3b0t - Revision history

OCA at 08:51, 11 October 2023

OCA — Wed, 11 Oct 2023 08:51:18 GMT

←Older revision		Revision as of 08:51, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='3b0t' size='340' side='right'caption='[[3b0t]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='3b0t' size='340' side='right'caption='[[3b0t]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3b0t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B0T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3b0t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B0T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MCZ:(1S,3R,5Z,7E,14BETA,17ALPHA,20S)-20-(3-HYDROXY-3-METHYLBUTOXY)-9,10-SECOPREGNA-5,7,10-TRIENE-1,3-DIOL'>MCZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VDR, NR1I1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MCZ:(1S,3R,5Z,7E,14BETA,17ALPHA,20S)-20-(3-HYDROXY-3-METHYLBUTOXY)-9,10-SECOPREGNA-5,7,10-TRIENE-1,3-DIOL'>MCZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0t OCA], [https://pdbe.org/3b0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b0t RCSB], [https://www.ebi.ac.uk/pdbsum/3b0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b0t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0t OCA], [https://pdbe.org/3b0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b0t RCSB], [https://www.ebi.ac.uk/pdbsum/3b0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b0t ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN]] Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:[https://omim.org/entry/277440 277440]]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.<ref>PMID:2849209</ref> <ref>PMID:8381803</ref> <ref>PMID:1652893</ref> <ref>PMID:2177843</ref> <ref>PMID:8106618</ref> <ref>PMID:8392085</ref> <ref>PMID:7828346</ref> <ref>PMID:8675579</ref> <ref>PMID:8961271</ref> <ref>PMID:9005998</ref>	+	[https://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN] Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:[https://omim.org/entry/277440 277440]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.<ref>PMID:2849209</ref> <ref>PMID:8381803</ref> <ref>PMID:1652893</ref> <ref>PMID:2177843</ref> <ref>PMID:8106618</ref> <ref>PMID:8392085</ref> <ref>PMID:7828346</ref> <ref>PMID:8675579</ref> <ref>PMID:8961271</ref> <ref>PMID:9005998</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:16252006</ref> <ref>PMID:10678179</ref> <ref>PMID:15728261</ref> <ref>PMID:16913708</ref>	+	[https://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:16252006</ref> <ref>PMID:10678179</ref> <ref>PMID:15728261</ref> <ref>PMID:16913708</ref>

	==See Also==		==See Also==
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hashimoto, H]]	+	[[Category: Hashimoto H]]
-	[[Category: Hishiki, A]]	+	[[Category: Hishiki A]]
-	[[Category: Sato, M]]	+	[[Category: Sato M]]
-	[[Category: Shimizu, T]]	+	[[Category: Shimizu T]]
-	~~[[Category: Gene regulation]]~~	+
-	~~[[Category: Nuclear receptor]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 11:19, 5 January 2022

OCA — Wed, 05 Jan 2022 11:19:47 GMT

←Older revision		Revision as of 11:19, 5 January 2022
Line 1:		Line 1:

	==Human VDR ligand binding domain in complex with maxacalcitol==		==Human VDR ligand binding domain in complex with maxacalcitol==
-	<StructureSection load='3b0t' size='340' side='right' caption='[[3b0t]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='3b0t' size='340' side='right'caption='[[3b0t]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3b0t]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3B0T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3b0t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B0T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MCZ:(1S,3R,5Z,7E,14BETA,17ALPHA,20S)-20-(3-HYDROXY-3-METHYLBUTOXY)-9,10-SECOPREGNA-5,7,10-TRIENE-1,3-DIOL'>MCZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MCZ:(1S,3R,5Z,7E,14BETA,17ALPHA,20S)-20-(3-HYDROXY-3-METHYLBUTOXY)-9,10-SECOPREGNA-5,7,10-TRIENE-1,3-DIOL'>MCZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VDR, NR1I1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VDR, NR1I1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3b0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0t OCA], [~~http~~://pdbe.org/3b0t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3b0t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3b0t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3b0t ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0t OCA], [https://pdbe.org/3b0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b0t RCSB], [https://www.ebi.ac.uk/pdbsum/3b0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b0t ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN]] Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:[~~http~~://omim.org/entry/277440 277440]]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.<ref>PMID:2849209</ref> <ref>PMID:8381803</ref> <ref>PMID:1652893</ref> <ref>PMID:2177843</ref> <ref>PMID:8106618</ref> <ref>PMID:8392085</ref> <ref>PMID:7828346</ref> <ref>PMID:8675579</ref> <ref>PMID:8961271</ref> <ref>PMID:9005998</ref>	+	[[https://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN]] Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:[https://omim.org/entry/277440 277440]]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.<ref>PMID:2849209</ref> <ref>PMID:8381803</ref> <ref>PMID:1652893</ref> <ref>PMID:2177843</ref> <ref>PMID:8106618</ref> <ref>PMID:8392085</ref> <ref>PMID:7828346</ref> <ref>PMID:8675579</ref> <ref>PMID:8961271</ref> <ref>PMID:9005998</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:16252006</ref> <ref>PMID:10678179</ref> <ref>PMID:15728261</ref> <ref>PMID:16913708</ref>	+	[[https://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:16252006</ref> <ref>PMID:10678179</ref> <ref>PMID:15728261</ref> <ref>PMID:16913708</ref>

