2zro - Revision history

OCA at 13:51, 1 November 2023

OCA — Wed, 01 Nov 2023 13:51:56 GMT

←Older revision		Revision as of 13:51, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='2zro' size='340' side='right'caption='[[2zro]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2zro' size='340' side='right'caption='[[2zro]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Mycs2 Mycs2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZRO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZRO FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADP:ADENOSINE~~-~~5-DIPHOSPHATE'>ADP</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1ubc\|1ubc]], [[2zr0\|2zr0]], [[2zrc\|2zrc]], [[2zrh\|2zrh]], [[2zrn\|2zrn]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zro OCA], [https://pdbe.org/2zro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zro RCSB], [https://www.ebi.ac.uk/pdbsum/2zro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zro ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zro OCA], [https://pdbe.org/2zro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zro RCSB], [https://www.ebi.ac.uk/pdbsum/2zro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zro ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RECA_MYCS2 RECA_MYCS2]] Required for homologous recombination (HR) and the bypass of mutagenic DNA lesions (double strand breaks, DSB) by the SOS response. Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. Numerous X-ray crystals have been resolved under different conditions which indicate the flexibility of the protein, essential to its function. Gln-196 contributes to this plasticity by acting as a switch residue, which transmits the effect of nucleotide binding to the DNA-binding region.<ref>PMID:17360246</ref> <ref>PMID:17496093</ref> <ref>PMID:21219454</ref>	+	[https://www.uniprot.org/uniprot/RECA_MYCS2 RECA_MYCS2] Required for homologous recombination (HR) and the bypass of mutagenic DNA lesions (double strand breaks, DSB) by the SOS response. Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. Numerous X-ray crystals have been resolved under different conditions which indicate the flexibility of the protein, essential to its function. Gln-196 contributes to this plasticity by acting as a switch residue, which transmits the effect of nucleotide binding to the DNA-binding region.<ref>PMID:17360246</ref> <ref>PMID:17496093</ref> <ref>PMID:21219454</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Deleted entry]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mycs2~~]]	+	[[Category: Mycolicibacterium smegmatis MC2 155]]
-	[[Category: Chandra~~, N R~~]]	+	[[Category: Chandra NR]]
-	[[Category: Manjunath~~, G P~~]]	+	[[Category: Manjunath GP]]
-	[[Category: Muniyappa, K]]	+	[[Category: Muniyappa K]]
-	[[Category: Prabu~~, J R~~]]	+	[[Category: Prabu JR]]
-	[[Category: Vijayan, M]]	+	[[Category: Vijayan M]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Dna damage]]~~	+
-	~~[[Category: Dna recombination]]~~	+
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Dna-repair]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Reca mutant]]~~	+
-	~~[[Category: Recombination]]~~	+
-	~~[[Category: Sos response~~]]	+

