3ah8 - Revision history

OCA at 12:00, 30 August 2023

OCA — Wed, 30 Aug 2023 12:00:34 GMT

←Older revision		Revision as of 12:00, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='3ah8' size='340' side='right'caption='[[3ah8]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3ah8' size='340' side='right'caption='[[3ah8]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ah8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bovin Bovin~~], [https://en.wikipedia.org/wiki/Chromobacterium_sp. Chromobacterium sp.] and [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AH8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ah8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Chromobacterium_sp. Chromobacterium sp.], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AH8 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GDP:GUANOSINE~~-~~5-DIPHOSPHATE'>GDP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAM:N-METHYL-ALPHA-BETA-DEHYDROALANINE'>DAM</scene>, <scene name='pdbligand=HF2:(2R)-2-HYDROXY-3-PHENYLPROPANOIC+ACID'>HF2</scene>, <scene name='pdbligand=HL2:(2S,3R)-2-AMINO-3-HYDROXY-4-METHYLPENTANOIC+ACID'>HL2</scene>, <scene name='pdbligand=MAA:N-METHYL-L-ALANINE'>MAA</scene>, <scene name='pdbligand=OTH:N,O-DIMETHYL-L-THREONINE'>OTH</scene>, <scene name='pdbligand=THC:N-METHYLCARBONYLTHREONINE'>THC</scene>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAM:N-METHYL-ALPHA-BETA-DEHYDROALANINE'>DAM</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=HF2:(2R)-2-HYDROXY-3-PHENYLPROPANOIC+ACID'>HF2</scene>, <scene name='pdbligand=HL2:(2S,3R)-2-AMINO-3-HYDROXY-4-METHYLPENTANOIC+ACID'>HL2</scene>, <scene name='pdbligand=MAA:N-METHYL-L-ALANINE'>MAA</scene>, <scene name='pdbligand=OTH:N,O-DIMETHYL-L-THREONINE'>OTH</scene>, <scene name='pdbligand=THC:N-METHYLCARBONYLTHREONINE'>THC</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gmhB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), GNB1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN]), GNG2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ah8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ah8 OCA], [https://pdbe.org/3ah8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ah8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ah8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ah8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ah8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ah8 OCA], [https://pdbe.org/3ah8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ah8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ah8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ah8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref> [[https://www.uniprot.org/uniprot/GBG2_BOVIN GBG2_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[https://www.uniprot.org/uniprot/GBB1_BOVIN GBB1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	+	[https://www.uniprot.org/uniprot/GNAQ_MOUSE GNAQ_MOUSE] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro).<ref>PMID:17938235</ref> <ref>PMID:20624888</ref> [https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
	[[Category: Chromobacterium sp]]		[[Category: Chromobacterium sp]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Hakoshima, T]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Itoh, H]]	+	[[Category: Hakoshima T]]
-	[[Category: Kitano, K]]	+	[[Category: Itoh H]]
-	[[Category: Mizuno, N]]	+	[[Category: Kitano K]]
-	[[Category: Nishimura, A]]	+	[[Category: Mizuno N]]
-	[[Category: Tago, K]]	+	[[Category: Nishimura A]]
-	[[Category: Takasaki, J]]	+	[[Category: Tago K]]
-	[[Category: Taniguchi, M]]	+	[[Category: Takasaki J]]
-	~~[[Category: Galpha-q]]~~	+	[[Category: Taniguchi M]]
-	~~[[Category: Gbeta]]~~	+
-	~~[[Category: Ggamma]]~~	+
-	~~[[Category: Gtpase]]~~	+
-	~~[[Category: Heterotrimeric g protein]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Signaling protein-inhibitor complex]]~~	+
-	~~[[Category: Ym-254890~~]]	+

OCA at 14:52, 29 December 2021

OCA — Wed, 29 Dec 2021 14:52:24 GMT

←Older revision		Revision as of 14:52, 29 December 2021
Line 1:		Line 1:

