2zvo - Revision history

OCA at 19:19, 29 May 2024

OCA — Wed, 29 May 2024 19:19:42 GMT

←Older revision		Revision as of 19:19, 29 May 2024
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	<StructureSection load='2zvo' size='340' side='right'caption='[[2zvo]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2zvo' size='340' side='right'caption='[[2zvo]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zvo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~] and [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZVO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zvo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZVO FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[2zvn\|2zvn]]~~, [[~~3f89~~\|~~3f89~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvo OCA], [https://pdbe.org/2zvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zvo RCSB], [https://www.ebi.ac.uk/pdbsum/2zvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zvo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvo OCA], [https://pdbe.org/2zvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zvo RCSB], [https://www.ebi.ac.uk/pdbsum/2zvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zvo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~NEMO_MOUSE NEMO_MOUSE~~]~~] Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading~~ to ~~the dissociation~~ of the ~~inhibitor/NF-kappa-B complex and ultimately~~ the ~~degradation~~ of the ~~inhibitor. Its binding to scaffolding~~ polyubiquitin ~~seems to play a role in IKK activation by multiple signaling receptor pathways~~. ~~Also considered~~ to be a ~~mediator for TAX activation~~ of NF-~~kappa~~-~~B. Could~~ be ~~implicated~~ in NF-~~kappa~~-~~B-mediated protection from cytokine toxicity. Involved~~ in ~~TLR3~~- and ~~IFIH1~~-~~mediated antiviral innate response~~; ~~this function requires '~~Lys-~~27'~~-linked ~~polyubiquitination~~ (~~By similarity~~).<ref>PMID:~~9927690~~</ref>	+	[https://www.uniprot.org/uniprot/UBC_HUMAN UBC_HUMAN] Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.<ref>PMID:16543144</ref> <ref>PMID:19754430</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Akutsu, M]]	+	[[Category: Akutsu M]]
-	[[Category: Bloor, S]]	+	[[Category: Bloor S]]
-	[[Category: Dikic, I]]	+	[[Category: Dikic I]]
-	[[Category: Ikeda, F]]	+	[[Category: Ikeda F]]
-	[[Category: Kato, R]]	+	[[Category: Kato R]]
-	[[Category: Kawasaki, M]]	+	[[Category: Kawasaki M]]
-	[[Category: Kensche, T]]	+	[[Category: Kensche T]]
-	[[Category: Komander, D]]	+	[[Category: Komander D]]
-	[[Category: Rahighi, S]]	+	[[Category: Rahighi S]]
-	[[Category: Randow, F]]	+	[[Category: Randow F]]
-	[[Category: Suzuki, N]]	+	[[Category: Suzuki N]]
-	[[Category: Uejima, T]]	+	[[Category: Uejima T]]
-	[[Category: Wakatsuki, S]]	+	[[Category: Wakatsuki S]]
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nf-kb signaling]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Transcription-signaling protein complex]]~~	+
-	~~[[Category: Ubiquitin binding]]~~	+
-	~~[[Category: Ubl conjugation]]~~	+
-	~~[[Category: Zinc]]~~	+
-	~~[[Category: Zinc-finger~~]]	+

OCA at 07:20, 10 November 2021

OCA — Wed, 10 Nov 2021 07:20:30 GMT

←Older revision		Revision as of 07:20, 10 November 2021
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	<StructureSection load='2zvo' size='340' side='right'caption='[[2zvo]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2zvo' size='340' side='right'caption='[[2zvo]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zvo]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZVO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zvo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZVO FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zvn\|2zvn]], [[3f89\|3f89]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zvn\|2zvn]], [[3f89\|3f89]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvo OCA], [~~http~~://pdbe.org/2zvo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zvo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zvo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zvo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvo OCA], [https://pdbe.org/2zvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zvo RCSB], [https://www.ebi.ac.uk/pdbsum/2zvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zvo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NEMO_MOUSE NEMO_MOUSE]] Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (By similarity).<ref>PMID:9927690</ref>	+	[[https://www.uniprot.org/uniprot/NEMO_MOUSE NEMO_MOUSE]] Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (By similarity).<ref>PMID:9927690</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[~~Ubiquitin~~\|~~Ubiquitin~~]]	+	*[[3D structures of ubiquitin\|3D structures of ubiquitin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:40, 31 July 2019

OCA — Wed, 31 Jul 2019 07:40:33 GMT

←Older revision		Revision as of 07:40, 31 July 2019
Line 1:		Line 1:

