2zr8 - Revision history

OCA at 13:50, 1 November 2023

OCA — Wed, 01 Nov 2023 13:50:59 GMT

←Older revision		Revision as of 13:50, 1 November 2023
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	<StructureSection load='2zr8' size='340' side='right'caption='[[2zr8]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2zr8' size='340' side='right'caption='[[2zr8]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Cbs_356 Cbs 356~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZR8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZR8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDD:N-(5-PHOSPHOPYRIDOXYL)-D-ALANINE'>PDD</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Serine_racemase Serine racemase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.18 5.1.1.18] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDD:N-(5-PHOSPHOPYRIDOXYL)-D-ALANINE'>PDD</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zr8 OCA], [https://pdbe.org/2zr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zr8 RCSB], [https://www.ebi.ac.uk/pdbsum/2zr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zr8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zr8 OCA], [https://pdbe.org/2zr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zr8 RCSB], [https://www.ebi.ac.uk/pdbsum/2zr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zr8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SRR_SCHPO SRR_SCHPO]] Catalyzes the synthesis of D-serine from L-serine. Has dehydratase activity towards both L-serine and D-serine.<ref>PMID:19640845</ref>	+	[https://www.uniprot.org/uniprot/SRR_SCHPO SRR_SCHPO] Catalyzes the synthesis of D-serine from L-serine. Has dehydratase activity towards both L-serine and D-serine.<ref>PMID:19640845</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cbs 356]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Serine racemase~~]]	+	[[Category: Schizosaccharomyces pombe]]
-	[[Category: Goto, M]]	+	[[Category: Goto M]]
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Plp-dependent]]~~	+
-	~~[[Category: Pyridoxal phosphate~~]]	+

OCA at 17:35, 15 December 2021

OCA — Wed, 15 Dec 2021 17:35:54 GMT

←Older revision		Revision as of 17:35, 15 December 2021
Line 3:		Line 3:
	<StructureSection load='2zr8' size='340' side='right'caption='[[2zr8]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2zr8' size='340' side='right'caption='[[2zr8]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zr8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZR8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZR8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZR8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDD:N-(5-PHOSPHOPYRIDOXYL)-D-ALANINE'>PDD</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDD:N-(5-PHOSPHOPYRIDOXYL)-D-ALANINE'>PDD</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Serine_racemase Serine racemase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.18 5.1.1.18] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Serine_racemase Serine racemase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.18 5.1.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zr8 OCA], [~~http~~://pdbe.org/2zr8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zr8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zr8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zr8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zr8 OCA], [https://pdbe.org/2zr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zr8 RCSB], [https://www.ebi.ac.uk/pdbsum/2zr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zr8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SRR_SCHPO SRR_SCHPO]] Catalyzes the synthesis of D-serine from L-serine. Has dehydratase activity towards both L-serine and D-serine.<ref>PMID:19640845</ref>	+	[[https://www.uniprot.org/uniprot/SRR_SCHPO SRR_SCHPO]] Catalyzes the synthesis of D-serine from L-serine. Has dehydratase activity towards both L-serine and D-serine.<ref>PMID:19640845</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:44, 31 July 2019

OCA — Wed, 31 Jul 2019 07:44:07 GMT

←Older revision		Revision as of 07:44, 31 July 2019
Line 1:		Line 1:

	==Crystal Structure of Modified Serine Racemase complexed with Serine==		==Crystal Structure of Modified Serine Racemase complexed with Serine==
-	<StructureSection load='2zr8' size='340' side='right' caption='[[2zr8]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2zr8' size='340' side='right'caption='[[2zr8]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZR8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZR8 FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zr/2zr8_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zr/2zr8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Cbs 356]]		[[Category: Cbs 356]]
		+	[[Category: Large Structures]]
	[[Category: Serine racemase]]		[[Category: Serine racemase]]
	[[Category: Goto, M]]		[[Category: Goto, M]]