OCA at 13:22, 4 May 2022

OCA — Wed, 04 May 2022 13:22:59 GMT

←Older revision		Revision as of 13:22, 4 May 2022
Line 3:		Line 3:
	<StructureSection load='2zro' size='340' side='right'caption='[[2zro]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2zro' size='340' side='right'caption='[[2zro]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zro]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2ZRO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZRO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ubc\|1ubc]], [[2zr0\|2zr0]], [[2zrc\|2zrc]], [[2zrh\|2zrh]], [[2zrn\|2zrn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ubc\|1ubc]], [[2zr0\|2zr0]], [[2zrc\|2zrc]], [[2zrh\|2zrh]], [[2zrn\|2zrn]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2zro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zro OCA], [~~http~~://pdbe.org/2zro PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zro RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zro PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zro ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zro OCA], [https://pdbe.org/2zro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zro RCSB], [https://www.ebi.ac.uk/pdbsum/2zro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zro ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RECA_MYCS2 RECA_MYCS2]] Required for homologous recombination (HR) and the bypass of mutagenic DNA lesions (double strand breaks, DSB) by the SOS response. Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. Numerous X-ray crystals have been resolved under different conditions which indicate the flexibility of the protein, essential to its function. Gln-196 contributes to this plasticity by acting as a switch residue, which transmits the effect of nucleotide binding to the DNA-binding region.<ref>PMID:17360246</ref> <ref>PMID:17496093</ref> <ref>PMID:21219454</ref>	+	[[https://www.uniprot.org/uniprot/RECA_MYCS2 RECA_MYCS2]] Required for homologous recombination (HR) and the bypass of mutagenic DNA lesions (double strand breaks, DSB) by the SOS response. Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. Numerous X-ray crystals have been resolved under different conditions which indicate the flexibility of the protein, essential to its function. Gln-196 contributes to this plasticity by acting as a switch residue, which transmits the effect of nucleotide binding to the DNA-binding region.<ref>PMID:17360246</ref> <ref>PMID:17496093</ref> <ref>PMID:21219454</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[~~Recombinase~~ A\|~~Recombinase~~ A]]	+	*[[3D structures of recombinase A\|3D structures of recombinase A]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:09, 29 July 2020

OCA — Wed, 29 Jul 2020 12:09:04 GMT

←Older revision		Revision as of 12:09, 29 July 2020
Line 1:		Line 1:

	==MsRecA ADP form IV==		==MsRecA ADP form IV==
-	<StructureSection load='2zro' size='340' side='right' caption='[[2zro]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='2zro' size='340' side='right'caption='[[2zro]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRO OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZRO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2ZRO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ubc\|1ubc]], [[2zr0\|2zr0]], [[2zrc\|2zrc]], [[2zrh\|2zrh]], [[2zrn\|2zrn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ubc\|1ubc]], [[2zr0\|2zr0]], [[2zrc\|2zrc]], [[2zrh\|2zrh]], [[2zrn\|2zrn]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zro OCA], [http://pdbe.org/2zro PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zro RCSB], [http://www.ebi.ac.uk/pdbsum/2zro PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zro ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2zro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zro OCA], [http://pdbe.org/2zro PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zro RCSB], [http://www.ebi.ac.uk/pdbsum/2zro PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zro ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Deleted entry]]		[[Category: Deleted entry]]
		+	[[Category: Large Structures]]
	[[Category: Mycs2]]		[[Category: Mycs2]]
	[[Category: Chandra, N R]]		[[Category: Chandra, N R]]

OCA at 04:40, 5 August 2016

OCA — Fri, 05 Aug 2016 04:40:58 GMT

←Older revision		Revision as of 04:40, 5 August 2016
Line 1:		Line 1:
		+
	==MsRecA ADP form IV==		==MsRecA ADP form IV==
	<StructureSection load='2zro' size='340' side='right' caption='[[2zro]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2zro' size='340' side='right' caption='[[2zro]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_smegmatis_str._mc2_155 Mycobacterium smegmatis str. mc2 155~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZRO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZRO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ubc\|1ubc]], [[2zr0\|2zr0]], [[2zrc\|2zrc]], [[2zrh\|2zrh]], [[2zrn\|2zrn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ubc\|1ubc]], [[2zr0\|2zr0]], [[2zrc\|2zrc]], [[2zrh\|2zrh]], [[2zrn\|2zrn]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zro OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zro RCSB], [http://www.ebi.ac.uk/pdbsum/2zro PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zro OCA], [http://pdbe.org/2zro PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zro RCSB], [http://www.ebi.ac.uk/pdbsum/2zro PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zro ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2zro" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Deleted entry]]		[[Category: Deleted entry]]
-	[[Category: ~~Mycobacterium smegmatis str. mc2 155~~]]	+	[[Category: Mycs2]]
	[[Category: Chandra, N R]]		[[Category: Chandra, N R]]
	[[Category: Manjunath, G P]]		[[Category: Manjunath, G P]]