	==See Also==		==See Also==
	*[[Sandbox vdr\|Sandbox vdr]]		*[[Sandbox vdr\|Sandbox vdr]]
-	*[[Vitamin D receptor\|Vitamin D receptor]]	+	*[[Vitamin D receptor 3D structures\|Vitamin D receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hashimoto, H]]		[[Category: Hashimoto, H]]
	[[Category: Hishiki, A]]		[[Category: Hishiki, A]]

OCA at 19:20, 5 August 2016

OCA — Fri, 05 Aug 2016 19:20:31 GMT

←Older revision		Revision as of 19:20, 5 August 2016
Line 1:		Line 1:
		+
	==Human VDR ligand binding domain in complex with maxacalcitol==		==Human VDR ligand binding domain in complex with maxacalcitol==
	<StructureSection load='3b0t' size='340' side='right' caption='[[3b0t]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='3b0t' size='340' side='right' caption='[[3b0t]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3b0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B0T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3b0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B0T FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MCZ:(1S,3R,5Z,7E,14BETA,17ALPHA,20S)-20-(3-HYDROXY-3-METHYLBUTOXY)-9,10-SECOPREGNA-5,7,10-TRIENE-1,3-DIOL'>MCZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MCZ:(1S,3R,5Z,7E,14BETA,17ALPHA,20S)-20-(3-HYDROXY-3-METHYLBUTOXY)-9,10-SECOPREGNA-5,7,10-TRIENE-1,3-DIOL'>MCZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VDR, NR1I1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VDR, NR1I1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b0t RCSB], [http://www.ebi.ac.uk/pdbsum/3b0t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0t OCA], [http://pdbe.org/3b0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3b0t RCSB], [http://www.ebi.ac.uk/pdbsum/3b0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3b0t ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hashimoto, H]]		[[Category: Hashimoto, H]]
	[[Category: Hishiki, A]]		[[Category: Hishiki, A]]

OCA at 14:20, 18 December 2014

OCA — Thu, 18 Dec 2014 14:20:15 GMT

←Older revision		Revision as of 14:20, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3b0t\| PDB=3b0t \| SCENE= }}~~	+	==Human VDR ligand binding domain in complex with maxacalcitol==
-	===Human VDR ligand binding domain in complex with maxacalcitol===	+	<StructureSection load='3b0t' size='340' side='right' caption='[[3b0t]], [[Resolution\|resolution]] 1.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3b0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B0T FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MCZ:(1S,3R,5Z,7E,14BETA,17ALPHA,20S)-20-(3-HYDROXY-3-METHYLBUTOXY)-9,10-SECOPREGNA-5,7,10-TRIENE-1,3-DIOL'>MCZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VDR, NR1I1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b0t RCSB], [http://www.ebi.ac.uk/pdbsum/3b0t PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN]] Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:[http://omim.org/entry/277440 277440]]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.<ref>PMID:2849209</ref> <ref>PMID:8381803</ref> <ref>PMID:1652893</ref> <ref>PMID:2177843</ref> <ref>PMID:8106618</ref> <ref>PMID:8392085</ref> <ref>PMID:7828346</ref> <ref>PMID:8675579</ref> <ref>PMID:8961271</ref> <ref>PMID:9005998</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:16252006</ref> <ref>PMID:10678179</ref> <ref>PMID:15728261</ref> <ref>PMID:16913708</ref>

