3b1o - Revision history

OCA at 08:51, 11 October 2023

OCA — Wed, 11 Oct 2023 08:51:46 GMT

←Older revision		Revision as of 08:51, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='3b1o' size='340' side='right'caption='[[3b1o]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3b1o' size='340' side='right'caption='[[3b1o]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3b1o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Burta Burta~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B1O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3b1o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_thailandensis_E264 Burkholderia thailandensis E264]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B1O FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3b1n\|3b1n]], [[3b1p\|3b1p]], [[3b1q\|3b1q]], [[3b1r\|3b1r]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">Bth_I1158 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271848 BURTA])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Diphosphate-purine_nucleoside_kinase Diphosphate-purine nucleoside kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1~~.143 2.7.1.143] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b1o OCA], [https://pdbe.org/3b1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b1o RCSB], [https://www.ebi.ac.uk/pdbsum/3b1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b1o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b1o OCA], [https://pdbe.org/3b1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b1o RCSB], [https://www.ebi.ac.uk/pdbsum/3b1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b1o ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q2SZE4_BURTA Q2SZE4_BURTA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Burta]]~~	+	[[Category: Burkholderia thailandensis E264]]
-	~~[[Category: Diphosphate-purine nucleoside kinase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hino, E]]	+	[[Category: Hino E]]
-	[[Category: Ota, H]]	+	[[Category: Ota H]]
-	[[Category: Sakasegawa, S]]	+	[[Category: Sakasegawa S]]
-	[[Category: Tamura, T]]	+	[[Category: Tamura T]]
-	[[Category: Yasutake, Y]]	+	[[Category: Yasutake Y]]
-	~~[[Category: Atp binding]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Mg binding]]~~	+
-	~~[[Category: Nucleoside binding]]~~	+
-	~~[[Category: Rossmann fold]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:20, 5 January 2022

OCA — Wed, 05 Jan 2022 11:20:30 GMT

←Older revision		Revision as of 11:20, 5 January 2022
Line 1:		Line 1:

	==Structure of Burkholderia thailandensis nucleoside kinase (BthNK) in ligand-free form==		==Structure of Burkholderia thailandensis nucleoside kinase (BthNK) in ligand-free form==
-	<StructureSection load='3b1o' size='340' side='right' caption='[[3b1o]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='3b1o' size='340' side='right'caption='[[3b1o]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3b1o]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Burta Burta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B1O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3B1O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3b1o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burta Burta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B1O FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b1n\|3b1n]], [[3b1p\|3b1p]], [[3b1q\|3b1q]], [[3b1r\|3b1r]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3b1n\|3b1n]], [[3b1p\|3b1p]], [[3b1q\|3b1q]], [[3b1r\|3b1r]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bth_I1158 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271848 BURTA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bth_I1158 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271848 BURTA])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Diphosphate-purine_nucleoside_kinase Diphosphate-purine nucleoside kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.143 2.7.1.143] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Diphosphate-purine_nucleoside_kinase Diphosphate-purine nucleoside kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.143 2.7.1.143] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3b1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b1o OCA], [~~http~~://pdbe.org/3b1o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3b1o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3b1o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3b1o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b1o OCA], [https://pdbe.org/3b1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b1o RCSB], [https://www.ebi.ac.uk/pdbsum/3b1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b1o ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 24:
	[[Category: Burta]]		[[Category: Burta]]
	[[Category: Diphosphate-purine nucleoside kinase]]		[[Category: Diphosphate-purine nucleoside kinase]]
		+	[[Category: Large Structures]]
	[[Category: Hino, E]]		[[Category: Hino, E]]
	[[Category: Ota, H]]		[[Category: Ota, H]]

