310d - Revision history

OCA at 09:25, 21 February 2024

OCA — Wed, 21 Feb 2024 09:25:16 GMT

←Older revision		Revision as of 09:25, 21 February 2024
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=310d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=310d OCA], [https://pdbe.org/310d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=310d RCSB], [https://www.ebi.ac.uk/pdbsum/310d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=310d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=310d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=310d OCA], [https://pdbe.org/310d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=310d RCSB], [https://www.ebi.ac.uk/pdbsum/310d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=310d ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The molecular and crystal structure of 2'-O-Me (CGCGCG)2 has been determined using synchrotron radiation at near-atomic resolution (1.30 A), the highest resolution to date in the RNA field. The crystal structure is a half-turn A-type helix with some helical parameters deviating from canonical A-RNA, such as low base pair rise, elevated helical twist and inclination angles. In CG steps, inter-strand guanines are parallel while cytosines are not parallel. In steps GC this motif is reversed. This type of regularity is not seen in other RNA crystal structures. The structure includes 44 water molecules and two hydrated Mg2+ions one of which lies exactly on the crystallographic 2-fold axis. There are distinct patterns of hydration in the major and the minor grooves. The major groove is stabilised by water clusters consisting of fused five- and six-membered rings. Minor groove contains only a single row of water molecules; each water bridges either two self-parallel cytosines or two self-parallel guanines by a pair of hydrogen bonds. The structure provides the first view of the hydration scheme of 2'-O-methylated RNA duplex.
-
-	Crystal structure of 2'-O-Me(CGCGCG)2, an RNA duplex at 1.30 A resolution. Hydration pattern of 2'-O-methylated RNA.,Adamiak DA, Milecki J, Popenda M, Adamiak RW, Dauter Z, Rypniewski WR Nucleic Acids Res. 1997 Nov 15;25(22):4599-607. PMID:9358171<ref>PMID:9358171</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 310d" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:38, 10 January 2024

OCA — Wed, 10 Jan 2024 12:38:55 GMT

←Older revision		Revision as of 12:38, 10 January 2024
Line 3:		Line 3:
	<StructureSection load='310d' size='340' side='right'caption='[[310d]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='310d' size='340' side='right'caption='[[310d]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[310d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=310D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=310D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[310d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=310D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=310D FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=310d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=310d OCA], [https://pdbe.org/310d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=310d RCSB], [https://www.ebi.ac.uk/pdbsum/310d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=310d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=310d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=310d OCA], [https://pdbe.org/310d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=310d RCSB], [https://www.ebi.ac.uk/pdbsum/310d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=310d ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Adamiak, D A~~]]	+	[[Category: Synthetic construct]]
-	[[Category: Adamiak~~, R W~~]]	+	[[Category: Adamiak DA]]
-	[[Category: ~~Dauter, Z~~]]	+	[[Category: Adamiak RW]]
-	[[Category: ~~Milecki, J~~]]	+	[[Category: Dauter Z]]
-	[[Category: ~~Rypniewski, W R~~]]	+	[[Category: Milecki J]]
-	[[Category: ~~A-rna]]~~	+	[[Category: Rypniewski WR]]
-	~~[[Category: Double helix]]~~	+
-	~~[[Category: Modified]]~~	+
-	~~[[Category: Rna~~]]	+

OCA at 11:16, 6 April 2022

OCA — Wed, 06 Apr 2022 11:16:52 GMT

←Older revision		Revision as of 11:16, 6 April 2022
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	<StructureSection load='310d' size='340' side='right'caption='[[310d]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='310d' size='340' side='right'caption='[[310d]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[310d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=310D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=310D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[310d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=310D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=310D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=310d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=310d OCA], [~~http~~://pdbe.org/310d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=310d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/310d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=310d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=310d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=310d OCA], [https://pdbe.org/310d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=310d RCSB], [https://www.ebi.ac.uk/pdbsum/310d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=310d ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 310d" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 310d" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Protein Data Bank\|Protein Data Bank]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:40, 25 June 2020

OCA — Thu, 25 Jun 2020 06:40:40 GMT

←Older revision		Revision as of 06:40, 25 June 2020
Line 1:		Line 1:

	==Crystal structure of 2'-O-Me(CGCGCG)2: an RNA duplex at 1.3 A resolution. Hydration pattern of 2'-O-methylated RNA==		==Crystal structure of 2'-O-Me(CGCGCG)2: an RNA duplex at 1.3 A resolution. Hydration pattern of 2'-O-methylated RNA==
-	<StructureSection load='310d' size='340' side='right' caption='[[310d]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='310d' size='340' side='right'caption='[[310d]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[310d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=310D OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=310D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[310d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=310D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=310D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=310d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=310d OCA], [http://pdbe.org/310d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=310d RCSB], [http://www.ebi.ac.uk/pdbsum/310d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=310d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=310d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=310d OCA], [http://pdbe.org/310d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=310d RCSB], [http://www.ebi.ac.uk/pdbsum/310d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=310d ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Adamiak, D A]]		[[Category: Adamiak, D A]]
	[[Category: Adamiak, R W]]		[[Category: Adamiak, R W]]