	==NEMO CoZi domain in complex with diubiquitin in C2 space group==		==NEMO CoZi domain in complex with diubiquitin in C2 space group==
-	<StructureSection load='2zvo' size='340' side='right' caption='[[2zvo]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='2zvo' size='340' side='right'caption='[[2zvo]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zvo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZVO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zvo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZVO FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/2zvo_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/2zvo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2zvo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2zvo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ubiquitin\|Ubiquitin]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Akutsu, M]]		[[Category: Akutsu, M]]

OCA at 11:16, 12 October 2017

OCA — Thu, 12 Oct 2017 11:16:10 GMT

←Older revision		Revision as of 11:16, 12 October 2017
Line 1:		Line 1:
		+
	==NEMO CoZi domain in complex with diubiquitin in C2 space group==		==NEMO CoZi domain in complex with diubiquitin in C2 space group==
	<StructureSection load='2zvo' size='340' side='right' caption='[[2zvo]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2zvo' size='340' side='right' caption='[[2zvo]], [[Resolution\|resolution]] 2.90Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2zvo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZVO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zvo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZVO FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zvn\|2zvn]], [[3f89\|3f89]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zvn\|2zvn]], [[3f89\|3f89]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvo OCA], [http://pdbe.org/2zvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zvo RCSB], [http://www.ebi.ac.uk/pdbsum/2zvo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvo OCA], [http://pdbe.org/2zvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zvo RCSB], [http://www.ebi.ac.uk/pdbsum/2zvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zvo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 2zvo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2zvo" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ubiquitin\|Ubiquitin]]
	== References ==		== References ==
	<references/>		<references/>
Line 49:		Line 47:
	[[Category: Uejima, T]]		[[Category: Uejima, T]]
	[[Category: Wakatsuki, S]]		[[Category: Wakatsuki, S]]
		+	[[Category: Coiled coil]]
		+	[[Category: Cytoplasm]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Nf-kb signaling]]		[[Category: Nf-kb signaling]]
Line 57:		Line 57:
	[[Category: Transcription-signaling protein complex]]		[[Category: Transcription-signaling protein complex]]
	[[Category: Ubiquitin binding]]		[[Category: Ubiquitin binding]]
		+	[[Category: Ubl conjugation]]
		+	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 04:28, 8 February 2016

OCA — Mon, 08 Feb 2016 04:28:00 GMT

←Older revision		Revision as of 04:28, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2zvo' size='340' side='right' caption='[[2zvo]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2zvo' size='340' side='right' caption='[[2zvo]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zvo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZVO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zvo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZVO FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zvn\|2zvn]], [[3f89\|3f89]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zvn\|2zvn]], [[3f89\|3f89]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zvo RCSB], [http://www.ebi.ac.uk/pdbsum/2zvo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvo OCA], [http://pdbe.org/2zvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zvo RCSB], [http://www.ebi.ac.uk/pdbsum/2zvo PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zvo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2zvo" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Akutsu, M]]		[[Category: Akutsu, M]]
	[[Category: Bloor, S]]		[[Category: Bloor, S]]

OCA at 20:37, 24 December 2014

OCA — Wed, 24 Dec 2014 20:37:02 GMT

←Older revision		Revision as of 20:37, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zvo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZVO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zvo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZVO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zvn\|2zvn]], [[3f89\|3f89]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zvn\|2zvn]], [[3f89\|3f89]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zvo RCSB], [http://www.ebi.ac.uk/pdbsum/2zvo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zvo RCSB], [http://www.ebi.ac.uk/pdbsum/2zvo PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NEMO_MOUSE NEMO_MOUSE]] Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (By similarity).<ref>PMID:9927690</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Akutsu, M.]]	+	[[Category: Akutsu, M]]
-	[[Category: Bloor, S.]]	+	[[Category: Bloor, S]]
-	[[Category: Dikic, I.]]	+	[[Category: Dikic, I]]
-	[[Category: Ikeda, F.]]	+	[[Category: Ikeda, F]]
-	[[Category: Kato, R.]]	+	[[Category: Kato, R]]
-	[[Category: Kawasaki, M.]]	+	[[Category: Kawasaki, M]]
-	[[Category: Kensche, T.]]	+	[[Category: Kensche, T]]
-	[[Category: Komander, D.]]	+	[[Category: Komander, D]]
-	[[Category: Rahighi, S.]]	+	[[Category: Rahighi, S]]
-	[[Category: Randow, F.]]	+	[[Category: Randow, F]]
-	[[Category: Suzuki, N.]]	+	[[Category: Suzuki, N]]
-	[[Category: Uejima, T.]]	+	[[Category: Uejima, T]]
-	[[Category: Wakatsuki, S.]]	+	[[Category: Wakatsuki, S]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Nf-kb signaling]]		[[Category: Nf-kb signaling]]

