3aye - Revision history

OCA at 08:49, 11 October 2023

OCA — Wed, 11 Oct 2023 08:49:32 GMT

←Older revision		Revision as of 08:49, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='3aye' size='340' side='right'caption='[[3aye]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3aye' size='340' side='right'caption='[[3aye]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3aye]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AYE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3aye]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AYE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BGC:BETA~~-~~D-GLUCOSE'>BGC</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3aya\|3aya]], [[3ayc\|3ayc]], [[3ayd\|3ayd]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PRD_900004:beta-lactose'>PRD_900004</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<~~tr id~~='~~gene~~'><~~td class="sblockLbl"~~><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">LGALS3, MAC2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aye OCA], [https://pdbe.org/3aye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aye RCSB], [https://www.ebi.ac.uk/pdbsum/3aye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aye ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aye OCA], [https://pdbe.org/3aye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aye RCSB], [https://www.ebi.ac.uk/pdbsum/3aye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aye ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>	+	[https://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bian~~, C F~~]]	+	[[Category: Bian CF]]
-	[[Category: Li~~, D F~~]]	+	[[Category: Li DF]]
-	[[Category: Wang~~, D C]]~~	+	[[Category: Wang DC]]
-	~~[[Category: A -galactose-binding protein]]~~	+
-	~~[[Category: Beta-galactoside]]~~	+
-	~~[[Category: Cell-surface]]~~	+
-	~~[[Category: Nuclear]]~~	+
-	~~[[Category: Rossmann fold]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 11:17, 5 January 2022

OCA — Wed, 05 Jan 2022 11:17:11 GMT

←Older revision		Revision as of 11:17, 5 January 2022
Line 1:		Line 1:

	==Crystal structure of galectin-3 CRD domian complexed with lactose==		==Crystal structure of galectin-3 CRD domian complexed with lactose==
-	<StructureSection load='3aye' size='340' side='right' caption='[[3aye]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3aye' size='340' side='right'caption='[[3aye]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3aye]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AYE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3AYE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3aye]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AYE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~LAT~~:BETA-~~LACTOSE~~'>~~LAT~~</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3aya\|3aya]], [[3ayc\|3ayc]], [[3ayd\|3ayd]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3aya\|3aya]], [[3ayc\|3ayc]], [[3ayd\|3ayd]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS3, MAC2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS3, MAC2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aye OCA], [~~http~~://pdbe.org/3aye PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3aye RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3aye PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3aye ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aye OCA], [https://pdbe.org/3aye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aye RCSB], [https://www.ebi.ac.uk/pdbsum/3aye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aye ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>	+	[[https://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Galectin\|Galectin]]	+	*[[Galectin 3D structures\|Galectin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bian, C F]]		[[Category: Bian, C F]]
	[[Category: Li, D F]]		[[Category: Li, D F]]

OCA at 23:06, 4 August 2016

OCA — Thu, 04 Aug 2016 23:06:48 GMT

←Older revision		Revision as of 23:06, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of galectin-3 CRD domian complexed with lactose==		==Crystal structure of galectin-3 CRD domian complexed with lactose==
	<StructureSection load='3aye' size='340' side='right' caption='[[3aye]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3aye' size='340' side='right' caption='[[3aye]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3aye]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AYE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AYE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3aye]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AYE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AYE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LAT:BETA-LACTOSE'>LAT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LAT:BETA-LACTOSE'>LAT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3aya\|3aya]], [[3ayc\|3ayc]], [[3ayd\|3ayd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3aya\|3aya]], [[3ayc\|3ayc]], [[3ayd\|3ayd]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS3, MAC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS3, MAC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aye OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3aye RCSB], [http://www.ebi.ac.uk/pdbsum/3aye PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aye OCA], [http://pdbe.org/3aye PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3aye RCSB], [http://www.ebi.ac.uk/pdbsum/3aye PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3aye ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3aye" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bian, C F]]		[[Category: Bian, C F]]
	[[Category: Li, D F]]		[[Category: Li, D F]]

OCA at 13:51, 25 December 2014

OCA — Thu, 25 Dec 2014 13:51:12 GMT

←Older revision		Revision as of 13:51, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aye OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3aye RCSB], [http://www.ebi.ac.uk/pdbsum/3aye PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aye OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3aye RCSB], [http://www.ebi.ac.uk/pdbsum/3aye PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bian, C F.]]	+	[[Category: Bian, C F]]
-	[[Category: Li, D F.]]	+	[[Category: Li, D F]]
-	[[Category: Wang, D C.]]	+	[[Category: Wang, D C]]
	[[Category: A -galactose-binding protein]]		[[Category: A -galactose-binding protein]]
	[[Category: Beta-galactoside]]		[[Category: Beta-galactoside]]

