2zup - Revision history

OCA at 13:55, 1 November 2023

OCA — Wed, 01 Nov 2023 13:55:44 GMT

←Older revision		Revision as of 13:55, 1 November 2023
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	<StructureSection load='2zup' size='340' side='right'caption='[[2zup]], [[Resolution\|resolution]] 3.70Å' scene=''>		<StructureSection load='2zup' size='340' side='right'caption='[[2zup]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zup]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZUP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zup]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZUP FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=UQ1:UBIQUINONE~~-~~1'>UQ1</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.7Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2hi7\|2hi7]]~~, ~~[[2zuq\|2zuq]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UQ1:UBIQUINONE-1'>UQ1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zup OCA], [https://pdbe.org/2zup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zup RCSB], [https://www.ebi.ac.uk/pdbsum/2zup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zup ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zup OCA], [https://pdbe.org/2zup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zup RCSB], [https://www.ebi.ac.uk/pdbsum/2zup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zup ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI]] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref> [[https://www.uniprot.org/uniprot/DSBB_ECOLI DSBB_ECOLI]] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by oxidizing the DsbA protein.<ref>PMID:8430071</ref> <ref>PMID:7688471</ref>	+	[https://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Protein disulfide oxidoreductase\|Protein disulfide oxidoreductase]]	+	*[[Protein disulfide oxidoreductase 3D structures\|Protein disulfide oxidoreductase 3D structures]]
	*[[Thiol:disulfide interchange protein 3D structures\|Thiol:disulfide interchange protein 3D structures]]		*[[Thiol:disulfide interchange protein 3D structures\|Thiol:disulfide interchange protein 3D structures]]
	== References ==		== References ==
Line 37:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Inaba, K]]	+	[[Category: Inaba K]]
-	[[Category: Murakami, S]]	+	[[Category: Murakami S]]
-	[[Category: Nakagawa, A]]	+	[[Category: Nakagawa A]]
-	[[Category: Suzuki, M]]	+	[[Category: Suzuki M]]
-	~~[[Category: Cell inner membrane]]~~	+
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: E. coli]]~~	+
-	~~[[Category: Electron transport]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Periplasm]]~~	+
-	~~[[Category: Redox-active center]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Transport~~]]	+

OCA at 07:20, 10 November 2021

OCA — Wed, 10 Nov 2021 07:20:27 GMT

←Older revision		Revision as of 07:20, 10 November 2021
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	<StructureSection load='2zup' size='340' side='right'caption='[[2zup]], [[Resolution\|resolution]] 3.70Å' scene=''>		<StructureSection load='2zup' size='340' side='right'caption='[[2zup]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zup]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZUP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zup]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZUP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UQ1:UBIQUINONE-1'>UQ1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UQ1:UBIQUINONE-1'>UQ1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hi7\|2hi7]], [[2zuq\|2zuq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hi7\|2hi7]], [[2zuq\|2zuq]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zup OCA], [~~http~~://pdbe.org/2zup PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zup RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zup PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zup ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zup OCA], [https://pdbe.org/2zup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zup RCSB], [https://www.ebi.ac.uk/pdbsum/2zup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zup ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI]] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref> [[~~http~~://www.uniprot.org/uniprot/DSBB_ECOLI DSBB_ECOLI]] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by oxidizing the DsbA protein.<ref>PMID:8430071</ref> <ref>PMID:7688471</ref>	+	[[https://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI]] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref> [[https://www.uniprot.org/uniprot/DSBB_ECOLI DSBB_ECOLI]] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by oxidizing the DsbA protein.<ref>PMID:8430071</ref> <ref>PMID:7688471</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	==See Also==		==See Also==
	*[[Protein disulfide oxidoreductase\|Protein disulfide oxidoreductase]]		*[[Protein disulfide oxidoreductase\|Protein disulfide oxidoreductase]]
		+	*[[Thiol:disulfide interchange protein 3D structures\|Thiol:disulfide interchange protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:55, 31 July 2019

OCA — Wed, 31 Jul 2019 07:55:54 GMT

←Older revision		Revision as of 07:55, 31 July 2019
Line 1:		Line 1:

	==Updated crystal structure of DsbB-DsbA complex from E. coli==		==Updated crystal structure of DsbB-DsbA complex from E. coli==
-	<StructureSection load='2zup' size='340' side='right' caption='[[2zup]], [[Resolution\|resolution]] 3.70Å' scene=''>	+	<StructureSection load='2zup' size='340' side='right'caption='[[2zup]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZUP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZUP FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zu/2zup_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zu/2zup_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2zup" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2zup" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Protein disulfide oxidoreductase\|Protein disulfide oxidoreductase]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: Inaba, K]]		[[Category: Inaba, K]]
	[[Category: Murakami, S]]		[[Category: Murakami, S]]

OCA at 09:43, 12 October 2017

OCA — Thu, 12 Oct 2017 09:43:57 GMT

←Older revision		Revision as of 09:43, 12 October 2017
Line 1:		Line 1:
		+
	==Updated crystal structure of DsbB-DsbA complex from E. coli==		==Updated crystal structure of DsbB-DsbA complex from E. coli==
	<StructureSection load='2zup' size='340' side='right' caption='[[2zup]], [[Resolution\|resolution]] 3.70Å' scene=''>		<StructureSection load='2zup' size='340' side='right' caption='[[2zup]], [[Resolution\|resolution]] 3.70Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UQ1:UBIQUINONE-1'>UQ1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UQ1:UBIQUINONE-1'>UQ1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hi7\|2hi7]], [[2zuq\|2zuq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hi7\|2hi7]], [[2zuq\|2zuq]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zup OCA], [http://pdbe.org/2zup PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zup RCSB], [http://www.ebi.ac.uk/pdbsum/2zup PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zup OCA], [http://pdbe.org/2zup PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zup RCSB], [http://www.ebi.ac.uk/pdbsum/2zup PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zup ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2zup" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2zup" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Protein disulfide oxidoreductase\|Protein disulfide oxidoreductase]]
	== References ==		== References ==
	<references/>		<references/>
Line 49:		Line 47:
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
		+	[[Category: Periplasm]]
	[[Category: Redox-active center]]		[[Category: Redox-active center]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	[[Category: Transport]]		[[Category: Transport]]

OCA at 17:27, 8 February 2016

OCA — Mon, 08 Feb 2016 17:27:05 GMT

←Older revision		Revision as of 17:27, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2zup' size='340' side='right' caption='[[2zup]], [[Resolution\|resolution]] 3.70Å' scene=''>		<StructureSection load='2zup' size='340' side='right' caption='[[2zup]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia coli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZUP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZUP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UQ1:UBIQUINONE-1'>UQ1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UQ1:UBIQUINONE-1'>UQ1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hi7\|2hi7]], [[2zuq\|2zuq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hi7\|2hi7]], [[2zuq\|2zuq]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zup OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zup RCSB], [http://www.ebi.ac.uk/pdbsum/2zup PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zup OCA], [http://pdbe.org/2zup PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zup RCSB], [http://www.ebi.ac.uk/pdbsum/2zup PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zup ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2zup" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia coli~~]]	+	[[Category: Ecoli]]
	[[Category: Inaba, K]]		[[Category: Inaba, K]]
	[[Category: Murakami, S]]		[[Category: Murakami, S]]

OCA at 00:58, 25 December 2014

OCA — Thu, 25 Dec 2014 00:58:54 GMT

←Older revision		Revision as of 00:58, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZUP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZUP FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UQ1:UBIQUINONE-1'>UQ1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UQ1:UBIQUINONE-1'>UQ1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hi7\|2hi7]], [[2zuq\|2zuq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hi7\|2hi7]], [[2zuq\|2zuq]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zup OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zup RCSB], [http://www.ebi.ac.uk/pdbsum/2zup PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zup OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zup RCSB], [http://www.ebi.ac.uk/pdbsum/2zup PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI]] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref> [[http://www.uniprot.org/uniprot/DSBB_ECOLI DSBB_ECOLI]] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by oxidizing the DsbA protein.<ref>PMID:8430071</ref> <ref>PMID:7688471</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Inaba, K.]]	+	[[Category: Inaba, K]]
-	[[Category: Murakami, S.]]	+	[[Category: Murakami, S]]
-	[[Category: Nakagawa, A.]]	+	[[Category: Nakagawa, A]]
-	[[Category: Suzuki, M.]]	+	[[Category: Suzuki, M]]
	[[Category: Cell inner membrane]]		[[Category: Cell inner membrane]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]