	==Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890==		==Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890==
-	<StructureSection load='3ah8' size='340' side='right' caption='[[3ah8]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='3ah8' size='340' side='right'caption='[[3ah8]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ah8]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin], [~~http~~://en.wikipedia.org/wiki/Chromobacterium_sp. Chromobacterium sp.] and [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AH8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3AH8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ah8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin], [https://en.wikipedia.org/wiki/Chromobacterium_sp. Chromobacterium sp.] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AH8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAM:N-METHYL-ALPHA-BETA-DEHYDROALANINE'>DAM</scene>, <scene name='pdbligand=HF2:(2R)-2-HYDROXY-3-PHENYLPROPANOIC+ACID'>HF2</scene>, <scene name='pdbligand=HL2:(2S,3R)-2-AMINO-3-HYDROXY-4-METHYLPENTANOIC+ACID'>HL2</scene>, <scene name='pdbligand=MAA:N-METHYL-L-ALANINE'>MAA</scene>, <scene name='pdbligand=OTH:N,O-DIMETHYL-L-THREONINE'>OTH</scene>, <scene name='pdbligand=THC:N-METHYLCARBONYLTHREONINE'>THC</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAM:N-METHYL-ALPHA-BETA-DEHYDROALANINE'>DAM</scene>, <scene name='pdbligand=HF2:(2R)-2-HYDROXY-3-PHENYLPROPANOIC+ACID'>HF2</scene>, <scene name='pdbligand=HL2:(2S,3R)-2-AMINO-3-HYDROXY-4-METHYLPENTANOIC+ACID'>HL2</scene>, <scene name='pdbligand=MAA:N-METHYL-L-ALANINE'>MAA</scene>, <scene name='pdbligand=OTH:N,O-DIMETHYL-L-THREONINE'>OTH</scene>, <scene name='pdbligand=THC:N-METHYLCARBONYLTHREONINE'>THC</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gmhB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), GNB1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN]), GNG2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gmhB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), GNB1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN]), GNG2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ah8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ah8 OCA], [~~http~~://pdbe.org/3ah8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ah8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ah8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ah8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ah8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ah8 OCA], [https://pdbe.org/3ah8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ah8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ah8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ah8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref> [[~~http~~://www.uniprot.org/uniprot/GBG2_BOVIN GBG2_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[~~http~~://www.uniprot.org/uniprot/GBB1_BOVIN GBB1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	+	[[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref> [[https://www.uniprot.org/uniprot/GBG2_BOVIN GBG2_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[https://www.uniprot.org/uniprot/GBB1_BOVIN GBB1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/3ah8_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/3ah8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Transducin\|Transducin]]	+	*[[Transducin 3D structures\|Transducin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	[[Category: Bovin]]		[[Category: Bovin]]
	[[Category: Chromobacterium sp]]		[[Category: Chromobacterium sp]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Hakoshima, T]]		[[Category: Hakoshima, T]]

OCA at 04:29, 5 August 2016

OCA — Fri, 05 Aug 2016 04:29:56 GMT

←Older revision		Revision as of 04:29, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890==		==Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890==
	<StructureSection load='3ah8' size='340' side='right' caption='[[3ah8]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3ah8' size='340' side='right' caption='[[3ah8]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ah8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~], [http://en.wikipedia.org/wiki/Chromobacterium_sp. Chromobacterium sp.] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AH8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AH8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ah8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin], [http://en.wikipedia.org/wiki/Chromobacterium_sp. Chromobacterium sp.] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AH8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AH8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAM:N-METHYL-ALPHA-BETA-DEHYDROALANINE'>DAM</scene>, <scene name='pdbligand=HF2:(2R)-2-HYDROXY-3-PHENYLPROPANOIC+ACID'>HF2</scene>, <scene name='pdbligand=HL2:(2S,3R)-2-AMINO-3-HYDROXY-4-METHYLPENTANOIC+ACID'>HL2</scene>, <scene name='pdbligand=MAA:N-METHYL-L-ALANINE'>MAA</scene>, <scene name='pdbligand=OTH:N,O-DIMETHYL-L-THREONINE'>OTH</scene>, <scene name='pdbligand=THC:N-METHYLCARBONYLTHREONINE'>THC</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAM:N-METHYL-ALPHA-BETA-DEHYDROALANINE'>DAM</scene>, <scene name='pdbligand=HF2:(2R)-2-HYDROXY-3-PHENYLPROPANOIC+ACID'>HF2</scene>, <scene name='pdbligand=HL2:(2S,3R)-2-AMINO-3-HYDROXY-4-METHYLPENTANOIC+ACID'>HL2</scene>, <scene name='pdbligand=MAA:N-METHYL-L-ALANINE'>MAA</scene>, <scene name='pdbligand=OTH:N,O-DIMETHYL-L-THREONINE'>OTH</scene>, <scene name='pdbligand=THC:N-METHYLCARBONYLTHREONINE'>THC</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gmhB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~]), GNB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 ~~Bos taurus~~]), GNG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 ~~Bos taurus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gmhB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), GNB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN]), GNG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ah8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ah8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ah8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ah8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ah8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ah8 OCA], [http://pdbe.org/3ah8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ah8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ah8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ah8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ah8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ah8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: Chromobacterium sp]]		[[Category: Chromobacterium sp]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Hakoshima, T]]		[[Category: Hakoshima, T]]
	[[Category: Itoh, H]]		[[Category: Itoh, H]]

