2zv9 - Revision history

OCA at 13:56, 1 November 2023

OCA — Wed, 01 Nov 2023 13:56:29 GMT

←Older revision		Revision as of 13:56, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='2zv9' size='340' side='right'caption='[[2zv9]], [[Resolution\|resolution]] 2.76Å' scene=''>		<StructureSection load='2zv9' size='340' side='right'caption='[[2zv9]], [[Resolution\|resolution]] 2.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zv9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2ZV9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zv9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZV9 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PP2:1~~-~~TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO~~[~~3,4-D~~]~~PYRIMIDIN-4-YLAMINE'>PP2</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.76Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[2zv7\|2zv7]], [[2zv8\|2zv8]], [[2zva\|2zva]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PP2:1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE'>PP2</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/Non~~-~~specific_protein~~-~~tyrosine_kinase Non~~-~~specific protein~~-~~tyrosine kinase]~~, ~~with EC number [http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2~~] </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zv9 OCA], [https://pdbe.org/2zv9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zv9 RCSB], [https://www.ebi.ac.uk/pdbsum/2zv9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zv9 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2zv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zv9 OCA], [~~http~~://pdbe.org/2zv9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zv9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zv9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zv9 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LYN_MOUSE LYN_MOUSE]] Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'.<ref>PMID:15335855</ref> <ref>PMID:7513017</ref> <ref>PMID:8128248</ref> <ref>PMID:7585947</ref> <ref>PMID:7584145</ref> <ref>PMID:8621063</ref> <ref>PMID:9064343</ref> <ref>PMID:8629002</ref> <ref>PMID:9252121</ref> <ref>PMID:9036984</ref> <ref>PMID:9573010</ref> <ref>PMID:9601638</ref> <ref>PMID:9480991</ref> <ref>PMID:9547345</ref> <ref>PMID:9469421</ref> <ref>PMID:9590210</ref> <ref>PMID:10594694</ref> <ref>PMID:10327049</ref> <ref>PMID:10672044</ref> <ref>PMID:10640270</ref> <ref>PMID:11007759</ref> <ref>PMID:11435302</ref> <ref>PMID:11672542</ref> <ref>PMID:12077122</ref> <ref>PMID:12874221</ref> <ref>PMID:14726379</ref> <ref>PMID:14525964</ref> <ref>PMID:16116174</ref> <ref>PMID:16034130</ref> <ref>PMID:16272347</ref> <ref>PMID:16249387</ref> <ref>PMID:16731527</ref> <ref>PMID:17640867</ref> <ref>PMID:19492092</ref> <ref>PMID:20189992</ref> <ref>PMID:20385881</ref>	+	[https://www.uniprot.org/uniprot/LYN_MOUSE LYN_MOUSE] Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'.<ref>PMID:15335855</ref> <ref>PMID:7513017</ref> <ref>PMID:8128248</ref> <ref>PMID:7585947</ref> <ref>PMID:7584145</ref> <ref>PMID:8621063</ref> <ref>PMID:9064343</ref> <ref>PMID:8629002</ref> <ref>PMID:9252121</ref> <ref>PMID:9036984</ref> <ref>PMID:9573010</ref> <ref>PMID:9601638</ref> <ref>PMID:9480991</ref> <ref>PMID:9547345</ref> <ref>PMID:9469421</ref> <ref>PMID:9590210</ref> <ref>PMID:10594694</ref> <ref>PMID:10327049</ref> <ref>PMID:10672044</ref> <ref>PMID:10640270</ref> <ref>PMID:11007759</ref> <ref>PMID:11435302</ref> <ref>PMID:11672542</ref> <ref>PMID:12077122</ref> <ref>PMID:12874221</ref> <ref>PMID:14726379</ref> <ref>PMID:14525964</ref> <ref>PMID:16116174</ref> <ref>PMID:16034130</ref> <ref>PMID:16272347</ref> <ref>PMID:16249387</ref> <ref>PMID:16731527</ref> <ref>PMID:17640867</ref> <ref>PMID:19492092</ref> <ref>PMID:20189992</ref> <ref>PMID:20385881</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice]]~~	+	[[Category: Mus musculus]]
-	~~[[Category: Non-specific protein-tyrosine kinase~~]]	+	[[Category: Rossjohn J]]
-	[[Category: Rossjohn, J]]	+	[[Category: Williams NK]]
-	[[Category: Williams~~, N K]]~~	+
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Lyn kinase pp2]]~~	+
-	~~[[Category: Myristate]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Palmitate]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Proto-oncogene]]~~	+
-	~~[[Category: Sh2 domain]]~~	+
-	~~[[Category: Sh3 domain]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Tyrosine-protein kinase~~]]	+