OCA at 23:03, 24 December 2014

OCA — Wed, 24 Dec 2014 23:03:07 GMT

←Older revision		Revision as of 23:03, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zro OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zro RCSB], [http://www.ebi.ac.uk/pdbsum/2zro PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zro OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zro RCSB], [http://www.ebi.ac.uk/pdbsum/2zro PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RECA_MYCS2 RECA_MYCS2]] Required for homologous recombination (HR) and the bypass of mutagenic DNA lesions (double strand breaks, DSB) by the SOS response. Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. Numerous X-ray crystals have been resolved under different conditions which indicate the flexibility of the protein, essential to its function. Gln-196 contributes to this plasticity by acting as a switch residue, which transmits the effect of nucleotide binding to the DNA-binding region.<ref>PMID:17360246</ref> <ref>PMID:17496093</ref> <ref>PMID:21219454</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Recombinase A\|Recombinase A]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Deleted entry]]		[[Category: Deleted entry]]
	[[Category: Mycobacterium smegmatis str. mc2 155]]		[[Category: Mycobacterium smegmatis str. mc2 155]]
-	[[Category: Chandra, N R.]]	+	[[Category: Chandra, N R]]
-	[[Category: Manjunath, G P.]]	+	[[Category: Manjunath, G P]]
-	[[Category: Muniyappa, K.]]	+	[[Category: Muniyappa, K]]
-	[[Category: Prabu, J R.]]	+	[[Category: Prabu, J R]]
-	[[Category: Vijayan, M.]]	+	[[Category: Vijayan, M]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Dna damage]]		[[Category: Dna damage]]

OCA at 11:52, 29 October 2014

OCA — Wed, 29 Oct 2014 11:52:13 GMT

←Older revision		Revision as of 11:52, 29 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2zro.~~png~~\|~~left~~\|~~200px~~]]	+	==MsRecA ADP form IV==
		+	<StructureSection load='2zro' size='340' side='right' caption='[[2zro]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2zro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_str._mc2_155 Mycobacterium smegmatis str. mc2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZRO FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ubc\|1ubc]], [[2zr0\|2zr0]], [[2zrc\|2zrc]], [[2zrh\|2zrh]], [[2zrn\|2zrn]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zro OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zro RCSB], [http://www.ebi.ac.uk/pdbsum/2zro PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structures of mutants of Mycobacterium smegmatis RecA (MsRecA) involving changes of Gln196 from glutamine to alanine, asparagine and glutamic acid, wild-type MsRecA and several of their nucleotide complexes have been determined using mostly low-temperature and partly room-temperature X-ray data. At both temperatures, nucleotide binding results in a movement of Gln196 towards the bound nucleotide in the wild-type protein. This movement is abolished in the mutants, thus establishing the structural basis for the triggering action of the residue in terms of the size, shape and the chemical nature of the side chain. The 19 crystal structures reported here, together with 11 previously reported MsRecA structures, provide further elaboration of the relation between the pitch of the ;inactive' RecA filament, the orientation of the C-terminal domain with respect to the main domain and the location of the switch residue. The low-temperature structures define one extreme of the range of positions the C-terminal domain can occupy. The movement of the C-terminal domain is correlated with those of the LexA-binding loop and the loop that connects the main and the N-terminal domains. These elements of molecular plasticity are made use of in the transition to the ;active' filament, as evidenced by the recently reported structures of RecA-DNA complexes. The available structures of RecA resulting from X-ray and electron-microscopic studies appear to represent different stages in the trajectory of the allosteric transformations of the RecA filament. The work reported here contributes to the description of the early stages of this trajectory and provides insight into structures relevant to the later stages.

