2zqk - Revision history

OCA at 13:49, 1 November 2023

OCA — Wed, 01 Nov 2023 13:49:07 GMT

←Older revision		Revision as of 13:49, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='2zqk' size='340' side='right'caption='[[2zqk]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2zqk' size='340' side='right'caption='[[2zqk]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zqk]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Eco57 Eco57~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZQK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zqk]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZQK FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2zwk\|2zwk]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">intimin adherence protein 747-934 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=83334 ECO57]), Tir 269-336 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zqk OCA], [https://pdbe.org/2zqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zqk RCSB], [https://www.ebi.ac.uk/pdbsum/2zqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zqk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zqk OCA], [https://pdbe.org/2zqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zqk RCSB], [https://www.ebi.ac.uk/pdbsum/2zqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zqk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/EAE_ECO57 EAE_ECO57]] Necessary for the production of attaching and effacing lesions on tissue culture cells. [[https://www.uniprot.org/uniprot/TIR_ECO57 TIR_ECO57]] Multifunctional protein that is required for efficient pedestal formation in host epithelial cells during infection. The extracellular region acts as a receptor for bacterial intimin, allowing the bacterium to attach tightly to the host-cell surface. Simultaneously, the intracellular region initiates a signaling cascade in the host cell, which leads to actin polymerization and formation of actin pedestals at the sites of bacterial adhesion. In strain EDL933, acts via the effector protein EspF(U), in a phosphotyrosine- and NCK-independent manner. Tir binds to host BAIAP2, which mediates association with EspF(U) and leads to stimulation of actin polymerization.<ref>PMID:10225900</ref> <ref>PMID:14764108</ref> <ref>PMID:16922867</ref> <ref>PMID:17521329</ref>	+	[https://www.uniprot.org/uniprot/EAE_ECO57 EAE_ECO57] Necessary for the production of attaching and effacing lesions on tissue culture cells.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zqk ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zqk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Eco57~~]]	+	[[Category: Escherichia coli O157:H7]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gao, F]]	+	[[Category: Gao F]]
-	[[Category: Gao~~, G F~~]]	+	[[Category: Gao GF]]
-	[[Category: Li, D F]]	+	[[Category: Li D-F]]
-	[[Category: Ma, Y]]	+	[[Category: Ma Y]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Cell outer membrane]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Protein-protein complex]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Unique intimin-tir trimer intermediate]]~~	+
-	~~[[Category: Virulence~~]]	+

OCA at 17:35, 15 December 2021

OCA — Wed, 15 Dec 2021 17:35:32 GMT

←Older revision		Revision as of 17:35, 15 December 2021
Line 1:		Line 1:

	==Crystal structure of intimin-Tir68 complex==		==Crystal structure of intimin-Tir68 complex==
-	<StructureSection load='2zqk' size='340' side='right' caption='[[2zqk]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='2zqk' size='340' side='right'caption='[[2zqk]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zqk]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Eco57 Eco57]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZQK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zqk]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Eco57 Eco57]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZQK FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zwk\|2zwk]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zwk\|2zwk]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">intimin adherence protein 747-934 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57]), Tir 269-336 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">intimin adherence protein 747-934 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57]), Tir 269-336 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zqk OCA], [~~http~~://pdbe.org/2zqk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zqk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zqk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zqk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zqk OCA], [https://pdbe.org/2zqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zqk RCSB], [https://www.ebi.ac.uk/pdbsum/2zqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zqk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/EAE_ECO57 EAE_ECO57]] Necessary for the production of attaching and effacing lesions on tissue culture cells. [[~~http~~://www.uniprot.org/uniprot/TIR_ECO57 TIR_ECO57]] Multifunctional protein that is required for efficient pedestal formation in host epithelial cells during infection. The extracellular region acts as a receptor for bacterial intimin, allowing the bacterium to attach tightly to the host-cell surface. Simultaneously, the intracellular region initiates a signaling cascade in the host cell, which leads to actin polymerization and formation of actin pedestals at the sites of bacterial adhesion. In strain EDL933, acts via the effector protein EspF(U), in a phosphotyrosine- and NCK-independent manner. Tir binds to host BAIAP2, which mediates association with EspF(U) and leads to stimulation of actin polymerization.<ref>PMID:10225900</ref> <ref>PMID:14764108</ref> <ref>PMID:16922867</ref> <ref>PMID:17521329</ref>	+	[[https://www.uniprot.org/uniprot/EAE_ECO57 EAE_ECO57]] Necessary for the production of attaching and effacing lesions on tissue culture cells. [[https://www.uniprot.org/uniprot/TIR_ECO57 TIR_ECO57]] Multifunctional protein that is required for efficient pedestal formation in host epithelial cells during infection. The extracellular region acts as a receptor for bacterial intimin, allowing the bacterium to attach tightly to the host-cell surface. Simultaneously, the intracellular region initiates a signaling cascade in the host cell, which leads to actin polymerization and formation of actin pedestals at the sites of bacterial adhesion. In strain EDL933, acts via the effector protein EspF(U), in a phosphotyrosine- and NCK-independent manner. Tir binds to host BAIAP2, which mediates association with EspF(U) and leads to stimulation of actin polymerization.<ref>PMID:10225900</ref> <ref>PMID:14764108</ref> <ref>PMID:16922867</ref> <ref>PMID:17521329</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Eco57]]		[[Category: Eco57]]
		+	[[Category: Large Structures]]
	[[Category: Gao, F]]		[[Category: Gao, F]]
	[[Category: Gao, G F]]		[[Category: Gao, G F]]

