2zxz - Revision history

OCA at 14:01, 1 November 2023

OCA — Wed, 01 Nov 2023 14:01:18 GMT

←Older revision		Revision as of 14:01, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='2zxz' size='340' side='right'caption='[[2zxz]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2zxz' size='340' side='right'caption='[[2zxz]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zxz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZXZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zxz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZXZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=P26:4~~-[~~2-(1,1,~~3~~,3-TETRAMETHYL-2,3-DIHYDRO-1H-INDEN-5-YL)-1,3-DIOXOLAN-2-YL]BENZOIC+ACID'>P26</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>~~[~~[1fby\|1fby]]~~, ~~[[1mvc\|1mvc]]~~, ~~[[1mv9\|1mv9]]~~, ~~[[2zy0\|2zy0]~~]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P26:4-[2-(1,1,3,3-TETRAMETHYL-2,3-DIHYDRO-1H-INDEN-5-YL)-1,3-DIOXOLAN-2-YL]BENZOIC+ACID'>P26</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zxz OCA], [https://pdbe.org/2zxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zxz RCSB], [https://www.ebi.ac.uk/pdbsum/2zxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zxz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zxz OCA], [https://pdbe.org/2zxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zxz RCSB], [https://www.ebi.ac.uk/pdbsum/2zxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zxz ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RXRA_HUMAN RXRA_HUMAN]] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref> <ref>PMID:11162439</ref> <ref>PMID:11915042</ref> <ref>PMID:20215566</ref> [[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>	+	[https://www.uniprot.org/uniprot/RXRA_HUMAN RXRA_HUMAN] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref> <ref>PMID:11162439</ref> <ref>PMID:11915042</ref> <ref>PMID:20215566</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Antony, P]]	+	[[Category: Antony P]]
-	[[Category: Moras, D]]	+	[[Category: Moras D]]
-	[[Category: Rochel, N]]	+	[[Category: Rochel N]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Sato Y]]
-	[[Category: Sato, Y]]	+
-	~~[[Category: Nuclear receptor]]~~	+
-	~~[[Category: Sgcge]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation~~]]	+

OCA at 16:10, 22 December 2021

OCA — Wed, 22 Dec 2021 16:10:45 GMT

←Older revision		Revision as of 16:10, 22 December 2021
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	<StructureSection load='2zxz' size='340' side='right'caption='[[2zxz]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2zxz' size='340' side='right'caption='[[2zxz]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zxz]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZXZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZXZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zxz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZXZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P26:4-[2-(1,1,3,3-TETRAMETHYL-2,3-DIHYDRO-1H-INDEN-5-YL)-1,3-DIOXOLAN-2-YL]BENZOIC+ACID'>P26</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P26:4-[2-(1,1,3,3-TETRAMETHYL-2,3-DIHYDRO-1H-INDEN-5-YL)-1,3-DIOXOLAN-2-YL]BENZOIC+ACID'>P26</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fby\|1fby]], [[1mvc\|1mvc]], [[1mv9\|1mv9]], [[2zy0\|2zy0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fby\|1fby]], [[1mvc\|1mvc]], [[1mv9\|1mv9]], [[2zy0\|2zy0]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zxz OCA], [~~http~~://pdbe.org/2zxz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zxz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zxz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zxz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zxz OCA], [https://pdbe.org/2zxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zxz RCSB], [https://www.ebi.ac.uk/pdbsum/2zxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zxz ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.	+	[[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RXRA_HUMAN RXRA_HUMAN]] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref> <ref>PMID:11162439</ref> <ref>PMID:11915042</ref> <ref>PMID:20215566</ref> [[~~http~~://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>	+	[[https://www.uniprot.org/uniprot/RXRA_HUMAN RXRA_HUMAN]] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref> <ref>PMID:11162439</ref> <ref>PMID:11915042</ref> <ref>PMID:20215566</ref> [[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[Retinoid X receptor\|Retinoid X receptor]]	+	*[[Retinoid X receptor 3D structures\|Retinoid X receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:30, 31 July 2019

OCA — Wed, 31 Jul 2019 07:30:50 GMT

←Older revision		Revision as of 07:30, 31 July 2019
Line 1:		Line 1:

	==Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide==		==Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide==
-	<StructureSection load='2zxz' size='340' side='right' caption='[[2zxz]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='2zxz' size='340' side='right'caption='[[2zxz]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZXZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZXZ FirstGlance]. <br>
Line 16:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zx/2zxz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zx/2zxz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 2zxz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2zxz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Retinoid X receptor\|Retinoid X receptor]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Antony, P]]		[[Category: Antony, P]]
	[[Category: Moras, D]]		[[Category: Moras, D]]