-	==~~Disease~~==	+	==See Also==
-	[[~~http://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN~~]] ~~Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A)~~ [~~MIM:~~[~~http://omim.org/entry/277440 277440]]. A disorder of vitamin~~ D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.<ref>PMID:2849209</ref><ref>PMID:8381803</ref><ref>PMID:1652893</ref><ref>PMID:2177843</ref><ref>PMID:8106618</ref><ref>PMID:8392085</ref><ref>PMID:7828346</ref><ref>PMID:8675579</ref><ref>PMID:8961271</ref><ref>PMID:9005998</ref>	+	*[[Sandbox vdr\|Sandbox vdr]]
-		+	*[[Vitamin D receptor\|Vitamin D receptor]]
-	~~==Function==~~	+	== References ==
-	~~[[http://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN]] Nuclear hormone~~ receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:16252006</ref><ref>PMID:10678179</ref><ref>PMID:15728261</ref><ref>PMID:16913708</ref>	+	<references/>
-		+	__TOC__
-	~~==About this Structure==~~	+	</StructureSection>
-	~~[[3b0t~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0T OCA].	+
-		+
-	==~~Reference~~==	+
-	<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hashimoto, H.]]	+	[[Category: Hashimoto, H]]
-	[[Category: Hishiki, A.]]	+	[[Category: Hishiki, A]]
-	[[Category: Sato, M.]]	+	[[Category: Sato, M]]
-	[[Category: Shimizu, T.]]	+	[[Category: Shimizu, T]]
	[[Category: Gene regulation]]		[[Category: Gene regulation]]
	[[Category: Nuclear receptor]]		[[Category: Nuclear receptor]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 04:01, 25 March 2013

OCA — Mon, 25 Mar 2013 04:01:54 GMT

←Older revision		Revision as of 04:01, 25 March 2013
Line 1:		Line 1:
-	[[Image:3b0t.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3b0t", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3b0t\| PDB=3b0t \| SCENE= }}		{{STRUCTURE_3b0t\| PDB=3b0t \| SCENE= }}
-
	===Human VDR ligand binding domain in complex with maxacalcitol===		===Human VDR ligand binding domain in complex with maxacalcitol===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN]] Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:[http://omim.org/entry/277440 277440]]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.<ref>PMID:2849209</ref><ref>PMID:8381803</ref><ref>PMID:1652893</ref><ref>PMID:2177843</ref><ref>PMID:8106618</ref><ref>PMID:8392085</ref><ref>PMID:7828346</ref><ref>PMID:8675579</ref><ref>PMID:8961271</ref><ref>PMID:9005998</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:16252006</ref><ref>PMID:10678179</ref><ref>PMID:15728261</ref><ref>PMID:16913708</ref>

	==About this Structure==		==About this Structure==
	[[3b0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0T OCA].		[[3b0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0T OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hashimoto, H.]]		[[Category: Hashimoto, H.]]

OCA at 06:11, 10 August 2011

OCA — Wed, 10 Aug 2011 06:11:33 GMT

←Older revision		Revision as of 06:11, 10 August 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3b0t.jpg\|left\|200px]]

-	The ~~entry 3b0t~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3b0t", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3b0t\| PDB=3b0t \| SCENE= }}

-	~~Authors: Hishiki, A., Hashimoto, H., Sato, M., Shimizu, T.~~	+	===Human VDR ligand binding domain in complex with maxacalcitol===

-	~~Description: Human VDR ligand binding domain in complex~~ with ~~maxacalcitol~~	+
		+	==About this Structure==
		+	[[3b0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0T OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Hashimoto, H.]]
		+	[[Category: Hishiki, A.]]
		+	[[Category: Sato, M.]]
		+	[[Category: Shimizu, T.]]
		+	[[Category: Gene regulation]]
		+	[[Category: Nuclear receptor]]
		+	[[Category: Transcription]]

OCA at 18:16, 6 July 2011

OCA — Wed, 06 Jul 2011 18:16:44 GMT

←Older revision		Revision as of 18:16, 6 July 2011
Line 5:		Line 5:
	Authors: Hishiki, A., Hashimoto, H., Sato, M., Shimizu, T.		Authors: Hishiki, A., Hashimoto, H., Sato, M., Shimizu, T.

-	Description: ~~human~~ VDR ligand binding domain in complex with maxacalcitol	+	Description: Human VDR ligand binding domain in complex with maxacalcitol

OCA: Protected "3b0t" [edit=sysop:move=sysop]

OCA — Wed, 22 Jun 2011 16:09:33 GMT

Protected "3b0t" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:09, 22 June 2011

OCA: New page: '''Unreleased structure''' The entry 3b0t is ON HOLD Authors: Hishiki, A., Hashimoto, H., Sato, M., Shimizu, T. Description: human VDR ligand binding domain in complex with maxacalcito...

OCA — Wed, 22 Jun 2011 16:09:32 GMT

New page: '''Unreleased structure''' The entry 3b0t is ON HOLD Authors: Hishiki, A., Hashimoto, H., Sato, M., Shimizu, T. Description: human VDR ligand binding domain in complex with maxacalcito...

New page

'''Unreleased structure'''

The entry 3b0t is ON HOLD

Authors: Hishiki, A., Hashimoto, H., Sato, M., Shimizu, T.

Description: human VDR ligand binding domain in complex with maxacalcitol