OCA at 06:51, 18 October 2018

OCA — Thu, 18 Oct 2018 06:51:57 GMT

←Older revision		Revision as of 06:51, 18 October 2018
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zq/2zqk_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zq/2zqk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:45, 5 August 2016

OCA — Fri, 05 Aug 2016 15:45:23 GMT

←Older revision		Revision as of 15:45, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of intimin-Tir68 complex==		==Crystal structure of intimin-Tir68 complex==
	<StructureSection load='2zqk' size='340' side='right' caption='[[2zqk]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2zqk' size='340' side='right' caption='[[2zqk]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zqk]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia coli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZQK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zqk]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Eco57 Eco57]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZQK FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zwk\|2zwk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zwk\|2zwk]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">intimin adherence protein 747-934 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~562 Escherichia coli~~]), Tir 269-336 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~562 Escherichia coli~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">intimin adherence protein 747-934 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57]), Tir 269-336 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zqk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zqk RCSB], [http://www.ebi.ac.uk/pdbsum/2zqk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zqk OCA], [http://pdbe.org/2zqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zqk RCSB], [http://www.ebi.ac.uk/pdbsum/2zqk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zqk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/EAE_ECO57 EAE_ECO57]] Necessary for the production of attaching and effacing lesions on tissue culture cells. [[http://www.uniprot.org/uniprot/~~Q7DB77_ECO57 Q7DB77_ECO57~~]] Multifunctional protein that is required for efficient pedestal formation in host epithelial cells during infection. The extracellular region acts as a receptor for bacterial intimin, allowing the bacterium to attach tightly to the host-cell surface. Simultaneously, the intracellular region initiates a signaling cascade in the host cell, which leads to actin polymerization and formation of actin pedestals at the sites of bacterial adhesion. In strain EDL933, acts via the effector protein EspF(U), in a phosphotyrosine- and NCK-independent manner. Tir binds to host BAIAP2, which mediates association with EspF(U) and leads to stimulation of actin polymerization.<ref>PMID:10225900</ref> <ref>PMID:14764108</ref> <ref>PMID:16922867</ref> <ref>PMID:17521329</ref>	+	[[http://www.uniprot.org/uniprot/EAE_ECO57 EAE_ECO57]] Necessary for the production of attaching and effacing lesions on tissue culture cells. [[http://www.uniprot.org/uniprot/TIR_ECO57 TIR_ECO57]] Multifunctional protein that is required for efficient pedestal formation in host epithelial cells during infection. The extracellular region acts as a receptor for bacterial intimin, allowing the bacterium to attach tightly to the host-cell surface. Simultaneously, the intracellular region initiates a signaling cascade in the host cell, which leads to actin polymerization and formation of actin pedestals at the sites of bacterial adhesion. In strain EDL933, acts via the effector protein EspF(U), in a phosphotyrosine- and NCK-independent manner. Tir binds to host BAIAP2, which mediates association with EspF(U) and leads to stimulation of actin polymerization.<ref>PMID:10225900</ref> <ref>PMID:14764108</ref> <ref>PMID:16922867</ref> <ref>PMID:17521329</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zqk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia coli~~]]	+	[[Category: Eco57]]
	[[Category: Gao, F]]		[[Category: Gao, F]]
	[[Category: Gao, G F]]		[[Category: Gao, G F]]

