3aq0 - Revision history

OCA at 15:51, 4 October 2023

OCA — Wed, 04 Oct 2023 15:51:59 GMT

←Older revision		Revision as of 15:51, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='3aq0' size='340' side='right'caption='[[3aq0]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='3aq0' size='340' side='right'caption='[[3aq0]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3aq0]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AQ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3aq0]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AQ0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ISY:3-METHYLBUT-3-ENYLSULFANYL(PHOSPHONOOXY)PHOSPHINIC+ACID'>ISY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3apz\|3apz]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ISY:3-METHYLBUT-3-ENYLSULFANYL(PHOSPHONOOXY)PHOSPHINIC+ACID'>ISY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AtNPPPS, gpps ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Heptaprenyl_diphosphate_synthase Heptaprenyl diphosphate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.30 2.5.1.30] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aq0 OCA], [https://pdbe.org/3aq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aq0 RCSB], [https://www.ebi.ac.uk/pdbsum/3aq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aq0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aq0 OCA], [https://pdbe.org/3aq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aq0 RCSB], [https://www.ebi.ac.uk/pdbsum/3aq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aq0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SPS3_ARATH SPS3_ARATH]] May be involved in the supply of solanesyl diphosphate for ubiquinone-9 biosynthesis in mitochondria. Synthesizes C25 to C45 medium / long-chain products depending on the type of substrate available. Can use geranyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrates, but not dimethylallyl diphosphate.<ref>PMID:11069698</ref> <ref>PMID:17877699</ref> <ref>PMID:21950843</ref> <ref>PMID:21220764</ref>	+	[https://www.uniprot.org/uniprot/SPS3_ARATH SPS3_ARATH] May be involved in the supply of solanesyl diphosphate for ubiquinone-9 biosynthesis in mitochondria. Synthesizes C25 to C45 medium / long-chain products depending on the type of substrate available. Can use geranyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrates, but not dimethylallyl diphosphate.<ref>PMID:11069698</ref> <ref>PMID:17877699</ref> <ref>PMID:21950843</ref> <ref>PMID:21220764</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath]]~~	+	[[Category: Arabidopsis thaliana]]
-	~~[[Category: Heptaprenyl diphosphate synthase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chang, T H]]	+	[[Category: Chang T-H]]
-	[[Category: Hsieh, F L]]	+	[[Category: Hsieh F-L]]
-	[[Category: Ko, T P]]	+	[[Category: Ko T-P]]
-	[[Category: Wang~~, A H.~~J]]	+	[[Category: Wang AH-J]]
-	~~[[Category: All alpha-helices fold]]~~	+
-	~~[[Category: Chroloplast]]~~	+
-	~~[[Category: Isoprenoid biosynthetic process]]~~	+
-	~~[[Category: Prenyltransferase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 15:00, 29 December 2021

OCA — Wed, 29 Dec 2021 15:00:47 GMT

←Older revision		Revision as of 15:00, 29 December 2021
Line 1:		Line 1:

	==Ligand-bound form of Arabidopsis medium/long-chain length prenyl pyrophosphate synthase (surface polar residue mutant)==		==Ligand-bound form of Arabidopsis medium/long-chain length prenyl pyrophosphate synthase (surface polar residue mutant)==
-	<StructureSection load='3aq0' size='340' side='right' caption='[[3aq0]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='3aq0' size='340' side='right'caption='[[3aq0]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3aq0]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AQ0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3AQ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3aq0]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AQ0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ISY:3-METHYLBUT-3-ENYLSULFANYL(PHOSPHONOOXY)PHOSPHINIC+ACID'>ISY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ISY:3-METHYLBUT-3-ENYLSULFANYL(PHOSPHONOOXY)PHOSPHINIC+ACID'>ISY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3apz\|3apz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3apz\|3apz]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AtNPPPS, gpps ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AtNPPPS, gpps ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Heptaprenyl_diphosphate_synthase Heptaprenyl diphosphate synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.30 2.5.1.30] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Heptaprenyl_diphosphate_synthase Heptaprenyl diphosphate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.30 2.5.1.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3aq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aq0 OCA], [~~http~~://pdbe.org/3aq0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3aq0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3aq0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3aq0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aq0 OCA], [https://pdbe.org/3aq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aq0 RCSB], [https://www.ebi.ac.uk/pdbsum/3aq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aq0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SPS3_ARATH SPS3_ARATH]] May be involved in the supply of solanesyl diphosphate for ubiquinone-9 biosynthesis in mitochondria. Synthesizes C25 to C45 medium / long-chain products depending on the type of substrate available. Can use geranyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrates, but not dimethylallyl diphosphate.<ref>PMID:11069698</ref> <ref>PMID:17877699</ref> <ref>PMID:21950843</ref> <ref>PMID:21220764</ref>	+	[[https://www.uniprot.org/uniprot/SPS3_ARATH SPS3_ARATH]] May be involved in the supply of solanesyl diphosphate for ubiquinone-9 biosynthesis in mitochondria. Synthesizes C25 to C45 medium / long-chain products depending on the type of substrate available. Can use geranyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrates, but not dimethylallyl diphosphate.<ref>PMID:11069698</ref> <ref>PMID:17877699</ref> <ref>PMID:21950843</ref> <ref>PMID:21220764</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	[[Category: Arath]]		[[Category: Arath]]
	[[Category: Heptaprenyl diphosphate synthase]]		[[Category: Heptaprenyl diphosphate synthase]]
		+	[[Category: Large Structures]]
	[[Category: Chang, T H]]		[[Category: Chang, T H]]
	[[Category: Hsieh, F L]]		[[Category: Hsieh, F L]]