OCA at 09:29, 5 November 2014

OCA — Wed, 05 Nov 2014 09:29:50 GMT

←Older revision		Revision as of 09:29, 5 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3aye.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of galectin-3 CRD domian complexed with lactose==
		+	<StructureSection load='3aye' size='340' side='right' caption='[[3aye]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3aye]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AYE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AYE FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LAT:BETA-LACTOSE'>LAT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3aya\|3aya]], [[3ayc\|3ayc]], [[3ayd\|3ayd]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS3, MAC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aye OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3aye RCSB], [http://www.ebi.ac.uk/pdbsum/3aye PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Thomsen-Friedenreich (TF or T) antigen, Galbeta1-3GalNAcalpha1-O-Ser/Thr, is the core 1 structure of O-linked mucin type glycans appearing in tumor-associated glycosylation. The TF antigen occurs in about 90% of human cancer cells and is a potential ligand for the human endogenous galectins. It has been reported that human galectin-1 (Gal-1) and galectin-3 (Gal-3) can perform their cancer-related functions via specifically recognizing TF antigen. However, the detailed binding properties have not been clarified and structurally characterized. In this work, first we identified the distinct TF-binding abilities of Gal-1 and Gal-3. The affinity to TF antigen for Gal-3 is two orders of magnitude higher than that for Gal-1. The structures of Gal-3 carbohydrate recognition domain (CRD) complexed with TF antigen and derivatives, TFN and GM1, were then determined. These structures show a unique Glu-water-Arg-water motif-based mode as previously observed in the mushroom galectin AAL. The observation demonstrates that this recognition mode is commonly adopted by TF-binding galectins, either as endogenous or exogenous ones. The detailed structural comparisons between Gal-1 and Gal-3 CRD and mutagenesis experiments reveal that a pentad residue motif ((51)AHGDA(55)) at the loop (g1-L4) connecting beta-strands 4 and 5 of Gal-1 produces a serious steric hindrance for TF binding. This motif is the main structural basis for Gal-1 with the low affinity to TF antigen. These findings provide the intrinsic structural elements for regulating the TF-binding activity of Gal-1 in some special conditions and also show certain target and approach for mediating some tumor-related bioactivities of human galectins.

-	~~{{STRUCTURE_3aye\| PDB=3aye \| SCENE= }}~~	+	Structural basis for distinct binding properties of the human galectins to thomsen-friedenreich antigen.,Bian CF, Zhang Y, Sun H, Li DF, Wang DC PLoS One. 2011;6(9):e25007. Epub 2011 Sep 20. PMID:21949831<ref>PMID:21949831</ref>

-	~~===Crystal structure~~ of ~~galectin-3 CRD domian complexed with lactose===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21949831}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3aye]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3AYE OCA].~~	+

	==See Also==		==See Also==
	*[[Galectin\|Galectin]]		*[[Galectin\|Galectin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021949831<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bian, C F.]]		[[Category: Bian, C F.]]

OCA at 17:27, 20 October 2012

OCA — Sat, 20 Oct 2012 17:27:52 GMT

←Older revision		Revision as of 17:27, 20 October 2012
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	[[Image:3aye.png\|left\|200px]]		[[Image:3aye.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3aye", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3aye\| PDB=3aye \| SCENE= }}		{{STRUCTURE_3aye\| PDB=3aye \| SCENE= }}

	===Crystal structure of galectin-3 CRD domian complexed with lactose===		===Crystal structure of galectin-3 CRD domian complexed with lactose===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21949831}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21949831 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21949831}}		{{ABSTRACT_PUBMED_21949831}}

	==About this Structure==		==About this Structure==
	[[3aye]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AYE OCA].		[[3aye]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AYE OCA].
		+
		+	==See Also==
		+	*[[Galectin\|Galectin]]

	==Reference==		==Reference==

OCA at 09:33, 30 October 2011

OCA — Sun, 30 Oct 2011 09:33:55 GMT

←Older revision		Revision as of 09:33, 30 October 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3aye.png\|left\|200px]]

-	The ~~entry 3aye~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3aye", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3aye\| PDB=3aye \| SCENE= }}

-	~~Authors: Bian, C.F., Li, D.F., Wang, D.C.~~	+	===Crystal structure of galectin-3 CRD domian complexed with lactose===

-	~~Description~~: ~~Crystal structure of galectin~~-~~3 CRD domian complexed~~ with ~~lactose~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21949831}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21949831 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21949831}}
		+
		+	==About this Structure==
		+	[[3aye]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AYE OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021949831</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Bian, C F.]]
		+	[[Category: Li, D F.]]
		+	[[Category: Wang, D C.]]
		+	[[Category: A -galactose-binding protein]]
		+	[[Category: Beta-galactoside]]
		+	[[Category: Cell-surface]]
		+	[[Category: Nuclear]]
		+	[[Category: Rossmann fold]]
		+	[[Category: Sugar binding protein]]

OCA at 04:42, 8 June 2011

OCA — Wed, 08 Jun 2011 04:42:36 GMT

←Older revision		Revision as of 04:42, 8 June 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3aye is ON HOLD	+	The entry 3aye is ON HOLD until Paper Publication

	Authors: Bian, C.F., Li, D.F., Wang, D.C.		Authors: Bian, C.F., Li, D.F., Wang, D.C.

	Description: Crystal structure of galectin-3 CRD domian complexed with lactose		Description: Crystal structure of galectin-3 CRD domian complexed with lactose

OCA: Protected "3aye" [edit=sysop:move=sysop]

OCA — Thu, 12 May 2011 04:13:16 GMT

Protected "3aye" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:13, 12 May 2011

OCA: New page: '''Unreleased structure''' The entry 3aye is ON HOLD Authors: Bian, C.F., Li, D.F., Wang, D.C. Description: Crystal structure of galectin-3 CRD domian complexed with lactose

OCA — Thu, 12 May 2011 04:13:14 GMT

New page: '''Unreleased structure''' The entry 3aye is ON HOLD Authors: Bian, C.F., Li, D.F., Wang, D.C. Description: Crystal structure of galectin-3 CRD domian complexed with lactose

New page

'''Unreleased structure'''

The entry 3aye is ON HOLD

Authors: Bian, C.F., Li, D.F., Wang, D.C.

Description: Crystal structure of galectin-3 CRD domian complexed with lactose