OCA at 10:51, 12 October 2017

OCA — Thu, 12 Oct 2017 10:51:07 GMT

←Older revision		Revision as of 10:51, 12 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide==		==Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide==
	<StructureSection load='2zxz' size='340' side='right' caption='[[2zxz]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2zxz' size='340' side='right' caption='[[2zxz]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P26:4-[2-(1,1,3,3-TETRAMETHYL-2,3-DIHYDRO-1H-INDEN-5-YL)-1,3-DIOXOLAN-2-YL]BENZOIC+ACID'>P26</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P26:4-[2-(1,1,3,3-TETRAMETHYL-2,3-DIHYDRO-1H-INDEN-5-YL)-1,3-DIOXOLAN-2-YL]BENZOIC+ACID'>P26</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fby\|1fby]], [[1mvc\|1mvc]], [[1mv9\|1mv9]], [[2zy0\|2zy0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fby\|1fby]], [[1mvc\|1mvc]], [[1mv9\|1mv9]], [[2zy0\|2zy0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zxz OCA], [http://pdbe.org/2zxz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zxz RCSB], [http://www.ebi.ac.uk/pdbsum/2zxz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zxz OCA], [http://pdbe.org/2zxz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zxz RCSB], [http://www.ebi.ac.uk/pdbsum/2zxz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zxz ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 30:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 2zxz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2zxz" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Retinoid X receptor\|Retinoid X receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:41, 9 February 2016

OCA — Tue, 09 Feb 2016 07:41:11 GMT

←Older revision		Revision as of 07:41, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2zxz' size='340' side='right' caption='[[2zxz]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2zxz' size='340' side='right' caption='[[2zxz]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZXZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZXZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P26:4-[2-(1,1,3,3-TETRAMETHYL-2,3-DIHYDRO-1H-INDEN-5-YL)-1,3-DIOXOLAN-2-YL]BENZOIC+ACID'>P26</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P26:4-[2-(1,1,3,3-TETRAMETHYL-2,3-DIHYDRO-1H-INDEN-5-YL)-1,3-DIOXOLAN-2-YL]BENZOIC+ACID'>P26</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fby\|1fby]], [[1mvc\|1mvc]], [[1mv9\|1mv9]], [[2zy0\|2zy0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fby\|1fby]], [[1mvc\|1mvc]], [[1mv9\|1mv9]], [[2zy0\|2zy0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zxz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zxz RCSB], [http://www.ebi.ac.uk/pdbsum/2zxz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zxz OCA], [http://pdbe.org/2zxz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zxz RCSB], [http://www.ebi.ac.uk/pdbsum/2zxz PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zxz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2zxz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Antony, P]]		[[Category: Antony, P]]
	[[Category: Moras, D]]		[[Category: Moras, D]]

OCA at 09:12, 20 January 2015

OCA — Tue, 20 Jan 2015 09:12:35 GMT

←Older revision		Revision as of 09:12, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZXZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZXZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P26:4-[2-(1,1,3,3-TETRAMETHYL-2,3-DIHYDRO-1H-INDEN-5-YL)-1,3-DIOXOLAN-2-YL]BENZOIC+ACID'>P26</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P26:4-[2-(1,1,3,3-TETRAMETHYL-2,3-DIHYDRO-1H-INDEN-5-YL)-1,3-DIOXOLAN-2-YL]BENZOIC+ACID'>P26</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fby\|1fby]], [[1mvc\|1mvc]], [[1mv9\|1mv9]], [[2zy0\|2zy0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fby\|1fby]], [[1mvc\|1mvc]], [[1mv9\|1mv9]], [[2zy0\|2zy0]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zxz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zxz RCSB], [http://www.ebi.ac.uk/pdbsum/2zxz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zxz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zxz RCSB], [http://www.ebi.ac.uk/pdbsum/2zxz PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.		[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Antony, P.]]	+	[[Category: Antony, P]]
-	[[Category: Moras, D.]]	+	[[Category: Moras, D]]
-	[[Category: Rochel, N.]]	+	[[Category: Rochel, N]]
-	[[Category: ~~SGCGES,~~ Structural ~~Genomics Consortium for Research on Gene Expression.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Sato, Y.]]	+	[[Category: Sato, Y]]
	[[Category: Nuclear receptor]]		[[Category: Nuclear receptor]]
	[[Category: Sgcge]]		[[Category: Sgcge]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium for research on gene expression]]
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

