3D structural studies on SARS-CoV-2 - Revision history

Joel L. Sussman at 11:18, 7 February 2022

Joel L. Sussman — Mon, 07 Feb 2022 11:18:09 GMT

←Older revision		Revision as of 11:18, 7 February 2022
Line 59:		Line 59:
	* Crystal structure of '''Nsp15 endoribonuclease NendoU from SARS-CoV-2''' in a study by scientists from USA<ref> Kim, et al. Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2: bioRxiv (online) 2020 [http://doi.org/10.1101/2020.03.02.968388 http://doi.org/10.1101/2020.03.02.968388]</ref>, PDB-ID [[6w01]].		* Crystal structure of '''Nsp15 endoribonuclease NendoU from SARS-CoV-2''' in a study by scientists from USA<ref> Kim, et al. Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2: bioRxiv (online) 2020 [http://doi.org/10.1101/2020.03.02.968388 http://doi.org/10.1101/2020.03.02.968388]</ref>, PDB-ID [[6w01]].

-	* '''The CoV spike (S) glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics'''. A study by McLellan and colleagues in "Science" on the Cryo-EM structure of the COVID-19 spike protein. This structure should greatly aid in the rapid development and evaluation of medical countermeasures to address the ongoing public health crisis<ref name="McLellan" />, PDB-ID [[6vsb]].	+	* '''The CoV spike (S) glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics'''. A study by McLellan and colleagues in "Science" on the Cryo-EM structure of the COVID-19 spike protein. This structure should greatly aid in the rapid development and evaluation of medical countermeasures to address the ongoing public health crisis<ref name="McLellan">PMID:32075877</ref>, PDB-ID [[6vsb]].

	* [http://github.com/thorn-lab/coronavirus_structural_task_force Public resource for the structures from beta-coronavirus with a focus on SARS-CoV and SARS-CoV-2]		* [http://github.com/thorn-lab/coronavirus_structural_task_force Public resource for the structures from beta-coronavirus with a focus on SARS-CoV and SARS-CoV-2]

Joel L. Sussman at 11:16, 7 February 2022

Joel L. Sussman — Mon, 07 Feb 2022 11:16:41 GMT

←Older revision		Revision as of 11:16, 7 February 2022
Line 11:		Line 11:
	[[Image:SARS-CoV-2 Prot Organization.jpg\|500px\|center\|thumb\|SARS-CoV-2 Protein Organization, redrawn from NY Times<ref name="NY Times COVID-19"/>]].		[[Image:SARS-CoV-2 Prot Organization.jpg\|500px\|center\|thumb\|SARS-CoV-2 Protein Organization, redrawn from NY Times<ref name="NY Times COVID-19"/>]].
	== 3D structural studies on SARS-CoV-2 virus==		== 3D structural studies on SARS-CoV-2 virus==
-	{{Template:COVID Validation}}
-
	* A team of UK & Israeli scientists determined the 3D structures of [http://www.diamond.ac.uk/covid-19/for-scientists/Main-protease-structure-and-XChem/Downloads.html '''over 90 fragments, 66 of which are in the active site'']. All the experimental details and results are available [http://www.diamond.ac.uk/covid-19/for-scientists/Main-protease-structure-and-XChem.html '''online at the Diamond Light Source'''].		* A team of UK & Israeli scientists determined the 3D structures of [http://www.diamond.ac.uk/covid-19/for-scientists/Main-protease-structure-and-XChem/Downloads.html '''over 90 fragments, 66 of which are in the active site'']. All the experimental details and results are available [http://www.diamond.ac.uk/covid-19/for-scientists/Main-protease-structure-and-XChem.html '''online at the Diamond Light Source'''].

Joel L. Sussman at 11:16, 7 February 2022

Joel L. Sussman — Mon, 07 Feb 2022 11:16:08 GMT

←Older revision		Revision as of 11:16, 7 February 2022
Line 10:		Line 10:

	[[Image:SARS-CoV-2 Prot Organization.jpg\|500px\|center\|thumb\|SARS-CoV-2 Protein Organization, redrawn from NY Times<ref name="NY Times COVID-19"/>]].		[[Image:SARS-CoV-2 Prot Organization.jpg\|500px\|center\|thumb\|SARS-CoV-2 Protein Organization, redrawn from NY Times<ref name="NY Times COVID-19"/>]].
		+	== 3D structural studies on SARS-CoV-2 virus==
		+	{{Template:COVID Validation}}
		+
		+	* A team of UK & Israeli scientists determined the 3D structures of [http://www.diamond.ac.uk/covid-19/for-scientists/Main-protease-structure-and-XChem/Downloads.html '''over 90 fragments, 66 of which are in the active site'']. All the experimental details and results are available [http://www.diamond.ac.uk/covid-19/for-scientists/Main-protease-structure-and-XChem.html '''online at the Diamond Light Source'''].
		+
		+	* A team of Chinese scientists determined, by Cryo-EM, the''' coronavirus spike receptor-binding domain complexed with its receptor ACE2 PDB-ID''' [[6lzg]] (To be published).
		+
		+	* A team of US and Chinese scientists determined the crystal structure of '''2019-nCoV spike receptor-binding domain bound with ACE2''' [[6m0j]]
		+
		+	* A team of US scientists determined, by Cryo-EM, the '''structure of the SARS-CoV-2 spike glycoprotein (open & closed states)''' <ref>PMID:32155444</ref>, PDB-ID [[6vxx]] and [[6vyb]]. See an [[SARS-CoV-2 protein S priming by furin\|animation of this transition]].
		+
		+	* Crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody CR3022 [[6w41]]
		+
		+	* Crystal Structure of the methyltransferase-stimulatory factor complex of NSP16 and NSP10 from SARS CoV-2 [[6w61]] (To be published).
		+
		+	* Crystal Structure of ADP ribose phosphatase of NSP3 from SARS CoV-2 in complex with AMP [[6w6y]] (To be published).
		+
		+	* Structure of NSP10 - NSP16 Complex from SARS-CoV-2 [[6w75]] (To be published).
		+
		+	* Crystal structure of SARS-CoV-2 nucleocapsid protein N-terminal RNA binding domain [[6m3m]] (To be published).
		+
		+	* Crystal structure of Nsp9 RNA binding protein of SARS CoV-2 [[6w4b]] (To be published).
		+
		+	* Crystal Structure of NSP16 - NSP10 Complex from SARS-CoV-2 [[6w4h]] (To be published).
		+
		+	* A Cryo-EM study by Zhou & colleagues on the structural basis for the '''recognition of the SARS-CoV-2 by full-length human ACE2''' gives insights to the molecular basis for coronavirus recognition and infection<ref>PMID:32132184</ref> [[6m17]].
		+
		+	* Crystal structure of RNA binding domain of nucleocapsid phosphoprotein from SARS coronavirus 2 [[6vyo]] (To be published).
		+
		+	* Crystal structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with a Citrate [[6w01]] (To be published).
		+
		+	* Crystal structure of ADP ribose phosphatase of NSP3 from SARS CoV-2 in the complex with ADP ribose [[6w02]] (To be published).
		+
		+	* Crystal structure of 2019-nCoV chimeric receptor-binding domain complexed with its receptor human ACE2 [[6vw1]]
		+
		+	* Crystal structure of NSP15 Endoribonuclease from SARS CoV-2 [[6vww]] (To be published).
		+
		+	* Crystal Structure of ADP ribose phosphatase of NSP3 from SARS CoV-2 [[6vxs]] (To be published).
		+
		+	* Crystal structure of the 2019-nCoV HR2 Domain [[6lvn]] (To be published).
		+
		+	* Crystal structure of post fusion core of 2019-nCoV S2 subunit [[6lxt]].
		+
		+	* Crystal structure of '''SARS-CoV-2 main protease''' provides a basis for design of improved α-ketoamide inhibitors, from the Hilgenfeld lab<ref>PMID:32198291</ref>, Apo Struture: PDB-ID [[6y2e]], and complexes with inhibitors: PDB-ID [[6y2f ]] and [[6y2g]].
		+
		+	* 3D Structure of '''RNA-dependent RNA polymerase from COVID-19''', a '''major antiviral drug target''' from the Rao lab in Beijing<ref> Gao, et al. Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target: bioRxiv (online) 2020 [http://doi.org/10.1101/2020.03.16.993386 http://doi.org/10.1101/2020.03.16.993386]</ref>.
		+
		+	* Crystal structure of the '''Mpro from COVID-19''' and '''discovery of inhibitors''' in a study by scientists from Shanghai & Beijing<ref>PMID: 32272481</ref>, PDB-ID [[6lu7]].
		+
		+	* Crystal structure of '''Nsp15 endoribonuclease NendoU from SARS-CoV-2''' in a study by scientists from USA<ref> Kim, et al. Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2: bioRxiv (online) 2020 [http://doi.org/10.1101/2020.03.02.968388 http://doi.org/10.1101/2020.03.02.968388]</ref>, PDB-ID [[6w01]].
		+
		+	* '''The CoV spike (S) glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics'''. A study by McLellan and colleagues in "Science" on the Cryo-EM structure of the COVID-19 spike protein. This structure should greatly aid in the rapid development and evaluation of medical countermeasures to address the ongoing public health crisis<ref name="McLellan" />, PDB-ID [[6vsb]].
		+
		+	* [http://github.com/thorn-lab/coronavirus_structural_task_force Public resource for the structures from beta-coronavirus with a focus on SARS-CoV and SARS-CoV-2]