OCA at 15:58, 12 October 2017

OCA — Thu, 12 Oct 2017 15:58:33 GMT

←Older revision		Revision as of 15:58, 12 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Modified Serine Racemase complexed with Serine==		==Crystal Structure of Modified Serine Racemase complexed with Serine==
	<StructureSection load='2zr8' size='340' side='right' caption='[[2zr8]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2zr8' size='340' side='right' caption='[[2zr8]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZR8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZR8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDD:N-(5-PHOSPHOPYRIDOXYL)-D-ALANINE'>PDD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDD:N-(5-PHOSPHOPYRIDOXYL)-D-ALANINE'>PDD</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine_racemase Serine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.18 5.1.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine_racemase Serine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.18 5.1.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zr8 OCA], [http://pdbe.org/2zr8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zr8 RCSB], [http://www.ebi.ac.uk/pdbsum/2zr8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zr8 OCA], [http://pdbe.org/2zr8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zr8 RCSB], [http://www.ebi.ac.uk/pdbsum/2zr8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zr8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 15:09, 8 February 2016

OCA — Mon, 08 Feb 2016 15:09:30 GMT

←Older revision		Revision as of 15:09, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2zr8' size='340' side='right' caption='[[2zr8]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2zr8' size='340' side='right' caption='[[2zr8]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Schizosaccharomyces_pombe Schizosaccharomyces pombe~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZR8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZR8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDD:N-(5-PHOSPHOPYRIDOXYL)-D-ALANINE'>PDD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDD:N-(5-PHOSPHOPYRIDOXYL)-D-ALANINE'>PDD</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine_racemase Serine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.18 5.1.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine_racemase Serine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.18 5.1.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zr8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zr8 RCSB], [http://www.ebi.ac.uk/pdbsum/2zr8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zr8 OCA], [http://pdbe.org/2zr8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zr8 RCSB], [http://www.ebi.ac.uk/pdbsum/2zr8 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~YCNE_SCHPO YCNE_SCHPO~~]] Catalyzes the synthesis of D-serine from L-serine. Has dehydratase activity towards both L-serine and D-serine.<ref>PMID:19640845</ref>	+	[[http://www.uniprot.org/uniprot/SRR_SCHPO SRR_SCHPO]] Catalyzes the synthesis of D-serine from L-serine. Has dehydratase activity towards both L-serine and D-serine.<ref>PMID:19640845</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zr8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2zr8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Schizosaccharomyces pombe~~]]	+	[[Category: Cbs 356]]
	[[Category: Serine racemase]]		[[Category: Serine racemase]]
	[[Category: Goto, M]]		[[Category: Goto, M]]

OCA at 00:14, 25 December 2014

OCA — Thu, 25 Dec 2014 00:14:32 GMT

←Older revision		Revision as of 00:14, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZR8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZR8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDD:N-(5-PHOSPHOPYRIDOXYL)-D-ALANINE'>PDD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDD:N-(5-PHOSPHOPYRIDOXYL)-D-ALANINE'>PDD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine_racemase Serine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.18 5.1.1.18] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine_racemase Serine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.18 5.1.1.18] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zr8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zr8 RCSB], [http://www.ebi.ac.uk/pdbsum/2zr8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zr8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zr8 RCSB], [http://www.ebi.ac.uk/pdbsum/2zr8 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/YCNE_SCHPO YCNE_SCHPO]] Catalyzes the synthesis of D-serine from L-serine. Has dehydratase activity towards both L-serine and D-serine.<ref>PMID:19640845</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
	[[Category: Serine racemase]]		[[Category: Serine racemase]]
-	[[Category: Goto, M.]]	+	[[Category: Goto, M]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Plp-dependent]]		[[Category: Plp-dependent]]
	[[Category: Pyridoxal phosphate]]		[[Category: Pyridoxal phosphate]]