OCA at 00:11, 5 August 2016

OCA — Fri, 05 Aug 2016 00:11:03 GMT

←Older revision		Revision as of 00:11, 5 August 2016
Line 1:		Line 1:
		+
	==Ligand-bound form of Arabidopsis medium/long-chain length prenyl pyrophosphate synthase (surface polar residue mutant)==		==Ligand-bound form of Arabidopsis medium/long-chain length prenyl pyrophosphate synthase (surface polar residue mutant)==
	<StructureSection load='3aq0' size='340' side='right' caption='[[3aq0]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='3aq0' size='340' side='right' caption='[[3aq0]], [[Resolution\|resolution]] 2.65Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AtNPPPS, gpps ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AtNPPPS, gpps ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Heptaprenyl_diphosphate_synthase Heptaprenyl diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.30 2.5.1.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Heptaprenyl_diphosphate_synthase Heptaprenyl diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.30 2.5.1.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aq0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3aq0 RCSB], [http://www.ebi.ac.uk/pdbsum/3aq0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aq0 OCA], [http://pdbe.org/3aq0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3aq0 RCSB], [http://www.ebi.ac.uk/pdbsum/3aq0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3aq0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3aq0" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:03, 24 December 2014

OCA — Wed, 24 Dec 2014 21:03:28 GMT

←Older revision		Revision as of 21:03, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3aq0\| PDB=3aq0 \| SCENE= }}~~	+	==Ligand-bound form of Arabidopsis medium/long-chain length prenyl pyrophosphate synthase (surface polar residue mutant)==
-	===Ligand-bound form of Arabidopsis medium/long-chain length prenyl pyrophosphate synthase (surface polar residue mutant)===	+	<StructureSection load='3aq0' size='340' side='right' caption='[[3aq0]], [[Resolution\|resolution]] 2.65Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21220764}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3aq0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AQ0 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ISY:3-METHYLBUT-3-ENYLSULFANYL(PHOSPHONOOXY)PHOSPHINIC+ACID'>ISY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3apz\|3apz]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AtNPPPS, gpps ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Heptaprenyl_diphosphate_synthase Heptaprenyl diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.30 2.5.1.30] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aq0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3aq0 RCSB], [http://www.ebi.ac.uk/pdbsum/3aq0 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/SPS3_ARATH SPS3_ARATH]] May be involved in the supply of solanesyl diphosphate for ubiquinone-9 biosynthesis in mitochondria. Synthesizes C25 to C45 medium / long-chain products depending on the type of substrate available. Can use geranyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrates, but not dimethylallyl diphosphate.<ref>PMID:11069698</ref> <ref>PMID:17877699</ref> <ref>PMID:21950843</ref> <ref>PMID:21220764</ref>		[[http://www.uniprot.org/uniprot/SPS3_ARATH SPS3_ARATH]] May be involved in the supply of solanesyl diphosphate for ubiquinone-9 biosynthesis in mitochondria. Synthesizes C25 to C45 medium / long-chain products depending on the type of substrate available. Can use geranyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrates, but not dimethylallyl diphosphate.<ref>PMID:11069698</ref> <ref>PMID:17877699</ref> <ref>PMID:21950843</ref> <ref>PMID:21220764</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Prenyltransferases (PTSs) are involved in the biosynthesis of terpenes with diverse functions. Here a novel PTS from Arabidopsis thaliana as a trans-type polyprenyl pyrophosphate synthase (AtPPPS), which forms a trans double bond during each homoallylic substrate condensation, rather than a homomeric C(10)-geranyl pyrophosphate synthase as originally proposed. Biochemical and genetic complementation analyses indicate that AtPPPS synthesizes C(25) to C(45) medium/long-chain products. Its close relationship to other long-chain PTSs is also uncovered by phylogenetic analysis. A mutant of contiguous surface polar residues was produced by replacing four charged surface amino acids with alanines to facilitate the crystallization of the enzyme. The crystal structures of AtPPPS determined here in apo and ligand-bound forms further reveal an active-site cavity sufficient to accommodate the medium/long-chain products. The two monomers in each dimer adopt different conformations at the entrance of the active site depending on the binding of substrates. Taken together, these results suggest that AtPPPS is endowed with a unique functionality among the known PTSs.