OCA at 05:24, 2 October 2014

OCA — Thu, 02 Oct 2014 05:24:45 GMT

←Older revision		Revision as of 05:24, 2 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2zxz\| PDB=2zxz \| SCENE= }}~~	+	==Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide==
-	===Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide===	+	<StructureSection load='2zxz' size='340' side='right' caption='[[2zxz]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19496083}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2zxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZXZ FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P26:4-[2-(1,1,3,3-TETRAMETHYL-2,3-DIHYDRO-1H-INDEN-5-YL)-1,3-DIOXOLAN-2-YL]BENZOIC+ACID'>P26</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fby\|1fby]], [[1mvc\|1mvc]], [[1mv9\|1mv9]], [[2zy0\|2zy0]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zxz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zxz RCSB], [http://www.ebi.ac.uk/pdbsum/2zxz PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.		[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RXRA_HUMAN RXRA_HUMAN]] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref> <ref>PMID:11162439</ref> <ref>PMID:11915042</ref> <ref>PMID:20215566</ref> [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zx/2zxz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	C/Si switch: Twofold sila-substitution (C/Si exchange) in the RXR-selective retinoids 4 a (SR11237) and 5 a leads to 4 b (disila-SR11237) and 5 b, respectively. Chemistry and biology of the C/Si pairs are reported.SR11237 (BMS649, 4 a) is a pan-RXR-selective retinoid agonist. Its silicon analogue, disila-SR11237 (4 b; twofold C/Si exchange), was prepared in a multistep synthesis by starting from 1,2-bis(ethynyldimethylsilyl)ethane. In addition, the related C/Si analogues 5 a and 5 b, with an indane (disila-indane) instead of a tetraline (disila-tetraline) skeleton, were synthesized. The C/Si pairs 4 a/4 b and 5 a/5 b were studied for their interaction with retinoid receptors and were demonstrated to be highly potent RXR-selective ("rexinoid") agonists. Interestingly, twofold C/Si exchange in the indane moiety of 5 a resulted in a 10-fold increase in biological activity of the corresponding silicon-containing rexinoid 5 b, possibly resulting from an increased receptor affinity or a divergent allosteric effect on co-regulator-binding surfaces. The crystal structures of the ternary complexes formed by 5 a and 5 b, respectively, with the ligand-binding domain of hRXRalpha and a peptide of the co-activator TIF2/GRIP1 revealed additional interactions of the disila analogue 5 b with the H7 and H11 residues, supporting the first option of increased binding affinity. This is the first demonstration of an increase in binding affinity of a ligand to a nuclear receptor by C/Si replacement, thereby adding this C/Si switch strategy to the repertoire of nuclear receptor ligand design.

-	~~==Function==~~	+	Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology.,Lippert WP, Burschka C, Gotz K, Kaupp M, Ivanova D, Gaudon C, Sato Y, Antony P, Rochel N, Moras D, Gronemeyer H, Tacke R ChemMedChem. 2009 Jul;4(7):1143-52. PMID:19496083<ref>PMID:19496083</ref>
-	[[http://www.uniprot.org/uniprot/RXRA_HUMAN RXRA_HUMAN]] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR ~~heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'~~-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (~~RARE~~) ~~composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5~~. ~~In the absence of ligand~~, ~~the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation~~, ~~chromatin condensation and transcriptional suppression. On ligand binding~~, ~~the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation~~. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref><ref>PMID:11162439</ref><ref>PMID:11915042</ref><ref>PMID:20215566</ref> [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (~~AF-2~~) ~~but not of the modulating N~~-~~terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues~~.<ref>PMID:~~9430642~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2zxz]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ZXZ OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Retinoid X receptor\|Retinoid X receptor]]		*[[Retinoid X receptor\|Retinoid X receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019496083</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Antony, P.]]		[[Category: Antony, P.]]

OCA at 04:32, 25 March 2013

OCA — Mon, 25 Mar 2013 04:32:16 GMT

←Older revision		Revision as of 04:32, 25 March 2013
Line 1:		Line 1:
-	[[Image:2zxz.png\|left\|200px]]
-
	{{STRUCTURE_2zxz\| PDB=2zxz \| SCENE= }}		{{STRUCTURE_2zxz\| PDB=2zxz \| SCENE= }}
-
	===Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide===		===Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide===
		+	{{ABSTRACT_PUBMED_19496083}}

-	~~{{ABSTRACT_PUBMED_19496083}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/RXRA_HUMAN RXRA_HUMAN]] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref><ref>PMID:11162439</ref><ref>PMID:11915042</ref><ref>PMID:20215566</ref> [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019496083</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019496083</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Antony, P.]]		[[Category: Antony, P.]]

OCA: Protected "2zxz" [edit=sysop:move=sysop]

OCA — Sat, 20 Oct 2012 13:09:13 GMT

Protected "2zxz" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:09, 20 October 2012

OCA at 13:09, 20 October 2012

OCA — Sat, 20 Oct 2012 13:09:09 GMT

←Older revision		Revision as of 13:09, 20 October 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2zxz.png\|left\|200px]]
-	[[Image:2zxz.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zxz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zxz\| PDB=2zxz \| SCENE= }}		{{STRUCTURE_2zxz\| PDB=2zxz \| SCENE= }}

	===Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide===		===Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19496083}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19496083 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19496083}}		{{ABSTRACT_PUBMED_19496083}}

	==About this Structure==		==About this Structure==
-	~~2ZXZ~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZXZ OCA].	+	[[2zxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZXZ OCA].
		+
		+	==See Also==
		+	*[[Retinoid X receptor\|Retinoid X receptor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19496083~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019496083</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Antony, P.]]		[[Category: Antony, P.]]
Line 34:		Line 25:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Structural genomics consortium for research on gene expression]]		[[Category: Structural genomics consortium for research on gene expression]]
		+	[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 12 12:40:35 2009''