2zvv - Revision history

OCA at 13:57, 1 November 2023

OCA — Wed, 01 Nov 2023 13:57:23 GMT

←Older revision		Revision as of 13:57, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='2zvv' size='340' side='right'caption='[[2zvv]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2zvv' size='340' side='right'caption='[[2zvv]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zvv]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2ZVV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zvv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZVV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[2zvw\|2zvw]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2zvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvv OCA], [~~http~~://pdbe.org/2zvv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zvv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zvv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zvv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvv OCA], [https://pdbe.org/2zvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zvv RCSB], [https://www.ebi.ac.uk/pdbsum/2zvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zvv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PCNA1_ARATH PCNA1_ARATH]] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (By similarity).[HAMAP-Rule:MF_00317] [[http://www.uniprot.org/uniprot/CDN1A_HUMAN CDN1A_HUMAN]] May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.<ref>PMID:8242751</ref> <ref>PMID:9106657</ref>	+	[https://www.uniprot.org/uniprot/PCNA1_ARATH PCNA1_ARATH] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (By similarity).[HAMAP-Rule:MF_00317]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Morikawa, K]]	+	[[Category: Morikawa K]]
-	[[Category: Oyama, T]]	+	[[Category: Oyama T]]
-	[[Category: Strzalka, W]]	+	[[Category: Strzalka W]]
-	[[Category: Tori, K]]	+	[[Category: Tori K]]
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Dna replication]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Protein-peptide complex~~]]	+

OCA at 12:10, 29 July 2020

OCA — Wed, 29 Jul 2020 12:10:38 GMT

←Older revision		Revision as of 12:10, 29 July 2020
Line 1:		Line 1:

	==Crystal structure of Proliferating cellular nuclear antigen 1 and Short peptide from human P21==		==Crystal structure of Proliferating cellular nuclear antigen 1 and Short peptide from human P21==
-	<StructureSection load='2zvv' size='340' side='right' caption='[[2zvv]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2zvv' size='340' side='right'caption='[[2zvv]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zvv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZVV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zvv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2ZVV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zvw\|2zvw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zvw\|2zvw]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvv OCA], [http://pdbe.org/2zvv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zvv RCSB], [http://www.ebi.ac.uk/pdbsum/2zvv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zvv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2zvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvv OCA], [http://pdbe.org/2zvv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zvv RCSB], [http://www.ebi.ac.uk/pdbsum/2zvv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zvv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Proliferating ~~Cell Nuclear Antigen~~\|Proliferating ~~Cell Nuclear Antigen~~]]	+	*[[Proliferating cell nuclear antigen 3D structures\|Proliferating cell nuclear antigen 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Arath]]		[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Morikawa, K]]		[[Category: Morikawa, K]]
	[[Category: Oyama, T]]		[[Category: Oyama, T]]

OCA at 07:16, 18 October 2018

OCA — Thu, 18 Oct 2018 07:16:40 GMT

←Older revision		Revision as of 07:16, 18 October 2018
Line 1:		Line 1:
		+
	==Crystal structure of Proliferating cellular nuclear antigen 1 and Short peptide from human P21==		==Crystal structure of Proliferating cellular nuclear antigen 1 and Short peptide from human P21==
	<StructureSection load='2zvv' size='340' side='right' caption='[[2zvv]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2zvv' size='340' side='right' caption='[[2zvv]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zvw\|2zvw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zvw\|2zvw]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvv OCA], [http://pdbe.org/2zvv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zvv RCSB], [http://www.ebi.ac.uk/pdbsum/2zvv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvv OCA], [http://pdbe.org/2zvv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zvv RCSB], [http://www.ebi.ac.uk/pdbsum/2zvv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zvv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/2zvv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/2zvv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:56, 8 February 2016

OCA — Mon, 08 Feb 2016 07:56:23 GMT

←Older revision		Revision as of 07:56, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2zvv' size='340' side='right' caption='[[2zvv]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2zvv' size='340' side='right' caption='[[2zvv]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zvv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZVV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zvv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZVV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zvw\|2zvw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zvw\|2zvw]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zvv RCSB], [http://www.ebi.ac.uk/pdbsum/2zvv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvv OCA], [http://pdbe.org/2zvv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zvv RCSB], [http://www.ebi.ac.uk/pdbsum/2zvv PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zvv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2zvv" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arabidopsis thaliana~~]]	+	[[Category: Arath]]
	[[Category: Morikawa, K]]		[[Category: Morikawa, K]]
	[[Category: Oyama, T]]		[[Category: Oyama, T]]

OCA at 21:48, 24 December 2014

OCA — Wed, 24 Dec 2014 21:48:26 GMT

←Older revision		Revision as of 21:48, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zvv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZVV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zvv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZVV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zvw\|2zvw]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zvw\|2zvw]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zvv RCSB], [http://www.ebi.ac.uk/pdbsum/2zvv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zvv RCSB], [http://www.ebi.ac.uk/pdbsum/2zvv PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PCNA1_ARATH PCNA1_ARATH]] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (By similarity).[HAMAP-Rule:MF_00317] [[http://www.uniprot.org/uniprot/CDN1A_HUMAN CDN1A_HUMAN]] May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.<ref>PMID:8242751</ref> <ref>PMID:9106657</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
-	[[Category: Morikawa, K.]]	+	[[Category: Morikawa, K]]
-	[[Category: Oyama, T.]]	+	[[Category: Oyama, T]]
-	[[Category: Strzalka, W.]]	+	[[Category: Strzalka, W]]
-	[[Category: Tori, K.]]	+	[[Category: Tori, K]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Dna replication]]		[[Category: Dna replication]]