-	~~{{STRUCTURE_2zro\| PDB=2zro \| SCENE= }}~~	+	Functionally important movements in RecA molecules and filaments: studies involving mutation and environmental changes.,Prabu JR, Manjunath GP, Chandra NR, Muniyappa K, Vijayan M Acta Crystallogr D Biol Crystallogr. 2008 Nov;64(Pt 11):1146-57. Epub 2008, Oct 18. PMID:19020353<ref>PMID:19020353</ref>

-	~~===MsRecA ADP form IV===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19020353}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2zro]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_smegmatis_str~~.~~_mc2_155 Mycobacterium smegmatis str. mc2 155]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRO OCA].~~	+	</StructureSection>
-		+
-	==~~See Also==~~	+
-	*[[Recombinase A\|Recombinase A]]	+
-		+
-	~~==Reference~~==	+
-	<~~ref group="xtra">PMID:019020353<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Deleted entry]]		[[Category: Deleted entry]]
	[[Category: Mycobacterium smegmatis str. mc2 155]]		[[Category: Mycobacterium smegmatis str. mc2 155]]

OCA at 10:01, 20 October 2012

OCA — Sat, 20 Oct 2012 10:01:04 GMT

←Older revision		Revision as of 10:01, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2zro]] is a 1 chain structure ~~of [[Recombinase A]]~~ with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_str._mc2_155 Mycobacterium smegmatis str. mc2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRO OCA].	+	[[2zro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_str._mc2_155 Mycobacterium smegmatis str. mc2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRO OCA].

	==See Also==		==See Also==

OCA at 00:42, 26 July 2012

OCA — Thu, 26 Jul 2012 00:42:21 GMT

←Older revision		Revision as of 00:42, 26 July 2012
Line 1:		Line 1:
	[[Image:2zro.png\|left\|200px]]		[[Image:2zro.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zro", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zro\| PDB=2zro \| SCENE= }}		{{STRUCTURE_2zro\| PDB=2zro \| SCENE= }}

	===MsRecA ADP form IV===		===MsRecA ADP form IV===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19020353}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19020353 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19020353}}		{{ABSTRACT_PUBMED_19020353}}

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	==See Also==		==See Also==
-	*[[Recombinase A]]	+	*[[Recombinase A\|Recombinase A]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19020353~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019020353</ref><references group="xtra"/>
	[[Category: Deleted entry]]		[[Category: Deleted entry]]
	[[Category: Mycobacterium smegmatis str. mc2 155]]		[[Category: Mycobacterium smegmatis str. mc2 155]]
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	[[Category: Vijayan, M.]]		[[Category: Vijayan, M.]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
-	[[Category: Cytoplasm]]
	[[Category: Dna damage]]		[[Category: Dna damage]]
	[[Category: Dna recombination]]		[[Category: Dna recombination]]

OCA: Protected "2zro" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 20:17:23 GMT

Protected "2zro" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:17, 26 December 2010

OCA at 20:17, 26 December 2010

OCA — Sun, 26 Dec 2010 20:17:21 GMT

←Older revision		Revision as of 20:17, 26 December 2010
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-	~~{{Seed}}~~	+	[[Image:2zro.png\|left\|200px]]
-	[[Image:2zro.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	~~2ZRO~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_str._mc2_155 Mycobacterium smegmatis str. mc2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRO OCA].	+	[[2zro]] is a 1 chain structure of [[Recombinase A]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_str._mc2_155 Mycobacterium smegmatis str. mc2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRO OCA].
		+
		+	==See Also==
		+	*[[Recombinase A]]

	==Reference==		==Reference==
-	Functionally important movements in RecA molecules and filaments: studies involving mutation and environmental changes., Prabu JR, Manjunath GP, Chandra NR, Muniyappa K, Vijayan M, Acta Crystallogr D Biol Crystallogr. 2008 Nov;64(Pt 11):1146-57. Epub 2008, Oct 18. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/19020353 19020353]~~	+	<ref group="xtra">PMID:19020353</ref><references group="xtra"/>
	[[Category: Deleted entry]]		[[Category: Deleted entry]]
	[[Category: Mycobacterium smegmatis str. mc2 155]]		[[Category: Mycobacterium smegmatis str. mc2 155]]
Line 43:		Line 45:
	[[Category: Recombination]]		[[Category: Recombination]]
	[[Category: Sos response]]		[[Category: Sos response]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 14:59:47 2008''