3ap4 - Revision history

OCA at 14:01, 13 March 2024

OCA — Wed, 13 Mar 2024 14:01:22 GMT

←Older revision		Revision as of 14:01, 13 March 2024
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/LEG8_HUMAN LEG8_HUMAN] Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.<ref>PMID:21288902</ref>		[https://www.uniprot.org/uniprot/LEG8_HUMAN LEG8_HUMAN] Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.<ref>PMID:21288902</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Galectin-8 has much higher affinity for 3'-O-sulfated or 3'-O-sialylated glycoconjugates and a Lewis X-containing glycan than for oligosaccharides terminating in Galbeta1-->3/4GlcNAc, and this specificity is mainly attributed to the N-terminal carbohydrate recognition domain (N-domain, CRD) (Ideo, H., Seko, A., Ishizuka, I., and Yamashita, K. (2003) Glycobiology 13, 713-723). In this study, we elucidated the crystal structures of the human galectin-8-N-domain (-8N) in the absence or presence of 4 ligands. The apo molecule forms a dimer, which is different from the canonical 2-fold symmetric dimer observed for galectin-1 and -2. In a galectin-8N-lactose complex, the lactose-recognizing amino acids are highly conserved among the galectins. However, Arg(45), Gln(47), Arg(59), and the long loop region between the S3 and S4 beta-strands are unique to galectin-8N. These amino acids directly or indirectly interact with the sulfate or sialic acid moieties of 3'-sialyl- and 3'-sulfolactose complexed with galectin-8N. Furthermore, in the LNF-III-galectin-8N complex, van der Waals interactions occur between the alpha1-3-branched fucose and galactose and between galactose and Tyr(141), and these interactions increase the affinity toward galectin-8N. Based on the findings of these x-ray crystallographic analyses, a mutagenesis study using surface plasmon resonance showed that Arg(45), Gln(47), and Arg(59) of galectin-8N are indispensable and coordinately contribute to the strong binding of galectins-8N to sialylated and sulfated oligosaccharides. Arg(59) is the most critical amino acid for binding in the S3-S4 loop region.
-
-	Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans.,Ideo H, Matsuzaka T, Nonaka T, Seko A, Yamashita K J Biol Chem. 2011 Apr 1;286(13):11346-55. Epub 2011 Feb 2. PMID:21288902<ref>PMID:21288902</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3ap4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 15:50, 4 October 2023

OCA — Wed, 04 Oct 2023 15:50:51 GMT

←Older revision		Revision as of 15:50, 4 October 2023
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	<StructureSection load='3ap4' size='340' side='right'caption='[[3ap4]], [[Resolution\|resolution]] 2.33Å' scene=''>		<StructureSection load='3ap4' size='340' side='right'caption='[[3ap4]], [[Resolution\|resolution]] 2.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ap4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AP4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ap4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AP4 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GLC:ALPHA~~-~~D-GLUCOSE'>GLC</scene>~~, ~~<scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.33Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3ap5\|3ap5]], [[3ap6\|3ap6]], [[3ap7\|3ap7]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900008:alpha-lactose'>PRD_900008</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">LGALS8 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ap4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ap4 OCA], [https://pdbe.org/3ap4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ap4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ap4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ap4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ap4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ap4 OCA], [https://pdbe.org/3ap4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ap4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ap4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ap4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LEG8_HUMAN LEG8_HUMAN]] Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.<ref>PMID:21288902</ref>	+	[https://www.uniprot.org/uniprot/LEG8_HUMAN LEG8_HUMAN] Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.<ref>PMID:21288902</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ideo, H]]	+	[[Category: Ideo H]]
-	[[Category: Matsuzaka, T]]	+	[[Category: Matsuzaka T]]
-	[[Category: Nonaka, T]]	+	[[Category: Nonaka T]]
-	[[Category: Yamashita, K]]	+	[[Category: Yamashita K]]
-	~~[[Category: Beta-sandwich]]~~	+
-	~~[[Category: Carbohydrate/sugar binding]]~~	+
-	~~[[Category: Galectin]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 14:59, 29 December 2021

OCA — Wed, 29 Dec 2021 14:59:45 GMT

←Older revision		Revision as of 14:59, 29 December 2021
Line 1:		Line 1:

	==Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with lactose==		==Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with lactose==
-	<StructureSection load='3ap4' size='340' side='right' caption='[[3ap4]], [[Resolution\|resolution]] 2.33Å' scene=''>	+	<StructureSection load='3ap4' size='340' side='right'caption='[[3ap4]], [[Resolution\|resolution]] 2.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ap4]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3AP4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ap4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AP4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~LBT~~:ALPHA-~~LACTOSE~~'>~~LBT~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ap5\|3ap5]], [[3ap6\|3ap6]], [[3ap7\|3ap7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ap5\|3ap5]], [[3ap6\|3ap6]], [[3ap7\|3ap7]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS8 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS8 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ap4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ap4 OCA], [~~http~~://pdbe.org/3ap4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ap4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ap4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ap4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ap4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ap4 OCA], [https://pdbe.org/3ap4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ap4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ap4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ap4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LEG8_HUMAN LEG8_HUMAN]] Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.<ref>PMID:21288902</ref>	+	[[https://www.uniprot.org/uniprot/LEG8_HUMAN LEG8_HUMAN]] Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.<ref>PMID:21288902</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3ap4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3ap4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Galectin 3D structures\|Galectin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ideo, H]]		[[Category: Ideo, H]]
	[[Category: Matsuzaka, T]]		[[Category: Matsuzaka, T]]

OCA at 11:57, 12 October 2017

OCA — Thu, 12 Oct 2017 11:57:56 GMT

←Older revision		Revision as of 11:57, 12 October 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3ap4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3ap4" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Galectin\|Galectin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:32, 4 August 2016

OCA — Thu, 04 Aug 2016 09:32:30 GMT

←Older revision		Revision as of 09:32, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with lactose==		==Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with lactose==
	<StructureSection load='3ap4' size='340' side='right' caption='[[3ap4]], [[Resolution\|resolution]] 2.33Å' scene=''>		<StructureSection load='3ap4' size='340' side='right' caption='[[3ap4]], [[Resolution\|resolution]] 2.33Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ap5\|3ap5]], [[3ap6\|3ap6]], [[3ap7\|3ap7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ap5\|3ap5]], [[3ap6\|3ap6]], [[3ap7\|3ap7]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ap4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ap4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ap4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ap4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ap4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ap4 OCA], [http://pdbe.org/3ap4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ap4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ap4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ap4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ap4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:53, 25 December 2014

OCA — Thu, 25 Dec 2014 07:53:27 GMT

←Older revision		Revision as of 07:53, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ap4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ap4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ap4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ap4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ap4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ap4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ap4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ap4 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LEG8_HUMAN LEG8_HUMAN]] Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.<ref>PMID:21288902</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 18:50, 21 December 2014

OCA — Sun, 21 Dec 2014 18:50:08 GMT

←Older revision		Revision as of 18:50, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ap4\| PDB=3ap4 \| SCENE= }}~~	+	==Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with lactose==
-	===Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with lactose===	+	<StructureSection load='3ap4' size='340' side='right' caption='[[3ap4]], [[Resolution\|resolution]] 2.33Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21288902}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ap4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AP4 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LBT:ALPHA-LACTOSE'>LBT</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ap5\|3ap5]], [[3ap6\|3ap6]], [[3ap7\|3ap7]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ap4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ap4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ap4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ap4 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Galectin-8 has much higher affinity for 3'-O-sulfated or 3'-O-sialylated glycoconjugates and a Lewis X-containing glycan than for oligosaccharides terminating in Galbeta1-->3/4GlcNAc, and this specificity is mainly attributed to the N-terminal carbohydrate recognition domain (N-domain, CRD) (Ideo, H., Seko, A., Ishizuka, I., and Yamashita, K. (2003) Glycobiology 13, 713-723). In this study, we elucidated the crystal structures of the human galectin-8-N-domain (-8N) in the absence or presence of 4 ligands. The apo molecule forms a dimer, which is different from the canonical 2-fold symmetric dimer observed for galectin-1 and -2. In a galectin-8N-lactose complex, the lactose-recognizing amino acids are highly conserved among the galectins. However, Arg(45), Gln(47), Arg(59), and the long loop region between the S3 and S4 beta-strands are unique to galectin-8N. These amino acids directly or indirectly interact with the sulfate or sialic acid moieties of 3'-sialyl- and 3'-sulfolactose complexed with galectin-8N. Furthermore, in the LNF-III-galectin-8N complex, van der Waals interactions occur between the alpha1-3-branched fucose and galactose and between galactose and Tyr(141), and these interactions increase the affinity toward galectin-8N. Based on the findings of these x-ray crystallographic analyses, a mutagenesis study using surface plasmon resonance showed that Arg(45), Gln(47), and Arg(59) of galectin-8N are indispensable and coordinately contribute to the strong binding of galectins-8N to sialylated and sulfated oligosaccharides. Arg(59) is the most critical amino acid for binding in the S3-S4 loop region.

