3a5m - Revision history

OCA at 14:11, 1 November 2023

OCA — Wed, 01 Nov 2023 14:11:35 GMT

←Older revision		Revision as of 14:11, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3a5m' size='340' side='right'caption='[[3a5m]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3a5m' size='340' side='right'caption='[[3a5m]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3a5m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_11735 Atcc 11735~~] and [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3a5m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A5M FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ATP:ADENOSINE~~-~~5-TRIPHOSPHATE'>ATP</scene>~~, ~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~HIC~~:4-~~METHYL~~-~~HISTIDINE~~'>~~HIC~~</scene><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<~~tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat"><div style~~=~~'overflow~~: ~~auto; max-height: 3em;~~'>~~[[1c0f\|1c0f]], [[3a5l\|3a5l]], [[3a5n\|3a5n]], [[3a5o\|3a5o]]~~</~~div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a5m OCA], [https://pdbe.org/3a5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a5m RCSB], [https://www.ebi.ac.uk/pdbsum/3a5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a5m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a5m OCA], [https://pdbe.org/3a5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a5m RCSB], [https://www.ebi.ac.uk/pdbsum/3a5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a5m ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN]] Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:[https://omim.org/entry/105120 105120]]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.<ref>PMID:2157434</ref> <ref>PMID:2153578</ref> <ref>PMID:2176481</ref> <ref>PMID:1338910</ref>	+	[https://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN] Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:[https://omim.org/entry/105120 105120]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.<ref>PMID:2157434</ref> <ref>PMID:2153578</ref> <ref>PMID:2176481</ref> <ref>PMID:1338910</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN]] Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.<ref>PMID:20393563</ref>	+	[https://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN] Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.<ref>PMID:20393563</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 30:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 11735~~]]	+	[[Category: Dictyostelium discoideum]]
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Murakami, K]]	+	[[Category: Murakami K]]
-	[[Category: Noguchi~~, T Q~~]]	+	[[Category: Noguchi TQ]]
-	[[Category: Uyeda~~, T Q~~]]	+	[[Category: Uyeda TQ]]
-	[[Category: Wakabayashi, T]]	+	[[Category: Wakabayashi T]]
-	[[Category: Yasunaga, T]]	+	[[Category: Yasunaga T]]
-	~~[[Category: Actin]]~~	+
-	~~[[Category: Actin capping]]~~	+
-	~~[[Category: Actin-binding]]~~	+
-	~~[[Category: Adp]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Contractile protein]]~~	+
-	~~[[Category: Cytoskeleton]]~~	+
-	~~[[Category: Hydrolysis]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 05:14, 3 August 2022

OCA — Wed, 03 Aug 2022 05:14:54 GMT

←Older revision		Revision as of 05:14, 3 August 2022
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	<StructureSection load='3a5m' size='340' side='right'caption='[[3a5m]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3a5m' size='340' side='right'caption='[[3a5m]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3a5m]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_11735 Atcc 11735] and [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3A5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3a5m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_11735 Atcc 11735] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A5M FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c0f\|1c0f]], [[3a5l\|3a5l]], [[3a5n\|3a5n]], [[3a5o\|3a5o]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c0f\|1c0f]], [[3a5l\|3a5l]], [[3a5n\|3a5n]], [[3a5o\|3a5o]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3a5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a5m OCA], [~~http~~://pdbe.org/3a5m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3a5m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3a5m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3a5m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a5m OCA], [https://pdbe.org/3a5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a5m RCSB], [https://www.ebi.ac.uk/pdbsum/3a5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a5m ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN]] Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:[~~http~~://omim.org/entry/105120 105120]]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.<ref>PMID:2157434</ref> <ref>PMID:2153578</ref> <ref>PMID:2176481</ref> <ref>PMID:1338910</ref>	+	[[https://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN]] Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:[https://omim.org/entry/105120 105120]]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.<ref>PMID:2157434</ref> <ref>PMID:2153578</ref> <ref>PMID:2176481</ref> <ref>PMID:1338910</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN]] Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.<ref>PMID:20393563</ref>	+	[[https://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN]] Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.<ref>PMID:20393563</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	==See Also==		==See Also==
	*[[Actin 3D structures\|Actin 3D structures]]		*[[Actin 3D structures\|Actin 3D structures]]
-	*[[3D ~~Structures of gelsolin~~\|3D ~~Structures of gelsolin~~]]	+	*[[Gelsolin 3D structures\|Gelsolin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:17, 29 July 2020

