3azj - Revision history

OCA at 14:39, 1 November 2023

OCA — Wed, 01 Nov 2023 14:39:25 GMT

←Older revision		Revision as of 14:39, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3azj' size='340' side='right'caption='[[3azj]], [[Resolution\|resolution]] 2.89Å' scene=''>		<StructureSection load='3azj' size='340' side='right'caption='[[3azj]], [[Resolution\|resolution]] 2.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3azj]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AZJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3azj]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AZJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.89Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3afa\|3afa]]~~, ~~[[3ayw\|3ayw]], [[3aze\|3aze]], [[3azf\|3azf]], [[3azg\|3azg]], [[3azh\|3azh]], [[3azi\|3azi]], [[3azk\|3azk]], [[3azl\|3azl]], [[3azm\|3azm]], [[3azn\|3azn]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3azj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3azj OCA], [https://pdbe.org/3azj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3azj RCSB], [https://www.ebi.ac.uk/pdbsum/3azj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3azj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3azj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3azj OCA], [https://pdbe.org/3azj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3azj RCSB], [https://www.ebi.ac.uk/pdbsum/3azj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3azj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~H2B1J_HUMAN H2B1J_HUMAN~~]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>	+	[https://www.uniprot.org/uniprot/H31_HUMAN H31_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Iwasaki, W]]	+	[[Category: Iwasaki W]]
-	[[Category: Kagawa, W]]	+	[[Category: Kagawa W]]
-	[[Category: Kawaguchi, K]]	+	[[Category: Kawaguchi K]]
-	[[Category: Kurumizaka, H]]	+	[[Category: Kurumizaka H]]
-	[[Category: Shibata, T]]	+	[[Category: Shibata T]]
-	[[Category: Tachiwana, H]]	+	[[Category: Tachiwana H]]
-	~~[[Category: Histone-fold]]~~	+
-	~~[[Category: Nucleosome]]~~	+
-	~~[[Category: Structural protein-dna complex~~]]	+

OCA at 06:49, 12 May 2022

OCA — Thu, 12 May 2022 06:49:03 GMT

←Older revision		Revision as of 06:49, 12 May 2022
Line 3:		Line 3:
	<StructureSection load='3azj' size='340' side='right'caption='[[3azj]], [[Resolution\|resolution]] 2.89Å' scene=''>		<StructureSection load='3azj' size='340' side='right'caption='[[3azj]], [[Resolution\|resolution]] 2.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3azj]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3AZJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3azj]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AZJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3afa\|3afa]], [[3ayw\|3ayw]], [[3aze\|3aze]], [[3azf\|3azf]], [[3azg\|3azg]], [[3azh\|3azh]], [[3azi\|3azi]], [[3azk\|3azk]], [[3azl\|3azl]], [[3azm\|3azm]], [[3azn\|3azn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3afa\|3afa]], [[3ayw\|3ayw]], [[3aze\|3aze]], [[3azf\|3azf]], [[3azg\|3azg]], [[3azh\|3azh]], [[3azi\|3azi]], [[3azk\|3azk]], [[3azl\|3azl]], [[3azm\|3azm]], [[3azn\|3azn]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3azj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3azj OCA], [~~http~~://pdbe.org/3azj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3azj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3azj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3azj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3azj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3azj OCA], [https://pdbe.org/3azj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3azj RCSB], [https://www.ebi.ac.uk/pdbsum/3azj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3azj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>	+	[[https://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:14, 5 August 2020

OCA — Wed, 05 Aug 2020 06:14:21 GMT

←Older revision		Revision as of 06:14, 5 August 2020
Line 1:		Line 1:

	==Crystal Structure of Human Nucleosome Core Particle Containing H4K44Q mutation==		==Crystal Structure of Human Nucleosome Core Particle Containing H4K44Q mutation==
-	<StructureSection load='3azj' size='340' side='right' caption='[[3azj]], [[Resolution\|resolution]] 2.89Å' scene=''>	+	<StructureSection load='3azj' size='340' side='right'caption='[[3azj]], [[Resolution\|resolution]] 2.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3azj]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZJ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3AZJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3azj]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3AZJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3afa\|3afa]], [[3ayw\|3ayw]], [[3aze\|3aze]], [[3azf\|3azf]], [[3azg\|3azg]], [[3azh\|3azh]], [[3azi\|3azi]], [[3azk\|3azk]], [[3azl\|3azl]], [[3azm\|3azm]], [[3azn\|3azn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3afa\|3afa]], [[3ayw\|3ayw]], [[3aze\|3aze]], [[3azf\|3azf]], [[3azg\|3azg]], [[3azh\|3azh]], [[3azi\|3azi]], [[3azk\|3azk]], [[3azl\|3azl]], [[3azm\|3azm]], [[3azn\|3azn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3azj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3azj OCA], [http://pdbe.org/3azj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3azj RCSB], [http://www.ebi.ac.uk/pdbsum/3azj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3azj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3azj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3azj OCA], [http://pdbe.org/3azj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3azj RCSB], [http://www.ebi.ac.uk/pdbsum/3azj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3azj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Histone\|Histone]]	+	*[[Histone 3D structures\|Histone 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Iwasaki, W]]		[[Category: Iwasaki, W]]
	[[Category: Kagawa, W]]		[[Category: Kagawa, W]]