OCA at 12:10, 29 July 2020

OCA — Wed, 29 Jul 2020 12:10:20 GMT

←Older revision		Revision as of 12:10, 29 July 2020
Line 1:		Line 1:

	==Lyn Tyrosine Kinase Domain-PP2 complex==		==Lyn Tyrosine Kinase Domain-PP2 complex==
-	<StructureSection load='2zv9' size='340' side='right' caption='[[2zv9]], [[Resolution\|resolution]] 2.76Å' scene=''>	+	<StructureSection load='2zv9' size='340' side='right'caption='[[2zv9]], [[Resolution\|resolution]] 2.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zv9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV9 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZV9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zv9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2ZV9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PP2:1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE'>PP2</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PP2:1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE'>PP2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zv7\|2zv7]], [[2zv8\|2zv8]], [[2zva\|2zva]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zv7\|2zv7]], [[2zv8\|2zv8]], [[2zva\|2zva]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zv9 OCA], [http://pdbe.org/2zv9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zv9 RCSB], [http://www.ebi.ac.uk/pdbsum/2zv9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zv9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2zv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zv9 OCA], [http://pdbe.org/2zv9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zv9 RCSB], [http://www.ebi.ac.uk/pdbsum/2zv9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zv9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Tyrosine kinase\|Tyrosine kinase]]	+	*[[Tyrosine kinase 3D structures\|Tyrosine kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]

OCA at 06:50, 18 October 2018

OCA — Thu, 18 Oct 2018 06:50:09 GMT

←Older revision		Revision as of 06:50, 18 October 2018
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/2zv9_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/2zv9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 41:		Line 41:
	[[Category: Rossjohn, J]]		[[Category: Rossjohn, J]]
	[[Category: Williams, N K]]		[[Category: Williams, N K]]
		+	[[Category: Alternative splicing]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Kinase]]		[[Category: Kinase]]

OCA at 16:56, 5 August 2016

OCA — Fri, 05 Aug 2016 16:56:24 GMT

←Older revision		Revision as of 16:56, 5 August 2016
Line 1:		Line 1:
		+
	==Lyn Tyrosine Kinase Domain-PP2 complex==		==Lyn Tyrosine Kinase Domain-PP2 complex==
	<StructureSection load='2zv9' size='340' side='right' caption='[[2zv9]], [[Resolution\|resolution]] 2.76Å' scene=''>		<StructureSection load='2zv9' size='340' side='right' caption='[[2zv9]], [[Resolution\|resolution]] 2.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zv9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZV9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zv9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZV9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PP2:1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE'>PP2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PP2:1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE'>PP2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zv7\|2zv7]], [[2zv8\|2zv8]], [[2zva\|2zva]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zv7\|2zv7]], [[2zv8\|2zv8]], [[2zva\|2zva]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zv9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zv9 RCSB], [http://www.ebi.ac.uk/pdbsum/2zv9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zv9 OCA], [http://pdbe.org/2zv9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zv9 RCSB], [http://www.ebi.ac.uk/pdbsum/2zv9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zv9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zv9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2zv9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]
	[[Category: Rossjohn, J]]		[[Category: Rossjohn, J]]