-	* [[SARS-CoV-2 Coronavirus Main Protease\| Main protease]]: it is a cysteine protease that is essential for the viral life cycle.
-	* [[SARS-CoV-2_protein_NSP1\|NSP1]]: ''Host translation inhibitor nsp1''. Inhibits host translation by interacting with the 40S ribosomal subunit.
-	* [[SARS-CoV-2_protein_NSP2\|NSP2]]: ''Non-structural protein 2''.
-	* [[SARS-CoV-2 enzyme Papain-like\|Papain-like proteinase]]
-	* [[SARS-CoV-2_protein_NSP4\|NSP4]]: ''Non-structural protein 4''.
-	* [[SARS-CoV-2 enzyme 3CL-PRO\|Proteinase 3CL-PRO]]
-	* '''''AlphaFold2 Theoretical Model''''' [[SARS-CoV-2_protein_NSP6\|NSP6]]: ''Non-structural protein 6''.
-	* [[SARS-CoV-2_protein_NSP7\|NSP7]]: ''Non-structural protein 7''.
-	* [[SARS-CoV-2_protein_NSP8\|NSP8]]: ''Non-structural protein 8''.
-	* [[SARS-CoV-2_protein_NSP9\|NSP9]]: ''Non-structural protein 9''.
-	* [[SARS-CoV-2_protein_NSP10\|NSP10]]: ''Non-structural protein 10''.
-	* [[SARS-CoV-2 enzyme RdRp\|RNA-directed RNA polymerase (RdRp)]]
-	* [[SARS-CoV-2 enzyme Hel\|Helicase (Hel)]]: Multi-functional protein with a zinc-binding domain in N-terminus
-	* [[SARS-CoV-2 enzyme ExoN\|Guanine-N7 methyltransferase (ExoN)]]
-	* [[SARS-CoV-2 enzyme NendoU\|Uridylate-specific endoribonuclease (NendoU)]]
-	* [[SARS-CoV-2 enzyme 2'-O-MT\|2'-O-methyltransferase (2'-O-MT)]]: Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs.
-	* [[SARS-CoV-2_protein_S\|Surface glycoprotein (S)]] and [[SARS-CoV-2 protein S priming by furin]]
-	* [[SARS-CoV-2 protein ORF3a\|ORF3a]]: Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release.
-	* [[SARS-CoV-2_protein_E\|Protein E]]: Plays a central role in virus morphogenesis and assembly.
-	* '''''AlphaFold2 Theoretical Model''''' [[SARS-CoV-2_protein_M\|Protein M]]: Component of the viral envelope.
-	* [[SARS-CoV-2 protein ORF6\|ORF6]]: Could be a determinant of virus virulence.
-	* [[SARS-CoV-2 protein ORF7a\|ORF7a]]: Non-structural protein which is dispensable for virus replication in cell culture.
-	* [[SARS-CoV-2 protein ORF8\|ORF8]]: Open Reading Frame 8.
-	* '''''AlphaFold2 Theoretical Model''''' [[SARS-CoV-2_protein_N\|Protein N]]: Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP).
-	* '''''AlphaFold2 Theoretical Model''''' [[SARS-CoV-2 protein ORF10\|ORF10‎]]: It is currently unclear whether this region translates into a functional protein.
	== References ==		== References ==
	<references/>		<references/>