OCA at 14:26, 5 August 2016

OCA — Fri, 05 Aug 2016 14:26:12 GMT

←Older revision		Revision as of 14:26, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Human Nucleosome Core Particle Containing H4K44Q mutation==		==Crystal Structure of Human Nucleosome Core Particle Containing H4K44Q mutation==
	<StructureSection load='3azj' size='340' side='right' caption='[[3azj]], [[Resolution\|resolution]] 2.89Å' scene=''>		<StructureSection load='3azj' size='340' side='right' caption='[[3azj]], [[Resolution\|resolution]] 2.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3azj]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AZJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3azj]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AZJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3afa\|3afa]], [[3ayw\|3ayw]], [[3aze\|3aze]], [[3azf\|3azf]], [[3azg\|3azg]], [[3azh\|3azh]], [[3azi\|3azi]], [[3azk\|3azk]], [[3azl\|3azl]], [[3azm\|3azm]], [[3azn\|3azn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3afa\|3afa]], [[3ayw\|3ayw]], [[3aze\|3aze]], [[3azf\|3azf]], [[3azg\|3azg]], [[3azh\|3azh]], [[3azi\|3azi]], [[3azk\|3azk]], [[3azl\|3azl]], [[3azm\|3azm]], [[3azn\|3azn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3azj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3azj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3azj RCSB], [http://www.ebi.ac.uk/pdbsum/3azj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3azj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3azj OCA], [http://pdbe.org/3azj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3azj RCSB], [http://www.ebi.ac.uk/pdbsum/3azj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3azj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3azj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Iwasaki, W]]		[[Category: Iwasaki, W]]
	[[Category: Kagawa, W]]		[[Category: Kagawa, W]]

OCA at 19:33, 25 December 2014

OCA — Thu, 25 Dec 2014 19:33:35 GMT

←Older revision		Revision as of 19:33, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3azj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3azj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3azj RCSB], [http://www.ebi.ac.uk/pdbsum/3azj PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3azj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3azj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3azj RCSB], [http://www.ebi.ac.uk/pdbsum/3azj PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Iwasaki, W.]]	+	[[Category: Iwasaki, W]]
-	[[Category: Kagawa, W.]]	+	[[Category: Kagawa, W]]
-	[[Category: Kawaguchi, K.]]	+	[[Category: Kawaguchi, K]]
-	[[Category: Kurumizaka, H.]]	+	[[Category: Kurumizaka, H]]
-	[[Category: Shibata, T.]]	+	[[Category: Shibata, T]]
-	[[Category: Tachiwana, H.]]	+	[[Category: Tachiwana, H]]
	[[Category: Histone-fold]]		[[Category: Histone-fold]]
	[[Category: Nucleosome]]		[[Category: Nucleosome]]
	[[Category: Structural protein-dna complex]]		[[Category: Structural protein-dna complex]]

OCA at 09:22, 5 November 2014

OCA — Wed, 05 Nov 2014 09:22:51 GMT

←Older revision		Revision as of 09:22, 5 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3azj.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of Human Nucleosome Core Particle Containing H4K44Q mutation==
		+	<StructureSection load='3azj' size='340' side='right' caption='[[3azj]], [[Resolution\|resolution]] 2.89Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3azj]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AZJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3afa\|3afa]], [[3ayw\|3ayw]], [[3aze\|3aze]], [[3azf\|3azf]], [[3azg\|3azg]], [[3azh\|3azh]], [[3azi\|3azi]], [[3azk\|3azk]], [[3azl\|3azl]], [[3azm\|3azm]], [[3azn\|3azn]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3azj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3azj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3azj RCSB], [http://www.ebi.ac.uk/pdbsum/3azj PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Post-translational modifications (PTMs) of histones play important roles in regulating the structure and function of chromatin in eukaryotes. Although histone PTMs were considered to mainly occur at the N-terminal tails of histones, recent studies have revealed that PTMs also exist in the histone-fold domains, which are commonly shared among the core histones H2A, H2B, H3, and H4. The lysine residue is a major target for histone PTM, and the lysine to glutamine (KQ) substitution is known to mimic the acetylated states of specific histone lysine residues in vivo. Human histones H3 and H4 contain 11 lysine residues in their histone-fold domains (five for H3 and six for H4), and eight of these lysine residues are known to be targets for acetylation. In the present study, we prepared 11 mutant nucleosomes, in which each of the lysine residues of the H3 and H4 histone-fold domains was replaced by glutamine: H3 K56Q, H3 K64Q, H3 K79Q, H3 K115Q, H3 K122Q, H4 K31Q, H4 K44Q, H4 K59Q, H4 K77Q, H4 K79Q, and H4 K91Q. The crystal structures of these mutant nucleosomes were determined at 2.4-3.5 A resolutions. Some of these amino acid substitutions altered the local protein-DNA interactions and the interactions between amino acid residues within the nucleosome. Interestingly, the C-terminal region of H2A was significantly disordered in the nucleosome containing H4 K44Q. These results provide an important structural basis for understanding how histone modifications and mutations affect chromatin structure and function.