OCA at 15:54, 4 August 2016

OCA — Thu, 04 Aug 2016 15:54:42 GMT

←Older revision		Revision as of 15:54, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of Burkholderia thailandensis nucleoside kinase (BthNK) in ligand-free form==		==Structure of Burkholderia thailandensis nucleoside kinase (BthNK) in ligand-free form==
	<StructureSection load='3b1o' size='340' side='right' caption='[[3b1o]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3b1o' size='340' side='right' caption='[[3b1o]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3b1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Burkholderia_thailandensis Burkholderia thailandensis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B1O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3b1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burta Burta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B1O FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b1n\|3b1n]], [[3b1p\|3b1p]], [[3b1q\|3b1q]], [[3b1r\|3b1r]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b1n\|3b1n]], [[3b1p\|3b1p]], [[3b1q\|3b1q]], [[3b1r\|3b1r]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bth_I1158 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~57975 Burkholderia thailandensis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bth_I1158 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271848 BURTA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diphosphate-purine_nucleoside_kinase Diphosphate-purine nucleoside kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.143 2.7.1.143] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diphosphate-purine_nucleoside_kinase Diphosphate-purine nucleoside kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.143 2.7.1.143] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b1o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b1o RCSB], [http://www.ebi.ac.uk/pdbsum/3b1o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b1o OCA], [http://pdbe.org/3b1o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3b1o RCSB], [http://www.ebi.ac.uk/pdbsum/3b1o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3b1o ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3b1o" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Burkholderia thailandensis~~]]	+	[[Category: Burta]]
	[[Category: Diphosphate-purine nucleoside kinase]]		[[Category: Diphosphate-purine nucleoside kinase]]
	[[Category: Hino, E]]		[[Category: Hino, E]]

OCA at 22:47, 3 January 2015

OCA — Sat, 03 Jan 2015 22:47:26 GMT

←Older revision		Revision as of 22:47, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3b1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_thailandensis Burkholderia thailandensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B1O FirstGlance]. <br>		<table><tr><td colspan='2'>[[3b1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_thailandensis Burkholderia thailandensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B1O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b1n\|3b1n]], [[3b1p\|3b1p]], [[3b1q\|3b1q]], [[3b1r\|3b1r]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b1n\|3b1n]], [[3b1p\|3b1p]], [[3b1q\|3b1q]], [[3b1r\|3b1r]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bth_I1158 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=57975 Burkholderia thailandensis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bth_I1158 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=57975 Burkholderia thailandensis])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diphosphate-purine_nucleoside_kinase Diphosphate-purine nucleoside kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.143 2.7.1.143] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diphosphate-purine_nucleoside_kinase Diphosphate-purine nucleoside kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.143 2.7.1.143] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b1o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b1o RCSB], [http://www.ebi.ac.uk/pdbsum/3b1o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b1o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b1o RCSB], [http://www.ebi.ac.uk/pdbsum/3b1o PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 14:
	Structures of Burkholderia thailandensis nucleoside kinase: implications for the catalytic mechanism and nucleoside selectivity.,Yasutake Y, Ota H, Hino E, Sakasegawa S, Tamura T Acta Crystallogr D Biol Crystallogr. 2011 Nov;67(Pt 11):945-56. Epub 2011 Oct 19. PMID:22101821<ref>PMID:22101821</ref>		Structures of Burkholderia thailandensis nucleoside kinase: implications for the catalytic mechanism and nucleoside selectivity.,Yasutake Y, Ota H, Hino E, Sakasegawa S, Tamura T Acta Crystallogr D Biol Crystallogr. 2011 Nov;67(Pt 11):945-56. Epub 2011 Oct 19. PMID:22101821<ref>PMID:22101821</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 22:		Line 22:
	[[Category: Burkholderia thailandensis]]		[[Category: Burkholderia thailandensis]]
	[[Category: Diphosphate-purine nucleoside kinase]]		[[Category: Diphosphate-purine nucleoside kinase]]
-	[[Category: Hino, E.]]	+	[[Category: Hino, E]]
-	[[Category: Ota, H.]]	+	[[Category: Ota, H]]
-	[[Category: Sakasegawa, S.]]	+	[[Category: Sakasegawa, S]]
-	[[Category: Tamura, T.]]	+	[[Category: Tamura, T]]
-	[[Category: Yasutake, Y.]]	+	[[Category: Yasutake, Y]]
	[[Category: Atp binding]]		[[Category: Atp binding]]
	[[Category: Kinase]]		[[Category: Kinase]]