OCA at 20:28, 25 December 2014

OCA — Thu, 25 Dec 2014 20:28:31 GMT

←Older revision		Revision as of 20:28, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zv9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZV9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zv9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZV9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PP2:1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE'>PP2</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PP2:1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE'>PP2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zv7\|2zv7]], [[2zv8\|2zv8]], [[2zva\|2zva]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zv7\|2zv7]], [[2zv8\|2zv8]], [[2zva\|2zva]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zv9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zv9 RCSB], [http://www.ebi.ac.uk/pdbsum/2zv9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zv9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zv9 RCSB], [http://www.ebi.ac.uk/pdbsum/2zv9 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LYN_MOUSE LYN_MOUSE]] Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'.<ref>PMID:15335855</ref> <ref>PMID:7513017</ref> <ref>PMID:8128248</ref> <ref>PMID:7585947</ref> <ref>PMID:7584145</ref> <ref>PMID:8621063</ref> <ref>PMID:9064343</ref> <ref>PMID:8629002</ref> <ref>PMID:9252121</ref> <ref>PMID:9036984</ref> <ref>PMID:9573010</ref> <ref>PMID:9601638</ref> <ref>PMID:9480991</ref> <ref>PMID:9547345</ref> <ref>PMID:9469421</ref> <ref>PMID:9590210</ref> <ref>PMID:10594694</ref> <ref>PMID:10327049</ref> <ref>PMID:10672044</ref> <ref>PMID:10640270</ref> <ref>PMID:11007759</ref> <ref>PMID:11435302</ref> <ref>PMID:11672542</ref> <ref>PMID:12077122</ref> <ref>PMID:12874221</ref> <ref>PMID:14726379</ref> <ref>PMID:14525964</ref> <ref>PMID:16116174</ref> <ref>PMID:16034130</ref> <ref>PMID:16272347</ref> <ref>PMID:16249387</ref> <ref>PMID:16731527</ref> <ref>PMID:17640867</ref> <ref>PMID:19492092</ref> <ref>PMID:20189992</ref> <ref>PMID:20385881</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]
-	[[Category: Rossjohn, J.]]	+	[[Category: Rossjohn, J]]
-	[[Category: Williams, N K.]]	+	[[Category: Williams, N K]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Kinase]]		[[Category: Kinase]]

OCA at 05:17, 2 October 2014

OCA — Thu, 02 Oct 2014 05:17:07 GMT

←Older revision		Revision as of 05:17, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2zv9.~~png~~\|~~left~~\|200px]]	+	==Lyn Tyrosine Kinase Domain-PP2 complex==
		+	<StructureSection load='2zv9' size='340' side='right' caption='[[2zv9]], [[Resolution\|resolution]] 2.76Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2zv9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZV9 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PP2:1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE'>PP2</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zv7\|2zv7]], [[2zv8\|2zv8]], [[2zva\|2zva]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zv9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zv9 RCSB], [http://www.ebi.ac.uk/pdbsum/2zv9 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/2zv9_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Src-family protein-tyrosine kinase (PTK) Lyn is the most important Src-family kinase in B cells, having both inhibitory and stimulatory activity that is dependent on the receptor, ligand, and developmental context of the B cell. An important role for Lyn has been reported in acute myeloid leukemia and chronic myeloid leukemia, as well as certain solid tumors. Although several Src-family inhibitors are available, the development of Lyn-specific inhibitors, or inhibitors with reduced off-target activity to Lyn, has been hampered by the lack of structural data on the Lyn kinase. Here we report the crystal structure of the non-liganded form of Lyn kinase domain, as well as in complex with three different inhibitors: the ATP analogue AMP-PNP; the pan Src kinase inhibitor PP2; and the BCR-Abl/Src-family inhibitor Dasatinib. The Lyn kinase domain was determined in its "active" conformation, but in the unphosphorylated state. All three inhibitors are bound at the ATP-binding site, with PP2 and Dasatinib extending into a hydrophobic pocket deep in the substrate cleft, thereby providing a basis for the Src-specific inhibition. Analysis of sequence and structural differences around the active site region of the Src-family PTKs were evident. Accordingly, our data provide valuable information for the further development of therapeutics targeting Lyn and the important Src-family of kinases.