OCA at 09:40, 5 August 2016

OCA — Fri, 05 Aug 2016 09:40:49 GMT

←Older revision		Revision as of 09:40, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of 2'-O-Me(CGCGCG)2: an RNA duplex at 1.3 A resolution. Hydration pattern of 2'-O-methylated RNA==		==Crystal structure of 2'-O-Me(CGCGCG)2: an RNA duplex at 1.3 A resolution. Hydration pattern of 2'-O-methylated RNA==
	<StructureSection load='310d' size='340' side='right' caption='[[310d]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='310d' size='340' side='right' caption='[[310d]], [[Resolution\|resolution]] 1.30Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=310d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=310d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=310d RCSB], [http://www.ebi.ac.uk/pdbsum/310d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=310d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=310d OCA], [http://pdbe.org/310d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=310d RCSB], [http://www.ebi.ac.uk/pdbsum/310d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=310d ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 310d" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 14:10, 17 December 2014

OCA — Wed, 17 Dec 2014 14:10:56 GMT

←Older revision		Revision as of 14:10, 17 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_310d\| PDB=310d \| SCENE= }}~~	+	==Crystal structure of 2'-O-Me(CGCGCG)2: an RNA duplex at 1.3 A resolution. Hydration pattern of 2'-O-methylated RNA==
-	===Crystal structure of 2'-O-Me(CGCGCG)2: an RNA duplex at 1.3 A resolution. Hydration pattern of 2'-O-methylated RNA===	+	<StructureSection load='310d' size='340' side='right' caption='[[310d]], [[Resolution\|resolution]] 1.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_9358171}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[310d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=310D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=310D FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=310d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=310d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=310d RCSB], [http://www.ebi.ac.uk/pdbsum/310d PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The molecular and crystal structure of 2'-O-Me (CGCGCG)2 has been determined using synchrotron radiation at near-atomic resolution (1.30 A), the highest resolution to date in the RNA field. The crystal structure is a half-turn A-type helix with some helical parameters deviating from canonical A-RNA, such as low base pair rise, elevated helical twist and inclination angles. In CG steps, inter-strand guanines are parallel while cytosines are not parallel. In steps GC this motif is reversed. This type of regularity is not seen in other RNA crystal structures. The structure includes 44 water molecules and two hydrated Mg2+ions one of which lies exactly on the crystallographic 2-fold axis. There are distinct patterns of hydration in the major and the minor grooves. The major groove is stabilised by water clusters consisting of fused five- and six-membered rings. Minor groove contains only a single row of water molecules; each water bridges either two self-parallel cytosines or two self-parallel guanines by a pair of hydrogen bonds. The structure provides the first view of the hydration scheme of 2'-O-methylated RNA duplex.

-	~~==About this Structure==~~	+	Crystal structure of 2'-O-Me(CGCGCG)2, an RNA duplex at 1.30 A resolution. Hydration pattern of 2'-O-methylated RNA.,Adamiak DA, Milecki J, Popenda M, Adamiak RW, Dauter Z, Rypniewski WR Nucleic Acids Res. 1997 Nov 15;25(22):4599-607. PMID:9358171<ref>PMID:9358171</ref>
-	~~[[310d]] is a 2 chain~~ structure. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=310D OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Protein Data Bank\|Protein Data Bank]]		*[[Protein Data Bank\|Protein Data Bank]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:009358171<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
-	[[Category: Adamiak, D A.]]	+	</StructureSection>
-	[[Category: Adamiak, R W.]]	+	[[Category: Adamiak, D A]]
-	[[Category: Dauter, Z.]]	+	[[Category: Adamiak, R W]]
-	[[Category: Milecki, J.]]	+	[[Category: Dauter, Z]]
-	[[Category: Rypniewski, W R.]]	+	[[Category: Milecki, J]]
		+	[[Category: Rypniewski, W R]]
	[[Category: A-rna]]		[[Category: A-rna]]
	[[Category: Double helix]]		[[Category: Double helix]]
	[[Category: Modified]]		[[Category: Modified]]
	[[Category: Rna]]		[[Category: Rna]]

OCA at 09:51, 11 March 2013

OCA — Mon, 11 Mar 2013 09:51:27 GMT

←Older revision		Revision as of 09:51, 11 March 2013
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-	[[Image:310d.png\|left\|200px]]
-
	{{STRUCTURE_310d\| PDB=310d \| SCENE= }}		{{STRUCTURE_310d\| PDB=310d \| SCENE= }}
-
	===Crystal structure of 2'-O-Me(CGCGCG)2: an RNA duplex at 1.3 A resolution. Hydration pattern of 2'-O-methylated RNA===		===Crystal structure of 2'-O-Me(CGCGCG)2: an RNA duplex at 1.3 A resolution. Hydration pattern of 2'-O-methylated RNA===
-
	{{ABSTRACT_PUBMED_9358171}}		{{ABSTRACT_PUBMED_9358171}}

