3aoa - Revision history

OCA at 15:50, 4 October 2023

OCA — Wed, 04 Oct 2023 15:50:21 GMT

←Older revision		Revision as of 15:50, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='3aoa' size='340' side='right'caption='[[3aoa]], [[Resolution\|resolution]] 3.35Å' scene=''>		<StructureSection load='3aoa' size='340' side='right'caption='[[3aoa]], [[Resolution\|resolution]] 3.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3aoa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AOA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3aoa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AOA FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~acrB~~, ~~acrE, b0462, EcDH1_3148, JW0451 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=83333 ECOLI])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.35Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aoa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aoa OCA], [https://pdbe.org/3aoa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aoa RCSB], [https://www.ebi.ac.uk/pdbsum/3aoa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aoa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aoa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aoa OCA], [https://pdbe.org/3aoa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aoa RCSB], [https://www.ebi.ac.uk/pdbsum/3aoa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aoa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI]] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>	+	[https://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Nakashima, R]]	+	[[Category: Nakashima R]]
-	[[Category: Sakurai, K]]	+	[[Category: Sakurai K]]
-	[[Category: Yamaguchi, A]]	+	[[Category: Yamaguchi A]]
-	~~[[Category: Inner membrane]]~~	+
-	~~[[Category: Membrane protein~~]]	+

OCA at 14:58, 29 December 2021

OCA — Wed, 29 Dec 2021 14:58:57 GMT

←Older revision		Revision as of 14:58, 29 December 2021
Line 1:		Line 1:

	==Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket==		==Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket==
-	<StructureSection load='3aoa' size='340' side='right' caption='[[3aoa]], [[Resolution\|resolution]] 3.35Å' scene=''>	+	<StructureSection load='3aoa' size='340' side='right'caption='[[3aoa]], [[Resolution\|resolution]] 3.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3aoa]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AOA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3AOA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3aoa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AOA FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">acrB, acrE, b0462, EcDH1_3148, JW0451 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">acrB, acrE, b0462, EcDH1_3148, JW0451 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3aoa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aoa OCA], [~~http~~://pdbe.org/3aoa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3aoa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3aoa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3aoa ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aoa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aoa OCA], [https://pdbe.org/3aoa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aoa RCSB], [https://www.ebi.ac.uk/pdbsum/3aoa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aoa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI]] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>	+	[[https://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI]] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: Nakashima, R]]		[[Category: Nakashima, R]]
	[[Category: Sakurai, K]]		[[Category: Sakurai, K]]

OCA at 19:51, 4 August 2016

OCA — Thu, 04 Aug 2016 19:51:27 GMT

←Older revision		Revision as of 19:51, 4 August 2016
Line 1:		Line 1:
		+
	==Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket==		==Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket==
	<StructureSection load='3aoa' size='340' side='right' caption='[[3aoa]], [[Resolution\|resolution]] 3.35Å' scene=''>		<StructureSection load='3aoa' size='340' side='right' caption='[[3aoa]], [[Resolution\|resolution]] 3.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3aoa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli_k-12 Escherichia coli k-12~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AOA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3aoa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AOA FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">acrB, acrE, b0462, EcDH1_3148, JW0451 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ~~Escherichia coli K-12~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">acrB, acrE, b0462, EcDH1_3148, JW0451 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aoa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aoa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3aoa RCSB], [http://www.ebi.ac.uk/pdbsum/3aoa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aoa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aoa OCA], [http://pdbe.org/3aoa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3aoa RCSB], [http://www.ebi.ac.uk/pdbsum/3aoa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3aoa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3aoa" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia coli k-12~~]]	+	[[Category: Ecoli]]
	[[Category: Nakashima, R]]		[[Category: Nakashima, R]]
	[[Category: Sakurai, K]]		[[Category: Sakurai, K]]

OCA at 12:34, 25 December 2014

OCA — Thu, 25 Dec 2014 12:34:57 GMT

←Older revision		Revision as of 12:34, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aoa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aoa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3aoa RCSB], [http://www.ebi.ac.uk/pdbsum/3aoa PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aoa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aoa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3aoa RCSB], [http://www.ebi.ac.uk/pdbsum/3aoa PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI]] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:15, 18 December 2014