-	~~{{STRUCTURE_2zv9\| PDB=2zv9 \| SCENE= }}~~	+	Crystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound state.,Williams NK, Lucet IS, Klinken SP, Ingley E, Rossjohn J J Biol Chem. 2009 Jan 2;284(1):284-91. Epub 2008 Nov 4. PMID:18984583<ref>PMID:18984583</ref>

-	~~===Lyn Tyrosine Kinase Domain-PP2 complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_18984583}}~~	+	==See Also==
-		+	*[[Tyrosine kinase\|Tyrosine kinase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2zv9~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV9 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:018984583<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]

OCA: Protected "2zv9" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 19:53:55 GMT

Protected "2zv9" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:53, 7 January 2013

OCA at 19:53, 7 January 2013

OCA — Mon, 07 Jan 2013 19:53:54 GMT

←Older revision		Revision as of 19:53, 7 January 2013
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-	{{Seed}}
	[[Image:2zv9.png\|left\|200px]]		[[Image:2zv9.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zv9", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zv9\| PDB=2zv9 \| SCENE= }}		{{STRUCTURE_2zv9\| PDB=2zv9 \| SCENE= }}

	===Lyn Tyrosine Kinase Domain-PP2 complex===		===Lyn Tyrosine Kinase Domain-PP2 complex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18984583}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18984583 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18984583}}		{{ABSTRACT_PUBMED_18984583}}

	==About this Structure==		==About this Structure==
-	~~2ZV9~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV9 OCA].	+	[[2zv9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV9 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18984583~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018984583</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]
	[[Category: Rossjohn, J.]]		[[Category: Rossjohn, J.]]
	[[Category: Williams, N K.]]		[[Category: Williams, N K.]]
-	[[Category: Alternative splicing]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Kinase]]		[[Category: Kinase]]
Line 42:		Line 29:
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Tyrosine-protein kinase]]		[[Category: Tyrosine-protein kinase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:15:05 2009''

OCA at 04:15, 18 February 2009

OCA — Wed, 18 Feb 2009 04:15:09 GMT

←Older revision		Revision as of 04:15, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2ZV9 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV9 OCA].	+	2ZV9 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV9 OCA].

	==Reference==		==Reference==
-	~~Crystal structures of the Lyn protein tyrosine kinase domain in its apo- and inhibitor-bound state., Williams NK, Lucet IS, Klinken SP, Ingley E, Rossjohn J, J Biol Chem. 2008 Nov 4.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18984583 18984583]~~	+	<ref group="xtra">PMID:18984583</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]
-	[[Category: ~~Single protein~~]]	+	[[Category: Rossjohn, J.]]
-	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx:audit_author~~.]]	+	[[Category: Williams, N K.]]
	[[Category: Alternative splicing]]		[[Category: Alternative splicing]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
Line 43:		Line 43:
	[[Category: Tyrosine-protein kinase]]		[[Category: Tyrosine-protein kinase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 14 20~~:21:56 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:15:05 2009''

OCA at 20:45, 15 January 2009

OCA — Thu, 15 Jan 2009 20:45:12 GMT

←Older revision		Revision as of 20:45, 15 January 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2ZV9 is a ~~1 chain~~ structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV9 OCA].	+	2ZV9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV9 OCA].

	==Reference==		==Reference==
Line 26:		Line 26:
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]
-	[[Category: ~~Rossjohn, J.~~]]	+	[[Category: Single protein]]
-	[[Category: ~~Williams~~, ~~N K~~.]]	+	[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
	[[Category: Alternative splicing]]		[[Category: Alternative splicing]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
Line 43:		Line 43:
	[[Category: Tyrosine-protein kinase]]		[[Category: Tyrosine-protein kinase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Nov~~ 20 07:54:~~03 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 14 20:21:56 2009''