3ab9 - Revision history

OCA at 14:17, 1 November 2023

OCA — Wed, 01 Nov 2023 14:17:22 GMT

←Older revision		Revision as of 14:17, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3ab9' size='340' side='right'caption='[[3ab9]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='3ab9' size='340' side='right'caption='[[3ab9]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ab9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AB9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ab9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AB9 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=LA2:N~6~-[(6R)-6,8-DISULFANYLOCTANOYL]-L-LYSINE'>LA2</scene>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LA2:N~6~-[(6R)-6,8-DISULFANYLOCTANOYL]-L-LYSINE'>LA2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hpc\|1hpc]], [[1htp\|1htp]], [[3a8i\|3a8i]], [[3a8j\|3a8j]], [[3a8k\|3a8k]]</div></td></tr>	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gcvH ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ab9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ab9 OCA], [https://pdbe.org/3ab9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ab9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ab9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ab9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ab9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ab9 OCA], [https://pdbe.org/3ab9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ab9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ab9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ab9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GCSH_ECOLI GCSH_ECOLI]] The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.[HAMAP-Rule:MF_00272]	+	[https://www.uniprot.org/uniprot/GCSH_ECOLI GCSH_ECOLI] The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.[HAMAP-Rule:MF_00272]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Maita, N]]	+	[[Category: Maita N]]
-	[[Category: Okamura-Ikeda, K]]	+	[[Category: Okamura-Ikeda K]]
-	~~[[Category: Glycine cleavage system]]~~	+
-	~~[[Category: Lipoyl]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 16:21, 22 December 2021

OCA — Wed, 22 Dec 2021 16:21:49 GMT

←Older revision		Revision as of 16:21, 22 December 2021
Line 1:		Line 1:

	==Crystal Structure of lipoylated E. coli H-protein (reduced form)==		==Crystal Structure of lipoylated E. coli H-protein (reduced form)==
-	<StructureSection load='3ab9' size='340' side='right' caption='[[3ab9]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='3ab9' size='340' side='right'caption='[[3ab9]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ab9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AB9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3AB9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ab9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AB9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LA2:N~6~-[(6R)-6,8-DISULFANYLOCTANOYL]-L-LYSINE'>LA2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LA2:N~6~-[(6R)-6,8-DISULFANYLOCTANOYL]-L-LYSINE'>LA2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hpc\|1hpc]], [[1htp\|1htp]], [[3a8i\|3a8i]], [[3a8j\|3a8j]], [[3a8k\|3a8k]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hpc\|1hpc]], [[1htp\|1htp]], [[3a8i\|3a8i]], [[3a8j\|3a8j]], [[3a8k\|3a8k]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gcvH ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gcvH ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ab9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ab9 OCA], [~~http~~://pdbe.org/3ab9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ab9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ab9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ab9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ab9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ab9 OCA], [https://pdbe.org/3ab9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ab9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ab9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ab9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GCSH_ECOLI GCSH_ECOLI]] The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.[HAMAP-Rule:MF_00272]	+	[[https://www.uniprot.org/uniprot/GCSH_ECOLI GCSH_ECOLI]] The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.[HAMAP-Rule:MF_00272]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: Maita, N]]		[[Category: Maita, N]]
	[[Category: Okamura-Ikeda, K]]		[[Category: Okamura-Ikeda, K]]

OCA at 07:51, 24 October 2018

OCA — Wed, 24 Oct 2018 07:51:07 GMT

←Older revision		Revision as of 07:51, 24 October 2018
Line 16:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ab/3ab9_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ab/3ab9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:51, 5 August 2016

OCA — Fri, 05 Aug 2016 22:51:46 GMT

←Older revision		Revision as of 22:51, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of lipoylated E. coli H-protein (reduced form)==		==Crystal Structure of lipoylated E. coli H-protein (reduced form)==
	<StructureSection load='3ab9' size='340' side='right' caption='[[3ab9]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='3ab9' size='340' side='right' caption='[[3ab9]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ab9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli_k-12 Escherichia coli k-12~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AB9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AB9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ab9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AB9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AB9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LA2:N~6~-[(6R)-6,8-DISULFANYLOCTANOYL]-L-LYSINE'>LA2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LA2:N~6~-[(6R)-6,8-DISULFANYLOCTANOYL]-L-LYSINE'>LA2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hpc\|1hpc]], [[1htp\|1htp]], [[3a8i\|3a8i]], [[3a8j\|3a8j]], [[3a8k\|3a8k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hpc\|1hpc]], [[1htp\|1htp]], [[3a8i\|3a8i]], [[3a8j\|3a8j]], [[3a8k\|3a8k]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gcvH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ~~Escherichia coli K-12~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gcvH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ab9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ab9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ab9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ab9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ab9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ab9 OCA], [http://pdbe.org/3ab9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ab9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ab9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ab9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ab9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ab9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia coli k-12~~]]	+	[[Category: Ecoli]]
	[[Category: Maita, N]]		[[Category: Maita, N]]
	[[Category: Okamura-Ikeda, K]]		[[Category: Okamura-Ikeda, K]]

OCA at 22:37, 25 December 2014

OCA — Thu, 25 Dec 2014 22:37:41 GMT

←Older revision		Revision as of 22:37, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ab9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ab9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ab9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ab9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ab9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ab9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ab9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ab9 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GCSH_ECOLI GCSH_ECOLI]] The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.[HAMAP-Rule:MF_00272]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:50, 18 December 2014

