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zme OCA], [http://pdbe.org/2zme PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zme RCSB], [http://www.ebi.ac.uk/pdbsum/2zme PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zme OCA], [http://pdbe.org/2zme PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zme RCSB], [http://www.ebi.ac.uk/pdbsum/2zme PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zme ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zm/2zme_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zm/2zme_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:06, 9 February 2016

OCA — Tue, 09 Feb 2016 21:06:10 GMT

←Older revision		Revision as of 21:06, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2zme' size='340' side='right' caption='[[2zme]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2zme' size='340' side='right' caption='[[2zme]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zme]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZME FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zme]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZME FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cuq\|3cuq]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cuq\|3cuq]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNF8, EAP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), VPS36, C13orf9, EAP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), VPS25, DERP9, EAP20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNF8, EAP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), VPS36, C13orf9, EAP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), VPS25, DERP9, EAP20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zme OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zme RCSB], [http://www.ebi.ac.uk/pdbsum/2zme PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zme OCA], [http://pdbe.org/2zme PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zme RCSB], [http://www.ebi.ac.uk/pdbsum/2zme PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zme ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2zme" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hurley, J H]]		[[Category: Hurley, J H]]
	[[Category: Im, Y J]]		[[Category: Im, Y J]]

OCA at 09:32, 25 December 2014

OCA — Thu, 25 Dec 2014 09:32:31 GMT

←Older revision		Revision as of 09:32, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zme]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZME FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zme]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZME FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cuq\|3cuq]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cuq\|3cuq]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNF8, EAP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), VPS36, C13orf9, EAP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), VPS25, DERP9, EAP20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNF8, EAP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), VPS36, C13orf9, EAP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), VPS25, DERP9, EAP20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zme OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zme RCSB], [http://www.ebi.ac.uk/pdbsum/2zme PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zme OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zme RCSB], [http://www.ebi.ac.uk/pdbsum/2zme PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SNF8_HUMAN SNF8_HUMAN]] Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.<ref>PMID:17959629</ref> <ref>PMID:17714434</ref> <ref>PMID:18031739</ref> [[http://www.uniprot.org/uniprot/VPS25_HUMAN VPS25_HUMAN]] Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses.<ref>PMID:18723511</ref> [[http://www.uniprot.org/uniprot/VPS36_HUMAN VPS36_HUMAN]] Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.<ref>PMID:15755741</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hurley, J H.]]	+	[[Category: Hurley, J H]]
-	[[Category: Im, Y J.]]	+	[[Category: Im, Y J]]
	[[Category: Endosome]]		[[Category: Endosome]]
	[[Category: Escrt]]		[[Category: Escrt]]

OCA at 05:08, 2 October 2014

OCA — Thu, 02 Oct 2014 05:08:54 GMT

←Older revision		Revision as of 05:08, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2zme.~~png~~\|~~left~~\|200px]]	+	==Integrated structural and functional model of the human ESCRT-II complex==
		+	<StructureSection load='2zme' size='340' side='right' caption='[[2zme]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2zme]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZME FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cuq\|3cuq]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNF8, EAP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), VPS36, C13orf9, EAP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), VPS25, DERP9, EAP20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zme OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zme RCSB], [http://www.ebi.ac.uk/pdbsum/2zme PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zm/2zme_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ESCRT-II plays a pivotal role in receptor downregulation and multivesicular body biogenesis and is conserved from yeast to humans. The crystal structures of two human ESCRT-II complex structures have been determined at 2.6 and 2.9 A resolution, respectively. The complex has three lobes and contains one copy each of VPS22 and VPS36 and two copies of VPS25. The structure reveals a dynamic helical domain to which both the VPS22 and VPS36 subunits contribute that connects the GLUE domain to the rest of the ESCRT-II core. Hydrodynamic analysis shows that intact ESCRT-II has a compact, closed conformation. ESCRT-II binds to the ESCRT-I VPS28 C-terminal domain subunit through a helix immediately C-terminal to the VPS36-GLUE domain. ESCRT-II is targeted to endosomal membranes by the lipid-binding activities of both the Vps36 GLUE domain and the first helix of Vps22. These data provide a unifying structural and functional framework for the ESCRT-II complex.