Joel L. Sussman at 11:14, 7 February 2022

Joel L. Sussman — Mon, 07 Feb 2022 11:14:34 GMT

←Older revision		Revision as of 11:14, 7 February 2022
Line 1:		Line 1:
-	~~==Your Heading Here (maybe something like 'Structure')==~~	+	[[Image:Ezgif.com-video-to-gif 240px 65pc speed.gif\|right\|240px\|thumb\|<span style="font-size:100%">SARS-CoV-2 virus. The <span style="color:blue">spikes</span>, that adorn the <span style="color:red">'''virus surface'''</span>, impart a '''''corona''''' like appearance [http://www.drugtargetreview.com/news/57287/3d-visualisation-of-covid-19-surface-released-for-researchers (Fusion Animation)].</span>]]
-	<~~StructureSection load~~=~~'1stp'~~ size=~~'340' side~~='~~right~~' ~~caption=~~'~~Caption for this structure~~' ~~scene=~~''>	+	<span style="font-size:100%">
-	~~This is~~ a ~~default text for your page~~ '''~~3D structural studies on SARS-CoV-2~~''~~'. Click above on~~ '''~~edit this page~~''~~' to modify~~. ~~Be careful with the < and > signs~~.	+
-	~~You may include any references to papers as in: the use~~ of ~~JSmol in Proteopedia <ref>DOI 10~~.~~1002/ijch.201300024~~</~~ref~~> ~~or to the article describing Jmol~~ <~~ref>PMID~~:~~21638687</ref~~> ~~to the rescue.~~	+

-	== ~~Function ==~~	+	{{Template:COVID Validation}}
		+	The genome of the SARS-CoV-2 virus codes for 28 proteins:
		+	Out of those, 19 have already been characterized structurally. For the rest there are accurate [[AlphaFold]]2 predicted structures.
		+	<br>
		+	Details of the '''3D structure & function''' of the key proteins & RNA inside the virus can be seen in the ''NY Times''<ref name="NY Times COVID-19">[https://www.nytimes.com/interactive/2020/04/03/science/coronavirus-genome-bad-news-wrapped-in-protein.html ''NY Times'' (3-Apr-2020) Bad News Wrapped in Protein: Inside the Coronavirus Genome]</ref>.
		+	"The first viral protein created inside the infected cell, ORF1ab, is actually a chain of 16 proteins joined together. Two of these proteins act like scissors, snipping the links between the different proteins and freeing them to do their jobs."<ref name="NY Times COVID-19"/>

-	=~~= Disease ==~~	+	[[Image:SARS-CoV-2 Prot Organization.jpg\|500px\|center\|thumb\|SARS-CoV-2 Protein Organization, redrawn from NY Times<ref name="NY Times COVID-19"/>]].