OCA at 07:06, 29 September 2014

OCA — Mon, 29 Sep 2014 07:06:12 GMT

←Older revision		Revision as of 07:06, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2zup.~~png~~\|~~left~~\|200px]]	+	==Updated crystal structure of DsbB-DsbA complex from E. coli==
		+	<StructureSection load='2zup' size='340' side='right' caption='[[2zup]], [[Resolution\|resolution]] 3.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2zup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZUP FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UQ1:UBIQUINONE-1'>UQ1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hi7\|2hi7]], [[2zuq\|2zuq]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zup OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zup RCSB], [http://www.ebi.ac.uk/pdbsum/2zup PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zu/2zup_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In the Escherichia coli system catalysing oxidative protein folding, disulphide bonds are generated by the cooperation of DsbB and ubiquinone and transferred to substrate proteins through DsbA. The structures solved so far for different forms of DsbB lack the Cys104-Cys130 initial-state disulphide that is directly donated to DsbA. Here, we report the 3.4 A crystal structure of a DsbB-Fab complex, in which DsbB has this principal disulphide. Its comparison with the updated structure of the DsbB-DsbA complex as well as with the recently reported NMR structure of a DsbB variant having the rearranged Cys41-Cys130 disulphide illuminated conformational transitions of DsbB induced by the binding and release of DsbA. Mutational studies revealed that the membrane-parallel short alpha-helix of DsbB has a key function in physiological electron flow, presumably by controlling the positioning of the Cys130-containing loop. These findings demonstrate that DsbB has developed the elaborate conformational dynamism to oxidize DsbA for continuous protein disulphide bond formation in the cell.

-	~~{{STRUCTURE_2zup\| PDB=2zup \| SCENE= }}~~	+	Dynamic nature of disulphide bond formation catalysts revealed by crystal structures of DsbB.,Inaba K, Murakami S, Nakagawa A, Iida H, Kinjo M, Ito K, Suzuki M EMBO J. 2009 Mar 18;28(6):779-91. Epub 2009 Feb 12. PMID:19214188<ref>PMID:19214188</ref>

-	~~===Updated crystal structure~~ of ~~DsbB-DsbA complex from E~~. ~~coli===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19214188}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2zup]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUP OCA].~~	+

	==See Also==		==See Also==
	*[[Protein disulfide oxidoreductase\|Protein disulfide oxidoreductase]]		*[[Protein disulfide oxidoreductase\|Protein disulfide oxidoreductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019214188<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Inaba, K.]]		[[Category: Inaba, K.]]

OCA at 10:53, 20 October 2012

OCA — Sat, 20 Oct 2012 10:53:59 GMT

←Older revision		Revision as of 10:53, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2zup]] is a 2 chain structure ~~of [[Protein disulfide oxidoreductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUP OCA].	+	[[2zup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUP OCA].

	==See Also==		==See Also==

OCA: Protected "2zup" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 03:37:13 GMT

Protected "2zup" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:37, 26 July 2012

OCA at 03:37, 26 July 2012

OCA — Thu, 26 Jul 2012 03:37:10 GMT

←Older revision		Revision as of 03:37, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2zup.png\|left\|200px]]		[[Image:2zup.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zup", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zup\| PDB=2zup \| SCENE= }}		{{STRUCTURE_2zup\| PDB=2zup \| SCENE= }}

	===Updated crystal structure of DsbB-DsbA complex from E. coli===		===Updated crystal structure of DsbB-DsbA complex from E. coli===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19214188}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19214188 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19214188}}		{{ABSTRACT_PUBMED_19214188}}

	==About this Structure==		==About this Structure==
-	~~2ZUP~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUP OCA].	+	[[2zup]] is a 2 chain structure of [[Protein disulfide oxidoreductase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUP OCA].
		+
		+	==See Also==
		+	*[[Protein disulfide oxidoreductase\|Protein disulfide oxidoreductase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19214188~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019214188</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Inaba, K.]]		[[Category: Inaba, K.]]
Line 38:		Line 29:
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-	[[Category: Periplasm]]
	[[Category: Redox-active center]]		[[Category: Redox-active center]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	[[Category: Transport]]		[[Category: Transport]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 10:48:30 2009''