OCA — Thu, 18 Dec 2014 14:15:30 GMT

←Older revision		Revision as of 14:15, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3aoa\| PDB=3aoa \| SCENE= }}~~	+	==Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket==
-	===Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket===	+	<StructureSection load='3aoa' size='340' side='right' caption='[[3aoa]], [[Resolution\|resolution]] 3.35Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22121023}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3aoa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AOA FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">acrB, acrE, b0462, EcDH1_3148, JW0451 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aoa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aoa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3aoa RCSB], [http://www.ebi.ac.uk/pdbsum/3aoa PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	AcrB and its homologues are the principal multidrug transporters in Gram-negative bacteria and are important in antibiotic drug tolerance. AcrB is a homotrimer that acts as a tripartite complex with the outer membrane channel TolC and the membrane fusion protein AcrA. Minocycline and doxorubicin have been shown to bind to the phenylalanine cluster region of the binding monomer. Here we report the crystal structures of AcrB bound to the high-molecular-mass drugs rifampicin and erythromycin. These drugs bind to the access monomer, and the binding sites are located in the proximal multisite binding pocket, which is separated from the phenylalanine cluster region (distal pocket) by the Phe-617 loop. Our structures indicate that there are two discrete multisite binding pockets along the intramolecular channel. High-molecular-mass drugs first bind to the proximal pocket in the access state and are then forced into the distal pocket in the binding state by a peristaltic mechanism involving subdomain movements that include a shift of the Phe-617 loop. By contrast, low-molecular-mass drugs, such as minocycline and doxorubicin, travel through the proximal pocket without specific binding and immediately bind to the distal pocket. The presence of two discrete, high-volume multisite binding pockets contributes to the remarkably broad substrate recognition of AcrB.

-	~~==Function==~~	+	Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket.,Nakashima R, Sakurai K, Yamasaki S, Nishino K, Yamaguchi A Nature. 2011 Nov 27;480(7378):565-9. doi: 10.1038/nature10641. PMID:22121023<ref>PMID:22121023</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/ACRB_ECOLI ACRB_ECOLI]] AcrAB is a drug efflux protein with a broad substrate specificity~~.~~<ref>~~PMID:~~16915237</ref> <ref>PMID:16946072</ref>~~ <ref>PMID:~~17194213~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3aoa]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3AOA OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:022121023</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli k-12]]		[[Category: Escherichia coli k-12]]
-	[[Category: Nakashima, R.]]	+	[[Category: Nakashima, R]]
-	[[Category: Sakurai, K.]]	+	[[Category: Sakurai, K]]
-	[[Category: Yamaguchi, A.]]	+	[[Category: Yamaguchi, A]]
	[[Category: Inner membrane]]		[[Category: Inner membrane]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 19:18, 7 August 2013

OCA — Wed, 07 Aug 2013 19:18:37 GMT

←Older revision		Revision as of 19:18, 7 August 2013
Line 1:		Line 1:
-	[[Image:3aoa.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3aoa", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3aoa\| PDB=3aoa \| SCENE= }}		{{STRUCTURE_3aoa\| PDB=3aoa \| SCENE= }}
-
	===Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket===		===Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket===
		+	{{ABSTRACT_PUBMED_22121023}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI]] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>

	==About this Structure==		==About this Structure==
-	[[3aoa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli~~ Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AOA OCA].	+	[[3aoa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AOA OCA].
-	[[Category: Escherichia coli]]	+
		+	==Reference==
		+	<ref group="xtra">PMID:022121023</ref><references group="xtra"/><references/>
		+	[[Category: Escherichia coli k-12]]
	[[Category: Nakashima, R.]]		[[Category: Nakashima, R.]]
	[[Category: Sakurai, K.]]		[[Category: Sakurai, K.]]

OCA at 08:08, 7 December 2011

OCA — Wed, 07 Dec 2011 08:08:19 GMT

←Older revision		Revision as of 08:08, 7 December 2011
Line 1:		Line 1:
-	[[Image:3aoa.~~jpg~~\|left\|200px]]	+	[[Image:3aoa.png\|left\|200px]]

	<!--		<!--

OCA: Protected "3aoa" [edit=sysop:move=sysop]

OCA — Wed, 30 Nov 2011 06:24:29 GMT

Protected "3aoa" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:24, 30 November 2011

OCA at 06:24, 30 November 2011

OCA — Wed, 30 Nov 2011 06:24:21 GMT

←Older revision		Revision as of 06:24, 30 November 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3aoa.jpg\|left\|200px]]

-	The ~~entry 3aoa~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3aoa", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3aoa\| PDB=3aoa \| SCENE= }}

-	~~Authors: Nakashima, R., Sakurai, K., Yamaguchi, A.~~	+	===Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket===

-	Description: Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Nov 10 06~~:25:~~57 2010''~~	+	==About this Structure==
		+	[[3aoa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AOA OCA].
		+	[[Category: Escherichia coli]]
		+	[[Category: Nakashima, R.]]
		+	[[Category: Sakurai, K.]]
		+	[[Category: Yamaguchi, A.]]
		+	[[Category: Inner membrane]]
		+	[[Category: Membrane protein]]

OCA at 03:15, 10 November 2010

OCA — Wed, 10 Nov 2010 03:15:01 GMT

←Older revision		Revision as of 03:15, 10 November 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3aoa is ON HOLD	+	The entry 3aoa is ON HOLD until Paper Publication

	Authors: Nakashima, R., Sakurai, K., Yamaguchi, A.		Authors: Nakashima, R., Sakurai, K., Yamaguchi, A.
Line 7:		Line 7:
	Description: Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket		Description: Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 13~~ 10:26:12 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 10 06:25:57 2010''