OCA at 11:03, 14 May 2014

OCA — Wed, 14 May 2014 11:03:21 GMT

←Older revision		Revision as of 11:03, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3b1o.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of Burkholderia thailandensis nucleoside kinase (BthNK) in ligand-free form==
		+	<StructureSection load='3b1o' size='340' side='right' caption='[[3b1o]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3b1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_thailandensis Burkholderia thailandensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B1O FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b1n\|3b1n]], [[3b1p\|3b1p]], [[3b1q\|3b1q]], [[3b1r\|3b1r]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bth_I1158 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=57975 Burkholderia thailandensis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diphosphate-purine_nucleoside_kinase Diphosphate-purine nucleoside kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.143 2.7.1.143] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b1o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b1o RCSB], [http://www.ebi.ac.uk/pdbsum/3b1o PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The nucleoside kinase (NK) from the mesophilic Gram-negative bacterium Burkholderia thailandensis (BthNK) is a member of the phosphofructokinase B (Pfk-B) family and catalyzes the Mg(2+)- and ATP-dependent phosphorylation of a broad range of nucleosides such as inosine (INO), adenosine (ADO) and mizoribine (MZR). BthNK is currently used in clinical practice to measure serum MZR levels. Here, crystal structures of BthNK in a ligand-free form and in complexes with INO, INO-ADP, MZR-ADP and AMP-Mg(2+)-AMP are described. The typical homodimeric architecture of Pfk-B enzymes was detected in three distinct conformational states: an asymmetric dimer with one subunit in an open conformation and the other in a closed conformation (the ligand-free form), a closed conformation (the binary complex with INO) and a fully closed conformation (the other ternary and quaternary complexes). The previously unreported fully closed structures suggest the possibility that Mg(2+) might directly interact with the beta- and gamma-phosphates of ATP to maintain neutralization of the negative charge throughout the reaction. The nucleoside-complex structures also showed that the base moiety of the bound nucleoside is partly exposed to the solvent, thereby enabling the recognition of a wide range of nucleoside bases. Gly170 is responsible for the solvent accessibility of the base moiety and is assumed to be a key residue for the broad nucleoside recognition of BthNK. Remarkably, the G170Q mutation increases the specificity of BthNK for ADO. These findings provide insight into the conformational dynamics, catalytic mechanism and nucleoside selectivity of BthNK and related enzymes.

-	~~<!--~~	+	Structures of Burkholderia thailandensis nucleoside kinase: implications for the catalytic mechanism and nucleoside selectivity.,Yasutake Y, Ota H, Hino E, Sakasegawa S, Tamura T Acta Crystallogr D Biol Crystallogr. 2011 Nov;67(Pt 11):945-56. Epub 2011 Oct 19. PMID:22101821<ref>PMID:22101821</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3b1o"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3b1o\| PDB=3b1o \| SCENE= }}~~	+

-	~~===Structure~~ of ~~Burkholderia thailandensis nucleoside kinase (BthNK) in ligand-free form===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22101821}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22101821 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22101821}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3b1o]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Burkholderia_thailandensis Burkholderia thailandensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B1O OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022101821<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Burkholderia thailandensis]]		[[Category: Burkholderia thailandensis]]
	[[Category: Diphosphate-purine nucleoside kinase]]		[[Category: Diphosphate-purine nucleoside kinase]]