-	~~==Function==~~	+	Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans.,Ideo H, Matsuzaka T, Nonaka T, Seko A, Yamashita K J Biol Chem. 2011 Apr 1;286(13):11346-55. Epub 2011 Feb 2. PMID:21288902<ref>PMID:21288902</ref>
-	~~[[http://www.uniprot.org/uniprot/LEG8_HUMAN LEG8_HUMAN]] Lectin with a marked preference for 3'~~-O-sialylated and ~~3'-O-~~sulfated glycans.<ref>PMID:21288902</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3ap4]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3AP4 OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Galectin\|Galectin]]		*[[Galectin\|Galectin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021288902</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Ideo, H.]]	+	[[Category: Ideo, H]]
-	[[Category: Matsuzaka, T.]]	+	[[Category: Matsuzaka, T]]
-	[[Category: Nonaka, T.]]	+	[[Category: Nonaka, T]]
-	[[Category: Yamashita, K.]]	+	[[Category: Yamashita, K]]
	[[Category: Beta-sandwich]]		[[Category: Beta-sandwich]]
	[[Category: Carbohydrate/sugar binding]]		[[Category: Carbohydrate/sugar binding]]
	[[Category: Galectin]]		[[Category: Galectin]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

OCA at 07:08, 15 January 2014

OCA — Wed, 15 Jan 2014 07:08:05 GMT

←Older revision		Revision as of 07:08, 15 January 2014
Line 1:		Line 1:
-	[[Image:3ap4.png\|left\|200px]]
-
	{{STRUCTURE_3ap4\| PDB=3ap4 \| SCENE= }}		{{STRUCTURE_3ap4\| PDB=3ap4 \| SCENE= }}
-
	===Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with lactose===		===Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with lactose===
		+	{{ABSTRACT_PUBMED_21288902}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/LEG8_HUMAN LEG8_HUMAN]] Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.<ref>PMID:21288902</ref>

	==About this Structure==		==About this Structure==
-	[[3ap4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP4 OCA].	+	[[3ap4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP4 OCA].

	==See Also==		==See Also==
	*[[Galectin\|Galectin]]		*[[Galectin\|Galectin]]
-	[[Category: ~~Homo sapiens~~]]	+
		+	==Reference==
		+	<ref group="xtra">PMID:021288902</ref><references group="xtra"/><references/>
		+	[[Category: Human]]
	[[Category: Ideo, H.]]		[[Category: Ideo, H.]]
	[[Category: Matsuzaka, T.]]		[[Category: Matsuzaka, T.]]

OCA at 14:21, 20 October 2012

OCA — Sat, 20 Oct 2012 14:21:49 GMT

←Older revision		Revision as of 14:21, 20 October 2012
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-	[[Image:3ap4.~~jpg~~\|left\|200px]]	+	[[Image:3ap4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ap4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_3ap4\| PDB=3ap4 \| SCENE= }}		{{STRUCTURE_3ap4\| PDB=3ap4 \| SCENE= }}

Line 14:		Line 8:
	==About this Structure==		==About this Structure==
	[[3ap4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP4 OCA].		[[3ap4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AP4 OCA].
		+
		+	==See Also==
		+	*[[Galectin\|Galectin]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ideo, H.]]		[[Category: Ideo, H.]]
Line 19:		Line 16:
	[[Category: Nonaka, T.]]		[[Category: Nonaka, T.]]
	[[Category: Yamashita, K.]]		[[Category: Yamashita, K.]]
		+	[[Category: Beta-sandwich]]
		+	[[Category: Carbohydrate/sugar binding]]
		+	[[Category: Galectin]]
		+	[[Category: Sugar binding protein]]

OCA: Protected "3ap4" [edit=sysop:move=sysop]

OCA — Wed, 26 Jan 2011 13:01:01 GMT

Protected "3ap4" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:01, 26 January 2011