-	~~{{STRUCTURE_2zme\| PDB=2zme \| SCENE= }}~~	+	Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex.,Im YJ, Hurley JH Dev Cell. 2008 Jun;14(6):902-13. PMID:18539118<ref>PMID:18539118</ref>

-	~~===Integrated structural and functional model~~ of the ~~human ESCRT-II complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18539118}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2zme]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ZME OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018539118<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hurley, J H.]]		[[Category: Hurley, J H.]]

OCA: Protected "2zme" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 21:03:22 GMT

Protected "2zme" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:03, 7 January 2013

OCA at 21:03, 7 January 2013

OCA — Mon, 07 Jan 2013 21:03:18 GMT

←Older revision		Revision as of 21:03, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2zme.png\|left\|200px]]		[[Image:2zme.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zme", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zme\| PDB=2zme \| SCENE= }}		{{STRUCTURE_2zme\| PDB=2zme \| SCENE= }}

	===Integrated structural and functional model of the human ESCRT-II complex===		===Integrated structural and functional model of the human ESCRT-II complex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18539118}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18539118 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18539118}}		{{ABSTRACT_PUBMED_18539118}}

	==About this Structure==		==About this Structure==
-	~~2ZME~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZME OCA].	+	[[2zme]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZME OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18539118~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018539118</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hurley, J H.]]		[[Category: Hurley, J H.]]
	[[Category: Im, Y J.]]		[[Category: Im, Y J.]]
-	[[Category: Alternative splicing]]
-	[[Category: Coiled coil]]
-	[[Category: Cytoplasm]]
	[[Category: Endosome]]		[[Category: Endosome]]
	[[Category: Escrt]]		[[Category: Escrt]]
Line 41:		Line 26:
	[[Category: Transport]]		[[Category: Transport]]
	[[Category: Vp]]		[[Category: Vp]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:44:50 2009''

OCA at 10:44, 17 February 2009

OCA — Tue, 17 Feb 2009 10:44:51 GMT

←Older revision		Revision as of 10:44, 17 February 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:2zme.~~jpg~~\|left\|200px]]	+	[[Image:2zme.png\|left\|200px]]

	<!--		<!--
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2ZME is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZME OCA].	+	2ZME is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZME OCA].

	==Reference==		==Reference==
-	~~Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex., Im YJ, Hurley JH, Dev Cell. 2008 Jun;14(6):902-13.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18539118 18539118]~~	+	<ref group="xtra">PMID:18539118</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Protein complex]]
	[[Category: Hurley, J H.]]		[[Category: Hurley, J H.]]
	[[Category: Im, Y J.]]		[[Category: Im, Y J.]]
Line 43:		Line 42:
	[[Category: Vp]]		[[Category: Vp]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Nov 5~~ 12:37:~~20 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:44:50 2009''

OCA at 10:37, 5 November 2008

OCA — Wed, 05 Nov 2008 10:37:20 GMT

←Older revision		Revision as of 10:37, 5 November 2008
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2zme.jpg\|left\|200px]]

-	The ~~entry 2zme~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2zme", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2zme\| PDB=2zme \| SCENE= }}

-	~~Authors: Im, Y.J., Hurley, J.H.~~	+	===Integrated structural and functional model of the human ESCRT-II complex===

-	Description: Integrated structural and functional model of the human ESCRT-II complex

		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18539118}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18539118 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18539118}}

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 11 09~~:21:53 2008''	+	==About this Structure==
		+	2ZME is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZME OCA].
		+
		+	==Reference==
		+	Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex., Im YJ, Hurley JH, Dev Cell. 2008 Jun;14(6):902-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18539118 18539118]
		+	[[Category: Homo sapiens]]
		+	[[Category: Protein complex]]
		+	[[Category: Hurley, J H.]]
		+	[[Category: Im, Y J.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Coiled coil]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Endosome]]
		+	[[Category: Escrt]]
		+	[[Category: Lipid-binding]]
		+	[[Category: Mbv]]
		+	[[Category: Nucleus]]
		+	[[Category: Protein transport]]
		+	[[Category: Sorting]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription regulation]]
		+	[[Category: Transport]]
		+	[[Category: Vp]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 5 12:37:20 2008''