-	~~== Relevance ==~~	+	* [[SARS-CoV-2 Coronavirus Main Protease\| Main protease]]: it is a cysteine protease that is essential for the viral life cycle.
-		+	* [[SARS-CoV-2_protein_NSP1\|NSP1]]: ''Host translation inhibitor nsp1''. Inhibits host translation by interacting with the 40S ribosomal subunit.
-	~~== Structural highlights ==~~	+	* [[SARS-CoV-2_protein_NSP2\|NSP2]]: ''Non-structural protein 2''.
-		+	* [[SARS-CoV-2 enzyme Papain-like\|Papain-like proteinase]]
-	~~This is a sample scene created~~ with ~~SAT~~ to ~~<scene name="/12/3456/Sample/1">color</scene> by Group,~~ and ~~another to make <scene name="/12/3456/Sample/~~2">a ~~transparent representation</scene>~~ of the ~~protein~~. ~~You can make your own scenes on SAT starting from scratch or loading and editing one~~ of ~~these sample scenes~~.	+	* [[SARS-CoV-2_protein_NSP4\|NSP4]]: ''Non-structural protein 4''.
-		+	* [[SARS-CoV-2 enzyme 3CL-PRO\|Proteinase 3CL-PRO]]
-	~~</StructureSection>~~	+	* '''''AlphaFold2 Theoretical Model''''' [[SARS-CoV-2_protein_NSP6\|NSP6]]: ''Non-structural protein 6''.
		+	* [[SARS-CoV-2_protein_NSP7\|NSP7]]: ''Non-structural protein 7''.
		+	* [[SARS-CoV-2_protein_NSP8\|NSP8]]: ''Non-structural protein 8''.
		+	* [[SARS-CoV-2_protein_NSP9\|NSP9]]: ''Non-structural protein 9''.
		+	* [[SARS-CoV-2_protein_NSP10\|NSP10]]: ''Non-structural protein 10''.
		+	* [[SARS-CoV-2 enzyme RdRp\|RNA-directed RNA polymerase (RdRp)]]
		+	* [[SARS-CoV-2 enzyme Hel\|Helicase (Hel)]]: Multi-functional protein with a zinc-binding domain in N-terminus
		+	* [[SARS-CoV-2 enzyme ExoN\|Guanine-N7 methyltransferase (ExoN)]]
		+	* [[SARS-CoV-2 enzyme NendoU\|Uridylate-specific endoribonuclease (NendoU)]]
		+	* [[SARS-CoV-2 enzyme 2'-O-MT\|2'-O-methyltransferase (2'-O-MT)]]: Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs.
		+	* [[SARS-CoV-2_protein_S\|Surface glycoprotein (S)]] and [[SARS-CoV-2 protein S priming by furin]]
		+	* [[SARS-CoV-2 protein ORF3a\|ORF3a]]: Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release.
		+	* [[SARS-CoV-2_protein_E\|Protein E]]: Plays a central role in virus morphogenesis and assembly.
		+	* '''''AlphaFold2 Theoretical Model''''' [[SARS-CoV-2_protein_M\|Protein M]]: Component of the viral envelope.
		+	* [[SARS-CoV-2 protein ORF6\|ORF6]]: Could be a determinant of virus virulence.
		+	* [[SARS-CoV-2 protein ORF7a\|ORF7a]]: Non-structural protein which is dispensable for virus replication in cell culture.
		+	* [[SARS-CoV-2 protein ORF8\|ORF8]]: Open Reading Frame 8.
		+	* '''''AlphaFold2 Theoretical Model''''' [[SARS-CoV-2_protein_N\|Protein N]]: Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP).
		+	* '''''AlphaFold2 Theoretical Model''''' [[SARS-CoV-2 protein ORF10\|ORF10‎]]: It is currently unclear whether this region translates into a functional protein.
	== References ==		== References ==
	<references/>		<references/>

Joel L. Sussman: New page: ==Your Heading Here (maybe something like 'Structure')== This is a default text for you...

Joel L. Sussman — Mon, 07 Feb 2022 11:13:15 GMT

New page: ==Your Heading Here (maybe something like 'Structure')== <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> This is a default text for you...

New page

==Your Heading Here (maybe something like 'Structure')==
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''3D structural studies on SARS-CoV-2'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

←Older revision		Revision as of 11:14, 7 February 2022
Line 1:		Line 1:
-	~~==Your Heading Here (maybe something like 'Structure')==~~	+	[[Image:Ezgif.com-video-to-gif 240px 65pc speed.gif\|right\|240px\|thumb\|<span style="font-size:100%">SARS-CoV-2 virus. The <span style="color:blue">spikes</span>, that adorn the <span style="color:red">'''virus surface'''</span>, impart a '''''corona''''' like appearance [http://www.drugtargetreview.com/news/57287/3d-visualisation-of-covid-19-surface-released-for-researchers (Fusion Animation)].</span>]]
-	<~~StructureSection load~~=~~'1stp'~~ size=~~'340' side~~='~~right~~' ~~caption=~~'~~Caption for this structure~~' ~~scene=~~''>	+	<span style="font-size:100%">
-	~~This is~~ a ~~default text for your page~~ '''~~3D structural studies on SARS-CoV-2~~''~~'. Click above on~~ '''~~edit this page~~''~~' to modify~~. ~~Be careful with the < and > signs~~.	+
-	~~You may include any references to papers as in: the use~~ of ~~JSmol in Proteopedia <ref>DOI 10~~.~~1002/ijch.201300024~~</~~ref~~> ~~or to the article describing Jmol~~ <~~ref>PMID~~:~~21638687</ref~~> ~~to the rescue.~~	+

-	== ~~Function ==~~	+	{{Template:COVID Validation}}
		+	The genome of the SARS-CoV-2 virus codes for 28 proteins:
		+	Out of those, 19 have already been characterized structurally. For the rest there are accurate [[AlphaFold]]2 predicted structures.
		+	<br>
		+	Details of the '''3D structure & function''' of the key proteins & RNA inside the virus can be seen in the ''NY Times''<ref name="NY Times COVID-19">[https://www.nytimes.com/interactive/2020/04/03/science/coronavirus-genome-bad-news-wrapped-in-protein.html ''NY Times'' (3-Apr-2020) Bad News Wrapped in Protein: Inside the Coronavirus Genome]</ref>.
		+	"The first viral protein created inside the infected cell, ORF1ab, is actually a chain of 16 proteins joined together. Two of these proteins act like scissors, snipping the links between the different proteins and freeing them to do their jobs."<ref name="NY Times COVID-19"/>

-	=~~= Disease ==~~	+	[[Image:SARS-CoV-2 Prot Organization.jpg\|500px\|center\|thumb\|SARS-CoV-2 Protein Organization, redrawn from NY Times<ref name="NY Times COVID-19"/>]].

