3ax4 - Revision history

OCA at 09:57, 14 February 2024

OCA — Wed, 14 Feb 2024 09:57:47 GMT

←Older revision		Revision as of 09:57, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='3ax4' size='340' side='right'caption='[[3ax4]], [[Resolution\|resolution]] 2.61Å' scene=''>		<StructureSection load='3ax4' size='340' side='right'caption='[[3ax4]], [[Resolution\|resolution]] 2.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ax4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Dioclea_violacea Dioclea violacea~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AX4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ax4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Macropsychanthus_violaceus Macropsychanthus violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AX4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.613Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gdf\|2gdf]], [[2zbj\|2zbj]], [[2jdz\|2jdz]], [[2je9\|2je9]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ax4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax4 OCA], [https://pdbe.org/3ax4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ax4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ax4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ax4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ax4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax4 OCA], [https://pdbe.org/3ax4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ax4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ax4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ax4 ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/I1SB09_DIOVO I1SB09_DIOVO]
-	Lectins from Diocleinae subtribe belong to the family of legume lectins and are characterized by high identity between their amino acids sequences. It has been shown that punctual differences in amino acid sequences, such as one single amino acid or an alternative conformation, represent changes in biological activities caused by these lectins. Therefore, a more detailed understanding of three-dimensional structures of these proteins is essential for accurate analyzing the relationship between structure and function. In this study lectins purified from the seeds of Dioclea violacea (DVL) and Dioclea rostrata (DRL) were compared with regard to crystal structure and vasorelaxant properties. Differences in structure of lectins were found to be reflected in differences in vasorelaxant effects based on their high specificity and selectivity for cell glycans. Binding activity was related to the position of specific residues in the carbohydrate recognition domain (CRD). DVL complexed structure was solved by X-ray crystallography and was compared to native DVL and DRL. Therefore, DVL was co-crystallized with X-Man, and a molecular modeling with X-Man complexed with DVL was done to compare the complexed and native forms adjusted fit. The relatively narrow and deep CRD in DVL promotes little interaction with carbohydrates; in contrast, the wider and shallower CRD in DRL favors interaction. This seems to explain differences in the level of relaxation induced by DVL (43%) and DRL (96%) in rat aortic rings.	+
-		+
-	Crystal structure of Dioclea violacea lectin and a comparative study of vasorelaxant properties with Dioclea rostrata lectin.,Bezerra MJ, Rodrigues NV, Pires Ade F, Bezerra GA, Nobre CB, Alencar KL, Soares PM, do Nascimento KS, Nagano CS, Martins JL, Gruber K, Sampaio AH, Delatorre P, Rocha BA, Assreuy AM, Cavada BS Int J Biochem Cell Biol. 2013 Apr;45(4):~~807-15. doi:, 10.1016~~/~~j.biocel.2013.01.012. Epub 2013 Jan 23. PMID:23353644<ref>PMID:23353644<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3ax4" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Dioclea violacea]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Assereuy~~, A M~~]]	+	[[Category: Macropsychanthus violaceus]]
-	[[Category: Bezerra~~, G A~~]]	+	[[Category: Assereuy AM]]
-	[[Category: Bezerra~~, M J.B~~]]	+	[[Category: Bezerra GA]]
-	[[Category: Cavada~~, B S~~]]	+	[[Category: Bezerra MJB]]
-	[[Category: Delatorre, P]]	+	[[Category: Cavada BS]]
-	[[Category: Gruber, K]]	+	[[Category: Delatorre P]]
-	[[Category: Martins~~, J L~~]]	+	[[Category: Gruber K]]
-	[[Category: Nagano~~, C S~~]]	+	[[Category: Martins JL]]
-	[[Category: Nascimento~~, K S~~]]	+	[[Category: Nagano CS]]
-	[[Category: Rocha~~, B A.M]]~~	+	[[Category: Nascimento KS]]
-	~~[[Category: Carbohydrate binding]]~~	+	[[Category: Rocha BAM]]
-	~~[[Category: Jelly-roll]]~~	+
-	~~[[Category: Lectin]]~~	+
-	~~[[Category: Seed protein body]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 06:48, 12 May 2022