OCA — Wed, 29 Jul 2020 12:17:10 GMT

←Older revision		Revision as of 12:17, 29 July 2020
Line 1:		Line 1:

	==Crystal Structure of a Dictyostelium P109I Mg2+-Actin in Complex with Human Gelsolin Segment 1==		==Crystal Structure of a Dictyostelium P109I Mg2+-Actin in Complex with Human Gelsolin Segment 1==
-	<StructureSection load='3a5m' size='340' side='right' caption='[[3a5m]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='3a5m' size='340' side='right'caption='[[3a5m]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3a5m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11735 Atcc 11735] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5M OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3A5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3a5m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11735 Atcc 11735] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5M OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3A5M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c0f\|1c0f]], [[3a5l\|3a5l]], [[3a5n\|3a5n]], [[3a5o\|3a5o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c0f\|1c0f]], [[3a5l\|3a5l]], [[3a5n\|3a5n]], [[3a5o\|3a5o]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3a5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a5m OCA], [http://pdbe.org/3a5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a5m RCSB], [http://www.ebi.ac.uk/pdbsum/3a5m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3a5m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3a5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a5m OCA], [http://pdbe.org/3a5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a5m RCSB], [http://www.ebi.ac.uk/pdbsum/3a5m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3a5m ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 24:

	==See Also==		==See Also==
-	*[[Actin\|Actin]]	+	*[[Actin 3D structures\|Actin 3D structures]]
-	*[[~~Gelsolin~~\|~~Gelsolin~~]]	+	*[[3D Structures of gelsolin\|3D Structures of gelsolin]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 32:
	[[Category: Atcc 11735]]		[[Category: Atcc 11735]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Murakami, K]]		[[Category: Murakami, K]]
	[[Category: Noguchi, T Q]]		[[Category: Noguchi, T Q]]

OCA at 11:10, 4 August 2016

OCA — Thu, 04 Aug 2016 11:10:29 GMT

←Older revision		Revision as of 11:10, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of a Dictyostelium P109I Mg2+-Actin in Complex with Human Gelsolin Segment 1==		==Crystal Structure of a Dictyostelium P109I Mg2+-Actin in Complex with Human Gelsolin Segment 1==
	<StructureSection load='3a5m' size='340' side='right' caption='[[3a5m]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3a5m' size='340' side='right' caption='[[3a5m]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3a5m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Dictyostelium_discoideum Dictyostelium discoideum~~] and [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3a5m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11735 Atcc 11735] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A5M FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c0f\|1c0f]], [[3a5l\|3a5l]], [[3a5n\|3a5n]], [[3a5o\|3a5o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c0f\|1c0f]], [[3a5l\|3a5l]], [[3a5n\|3a5n]], [[3a5o\|3a5o]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a5m RCSB], [http://www.ebi.ac.uk/pdbsum/3a5m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a5m OCA], [http://pdbe.org/3a5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a5m RCSB], [http://www.ebi.ac.uk/pdbsum/3a5m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3a5m ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3a5m" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 28:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dictyostelium discoideum~~]]	+	[[Category: Atcc 11735]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Murakami, K]]		[[Category: Murakami, K]]
	[[Category: Noguchi, T Q]]		[[Category: Noguchi, T Q]]