-	~~== Relevance ==~~	+	* [[SARS-CoV-2 Coronavirus Main Protease\| Main protease]]: it is a cysteine protease that is essential for the viral life cycle.
-		+	* [[SARS-CoV-2_protein_NSP1\|NSP1]]: ''Host translation inhibitor nsp1''. Inhibits host translation by interacting with the 40S ribosomal subunit.
-	~~== Structural highlights ==~~	+	* [[SARS-CoV-2_protein_NSP2\|NSP2]]: ''Non-structural protein 2''.
-		+	* [[SARS-CoV-2 enzyme Papain-like\|Papain-like proteinase]]
-	~~This is a sample scene created~~ with ~~SAT~~ to ~~<scene name="/12/3456/Sample/1">color</scene> by Group,~~ and ~~another to make <scene name="/12/3456/Sample/~~2">a ~~transparent representation</scene>~~ of the ~~protein~~. ~~You can make your own scenes on SAT starting from scratch or loading and editing one~~ of ~~these sample scenes~~.	+	* [[SARS-CoV-2_protein_NSP4\|NSP4]]: ''Non-structural protein 4''.
-		+	* [[SARS-CoV-2 enzyme 3CL-PRO\|Proteinase 3CL-PRO]]
-	~~</StructureSection>~~	+	* '''''AlphaFold2 Theoretical Model''''' [[SARS-CoV-2_protein_NSP6\|NSP6]]: ''Non-structural protein 6''.
		+	* [[SARS-CoV-2_protein_NSP7\|NSP7]]: ''Non-structural protein 7''.
		+	* [[SARS-CoV-2_protein_NSP8\|NSP8]]: ''Non-structural protein 8''.
		+	* [[SARS-CoV-2_protein_NSP9\|NSP9]]: ''Non-structural protein 9''.
		+	* [[SARS-CoV-2_protein_NSP10\|NSP10]]: ''Non-structural protein 10''.
		+	* [[SARS-CoV-2 enzyme RdRp\|RNA-directed RNA polymerase (RdRp)]]
		+	* [[SARS-CoV-2 enzyme Hel\|Helicase (Hel)]]: Multi-functional protein with a zinc-binding domain in N-terminus
		+	* [[SARS-CoV-2 enzyme ExoN\|Guanine-N7 methyltransferase (ExoN)]]
		+	* [[SARS-CoV-2 enzyme NendoU\|Uridylate-specific endoribonuclease (NendoU)]]
		+	* [[SARS-CoV-2 enzyme 2'-O-MT\|2'-O-methyltransferase (2'-O-MT)]]: Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs.
		+	* [[SARS-CoV-2_protein_S\|Surface glycoprotein (S)]] and [[SARS-CoV-2 protein S priming by furin]]
		+	* [[SARS-CoV-2 protein ORF3a\|ORF3a]]: Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release.
		+	* [[SARS-CoV-2_protein_E\|Protein E]]: Plays a central role in virus morphogenesis and assembly.
		+	* '''''AlphaFold2 Theoretical Model''''' [[SARS-CoV-2_protein_M\|Protein M]]: Component of the viral envelope.
		+	* [[SARS-CoV-2 protein ORF6\|ORF6]]: Could be a determinant of virus virulence.
		+	* [[SARS-CoV-2 protein ORF7a\|ORF7a]]: Non-structural protein which is dispensable for virus replication in cell culture.
		+	* [[SARS-CoV-2 protein ORF8\|ORF8]]: Open Reading Frame 8.
		+	* '''''AlphaFold2 Theoretical Model''''' [[SARS-CoV-2_protein_N\|Protein N]]: Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP).
		+	* '''''AlphaFold2 Theoretical Model''''' [[SARS-CoV-2 protein ORF10\|ORF10‎]]: It is currently unclear whether this region translates into a functional protein.
	== References ==		== References ==
	<references/>		<references/>