OCA — Thu, 12 May 2022 06:48:22 GMT

←Older revision		Revision as of 06:48, 12 May 2022
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	<StructureSection load='3ax4' size='340' side='right'caption='[[3ax4]], [[Resolution\|resolution]] 2.61Å' scene=''>		<StructureSection load='3ax4' size='340' side='right'caption='[[3ax4]], [[Resolution\|resolution]] 2.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ax4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Dioclea_violacea Dioclea violacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3AX4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ax4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dioclea_violacea Dioclea violacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AX4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gdf\|2gdf]], [[2zbj\|2zbj]], [[2jdz\|2jdz]], [[2je9\|2je9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gdf\|2gdf]], [[2zbj\|2zbj]], [[2jdz\|2jdz]], [[2je9\|2je9]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3ax4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax4 OCA], [~~http~~://pdbe.org/3ax4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ax4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ax4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ax4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ax4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax4 OCA], [https://pdbe.org/3ax4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ax4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ax4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ax4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:13, 5 August 2020

OCA — Wed, 05 Aug 2020 06:13:39 GMT

←Older revision		Revision as of 06:13, 5 August 2020
Line 1:		Line 1:

	==Three-dimensional structure of lectin from Dioclea violacea and comparative vasorelaxant effects with Dioclea rostrata==		==Three-dimensional structure of lectin from Dioclea violacea and comparative vasorelaxant effects with Dioclea rostrata==
-	<StructureSection load='3ax4' size='340' side='right' caption='[[3ax4]], [[Resolution\|resolution]] 2.61Å' scene=''>	+	<StructureSection load='3ax4' size='340' side='right'caption='[[3ax4]], [[Resolution\|resolution]] 2.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ax4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_violacea Dioclea violacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX4 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3AX4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ax4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_violacea Dioclea violacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3AX4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gdf\|2gdf]], [[2zbj\|2zbj]], [[2jdz\|2jdz]], [[2je9\|2je9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gdf\|2gdf]], [[2zbj\|2zbj]], [[2jdz\|2jdz]], [[2je9\|2je9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ax4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax4 OCA], [http://pdbe.org/3ax4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ax4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ax4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ax4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3ax4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax4 OCA], [http://pdbe.org/3ax4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ax4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ax4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ax4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Dioclea violacea]]		[[Category: Dioclea violacea]]
		+	[[Category: Large Structures]]
	[[Category: Assereuy, A M]]		[[Category: Assereuy, A M]]
	[[Category: Bezerra, G A]]		[[Category: Bezerra, G A]]

OCA at 09:06, 4 August 2016

OCA — Thu, 04 Aug 2016 09:06:02 GMT

←Older revision		Revision as of 09:06, 4 August 2016
Line 1:		Line 1:
		+
	==Three-dimensional structure of lectin from Dioclea violacea and comparative vasorelaxant effects with Dioclea rostrata==		==Three-dimensional structure of lectin from Dioclea violacea and comparative vasorelaxant effects with Dioclea rostrata==
	<StructureSection load='3ax4' size='340' side='right' caption='[[3ax4]], [[Resolution\|resolution]] 2.61Å' scene=''>		<StructureSection load='3ax4' size='340' side='right' caption='[[3ax4]], [[Resolution\|resolution]] 2.61Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gdf\|2gdf]], [[2zbj\|2zbj]], [[2jdz\|2jdz]], [[2je9\|2je9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gdf\|2gdf]], [[2zbj\|2zbj]], [[2jdz\|2jdz]], [[2je9\|2je9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ax4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ax4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ax4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ax4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax4 OCA], [http://pdbe.org/3ax4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ax4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ax4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ax4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ax4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:02, 3 January 2015