OCA at 10:04, 29 September 2014

OCA — Mon, 29 Sep 2014 10:04:34 GMT

←Older revision		Revision as of 10:04, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2zvv.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Proliferating cellular nuclear antigen 1 and Short peptide from human P21==
		+	<StructureSection load='2zvv' size='340' side='right' caption='[[2zvv]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2zvv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZVV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zvw\|2zvw]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zvv RCSB], [http://www.ebi.ac.uk/pdbsum/2zvv PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/2zvv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The proliferating cell nuclear antigen (PCNA) is well recognized as one of the essential cellular components of the DNA replication machinery in all eukaryotic organisms. Despite their prominent importance, very little biochemical and structural information about plant PCNAs is available, in comparison with that obtained from other eukaryotic organisms. We have determined the atomic resolution crystal structures of the two distinct Arabidopsis thaliana PCNAs (AtPCNA), both complexed with the C-terminal segment of human p21. Both AtPCNAs form homotrimeric ring structures, which are essentially identical to each other, including the major contacts with the p21 peptide. The structure of the amino-terminal half of the p21 peptide, containing the typical PIP box sequence, is remarkably similar to those observed in the previously reported crystal structures of the human and archaeal PCNA-PIP box complexes. Meanwhile, the carboxy-terminal halves of the p21 peptide in the plant PCNA complexes are bound to the protein in a unique manner, most probably because of crystal packing effects. A surface plasmon resonance analysis revealed high affinity between each AtPCNA and the C-terminal fragment of human p21. This result strongly suggests that the interaction is functionally significant, although no plant homologs of p21 have been identified yet. We also discovered that AtPCNA1 and AtPCNA2 form heterotrimers, implying that hetero-PCNA rings may play critical roles in cellular signal transduction, particularly in DNA repair.

-	~~{{STRUCTURE_2zvv\| PDB=2zvv \| SCENE= }}~~	+	Crystal structures of the Arabidopsis thaliana proliferating cell nuclear antigen 1 and 2 proteins complexed with the human p21 C-terminal segment.,Strzalka W, Oyama T, Tori K, Morikawa K Protein Sci. 2009 May;18(5):1072-80. PMID:19388052<ref>PMID:19388052</ref>

-	~~===Crystal structure~~ of ~~Proliferating cellular nuclear antigen 1 and Short peptide from human P21===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19388052}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2zvv]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVV OCA].~~	+

	==See Also==		==See Also==
	*[[Proliferating Cell Nuclear Antigen\|Proliferating Cell Nuclear Antigen]]		*[[Proliferating Cell Nuclear Antigen\|Proliferating Cell Nuclear Antigen]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019388052<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Morikawa, K.]]		[[Category: Morikawa, K.]]

OCA at 09:28, 20 October 2012

OCA — Sat, 20 Oct 2012 09:28:19 GMT

←Older revision		Revision as of 09:28, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2zvv]] is a 4 chain structure ~~of [[Proliferating Cell Nuclear Antigen]]~~ with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVV OCA].	+	[[2zvv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVV OCA].

	==See Also==		==See Also==

OCA: Protected "2zvv" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 22:57:32 GMT

Protected "2zvv" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:57, 25 July 2012

OCA at 22:57, 25 July 2012

OCA — Wed, 25 Jul 2012 22:57:28 GMT

←Older revision		Revision as of 22:57, 25 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2zvv.png\|left\|200px]]
-	[[Image:2zvv.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zvv", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zvv\| PDB=2zvv \| SCENE= }}		{{STRUCTURE_2zvv\| PDB=2zvv \| SCENE= }}

	===Crystal structure of Proliferating cellular nuclear antigen 1 and Short peptide from human P21===		===Crystal structure of Proliferating cellular nuclear antigen 1 and Short peptide from human P21===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19388052}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19388052 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19388052}}		{{ABSTRACT_PUBMED_19388052}}

	==About this Structure==		==About this Structure==
-	~~2ZVV~~ is a 4 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVV OCA].	+	[[2zvv]] is a 4 chain structure of [[Proliferating Cell Nuclear Antigen]] with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVV OCA].
		+
		+	==See Also==
		+	*[[Proliferating Cell Nuclear Antigen\|Proliferating Cell Nuclear Antigen]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19388052~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019388052</ref><references group="xtra"/>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Morikawa, K.]]		[[Category: Morikawa, K.]]
Line 34:		Line 25:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Protein-peptide complex]]		[[Category: Protein-peptide complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 4 07:23:41 2009''

OCA at 04:23, 4 June 2009

OCA — Thu, 04 Jun 2009 04:23:43 GMT

←Older revision		Revision as of 04:23, 4 June 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2zvv.jpg\|left\|200px]]

-	The ~~entry 2zvv~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2zvv", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2zvv\| PDB=2zvv \| SCENE= }}

-	~~Authors: Strzalka, W., Oyama, T., Tori, K., Morikawa, K.~~	+	===Crystal structure of Proliferating cellular nuclear antigen 1 and Short peptide from human P21===

-	Description:

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Dec 10 14~~:34:~~11 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19388052}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19388052 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19388052}}
		+
		+	==About this Structure==
		+	2ZVV is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVV OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19388052</ref><references group="xtra"/>
		+	[[Category: Arabidopsis thaliana]]
		+	[[Category: Morikawa, K.]]
		+	[[Category: Oyama, T.]]
		+	[[Category: Strzalka, W.]]
		+	[[Category: Tori, K.]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Dna replication]]
		+	[[Category: Dna-binding]]
		+	[[Category: Nucleus]]
		+	[[Category: Protein-peptide complex]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 4 07:23:41 2009''