OCA at 20:01, 25 December 2014

OCA — Thu, 25 Dec 2014 20:01:00 GMT

←Older revision		Revision as of 20:01, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zqk]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZQK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zqk]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZQK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zwk\|2zwk]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zwk\|2zwk]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">intimin adherence protein 747-934 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), Tir 269-336 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">intimin adherence protein 747-934 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), Tir 269-336 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zqk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zqk RCSB], [http://www.ebi.ac.uk/pdbsum/2zqk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zqk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zqk RCSB], [http://www.ebi.ac.uk/pdbsum/2zqk PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/EAE_ECO57 EAE_ECO57]] Necessary for the production of attaching and effacing lesions on tissue culture cells. [[http://www.uniprot.org/uniprot/Q7DB77_ECO57 Q7DB77_ECO57]] Multifunctional protein that is required for efficient pedestal formation in host epithelial cells during infection. The extracellular region acts as a receptor for bacterial intimin, allowing the bacterium to attach tightly to the host-cell surface. Simultaneously, the intracellular region initiates a signaling cascade in the host cell, which leads to actin polymerization and formation of actin pedestals at the sites of bacterial adhesion. In strain EDL933, acts via the effector protein EspF(U), in a phosphotyrosine- and NCK-independent manner. Tir binds to host BAIAP2, which mediates association with EspF(U) and leads to stimulation of actin polymerization.<ref>PMID:10225900</ref> <ref>PMID:14764108</ref> <ref>PMID:16922867</ref> <ref>PMID:17521329</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Gao, F.]]	+	[[Category: Gao, F]]
-	[[Category: Gao, G F.]]	+	[[Category: Gao, G F]]
-	[[Category: Li, D F.]]	+	[[Category: Li, D F]]
-	[[Category: Ma, Y.]]	+	[[Category: Ma, Y]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]

OCA at 04:47, 2 October 2014

OCA — Thu, 02 Oct 2014 04:47:15 GMT

←Older revision		Revision as of 04:47, 2 October 2014
Line 1:		Line 1:
-	~~[[Image:2zqk.png\|left\|200px]]~~	+	==Crystal structure of intimin-Tir68 complex==
-		+	<StructureSection load='2zqk' size='340' side='right' caption='[[2zqk]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{STRUCTURE_2zqk\| PDB=2zqk \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2zqk]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZQK FirstGlance]. <br>
-	===Crystal structure of intimin-Tir68 complex===	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zwk\|2zwk]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">intimin adherence protein 747-934 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), Tir 269-336 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zqk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zqk RCSB], [http://www.ebi.ac.uk/pdbsum/2zqk PDBsum]</span></td></tr>
-	==~~About this Structure~~==	+	<table>
-	[[2zqk]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQK OCA].	+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zq/2zqk_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Gao, F.]]		[[Category: Gao, F.]]

OCA: Protected "2zqk" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 19:14:20 GMT

Protected "2zqk" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:14, 7 January 2013

OCA at 19:14, 7 January 2013

OCA — Mon, 07 Jan 2013 19:14:15 GMT

←Older revision		Revision as of 19:14, 7 January 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2zqk.png\|left\|200px]]
-	[[Image:2zqk.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zqk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zqk\| PDB=2zqk \| SCENE= }}		{{STRUCTURE_2zqk\| PDB=2zqk \| SCENE= }}

Line 14:		Line 7:

	==About this Structure==		==About this Structure==
-	~~2ZQK~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQK OCA].	+	[[2zqk]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQK OCA].
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Gao, F.]]		[[Category: Gao, F.]]
Line 29:		Line 22:
	[[Category: Unique intimin-tir trimer intermediate]]		[[Category: Unique intimin-tir trimer intermediate]]
	[[Category: Virulence]]		[[Category: Virulence]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 19 13:24:03 2009''

OCA at 10:24, 19 August 2009

OCA — Wed, 19 Aug 2009 10:24:06 GMT

←Older revision		Revision as of 10:24, 19 August 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2zqk.jpg\|left\|200px]]

-	The ~~entry 2zqk~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2zqk", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2zqk\| PDB=2zqk \| SCENE= }}

-	~~Authors: Ma, Y., Gao, F., Li, D.~~-~~F., Gao, G.F.~~	+	===Crystal structure of intimin-Tir68 complex===

-	Description: Crystal structure of intimin-Tir68 complex

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug ~~12 12~~:20:09 2009''	+	==About this Structure==
		+	2ZQK is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQK OCA].
		+	[[Category: Escherichia coli]]
		+	[[Category: Gao, F.]]
		+	[[Category: Gao, G F.]]
		+	[[Category: Li, D F.]]
		+	[[Category: Ma, Y.]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Cell membrane]]
		+	[[Category: Cell outer membrane]]
		+	[[Category: Membrane]]
		+	[[Category: Protein-protein complex]]
		+	[[Category: Receptor]]
		+	[[Category: Transmembrane]]
		+	[[Category: Unique intimin-tir trimer intermediate]]
		+	[[Category: Virulence]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 19 13:24:03 2009''

OCA at 09:20, 12 August 2009

OCA — Wed, 12 Aug 2009 09:20:09 GMT

←Older revision		Revision as of 09:20, 12 August 2009
Line 3:		Line 3:
	The entry 2zqk is ON HOLD until Paper Publication		The entry 2zqk is ON HOLD until Paper Publication

-	Authors: Ma, Y., ~~Zou~~, Q., Gao, G.F.	+	Authors: Ma, Y., Gao, F., Li, D.-F., Gao, G.F.

	Description: Crystal structure of intimin-Tir68 complex		Description: Crystal structure of intimin-Tir68 complex

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 10~~ 12:29:~~17 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 12 12:20:09 2009''