OCA — Sat, 03 Jan 2015 23:02:38 GMT

←Older revision		Revision as of 23:02, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ax4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_violacea Dioclea violacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AX4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ax4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_violacea Dioclea violacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AX4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gdf\|2gdf]], [[2zbj\|2zbj]], [[2jdz\|2jdz]], [[2je9\|2je9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gdf\|2gdf]], [[2zbj\|2zbj]], [[2jdz\|2jdz]], [[2je9\|2je9]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ax4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ax4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ax4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ax4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ax4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ax4 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 13:
	Crystal structure of Dioclea violacea lectin and a comparative study of vasorelaxant properties with Dioclea rostrata lectin.,Bezerra MJ, Rodrigues NV, Pires Ade F, Bezerra GA, Nobre CB, Alencar KL, Soares PM, do Nascimento KS, Nagano CS, Martins JL, Gruber K, Sampaio AH, Delatorre P, Rocha BA, Assreuy AM, Cavada BS Int J Biochem Cell Biol. 2013 Apr;45(4):807-15. doi:, 10.1016/j.biocel.2013.01.012. Epub 2013 Jan 23. PMID:23353644<ref>PMID:23353644</ref>		Crystal structure of Dioclea violacea lectin and a comparative study of vasorelaxant properties with Dioclea rostrata lectin.,Bezerra MJ, Rodrigues NV, Pires Ade F, Bezerra GA, Nobre CB, Alencar KL, Soares PM, do Nascimento KS, Nagano CS, Martins JL, Gruber K, Sampaio AH, Delatorre P, Rocha BA, Assreuy AM, Cavada BS Int J Biochem Cell Biol. 2013 Apr;45(4):807-15. doi:, 10.1016/j.biocel.2013.01.012. Epub 2013 Jan 23. PMID:23353644<ref>PMID:23353644</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Dioclea violacea]]		[[Category: Dioclea violacea]]
-	[[Category: Assereuy, A M.]]	+	[[Category: Assereuy, A M]]
-	[[Category: Bezerra, G A.]]	+	[[Category: Bezerra, G A]]
-	[[Category: Bezerra, M J.B.]]	+	[[Category: Bezerra, M J.B]]
-	[[Category: Cavada, B S.]]	+	[[Category: Cavada, B S]]
-	[[Category: Delatorre, P.]]	+	[[Category: Delatorre, P]]
-	[[Category: Gruber, K.]]	+	[[Category: Gruber, K]]
-	[[Category: Martins, J L.]]	+	[[Category: Martins, J L]]
-	[[Category: Nagano, C S.]]	+	[[Category: Nagano, C S]]
-	[[Category: Nascimento, K S.]]	+	[[Category: Nascimento, K S]]
-	[[Category: Rocha, B A.M.]]	+	[[Category: Rocha, B A.M]]
	[[Category: Carbohydrate binding]]		[[Category: Carbohydrate binding]]
	[[Category: Jelly-roll]]		[[Category: Jelly-roll]]

OCA at 06:57, 28 May 2014

OCA — Wed, 28 May 2014 06:57:59 GMT

←Older revision		Revision as of 06:57, 28 May 2014
Line 7:		Line 7:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ax4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ax4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ax4 PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ax4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ax4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ax4 PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lectins from Diocleinae subtribe belong to the family of legume lectins and are characterized by high identity between their amino acids sequences. It has been shown that punctual differences in amino acid sequences, such as one single amino acid or an alternative conformation, represent changes in biological activities caused by these lectins. Therefore, a more detailed understanding of three-dimensional structures of these proteins is essential for accurate analyzing the relationship between structure and function. In this study lectins purified from the seeds of Dioclea violacea (DVL) and Dioclea rostrata (DRL) were compared with regard to crystal structure and vasorelaxant properties. Differences in structure of lectins were found to be reflected in differences in vasorelaxant effects based on their high specificity and selectivity for cell glycans. Binding activity was related to the position of specific residues in the carbohydrate recognition domain (CRD). DVL complexed structure was solved by X-ray crystallography and was compared to native DVL and DRL. Therefore, DVL was co-crystallized with X-Man, and a molecular modeling with X-Man complexed with DVL was done to compare the complexed and native forms adjusted fit. The relatively narrow and deep CRD in DVL promotes little interaction with carbohydrates; in contrast, the wider and shallower CRD in DRL favors interaction. This seems to explain differences in the level of relaxation induced by DVL (43%) and DRL (96%) in rat aortic rings.
		+
		+	Crystal structure of Dioclea violacea lectin and a comparative study of vasorelaxant properties with Dioclea rostrata lectin.,Bezerra MJ, Rodrigues NV, Pires Ade F, Bezerra GA, Nobre CB, Alencar KL, Soares PM, do Nascimento KS, Nagano CS, Martins JL, Gruber K, Sampaio AH, Delatorre P, Rocha BA, Assreuy AM, Cavada BS Int J Biochem Cell Biol. 2013 Apr;45(4):807-15. doi:, 10.1016/j.biocel.2013.01.012. Epub 2013 Jan 23. PMID:23353644<ref>PMID:23353644</ref>
		+
		+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:03, 14 May 2014