OCA: Protected "310d" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 18:02:11 GMT

Protected "310d" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:02, 14 August 2012

OCA at 18:02, 14 August 2012

OCA — Tue, 14 Aug 2012 18:02:09 GMT

←Older revision		Revision as of 18:02, 14 August 2012
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-	{{Seed}}
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	{{STRUCTURE_310d\| PDB=310d \| SCENE= }}		{{STRUCTURE_310d\| PDB=310d \| SCENE= }}

-	===~~CRYSTAL STRUCTURE OF~~ 2'-O-ME(CGCGCG)2: AN RNA ~~DUPLEX AT~~ 1.3 A ~~RESOLUTION~~. ~~HYDRATION PATTERN OF~~ 2'-O-~~METHYLATED~~ RNA===	+	===Crystal structure of 2'-O-Me(CGCGCG)2: an RNA duplex at 1.3 A resolution. Hydration pattern of 2'-O-methylated RNA===

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	{{ABSTRACT_PUBMED_9358171}}		{{ABSTRACT_PUBMED_9358171}}

	==About this Structure==		==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=310D OCA].	+	[[310d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=310D OCA].
		+
		+	==See Also==
		+	*[[Protein Data Bank\|Protein Data Bank]]

	==Reference==		==Reference==
-	Crystal structure of 2'-O-Me(CGCGCG)2, an RNA duplex at 1.30 A resolution. Hydration pattern of 2'-O-methylated RNA., Adamiak DA, Milecki J, Popenda M, Adamiak RW, Dauter Z, Rypniewski WR, Nucleic Acids Res. 1997 Nov 15;25(22):4599-607. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~9358171 9358171]~~	+	<ref group="xtra">PMID:009358171</ref><references group="xtra"/>
	[[Category: Adamiak, D A.]]		[[Category: Adamiak, D A.]]
	[[Category: Adamiak, R W.]]		[[Category: Adamiak, R W.]]
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	[[Category: Double helix]]		[[Category: Double helix]]
	[[Category: Modified]]		[[Category: Modified]]
-		+	[[Category: Rna]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Jul 28 05:38:28 2008''~~	+

OCA at 02:38, 28 July 2008

OCA — Mon, 28 Jul 2008 02:38:35 GMT

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	{{STRUCTURE_310d\| PDB=310d \| SCENE= }}		{{STRUCTURE_310d\| PDB=310d \| SCENE= }}

-	~~'''~~CRYSTAL STRUCTURE OF 2'-O-ME(CGCGCG)2: AN RNA DUPLEX AT 1.3 A RESOLUTION. HYDRATION PATTERN OF 2'-O-METHYLATED RNA~~'''~~	+	===CRYSTAL STRUCTURE OF 2'-O-ME(CGCGCG)2: AN RNA DUPLEX AT 1.3 A RESOLUTION. HYDRATION PATTERN OF 2'-O-METHYLATED RNA===


-	~~==Overview==~~	+	<!--
-	The ~~molecular and crystal structure of 2'-O-Me (CGCGCG)2 has been determined using synchrotron radiation at near-atomic resolution (1.30 A)~~, the ~~highest resolution~~ to ~~date in~~ the ~~RNA field. The crystal structure is a half-turn A-type helix with some helical parameters deviating from canonical A-RNA, such~~ as ~~low base pair rise, elevated helical twist and inclination angles~~. ~~In CG steps~~, ~~inter-strand guanines are parallel while cytosines are not parallel. In steps GC this motif~~ is ~~reversed. This type of regularity is not seen in other RNA crystal structures. The structure includes 44 water molecules and two hydrated Mg2+ions one of which lies exactly on~~ the ~~crystallographic 2-fold axis~~. ~~There are distinct patterns of hydration in the major and the minor grooves. The major groove is stabilised by water clusters consisting of fused five~~- ~~and six~~-membered rings. Minor groove contains only a single row of water molecules; each water bridges either two self-parallel cytosines or two self-parallel guanines by a pair of hydrogen bonds. The structure provides the first view of the hydration scheme of 2'-O-methylated RNA duplex.	+	The line below this paragraph, {{ABSTRACT_PUBMED_9358171}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 9358171 is the PubMed ID number.
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		+	{{ABSTRACT_PUBMED_9358171}}

	==About this Structure==		==About this Structure==
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	[[Category: Double helix]]		[[Category: Double helix]]
	[[Category: Modified]]		[[Category: Modified]]
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