OCA at 13:33, 18 December 2014

OCA — Thu, 18 Dec 2014 13:33:02 GMT

←Older revision		Revision as of 13:33, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3a5m\| PDB=3a5m \| SCENE= }}~~	+	==Crystal Structure of a Dictyostelium P109I Mg2+-Actin in Complex with Human Gelsolin Segment 1==
-	===Crystal Structure of a Dictyostelium P109I Mg2+-Actin in Complex with Human Gelsolin Segment 1===	+	<StructureSection load='3a5m' size='340' side='right' caption='[[3a5m]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20946985}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3a5m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A5M FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c0f\|1c0f]], [[3a5l\|3a5l]], [[3a5n\|3a5n]], [[3a5o\|3a5o]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a5m RCSB], [http://www.ebi.ac.uk/pdbsum/3a5m PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN]] Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:[http://omim.org/entry/105120 105120]]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.<ref>PMID:2157434</ref> <ref>PMID:2153578</ref> <ref>PMID:2176481</ref> <ref>PMID:1338910</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN]] Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.<ref>PMID:20393563</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Assembled actin filaments support cellular signaling, intracellular trafficking, and cytokinesis. ATP hydrolysis triggered by actin assembly provides the structural cues for filament turnover in vivo. Here, we present the cryo-electron microscopic (cryo-EM) structure of filamentous actin (F-actin) in the presence of phosphate, with the visualization of some alpha-helical backbones and large side chains. A complete atomic model based on the EM map identified intermolecular interactions mediated by bound magnesium and phosphate ions. Comparison of the F-actin model with G-actin monomer crystal structures reveals a critical role for bending of the conserved proline-rich loop in triggering phosphate release following ATP hydrolysis. Crystal structures of G-actin show that mutations in this loop trap the catalytic site in two intermediate states of the ATPase cycle. The combined structural information allows us to propose a detailed molecular mechanism for the biochemical events, including actin polymerization and ATPase activation, critical for actin filament dynamics.

-	~~==Disease==~~	+	Structural basis for actin assembly, activation of ATP hydrolysis, and delayed phosphate release.,Murakami K, Yasunaga T, Noguchi TQ, Gomibuchi Y, Ngo KX, Uyeda TQ, Wakabayashi T Cell. 2010 Oct 15;143(2):275-87. PMID:20946985<ref>PMID:20946985</ref>
-	~~[[http://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN]] Defects in GSN are the cause~~ of amyloidosis type 5 (AMYL5) [MIM:[http://omim.org/entry/105120 105120]]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and ~~lattice corneal dystrophy~~. ~~Most patients have modest involvement of internal organs~~, ~~but severe systemic disease can develop in some individuals causing peripheral polyneuropathy~~, ~~amyloid cardiomyopathy~~, ~~and nephrotic syndrome leading to renal failure~~.~~<ref>PMID~~:~~2157434</ref><ref>~~PMID:~~2153578</ref><ref>PMID:2176481</ref>~~<ref>PMID:~~1338910~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http://www.uniprot.org/uniprot~~/~~GELS_HUMAN GELS_HUMAN]] Calcium-regulated~~, ~~actin-modulating protein that binds to~~ the ~~plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping)~~. ~~It can promote the assembly~~ of ~~monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis~~.<~~ref~~>~~PMID:20393563~~</~~ref~~>	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[3a5m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5M OCA].	+

	==See Also==		==See Also==
	*[[Actin\|Actin]]		*[[Actin\|Actin]]
	*[[Gelsolin\|Gelsolin]]		*[[Gelsolin\|Gelsolin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020946985</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Dictyostelium discoideum]]		[[Category: Dictyostelium discoideum]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Murakami, K.]]	+	[[Category: Murakami, K]]
-	[[Category: Noguchi, T Q.]]	+	[[Category: Noguchi, T Q]]
-	[[Category: Uyeda, T Q.]]	+	[[Category: Uyeda, T Q]]
-	[[Category: Wakabayashi, T.]]	+	[[Category: Wakabayashi, T]]
-	[[Category: Yasunaga, T.]]	+	[[Category: Yasunaga, T]]
	[[Category: Actin]]		[[Category: Actin]]
	[[Category: Actin capping]]		[[Category: Actin capping]]

OCA at 17:16, 24 March 2013

OCA — Sun, 24 Mar 2013 17:16:51 GMT

←Older revision		Revision as of 17:16, 24 March 2013
Line 1:		Line 1:
-	[[Image:3a5m.png\|left\|200px]]
-
	{{STRUCTURE_3a5m\| PDB=3a5m \| SCENE= }}		{{STRUCTURE_3a5m\| PDB=3a5m \| SCENE= }}
-
	===Crystal Structure of a Dictyostelium P109I Mg2+-Actin in Complex with Human Gelsolin Segment 1===		===Crystal Structure of a Dictyostelium P109I Mg2+-Actin in Complex with Human Gelsolin Segment 1===
		+	{{ABSTRACT_PUBMED_20946985}}