-	~~{{STRUCTURE_3azj\| PDB=3azj \| SCENE= }}~~	+	Comprehensive Structural Analysis of Mutant Nucleosomes Containing Lysine to Glutamine (KQ) Substitutions in the H3 and H4 Histone-Fold Domains.,Iwasaki W, Tachiwana H, Kawaguchi K, Shibata T, Kagawa W, Kurumizaka H Biochemistry. 2011 Sep 13;50(36):7822-32. Epub 2011 Aug 17. PMID:21812398<ref>PMID:21812398</ref>

-	~~===Crystal Structure~~ of ~~Human Nucleosome Core Particle Containing H4K44Q mutation===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21812398}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3azj]] is a 10 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3AZJ OCA].~~	+

	==See Also==		==See Also==
	*[[Histone\|Histone]]		*[[Histone\|Histone]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021812398<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Iwasaki, W.]]		[[Category: Iwasaki, W.]]

OCA at 20:35, 20 October 2012

OCA — Sat, 20 Oct 2012 20:35:25 GMT

←Older revision		Revision as of 20:35, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3azj]] is a 10 chain structure ~~of [[Histone]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZJ OCA].	+	[[3azj]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZJ OCA].

	==See Also==		==See Also==

OCA at 10:58, 27 July 2012

OCA — Fri, 27 Jul 2012 10:58:57 GMT

←Older revision		Revision as of 10:58, 27 July 2012
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-	[[Image:3azj.~~jpg~~\|left\|200px]]	+	[[Image:3azj.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3azj", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3azj\| PDB=3azj \| SCENE= }}		{{STRUCTURE_3azj\| PDB=3azj \| SCENE= }}

	===Crystal Structure of Human Nucleosome Core Particle Containing H4K44Q mutation===		===Crystal Structure of Human Nucleosome Core Particle Containing H4K44Q mutation===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21812398}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21812398 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21812398}}		{{ABSTRACT_PUBMED_21812398}}

	==About this Structure==		==About this Structure==
-	[[3azj]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZJ OCA].	+	[[3azj]] is a 10 chain structure of [[Histone]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZJ OCA].
		+
		+	==See Also==
		+	*[[Histone\|Histone]]

	==Reference==		==Reference==

OCA at 05:58, 21 September 2011

OCA — Wed, 21 Sep 2011 05:58:09 GMT

←Older revision		Revision as of 05:58, 21 September 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3azj.jpg\|left\|200px]]

-	The ~~entry 3azj~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3azj", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3azj\| PDB=3azj \| SCENE= }}

-	~~Authors: Iwasaki, W., Tachiwana, H., Kawaguchi, K., Shibata, T., Kagawa, W., Kurumizaka, H.~~	+	===Crystal Structure of Human Nucleosome Core Particle Containing H4K44Q mutation===

-	~~Description~~: ~~Crystal~~ Structure ~~of Human~~ Nucleosome ~~Core Particle Containing H4K44Q mutation~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21812398}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21812398 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21812398}}
		+
		+	==About this Structure==
		+	[[3azj]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZJ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021812398</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Iwasaki, W.]]
		+	[[Category: Kagawa, W.]]
		+	[[Category: Kawaguchi, K.]]
		+	[[Category: Kurumizaka, H.]]
		+	[[Category: Shibata, T.]]
		+	[[Category: Tachiwana, H.]]
		+	[[Category: Histone-fold]]
		+	[[Category: Nucleosome]]
		+	[[Category: Structural protein-dna complex]]

OCA at 06:02, 20 July 2011

OCA — Wed, 20 Jul 2011 06:02:22 GMT

←Older revision		Revision as of 06:02, 20 July 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3azj is ON HOLD	+	The entry 3azj is ON HOLD until Paper Publication

	Authors: Iwasaki, W., Tachiwana, H., Kawaguchi, K., Shibata, T., Kagawa, W., Kurumizaka, H.		Authors: Iwasaki, W., Tachiwana, H., Kawaguchi, K., Shibata, T., Kagawa, W., Kurumizaka, H.

	Description: Crystal Structure of Human Nucleosome Core Particle Containing H4K44Q mutation		Description: Crystal Structure of Human Nucleosome Core Particle Containing H4K44Q mutation