-	~~==About this~~ Structure==	+	Structure and mechanism of an Arabidopsis medium/long-chain length prenyl pyrophosphate synthase.,Hsieh FL, Chang TH, Ko TP, Wang AH Plant Physiol. 2011 Jan 10. PMID:21220764<ref>PMID:21220764</ref>
-	~~[[3aq0]] is a 8~~ chain ~~structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Arath Arath]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3AQ0 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:021220764</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Arath]]		[[Category: Arath]]
	[[Category: Heptaprenyl diphosphate synthase]]		[[Category: Heptaprenyl diphosphate synthase]]
-	[[Category: Chang, T H.]]	+	[[Category: Chang, T H]]
-	[[Category: Hsieh, F L.]]	+	[[Category: Hsieh, F L]]
-	[[Category: Ko, T P.]]	+	[[Category: Ko, T P]]
-	[[Category: Wang, A H.J.]]	+	[[Category: Wang, A H.J]]
	[[Category: All alpha-helices fold]]		[[Category: All alpha-helices fold]]
	[[Category: Chroloplast]]		[[Category: Chroloplast]]

OCA at 05:35, 29 January 2014

OCA — Wed, 29 Jan 2014 05:35:24 GMT

←Older revision		Revision as of 05:35, 29 January 2014
Line 1:		Line 1:
-	[[Image:3aq0.png\|left\|200px]]
-
	{{STRUCTURE_3aq0\| PDB=3aq0 \| SCENE= }}		{{STRUCTURE_3aq0\| PDB=3aq0 \| SCENE= }}
-
	===Ligand-bound form of Arabidopsis medium/long-chain length prenyl pyrophosphate synthase (surface polar residue mutant)===		===Ligand-bound form of Arabidopsis medium/long-chain length prenyl pyrophosphate synthase (surface polar residue mutant)===
		+	{{ABSTRACT_PUBMED_21220764}}

-	~~{{ABSTRACT_PUBMED_21220764}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/SPS3_ARATH SPS3_ARATH]] May be involved in the supply of solanesyl diphosphate for ubiquinone-9 biosynthesis in mitochondria. Synthesizes C25 to C45 medium / long-chain products depending on the type of substrate available. Can use geranyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrates, but not dimethylallyl diphosphate.<ref>PMID:11069698</ref> <ref>PMID:17877699</ref> <ref>PMID:21950843</ref> <ref>PMID:21220764</ref>

	==About this Structure==		==About this Structure==
-	[[3aq0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AQ0 OCA].	+	[[3aq0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AQ0 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021220764</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021220764</ref><references group="xtra"/><references/>
-	[[Category: ~~Arabidopsis thaliana~~]]	+	[[Category: Arath]]
-	[[Category: ~~Trans-hexaprenyltranstransferase~~]]	+	[[Category: Heptaprenyl diphosphate synthase]]
	[[Category: Chang, T H.]]		[[Category: Chang, T H.]]
	[[Category: Hsieh, F L.]]		[[Category: Hsieh, F L.]]