OCA at 06:48, 18 April 2012

OCA — Wed, 18 Apr 2012 06:48:55 GMT

←Older revision		Revision as of 06:48, 18 April 2012
Line 1:		Line 1:
-	[[Image:3b1o.~~jpg~~\|left\|200px]]	+	[[Image:3b1o.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Structure of Burkholderia thailandensis nucleoside kinase (BthNK) in ligand-free form===		===Structure of Burkholderia thailandensis nucleoside kinase (BthNK) in ligand-free form===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22101821}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22101821 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22101821}}

	==About this Structure==		==About this Structure==
	[[3b1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_thailandensis Burkholderia thailandensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B1O OCA].		[[3b1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_thailandensis Burkholderia thailandensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B1O OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022101821</ref><references group="xtra"/>
	[[Category: Burkholderia thailandensis]]		[[Category: Burkholderia thailandensis]]
	[[Category: Diphosphate-purine nucleoside kinase]]		[[Category: Diphosphate-purine nucleoside kinase]]

OCA at 08:30, 2 November 2011

OCA — Wed, 02 Nov 2011 08:30:11 GMT

←Older revision		Revision as of 08:30, 2 November 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3b1o.jpg\|left\|200px]]

-	The ~~entry 3b1o~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3b1o", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3b1o\| PDB=3b1o \| SCENE= }}

-	~~Authors: Yasutake, Y., Ota, H., Hino, E., Sakasegawa, S., Tamura, T.~~	+	===Structure of Burkholderia thailandensis nucleoside kinase (BthNK) in ligand-free form===

-	~~Description:~~ Structure of Burkholderia thailandensis nucleoside kinase ~~(BthNK) in ligand-free form~~	+
		+	==About this Structure==
		+	[[3b1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_thailandensis Burkholderia thailandensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B1O OCA].
		+	[[Category: Burkholderia thailandensis]]
		+	[[Category: Diphosphate-purine nucleoside kinase]]
		+	[[Category: Hino, E.]]
		+	[[Category: Ota, H.]]
		+	[[Category: Sakasegawa, S.]]
		+	[[Category: Tamura, T.]]
		+	[[Category: Yasutake, Y.]]
		+	[[Category: Atp binding]]
		+	[[Category: Kinase]]
		+	[[Category: Mg binding]]
		+	[[Category: Nucleoside binding]]
		+	[[Category: Rossmann fold]]
		+	[[Category: Transferase]]

OCA at 05:31, 27 July 2011

OCA — Wed, 27 Jul 2011 05:31:17 GMT

←Older revision		Revision as of 05:31, 27 July 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3b1o is ON HOLD	+	The entry 3b1o is ON HOLD until Paper Publication

	Authors: Yasutake, Y., Ota, H., Hino, E., Sakasegawa, S., Tamura, T.		Authors: Yasutake, Y., Ota, H., Hino, E., Sakasegawa, S., Tamura, T.

	Description: Structure of Burkholderia thailandensis nucleoside kinase (BthNK) in ligand-free form		Description: Structure of Burkholderia thailandensis nucleoside kinase (BthNK) in ligand-free form

OCA: Protected "3b1o" [edit=sysop:move=sysop]

OCA — Wed, 13 Jul 2011 06:42:23 GMT

Protected "3b1o" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:42, 13 July 2011

OCA: New page: '''Unreleased structure''' The entry 3b1o is ON HOLD Authors: Yasutake, Y., Ota, H., Hino, E., Sakasegawa, S., Tamura, T. Description: Structure of Burkholderia thailandensis nucleosid...

OCA — Wed, 13 Jul 2011 06:42:22 GMT

New page: '''Unreleased structure''' The entry 3b1o is ON HOLD Authors: Yasutake, Y., Ota, H., Hino, E., Sakasegawa, S., Tamura, T. Description: Structure of Burkholderia thailandensis nucleosid...

New page

'''Unreleased structure'''

The entry 3b1o is ON HOLD

Authors: Yasutake, Y., Ota, H., Hino, E., Sakasegawa, S., Tamura, T.

Description: Structure of Burkholderia thailandensis nucleoside kinase (BthNK) in ligand-free form