-	~~{{ABSTRACT_PUBMED_20946985}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN]] Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:[http://omim.org/entry/105120 105120]]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.<ref>PMID:2157434</ref><ref>PMID:2153578</ref><ref>PMID:2176481</ref><ref>PMID:1338910</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN]] Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.<ref>PMID:20393563</ref>

	==About this Structure==		==About this Structure==
Line 15:		Line 17:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020946985</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020946985</ref><references group="xtra"/><references/>
	[[Category: Dictyostelium discoideum]]		[[Category: Dictyostelium discoideum]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 14:45, 20 October 2012

OCA — Sat, 20 Oct 2012 14:45:10 GMT

←Older revision		Revision as of 14:45, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3a5m]] is a 2 chain structure ~~of [[Actin]] and [[Gelsolin]]~~ with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5M OCA].	+	[[3a5m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5M OCA].

	==See Also==		==See Also==

OCA: Protected "3a5m" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 16:07:41 GMT

Protected "3a5m" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:07, 26 July 2012

OCA at 16:07, 26 July 2012

OCA — Thu, 26 Jul 2012 16:07:39 GMT

←Older revision		Revision as of 16:07, 26 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3a5m.png\|left\|200px]]
-	[[Image:3a5m.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3a5m", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3a5m\| PDB=3a5m \| SCENE= }}		{{STRUCTURE_3a5m\| PDB=3a5m \| SCENE= }}

	===Crystal Structure of a Dictyostelium P109I Mg2+-Actin in Complex with Human Gelsolin Segment 1===		===Crystal Structure of a Dictyostelium P109I Mg2+-Actin in Complex with Human Gelsolin Segment 1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20946985}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20946985 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20946985}}		{{ABSTRACT_PUBMED_20946985}}

	==About this Structure==		==About this Structure==
-	~~3A5M~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5M OCA].	+	[[3a5m]] is a 2 chain structure of [[Actin]] and [[Gelsolin]] with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5M OCA].
		+
		+	==See Also==
		+	*[[Actin\|Actin]]
		+	*[[Gelsolin\|Gelsolin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20946985~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020946985</ref><references group="xtra"/>
	[[Category: Dictyostelium discoideum]]		[[Category: Dictyostelium discoideum]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 41:		Line 33:
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Structural protein]]		[[Category: Structural protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 12:06:20 2010''

OCA at 08:55, 27 October 2010

OCA — Wed, 27 Oct 2010 08:55:58 GMT

←Older revision		Revision as of 08:55, 27 October 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3a5m.jpg\|left\|200px]]

-	The ~~entry 3a5m~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3a5m", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3a5m\| PDB=3a5m \| SCENE= }}

-	~~Authors: Murakami, K., Yasunaga, T., Noguchi, T.Q., Uyeda, T.Q., Wakabayashi, T.~~	+	===Crystal Structure of a Dictyostelium P109I Mg2+-Actin in Complex with Human Gelsolin Segment 1===

-	Description:

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan~~ 27 19:10:45 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20946985}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20946985 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20946985}}
		+
		+	==About this Structure==
		+	3A5M is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5M OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20946985</ref><references group="xtra"/>
		+	[[Category: Dictyostelium discoideum]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Murakami, K.]]
		+	[[Category: Noguchi, T Q.]]
		+	[[Category: Uyeda, T Q.]]
		+	[[Category: Wakabayashi, T.]]
		+	[[Category: Yasunaga, T.]]
		+	[[Category: Actin]]
		+	[[Category: Actin capping]]
		+	[[Category: Actin-binding]]
		+	[[Category: Adp]]
		+	[[Category: Atp-binding]]
		+	[[Category: Contractile protein]]
		+	[[Category: Cytoskeleton]]
		+	[[Category: Hydrolysis]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Structural protein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 12:06:20 2010''