OCA — Wed, 14 May 2014 11:03:47 GMT

←Older revision		Revision as of 11:03, 14 May 2014
Line 1:		Line 1:
-	~~[[Image:3ax4.jpg\|left\|200px]]~~	+	==Three-dimensional structure of lectin from Dioclea violacea and comparative vasorelaxant effects with Dioclea rostrata==
-		+	<StructureSection load='3ax4' size='340' side='right' caption='[[3ax4]], [[Resolution\|resolution]] 2.61Å' scene=''>
-	~~<!--~~	+	== Structural highlights ==
-	~~The line below this paragraph, containing "STRUCTURE_3ax4", creates the "Structure Box" on the page.~~	+	<table><tr><td colspan='2'>[[3ax4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_violacea Dioclea violacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AX4 FirstGlance]. <br>
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene><br>
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gdf\|2gdf]], [[2zbj\|2zbj]], [[2jdz\|2jdz]], [[2je9\|2je9]]</td></tr>
-	~~or leave the SCENE parameter empty for the default display.~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ax4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ax4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ax4 PDBsum]</span></td></tr>
-	~~-->~~	+	<table>
-	~~{{STRUCTURE_3ax4\| PDB=3ax4 \| SCENE= }}~~	+	__TOC__
-		+	</StructureSection>
-	===Three-dimensional structure of lectin from Dioclea violacea and comparative vasorelaxant effects with Dioclea rostrata===	+
-		+
-		+
-	==~~About this Structure~~==	+
-	[[3ax4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_violacea Dioclea violacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX4 OCA].	+
	[[Category: Dioclea violacea]]		[[Category: Dioclea violacea]]
	[[Category: Assereuy, A M.]]		[[Category: Assereuy, A M.]]

OCA at 06:11, 4 April 2012

OCA — Wed, 04 Apr 2012 06:11:04 GMT

←Older revision		Revision as of 06:11, 4 April 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3ax4.jpg\|left\|200px]]

-	The ~~entry 3ax4~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ax4", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ax4\| PDB=3ax4 \| SCENE= }}

-	~~Authors: Bezerra, M.J.B., Bezerra, G.A., Martins, J.L., Nascimento, K.S., Nagano, C.S., Gruber, K., Assereuy, A.M., Delatorre, P., Rocha, B.A.M., Cavada, B.S.~~	+	===Three-dimensional structure of lectin from Dioclea violacea and comparative vasorelaxant effects with Dioclea rostrata===

-	~~Description: Three-dimensional~~ structure ~~of lectin~~ from Dioclea violacea ~~and comparative vasorelaxant effects with~~ Dioclea ~~rostrata~~	+
		+	==About this Structure==
		+	[[3ax4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dioclea_violacea Dioclea violacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX4 OCA].
		+	[[Category: Dioclea violacea]]
		+	[[Category: Assereuy, A M.]]
		+	[[Category: Bezerra, G A.]]
		+	[[Category: Bezerra, M J.B.]]
		+	[[Category: Cavada, B S.]]
		+	[[Category: Delatorre, P.]]
		+	[[Category: Gruber, K.]]
		+	[[Category: Martins, J L.]]
		+	[[Category: Nagano, C S.]]
		+	[[Category: Nascimento, K S.]]
		+	[[Category: Rocha, B A.M.]]
		+	[[Category: Carbohydrate binding]]
		+	[[Category: Jelly-roll]]
		+	[[Category: Lectin]]
		+	[[Category: Seed protein body]]
		+	[[Category: Sugar binding protein]]

OCA at 08:11, 3 August 2011

OCA — Wed, 03 Aug 2011 08:11:27 GMT

←Older revision		Revision as of 08:11, 3 August 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3ax4 is ON HOLD	+	The entry 3ax4 is ON HOLD until Paper Publication

	Authors: Bezerra, M.J.B., Bezerra, G.A., Martins, J.L., Nascimento, K.S., Nagano, C.S., Gruber, K., Assereuy, A.M., Delatorre, P., Rocha, B.A.M., Cavada, B.S.		Authors: Bezerra, M.J.B., Bezerra, G.A., Martins, J.L., Nascimento, K.S., Nagano, C.S., Gruber, K., Assereuy, A.M., Delatorre, P., Rocha, B.A.M., Cavada, B.S.

	Description: Three-dimensional structure of lectin from Dioclea violacea and comparative vasorelaxant effects with Dioclea rostrata		Description: Three-dimensional structure of lectin from Dioclea violacea and comparative vasorelaxant effects with Dioclea rostrata

OCA: Protected "3ax4" [edit=sysop:move=sysop]

OCA — Wed, 06 Apr 2011 08:29:58 GMT

Protected "3ax4" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:29, 6 April 2011