OCA at 07:50, 29 September 2014

OCA — Mon, 29 Sep 2014 07:50:42 GMT

←Older revision		Revision as of 07:50, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2zvo.~~png~~\|~~left~~\|200px]]	+	==NEMO CoZi domain in complex with diubiquitin in C2 space group==
		+	<StructureSection load='2zvo' size='340' side='right' caption='[[2zvo]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2zvo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZVO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zvn\|2zvn]], [[3f89\|3f89]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zvo RCSB], [http://www.ebi.ac.uk/pdbsum/2zvo PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/2zvo_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Activation of nuclear factor-kappaB (NF-kappaB), a key mediator of inducible transcription in immunity, requires binding of NF-kappaB essential modulator (NEMO) to ubiquitinated substrates. Here, we report that the UBAN (ubiquitin binding in ABIN and NEMO) motif of NEMO selectively binds linear (head-to-tail) ubiquitin chains. Crystal structures of the UBAN motif revealed a parallel coiled-coil dimer that formed a heterotetrameric complex with two linear diubiquitin molecules. The UBAN dimer contacted all four ubiquitin moieties, and the integrity of each binding site was required for efficient NF-kappaB activation. Binding occurred via a surface on the proximal ubiquitin moiety and the canonical Ile44 surface on the distal one, thereby providing specificity for linear chain recognition. Residues of NEMO involved in binding linear ubiquitin chains are required for NF-kappaB activation by TNF-alpha and other agonists, providing an explanation for the detrimental effect of NEMO mutations in patients suffering from X-linked ectodermal dysplasia and immunodeficiency.

-	~~{{STRUCTURE_2zvo\| PDB=2zvo \| SCENE= }}~~	+	Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation.,Rahighi S, Ikeda F, Kawasaki M, Akutsu M, Suzuki N, Kato R, Kensche T, Uejima T, Bloor S, Komander D, Randow F, Wakatsuki S, Dikic I Cell. 2009 Mar 20;136(6):1098-109. PMID:19303852<ref>PMID:19303852</ref>

-	~~===NEMO CoZi domain in complex with diubiquitin in C2 space group===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19303852}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2zvo]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/~~wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVO OCA].~~	+

	==See Also==		==See Also==
	*[[Ubiquitin\|Ubiquitin]]		*[[Ubiquitin\|Ubiquitin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019303852<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 08:54, 20 October 2012

OCA — Sat, 20 Oct 2012 08:54:39 GMT

←Older revision		Revision as of 08:54, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2zvo]] is a 4 chain structure ~~of [[Ubiquitin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVO OCA].	+	[[2zvo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVO OCA].

	==See Also==		==See Also==

OCA at 21:10, 25 July 2012

OCA — Wed, 25 Jul 2012 21:10:02 GMT

←Older revision		Revision as of 21:10, 25 July 2012
Line 1:		Line 1:
	[[Image:2zvo.png\|left\|200px]]		[[Image:2zvo.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zvo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zvo\| PDB=2zvo \| SCENE= }}		{{STRUCTURE_2zvo\| PDB=2zvo \| SCENE= }}

	===NEMO CoZi domain in complex with diubiquitin in C2 space group===		===NEMO CoZi domain in complex with diubiquitin in C2 space group===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19303852}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19303852 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19303852}}		{{ABSTRACT_PUBMED_19303852}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Ubiquitin]]	+	*[[Ubiquitin\|Ubiquitin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19303852~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019303852</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
Line 41:		Line 30:
	[[Category: Uejima, T.]]		[[Category: Uejima, T.]]
	[[Category: Wakatsuki, S.]]		[[Category: Wakatsuki, S.]]
-	[[Category: Coiled coil]]
-	[[Category: Cytoplasm]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Nf-kb signaling]]		[[Category: Nf-kb signaling]]
Line 49:		Line 36:
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
-	[[Category: Transcription/signaling protein complex]]	+	[[Category: Transcription-signaling protein complex]]
	[[Category: Ubiquitin binding]]		[[Category: Ubiquitin binding]]
-	[[Category: Ubl conjugation]]
-	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA: Protected "2zvo" [edit=sysop:move=sysop]

OCA — Mon, 27 Dec 2010 01:33:04 GMT

Protected "2zvo" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:33, 27 December 2010