OCA at 15:49, 25 December 2014

OCA — Thu, 25 Dec 2014 15:49:16 GMT

←Older revision		Revision as of 15:49, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ah8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ah8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ah8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ah8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ah8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ah8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ah8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ah8 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref> [[http://www.uniprot.org/uniprot/GBG2_BOVIN GBG2_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[http://www.uniprot.org/uniprot/GBB1_BOVIN GBB1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Chromobacterium sp.]]	+	[[Category: Chromobacterium sp]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Hakoshima, T.]]	+	[[Category: Hakoshima, T]]
-	[[Category: Itoh, H.]]	+	[[Category: Itoh, H]]
-	[[Category: Kitano, K.]]	+	[[Category: Kitano, K]]
-	[[Category: Mizuno, N.]]	+	[[Category: Mizuno, N]]
-	[[Category: Nishimura, A.]]	+	[[Category: Nishimura, A]]
-	[[Category: Tago, K.]]	+	[[Category: Tago, K]]
-	[[Category: Takasaki, J.]]	+	[[Category: Takasaki, J]]
-	[[Category: Taniguchi, M.]]	+	[[Category: Taniguchi, M]]
	[[Category: Galpha-q]]		[[Category: Galpha-q]]
	[[Category: Gbeta]]		[[Category: Gbeta]]

OCA at 09:32, 5 November 2014

OCA — Wed, 05 Nov 2014 09:32:23 GMT

←Older revision		Revision as of 09:32, 5 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3ah8.~~png~~\|~~left~~\|200px]]	+	==Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890==
		+	<StructureSection load='3ah8' size='340' side='right' caption='[[3ah8]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ah8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Chromobacterium_sp. Chromobacterium sp.] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AH8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AH8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DAM:N-METHYL-ALPHA-BETA-DEHYDROALANINE'>DAM</scene>, <scene name='pdbligand=HF2:(2R)-2-HYDROXY-3-PHENYLPROPANOIC+ACID'>HF2</scene>, <scene name='pdbligand=HL2:(2S,3R)-2-AMINO-3-HYDROXY-4-METHYLPENTANOIC+ACID'>HL2</scene>, <scene name='pdbligand=MAA:N-METHYL-L-ALANINE'>MAA</scene>, <scene name='pdbligand=OTH:N,O-DIMETHYL-L-THREONINE'>OTH</scene>, <scene name='pdbligand=THC:N-METHYLCARBONYLTHREONINE'>THC</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gmhB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), GNB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus]), GNG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ah8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ah8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ah8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ah8 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/3ah8_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Heterotrimeric GTP-binding proteins (G proteins) transmit extracellular stimuli perceived by G protein-coupled receptors (GPCRs) to intracellular signaling cascades. Hundreds of GPCRs exist in humans and are the targets of a large percentage of the pharmaceutical drugs used today. Because G proteins are regulated by GPCRs, small molecules that directly modulate G proteins have the potential to become therapeutic agents. However, strategies to develop modulators have been hampered by a lack of structural knowledge of targeting sites for specific modulator binding. Here we present the mechanism of action of the cyclic depsipeptide YM-254890, which is a recently discovered G(q)-selective inhibitor. YM-254890 specifically inhibits the GDP/GTP exchange reaction of alpha subunit of G(q) protein (Galpha(q)) by inhibiting the GDP release from Galpha(q). X-ray crystal structure analysis of the Galpha(q)betagamma-YM-254890 complex shows that YM-254890 binds the hydrophobic cleft between two interdomain linkers connecting the GTPase and helical domains of the Galpha(q). The binding stabilizes an inactive GDP-bound form through direct interactions with switch I and impairs the linker flexibility. Our studies provide a novel targeting site for the development of small molecules that selectively inhibit each Galpha subunit and an insight into the molecular mechanism of G protein activation.

-	~~{{STRUCTURE_3ah8\| PDB=3ah8 \| SCENE= }}~~	+	Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule.,Nishimura A, Kitano K, Takasaki J, Taniguchi M, Mizuno N, Tago K, Hakoshima T, Itoh H Proc Natl Acad Sci U S A. 2010 Jul 16. PMID:20639466<ref>PMID:20639466</ref>

-	~~===Structure~~ of ~~heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_20639466}}~~	+	==See Also==
-		+	*[[Transducin\|Transducin]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3ah8~~]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Chromobacterium_sp. Chromobacterium sp.] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AH8 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:020639466<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Chromobacterium sp.]]		[[Category: Chromobacterium sp.]]