OCA — Thu, 18 Dec 2014 13:50:12 GMT

←Older revision		Revision as of 13:50, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ab9\| PDB=3ab9 \| SCENE= }}~~	+	==Crystal Structure of lipoylated E. coli H-protein (reduced form)==
-	===Crystal Structure of lipoylated E. coli H-protein (reduced form)===	+	<StructureSection load='3ab9' size='340' side='right' caption='[[3ab9]], [[Resolution\|resolution]] 1.65Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20375021}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ab9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AB9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AB9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LA2:N~6~-[(6R)-6,8-DISULFANYLOCTANOYL]-L-LYSINE'>LA2</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hpc\|1hpc]], [[1htp\|1htp]], [[3a8i\|3a8i]], [[3a8j\|3a8j]], [[3a8k\|3a8k]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gcvH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ab9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ab9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ab9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ab9 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ab/3ab9_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aminomethyltransferase, a component of the glycine cleavage system termed T-protein, reversibly catalyzes the degradation of the aminomethyl moiety of glycine attached to the lipoate cofactor of H-protein, resulting in the production of ammonia, 5,10-methylenetetrahydrofolate, and dihydrolipoate-bearing H-protein in the presence of tetrahydrofolate. Several mutations in the human T-protein gene are known to cause nonketotic hyperglycinemia. Here, we report the crystal structure of Escherichia coli T-protein in complex with dihydrolipoate-bearing H-protein and 5-methyltetrahydrofolate, a complex mimicking the ternary complex in the reverse reaction. The structure of the complex shows a highly interacting intermolecular interface limited to a small area and the protein-bound dihydrolipoyllysine arm inserted into the active site cavity of the T-protein. Invariant Arg(292) of the T-protein is essential for complex assembly. The structure also provides novel insights in understanding the disease-causing mutations, in addition to the disease-related impairment in the cofactor-enzyme interactions reported previously. Furthermore, structural and mutational analyses suggest that the reversible transfer of the methylene group between the lipoate and tetrahydrofolate should proceed through the electron relay-assisted iminium intermediate formation.

-	~~==Function==~~	+	Crystal structure of aminomethyltransferase in complex with dihydrolipoyl-H-protein of the glycine cleavage system: implications for recognition of lipoyl protein substrate, disease-related mutations, and reaction mechanism.,Okamura-Ikeda K, Hosaka H, Maita N, Fujiwara K, Yoshizawa AC, Nakagawa A, Taniguchi H J Biol Chem. 2010 Jun 11;285(24):18684-92. Epub 2010 Apr 6. PMID:20375021<ref>PMID:20375021</ref>
-	~~[[http://www.uniprot.org/uniprot/GCSH_ECOLI GCSH_ECOLI]] The glycine cleavage system catalyzes the degradation~~ of ~~glycine. The~~ H protein ~~shuttles the methylamine group~~ of ~~glycine from~~ the ~~P protein to the T~~ protein.~~[HAMAP~~-~~Rule~~:~~MF_00272]~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3ab9]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3AB9 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020375021</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli k-12]]		[[Category: Escherichia coli k-12]]
-	[[Category: Maita, N.]]	+	[[Category: Maita, N]]
-	[[Category: Okamura-Ikeda, K.]]	+	[[Category: Okamura-Ikeda, K]]
	[[Category: Glycine cleavage system]]		[[Category: Glycine cleavage system]]
	[[Category: Lipoyl]]		[[Category: Lipoyl]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 08:29, 21 August 2013

OCA — Wed, 21 Aug 2013 08:29:03 GMT

←Older revision		Revision as of 08:29, 21 August 2013
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-	[[Image:3ab9.png\|left\|200px]]
-
	{{STRUCTURE_3ab9\| PDB=3ab9 \| SCENE= }}		{{STRUCTURE_3ab9\| PDB=3ab9 \| SCENE= }}
-
	===Crystal Structure of lipoylated E. coli H-protein (reduced form)===		===Crystal Structure of lipoylated E. coli H-protein (reduced form)===
		+	{{ABSTRACT_PUBMED_20375021}}

-	~~{{ABSTRACT_PUBMED_020375021}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/GCSH_ECOLI GCSH_ECOLI]] The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.[HAMAP-Rule:MF_00272]

	==About this Structure==		==About this Structure==
-	[[3ab9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli~~ Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AB9 OCA].	+	[[3ab9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AB9 OCA].
-	[[Category: Escherichia coli]]	+
		+	==Reference==
		+	<ref group="xtra">PMID:020375021</ref><references group="xtra"/><references/>
		+	[[Category: Escherichia coli k-12]]
	[[Category: Maita, N.]]		[[Category: Maita, N.]]
	[[Category: Okamura-Ikeda, K.]]		[[Category: Okamura-Ikeda, K.]]

OCA: Protected "3ab9" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 22:59:45 GMT

Protected "3ab9" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:59, 7 January 2013

OCA at 22:59, 7 January 2013

OCA — Mon, 07 Jan 2013 22:59:39 GMT

←Older revision

Revision as of 22:59, 7 January 2013

OCA at 07:45, 7 April 2010

OCA — Wed, 07 Apr 2010 07:45:41 GMT

←Older revision		Revision as of 07:45, 7 April 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ab9.jpg\|left\|200px]]

-	The ~~entry 3ab9~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ab9", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ab9\| PDB=3ab9 \| SCENE= }}

-	~~Authors: Okamura~~-~~Ikeda, K., Maita, N.~~	+	===Crystal Structure of lipoylated E. coli H-protein (reduced form)===

-	Description: Crystal Structure of lipoylated E. coli H-protein (reduced form)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan~~ ~~6 09~~:09:17 2010''	+	==About this Structure==
		+	3AB9 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AB9 OCA].
		+	[[Category: Escherichia coli]]
		+	[[Category: Maita, N.]]
		+	[[Category: Okamura-Ikeda, K.]]
		+	[[Category: Glycine cleavage system]]
		+	[[Category: Lipoyl]]
		+	[[Category: Transport protein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 10:45:40 2010''