OCA at 22:00, 7 January 2013

OCA — Mon, 07 Jan 2013 22:00:54 GMT

←Older revision		Revision as of 22:00, 7 January 2013
Line 1:		Line 1:
-	[[Image:3aq0.~~jpg~~\|left\|200px]]	+	[[Image:3aq0.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3aq0", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3aq0\| PDB=3aq0 \| SCENE= }}		{{STRUCTURE_3aq0\| PDB=3aq0 \| SCENE= }}

	===Ligand-bound form of Arabidopsis medium/long-chain length prenyl pyrophosphate synthase (surface polar residue mutant)===		===Ligand-bound form of Arabidopsis medium/long-chain length prenyl pyrophosphate synthase (surface polar residue mutant)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21220764}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21220764 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21220764}}		{{ABSTRACT_PUBMED_21220764}}

Line 22:		Line 11:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21220764~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021220764</ref><references group="xtra"/>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Trans-hexaprenyltranstransferase]]		[[Category: Trans-hexaprenyltranstransferase]]
Line 29:		Line 18:
	[[Category: Ko, T P.]]		[[Category: Ko, T P.]]
	[[Category: Wang, A H.J.]]		[[Category: Wang, A H.J.]]
		+	[[Category: All alpha-helices fold]]
		+	[[Category: Chroloplast]]
		+	[[Category: Isoprenoid biosynthetic process]]
		+	[[Category: Prenyltransferase]]
		+	[[Category: Transferase]]

OCA: Protected "3aq0" [edit=sysop:move=sysop]

OCA — Wed, 19 Jan 2011 06:18:02 GMT

Protected "3aq0" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:18, 19 January 2011

OCA at 06:18, 19 January 2011

OCA — Wed, 19 Jan 2011 06:18:00 GMT

←Older revision		Revision as of 06:18, 19 January 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3aq0.jpg\|left\|200px]]

-	The ~~entry 3aq0~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3aq0", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3aq0\| PDB=3aq0 \| SCENE= }}

-	~~Authors: Hsieh, F.~~-~~L., Chang, T.~~-~~H., Ko, T.-P., Wang, A.H.-J.~~	+	===Ligand-bound form of Arabidopsis medium/long-chain length prenyl pyrophosphate synthase (surface polar residue mutant)===

-	Description: Ligand-bound form of Arabidopsis medium/long-chain length prenyl pyrophosphate synthase (surface polar residue mutant)

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Thu Nov 18 00~~:28:~~01 2010''~~	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21220764}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21220764 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21220764}}
		+
		+	==About this Structure==
		+	[[3aq0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AQ0 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21220764</ref><references group="xtra"/>
		+	[[Category: Arabidopsis thaliana]]
		+	[[Category: Trans-hexaprenyltranstransferase]]
		+	[[Category: Chang, T H.]]
		+	[[Category: Hsieh, F L.]]
		+	[[Category: Ko, T P.]]
		+	[[Category: Wang, A H.J.]]

OCA at 21:16, 17 November 2010

OCA — Wed, 17 Nov 2010 21:16:46 GMT

←Older revision		Revision as of 21:16, 17 November 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3aq0 is ON HOLD	+	The entry 3aq0 is ON HOLD until Paper Publication

-	Authors: Hsieh, Fu-~~Lien~~, Chang, ~~Tao~~-~~Hsin~~, Ko, ~~Tzu~~-~~Ping~~, Wang, ~~Andrew~~ H.-J.	+	Authors: Hsieh, F.-L., Chang, T.-H., Ko, T.-P., Wang, A.H.-J.

-	Description: ~~Structure and mechanism~~ of an Arabidopsis medium/long-chain length prenyl pyrophosphate synthase	+	Description: Ligand-bound form of Arabidopsis medium/long-chain length prenyl pyrophosphate synthase (surface polar residue mutant)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed~~ Nov ~~3 09~~:58:40 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:28:01 2010''

OCA: New page: '''Unreleased structure''' The entry 3aq0 is ON HOLD Authors: Hsieh, Fu-Lien, Chang, Tao-Hsin, Ko, Tzu-Ping, Wang, Andrew H.-J. Description: Structure and mechanism of an Arabidopsis m...

OCA — Wed, 03 Nov 2010 06:48:02 GMT

New page: '''Unreleased structure''' The entry 3aq0 is ON HOLD Authors: Hsieh, Fu-Lien, Chang, Tao-Hsin, Ko, Tzu-Ping, Wang, Andrew H.-J. Description: Structure and mechanism of an Arabidopsis m...

New page

'''Unreleased structure'''

The entry 3aq0 is ON HOLD

Authors: Hsieh, Fu-Lien, Chang, Tao-Hsin, Ko, Tzu-Ping, Wang, Andrew H.-J.

Description: Structure and mechanism of an Arabidopsis medium/long-chain length prenyl pyrophosphate synthase

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 3 09:58:40 2010''