OCA: Protected "3ah8" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 18:46:34 GMT

Protected "3ah8" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:46, 7 January 2013

OCA at 18:46, 7 January 2013

OCA — Mon, 07 Jan 2013 18:46:31 GMT

←Older revision		Revision as of 18:46, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3ah8.png\|left\|200px]]		[[Image:3ah8.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ah8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ah8\| PDB=3ah8 \| SCENE= }}		{{STRUCTURE_3ah8\| PDB=3ah8 \| SCENE= }}

	===Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890===		===Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20639466}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20639466 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20639466}}		{{ABSTRACT_PUBMED_20639466}}

	==About this Structure==		==About this Structure==
-	~~3AH8~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Chromobacterium_sp. Chromobacterium sp.] and [http://en.wikipedia.org/wiki/~~Rattus_norvegicus,_mus_musculus Rattus norvegicus, mus~~ musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AH8 OCA].	+	[[3ah8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Chromobacterium_sp. Chromobacterium sp.] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AH8 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20639466~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020639466</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Chromobacterium sp.]]		[[Category: Chromobacterium sp.]]
-	[[Category: ~~Rattus norvegicus, mus~~ musculus]]	+	[[Category: Mus musculus]]
	[[Category: Hakoshima, T.]]		[[Category: Hakoshima, T.]]
	[[Category: Itoh, H.]]		[[Category: Itoh, H.]]
Line 44:		Line 32:
	[[Category: Signaling protein-inhibitor complex]]		[[Category: Signaling protein-inhibitor complex]]
	[[Category: Ym-254890]]		[[Category: Ym-254890]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:15:31 2010''

OCA at 08:08, 28 July 2010

OCA — Wed, 28 Jul 2010 08:08:49 GMT

←Older revision		Revision as of 08:08, 28 July 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3ah8.~~jpg~~\|left\|200px]]	+	[[Image:3ah8.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890===		===Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20639466}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20639466 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20639466}}

	==About this Structure==		==About this Structure==
	3AH8 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Chromobacterium_sp. Chromobacterium sp.] and [http://en.wikipedia.org/wiki/Rattus_norvegicus,_mus_musculus Rattus norvegicus, mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AH8 OCA].		3AH8 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Chromobacterium_sp. Chromobacterium sp.] and [http://en.wikipedia.org/wiki/Rattus_norvegicus,_mus_musculus Rattus norvegicus, mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AH8 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20639466</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Chromobacterium sp.]]		[[Category: Chromobacterium sp.]]
Line 36:		Line 45:
	[[Category: Ym-254890]]		[[Category: Ym-254890]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul ~~21 10~~:15:38 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:15:31 2010''

OCA at 06:09, 21 July 2010

OCA — Wed, 21 Jul 2010 06:09:14 GMT

←Older revision		Revision as of 06:09, 21 July 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ah8.jpg\|left\|200px]]

-	The ~~entry 3ah8~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ah8", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ah8\| PDB=3ah8 \| SCENE= }}

-	~~Authors: Nishimura, A., Kitano, K., Takasaki, J., Taniguchi, M., Mizuno, N., Tago, K., Hakoshima, T., Itoh, H.~~	+	===Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890===

-	Description: Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul ~~14 16~~:02:16 2010''	+	==About this Structure==
		+	3AH8 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Chromobacterium_sp. Chromobacterium sp.] and [http://en.wikipedia.org/wiki/Rattus_norvegicus,_mus_musculus Rattus norvegicus, mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AH8 OCA].
		+	[[Category: Bos taurus]]
		+	[[Category: Chromobacterium sp.]]
		+	[[Category: Rattus norvegicus, mus musculus]]
		+	[[Category: Hakoshima, T.]]
		+	[[Category: Itoh, H.]]
		+	[[Category: Kitano, K.]]
		+	[[Category: Mizuno, N.]]
		+	[[Category: Nishimura, A.]]
		+	[[Category: Tago, K.]]
		+	[[Category: Takasaki, J.]]
		+	[[Category: Taniguchi, M.]]
		+	[[Category: Galpha-q]]
		+	[[Category: Gbeta]]
		+	[[Category: Ggamma]]
		+	[[Category: Gtpase]]
		+	[[Category: Heterotrimeric g protein]]
		+	[[Category: Inhibitor]]
		+	[[Category: Signaling protein]]
		+	[[Category: Signaling protein-inhibitor complex]]
		+	[[Category: Ym-254890]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 21 10:15:38 2010''

OCA at 11:56, 14 July 2010

OCA — Wed, 14 Jul 2010 11:56:07 GMT

←Older revision		Revision as of 11:56, 14 July 2010
Line 5:		Line 5:
	Authors: Nishimura, A., Kitano, K., Takasaki, J., Taniguchi, M., Mizuno, N., Tago, K., Hakoshima, T., Itoh, H.		Authors: Nishimura, A., Kitano, K., Takasaki, J., Taniguchi, M., Mizuno, N., Tago, K., Hakoshima, T., Itoh, H.

-	Description:	+	Description: Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul ~~7 08~~:23:17 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 14 16:02:16 2010''