OCA at 05:31, 2 October 2014

OCA — Thu, 02 Oct 2014 05:31:47 GMT

←Older revision		Revision as of 05:31, 2 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2zr8\| PDB=2zr8 \| SCENE= }}~~	+	==Crystal Structure of Modified Serine Racemase complexed with Serine==
-	===Crystal Structure of Modified Serine Racemase complexed with Serine===	+	<StructureSection load='2zr8' size='340' side='right' caption='[[2zr8]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19640845}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2zr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZR8 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDD:N-(5-PHOSPHOPYRIDOXYL)-D-ALANINE'>PDD</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine_racemase Serine racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.18 5.1.1.18] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zr8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zr8 RCSB], [http://www.ebi.ac.uk/pdbsum/2zr8 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zr/2zr8_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	D-serine is an endogenous coagonist for the N-methyl-D-aspartate receptor and is involved in excitatory neurotransmission in the brain. Mammalian pyridoxal 5'-phosphate-dependent serine racemase, which is localized in the mammalian brain, catalyzes the racemization of L-serine to yield D-serine and vice versa. The enzyme also catalyzes the dehydration of D- and L-serine. Both reactions are enhanced by Mg.ATP in vivo. We have determined the structures of the following three forms of the mammalian enzyme homolog from Schizosaccharomyces pombe: the wild-type enzyme, the wild-type enzyme in the complex with an ATP analog, and the modified enzyme in the complex with serine at 1.7, 1.9, and 2.2 A resolution, respectively. On binding of the substrate, the small domain rotates toward the large domain to close the active site. The ATP binding site was identified at the domain and the subunit interface. Computer graphics models of the wild-type enzyme complexed with L-serine and D-serine provided an insight into the catalytic mechanisms of both reactions. Lys-57 and Ser-82 located on the protein and solvent sides, respectively, with respect to the cofactor plane, are acid-base catalysts that shuttle protons to the substrate. The modified enzyme, which has a unique "lysino-D-alanyl" residue at the active site, also exhibits catalytic activities. The crystal-soaking experiment showed that the substrate serine was actually trapped in the active site of the modified enzyme, suggesting that the lysino-D-alanyl residue acts as a catalytic base in the same manner as inherent Lys-57 of the wild-type enzyme.

-	~~==Function==~~	+	Crystal structure of a homolog of mammalian serine racemase from Schizosaccharomyces pombe.,Goto M, Yamauchi T, Kamiya N, Miyahara I, Yoshimura T, Mihara H, Kurihara T, Hirotsu K, Esaki N J Biol Chem. 2009 Sep 18;284(38):25944-52. Epub 2009 Jul 28. PMID:19640845<ref>PMID:19640845</ref>
-	~~[[http://www.uniprot.org/uniprot/YCNE_SCHPO YCNE_SCHPO]] Catalyzes the synthesis~~ of D-serine from ~~L-serine~~. ~~Has dehydratase activity towards both L~~-~~serine and D-serine~~.<ref>PMID:19640845</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2zr8]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ZR8 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019640845</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
	[[Category: Serine racemase]]		[[Category: Serine racemase]]

OCA at 09:18, 27 March 2013

OCA — Wed, 27 Mar 2013 09:18:15 GMT

←Older revision		Revision as of 09:18, 27 March 2013
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-	[[Image:2zr8.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zr8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zr8\| PDB=2zr8 \| SCENE= }}		{{STRUCTURE_2zr8\| PDB=2zr8 \| SCENE= }}
-
	===Crystal Structure of Modified Serine Racemase complexed with Serine===		===Crystal Structure of Modified Serine Racemase complexed with Serine===
		+	{{ABSTRACT_PUBMED_19640845}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/YCNE_SCHPO YCNE_SCHPO]] Catalyzes the synthesis of D-serine from L-serine. Has dehydratase activity towards both L-serine and D-serine.<ref>PMID:19640845</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_19640845}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 19640845 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_19640845}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019640845</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019640845</ref><references group="xtra"/><references/>
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
	[[Category: Serine racemase]]		[[Category: Serine racemase]]

OCA: Protected "2zr8" [edit=sysop:move=sysop]

OCA — Thu, 26 May 2011 11:34:08 GMT

Protected "2zr8" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:34, 26 May 2011

OCA at 11:34, 26 May 2011

OCA — Thu, 26 May 2011 11:34:06 GMT

←Older revision		Revision as of 11:34, 26 May 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2zr8.png\|left\|200px]]		[[Image:2zr8.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~2ZR8~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZR8 OCA].	+	[[2zr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZR8 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19640845~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019640845</ref><references group="xtra"/>
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
	[[Category: Serine racemase]]		[[Category: Serine racemase]]
Line 31:		Line 30:
	[[Category: Plp-dependent]]		[[Category: Plp-dependent]]
	[[Category: Pyridoxal phosphate]]		[[Category: Pyridoxal phosphate]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 12 12:41:20 2009''